Struggling Student System<\/title>\r\n <link rel=\"stylesheet\" href=\"\/lib\/bootstrap\/dist\/css\/bootstrap.min.css\" \/>\r\n <link rel=\"stylesheet\" href=\"\/css\/site.css?v=AKvNjO3dCPPS0eSU1Ez8T2wI280i08yGycV9ndytL-c\" \/>\r\n <link rel=\"stylesheet\" href=\"\/Informative_Exam_System.styles.css?v=BGdvP_FBOWiMWg-g4mzfuCD-pFWud7Q8bDVVE6HC9zc\" \/>\r\n <link rel=\"icon\" type=\"image\/png\" href=\"\/images\/MertLog12.png\" sizes=\"16x16\" style=\"border:1px;border-radius:50%\">\r\n <link href=\"\/css\/all.min.css\" rel=\"stylesheet\" \/>\r\n\r\n <link href=\"\/datatable\/datatables.min.css\" rel=\"stylesheet\" \/>\r\n\r\n <style>\r\n\r\n .ac {\r\n text-decoration: none;\r\n transition: 0.4s;\r\n border-radius: 5px;\r\n }\r\n\r\n \/* .ac:hover {\r\n box-shadow: 0 4px 8px 0 rgba(0, 0, 0, 0.2);\r\n background: maroon;\r\n } *\/\r\n .act {\r\n box-shadow: 0 4px 8px 0 rgba(0, 0, 0, 0.2);\r\n background-color: #1e81b0;\r\n color: white !important;\r\n }\r\n\r\n\r\n 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initial-scale=1.0\">\r\n <title>Research Publications Database<\/title>\r\n <style>\r\n * {\r\n box-sizing: border-box;\r\n margin: 0;\r\n padding: 0;\r\n font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif;\r\n }\r\n \r\n body {\r\n background-color: #f5f7fa;\r\n color: #333;\r\n line-height: 1.6;\r\n }\r\n \r\n .container {\r\n max-width: 1200px;\r\n margin: 0 auto;\r\n padding: 20px;\r\n }\r\n \r\n \r\n \r\n h1 {\r\n font-size: 2.5rem;\r\n margin-bottom: 10px;\r\n }\r\n \r\n .subtitle {\r\n font-size: 1.2rem;\r\n opacity: 0.9;\r\n }\r\n \r\n .search-section {\r\n background-color: white;\r\n padding: 25px;\r\n border-radius: 8px;\r\n box-shadow: 0 4px 8px rgba(0, 0, 0, 0.05);\r\n margin-bottom: 30px;\r\n }\r\n \r\n .search-box {\r\n display: flex;\r\n gap: 15px;\r\n margin-bottom: 20px;\r\n }\r\n \r\n input[type=\"text\"] {\r\n flex: 1;\r\n padding: 12px 15px;\r\n border: 1px solid #ddd;\r\n border-radius: 4px;\r\n font-size: 1rem;\r\n transition: border 0.3s;\r\n }\r\n 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data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1>\r\n <div class=\"container\">\r\n <header>\r\n <h1 style=\"margin-top:25px\">Merit University - Scopus Indexed Publications<\/h1>\r\n \r\n <\/header>\r\n \r\n <section class=\"search-section\">\r\n <div class=\"search-box\">\r\n <input type=\"text\" id=\"searchInput\" placeholder=\"Search publications by title, author, keywords, or abstract...\">\r\n <button id=\"searchButton\">Search<\/button>\r\n <\/div>\r\n \r\n <div class=\"filters\">\r\n <div class=\"filter-group\">\r\n <label for=\"authorFilter\">Filter by Author<\/label>\r\n <select id=\"authorFilter\">\r\n <option value=\"\" style=\"height:3.25em\">All Authors<\/option>\r\n <\/select>\r\n <\/div>\r\n \r\n <div class=\"filter-group\">\r\n <label for=\"keywordFilter\">Filter by Keyword<\/label>\r\n <select id=\"keywordFilter\">\r\n <option value=\"\" style=\"height:3.25em\">All Keywords<\/option>\r\n <\/select>\r\n <\/div>\r\n \r\n <div class=\"filter-group\">\r\n <label for=\"yearFilter\" >Filter by Year<\/label>\r\n <select id=\"yearFilter\" >\r\n <option value=\"\" style=\"height:3.25em\">All Years<\/option>\r\n <option value=\"2025\">2025<\/option>\r\n <option value=\"2024\">2024<\/option>\r\n \r\n <\/select>\r\n <\/div>\r\n <\/div>\r\n \r\n <div class=\"results-info\">\r\n Showing <span id=\"resultsCount\">1<\/span> publications\r\n <\/div>\r\n <\/section>\r\n \r\n <section id=\"publicationsList\">\r\n \r\n <\/section>\r\n \r\n <footer>\r\n <p>Research Publications Database © 2025 | Merit University<\/p>\r\n <\/footer>\r\n <\/div>\r\n\r\n\r\n \r\n\r\n<\/body>\r\n<\/html>\r\n\r\n <\/main>\r\n <\/div>\r\n\r\n \r\n\r\n \r\n \r\n <script>\r\n \/\/ Sample data - in a real application, this would come from a database\r\n\r\n\r\n const publications = [\r\n {\r\n \"id\": 1,\r\n \"title\": \"Ashour, Marwa M.N. (60165514700); Abd-Eldayem, Ahmed Mohammed (57195596545); El-Shoura, Ehab A.M. (57203193884); Messiha, Basim Anwar Shehata (56431085800); Sharkawi, Souty Mouner Zaky (57202833715)\",\r\n \"authors\": \"Nicardipine protects against gentamicin-induced nephrotoxicity: Potential involvement of IL-23R, NRF2, and Beclin-1 perturbation\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105020395373&doi=10.1016%2Fj.lfs.2025.124042&partnerID=40&md5=77c1f64e45ed468f9748ca6571d5a879\",\r\n \"affiliations\": \"Department of Pharmacology, Merit University, Sohag, Egypt; Department of Medical Pharmacology, Faculty of Medicine, Asyut, Egypt; Department of Basic Sciences, Fahad Bin Sultan University, Tabuk, Saudi Arabia; Department of Clinical Pharmacy, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni Suef, Egypt\",\r\n \"abstract\": \"Aims: Gentamicin (GNT) remains a cornerstone in the treatment of severe Gram-negative infections; however, its clinical utility is constrained by dose-limiting nephrotoxicity. Emerging evidence implicates nicardipine (NIC), a dihydropyridine calcium channel blocker, in renoprotection via mechanisms distinct from its canonical vascular effects. In this study, we delineate an unprecedented nephroprotective mechanism of NIC in the context of GNT-induced renal injury, with a particular focus on its capacity to modulate oxidative stress, inflammatory signaling, autophagic, and apoptotic pathways. Materials and methods: Experimental groups comprised control rats, GNT-treated rats, NIC-treated rats, and animals that received NIC + GNT. Renal function was rigorously evaluated through measuring serum creatinine and blood urea nitrogen (BUN), alongside a multidimensional analysis encompassing oxidative stress indices, inflammatory mediators, histopathological alterations, and expression profiles of apoptosis- and autophagy-associated proteins. Mechanistic interrogation centered on nuclear factor erythroid 2-related factor 2 (NRF2), a master regulator of antioxidant defense; interleukin-23 receptor (IL-23R), a pivotal mediator of proinflammatory signaling; and Beclin-1, a crucial autophagy-related factor underlying NIC's renoprotective action. Key findings: Co-administration of NIC markedly ameliorated GNT-induced renal injury, as reflected by improved biochemical indices of kidney function, preservation of renal histoarchitecture, attenuation of caspase-3-mediated apoptosis, upregulation of NRF2-driven antioxidant responses, suppression of IL-23R\u2013dependent inflammatory signaling, and modulation of Beclin-1\u2013associated autophagic activity. Significance: These findings delineate a novel mechanistic axis by which NIC exerts coordinated antioxidant, anti-inflammatory, autophagic, and anti-apoptotic effects. This multifactorial cytoprotection highlights NIC's therapeutic potential for targeted intervention in aminoglycoside-induced nephrotoxicity. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Gentamicin\",\r\n \" IL-23R\",\r\n \" Inflammation\",\r\n \" Nephrotoxicity\",\r\n \" Nicardipine\",\r\n \" Oxidative stress\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 2,\r\n \"title\": \"Badawy, Mohamed A.S. (60081641500); Abdel-Aziz, Mohamed A. (57200642898); Abdel-Rahman, Hamdy M. (8783095600); Ali, Taha F.S. (56765352500)\",\r\n \"authors\": \"Targeting melanoma resistance: Novel oxindole and non-oxindole-based benzimidazole derivatives as potent dual inhibitors of BRAFV600E and ABL2 kinases\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105014804250&doi=10.1016%2Fj.ejmech.2025.118096&partnerID=40&md5=dc17a810259d997d1778ece1cb14d9c7\",\r\n \"affiliations\": \"Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutical Chemistry, School of Pharmacy, Asyut, Egypt\",\r\n \"abstract\": \"Melanoma is one of the deadliest forms of cancer. The disease is incurable for many due to its aggressive, metastatic characteristics and its elevated resistance. Herein, we design and synthesize two series of target compounds oxindole-based (7a-h) and non-oxindole-based (8a-h) benzimidazole. Selected compounds were evaluated against mutant BRAFV600E and ABL2 kinases upon evaluating for anti-tumor efficacy against a preliminary 60-tumor cell line panel at NCI, USA. The NCI selected six compounds (7c, 7d, 7g, 7h, 8b, and 8h) for evaluation at five doses. Compounds 8b and 8h exhibited the highest cytotoxic potency against SK-MEL-5 with IC<inf>50<\/inf> = 1.00 and 0.54 \u03bcM, respectively. Compounds 7c and 8h were the most potent to inhibit BRAFV600E with IC<inf>50<\/inf> = 0.072 and 0.088 \u03bcM, respectively. While compounds 7c and 8b showed the most potent inhibitory activity against ABL2 kinases (IC<inf>50<\/inf> = 0.143 and 0.236 \u03bcM, respectively). Compound 8h diminished P-glycoprotein expression by 0.2732. Molecular docking findings showed that compound 8b exhibits the highest binding affinity for the ABL2 kinase enzyme. Cytotoxicity assays in resistant melanoma cells showed IC<inf>50<\/inf> values of 12.3 \u03bcM (A375) and 20.1 \u03bcM (A375-R), demonstrating potency comparable to vemurafenib. Western blot analysis showed that 8h effectively inhibited p-CrkL (Abl2 signaling) and p-ERK1\/2 (BRAFV600E pathway) in A375-R melanoma cells. Compounds 8h, 7c, and 8b demonstrated the highest binding affinities for BRAFV600E. Compound 8h causes cell cycle arrest at the G1 phase, inhibiting progression to the S phase and subsequent phases (28.55 % compared to 39.02 %) and G2\/M phase (13.33 % compared to 16.35 %). Furthermore, the apoptotic efficacy of 8h demonstrated a significant increase in the percentage of late apoptotic cells, reaching 13.89 % in treated cells, in contrast to 0.15 % in untreated cells. In Silico ADME profiling indicated that the proposed compounds are suitable drug candidates. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"ABL2\",\r\n \" ADME\",\r\n \" Anticancer\",\r\n \" Benzimidazoles\",\r\n \" BRAFV600E\",\r\n \" Melanoma\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 3,\r\n \"title\": \"Abo-Zeid, Mohamed Gamal (58866318400); Elrosasy, Amr M. (58299324200); Alkousheh, Hazim (59373757700); Mohamed, Rashad G. (58959162200); AlEdani, Esraa M. (58691452900); Zabady, Ahmed Hamdy (59394731500); Alhammad, Norah S. (59675119700); Alhussainy, Nabeel Hussain (56558795600); Yousef, Hanaa Sayed Suliman (59674353200)\",\r\n \"authors\": \"A comprehensive evaluation of Naftifine's efficacy and safety in treating dermatophyte infections; systematic review and meta-analysis\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-86000309422&doi=10.1007%2Fs00403-025-04044-x&partnerID=40&md5=b3402bf145b5e89a82f531c507c4c3e9\",\r\n \"affiliations\": \"Faculty of Medicine, Tanta, Egypt; Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Hashemite University, Zarqa, Jordan; Mansoura Manchester Program for Medical Education, Faculty of Medicine, Mansoura, Egypt; University of Basrah, Basra, Iraq; Department of Microbiology, Faculty of Science, Damanhour, Egypt; Department of Dermatology, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia; Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Clinical Pharmacy & Pharmacy practice, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Dermatophyte infections, including tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch), are widespread fungal infections that significantly impact global health and quality of life. Naftifine, an allylamine antifungal agent, is noted for its potent fungicidal activity, targeting fungal cell membranes by inhibiting squalene epoxidase. Additionally, Naftifine has anti-inflammatory and antibacterial properties, enhancing its therapeutic potential. This systematic review and meta-analysis aims to comprehensively evaluate the efficacy and safety of Naftifine in treating tinea pedis, tinea corporis, and tinea cruris, focusing on clinical outcomes, cure rates, and adverse effects to provide a thorough understanding of its effectiveness in managing these infections. This meta-analysis followed the PRISMA guidelines and included randomized controlled trials (RCTs) assessing naftifine's efficacy and safety in treating tinea pedis, corporis, and cruris. A systematic search was conducted in major databases from inception until February 9th, 2024. Eligible studies were selected based on predefined inclusion criteria, and data were extracted and analyzed using RevMan software. Seven multicenter RCTs were included in the meta-analysis. Naftifine demonstrated superior efficacy compared to vehicle control in terms of complete cure rate (RR = 5.83, 95% CI [3.73 to 9.10]) with no significant heterogeneity (I2 = 0%), clinical improvement [RR = 1.55, 95% CI (1.21\u20132.00)], and treatment effectiveness [RR = 3.93, 95% CI (2.44\u20136.33)] for tinea pedis. Similarly, for tinea corporis and cruris, Naftifine demonstrated significant efficacy compared to vehicle control regarding complete cure rate, mycological cure rate, clinical improvement, and treatment effectiveness. However, there was no significant difference in adverse events between Naftifine and the vehicle across all three conditions. Naftifine is an effective topical treatment for tinea pedis, corporis, and cruris, with a favorable safety profile with no significant difference in adverse events compared to the vehicle. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Dermatophytes\",\r\n \" Naftifine\",\r\n \" Tinea corporis\",\r\n \" Tinea cruris\",\r\n \" Tinea pedis\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 4,\r\n \"title\": \"El-Masry, Yassin M. (57966931700); Zaghloul, T. I. (6602904235)\",\r\n \"authors\": \"Recombinant Bacillus subtilis-derived alkaline protease: a novel agent for skin depigmentation and hair follicle neogenesis\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85214437660&doi=10.1007%2Fs00403-024-03744-0&partnerID=40&md5=ee1745dabfda6afe3a2a5d2f7467c310\",\r\n \"affiliations\": \"Department of Medical Biochemistry, Merit University, Sohag, Egypt; Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria, Egypt\",\r\n \"abstract\": \"[No abstract available]\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 5,\r\n \"title\": \"Ahmed, Mohamed Abdelmoaty (60054729200); AbdelMoety, Ahmed (57214272287); Soliman, Asmaa Mohamed Ahmed (54780550200)\",\r\n \"authors\": \"Predicting cancer risk using machine learning on lifestyle and genetic data\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105013670024&doi=10.1038%2Fs41598-025-15656-8&partnerID=40&md5=9ba0fa0e98d3656f6c878713787f5501\",\r\n \"affiliations\": \"Faculty of Medicine, Merit University, Sohag, Egypt; Faculty of Engineering, Qena, Egypt; Department of Public Health and Community Medicine, Faculty of Medicine, Asyut, Egypt\",\r\n \"abstract\": \"Cancer remains one of the leading causes of mortality worldwide, where early detection significantly improves patient outcomes and reduces treatment burden. This study investigates the application of Machine Learning (ML) techniques to predict cancer risk based on a combination of genetic and lifestyle factors. A structured dataset of 1,200 patient records was used, comprising features such as age, gender, Body Mass Index (BMI), smoking status, alcohol intake, physical activity, genetic risk level, and personal history of cancer. A full end-to-end ML pipeline was implemented, encompassing data exploration, preprocessing, feature scaling, model training, and evaluation using stratified cross-validation and a separate test set. Nine supervised learning algorithms were evaluated and compared, including Logistic Regression (LR), Decision Tree (DT), Random Forest (RF), Support Vector Machines (SVMs), and several ensemble methods. Among these, Categorical Boosting (CatBoost) achieved the highest predictive performance, with a test accuracy of 98.75% and an F1-score of 0.9820, outperforming both traditional and other advanced models. Feature importance analysis confirmed the strong influence of cancer history, genetic risk, and smoking status on prediction outcomes. The findings highlight the effectiveness of boosting-based ensemble models in capturing complex interactions within health data and support their potential use in personalized cancer risk assessment. This research underscores the value of integrating genetic and modifiable lifestyle variables into predictive modeling to enhance early detection and preventive healthcare strategies. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Cancer prediction\",\r\n \" Genetic risk\",\r\n \" Lifestyle factors\",\r\n \" Machine learning\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 6,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Hussain, Abdulzahra Abdulsamad (16417168400); Aiolfi, Alberto (6508362055); Lled\u00f3, Jos\u00e9 Bueno (24462324800); Chiaretti, Massimo (6603417473); Kryvoruchko, Igor A. (59374914600); Kermansaravi, Mohammad (57192913150); Nimeri, Abdelrahman A. (12795619600); Elias, Abd Al Kareem (57349114100); Ahmed, Saad Mohamed Ali (59781389000); Awad, Esmail Tharwat Kamel (57338443100); Ali, Mohamed A. (57693482500); Khyrallh, Ahmed (57199997926); Alsayed, Mohammed H. (57932903000); Labib, Mohamed Fathy (57221263028); Teama, Sobhy Rezk Ahmed (58023821600); Seleem, Abdelhafez (57657407600); Elshafey, Mohammed Hassan (57212769328); Mostafa, Mostafa Mahmoud Salama (58838861600); Elbelkasi, Hamdi (58744062800); Zaid, Mahmoud Ali Abou (59781038500); Hamdy, Ahmed (57528237700); Abo Alsaad, Mohamed Ibrahim (58743979200); Youssef, Maged Z. (60004133100); Ali, Rasha Mohamed Motawea (60004778200); Shamy, Ibtsam Abdel Maksoud Mohamed El (59781612100); Arafa, Ahmed Salah (57209472931); Heggy, Ibrahim A. (59018529000); Naguib, Sameh Mohamed (57204030809); Wasefy, Tamer (57748757500); Abozaid, Mohamed Mehriz Naguib (57720672400); Elshahidy, Tamer Mohamed Mahmoud (57219158772); Mostafa, Abdelshafy (58744089300); Elnemr, Mohamed M. (57219125086); Nawar, Abdelrahman Mohamed Hasanin (59781844900); Khairy, Mostafa Mohamed (57816377300); Abdelaziz, Ahmed Mesbah (58894628000); Abdelwanis, Abdelfatah H. (58303777800); El Teliti, Ahmed M. (57203877548)\",\r\n \"authors\": \"Frailty predicts recurrence after laparoscopic Nissen fundoplication with mesh cruroplasty for giant sliding hiatal hernia with severe reflux esophagitis in elderly patients: a multicenter retrospective study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105011052336&doi=10.1007%2Fs10029-025-03416-6&partnerID=40&md5=644513a6324ef885f92734acdc7645cb\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; Department of General Surgery, Homerton University Hospital NHS Foundation Trust, London, United Kingdom; University of Alkafeel, Najaf, Iraq; Department of Biomedical Science for Health, Universit\u00e0 degli Studi di Milano, Milan, Italy; Hospital Universitari i Polit\u00e8cnic La Fe, Valencia, Spain; Department of General Surgery and Organ Transplantation, Sapienza Universit\u00e0 di Roma, Rome, Italy; Department of Surgery, Kharkiv National Medical University, Kharkiv, Ukraine; Department of Surgery, IUMS Minimally Invasive Surgery Research Center, Tehran, Iran; Department of Surgery, Harvard Medical School, Boston, United States; Department of General Surgery, Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Cairo, Egypt; Mataryia Teaching Hospital (GOTHI), Cairo, Egypt; General Surgery Department, El Mahala Hepatic Institute, Al Gharbia, Egypt; National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; General Surgery Department-Faculty of Medicine, Merit University, Sohag, Egypt; Department of General Surgery, Faculty of Medicine, 6th October, Egypt; Faculty of Medicine, Cairo, Egypt\",\r\n \"abstract\": \"Purpose: Giant sliding hiatal hernias (HH) are prevalent in the elderly population (EP) and often present with multiple comorbidities and a high surgical risk. Frailty has been increasingly recognized as a predictor of surgical outcomes in the EP. This study assessed the rate of recurrent sliding HH following mesh cruroplasty and laparoscopic Nissen fundoplication (LNF), and evaluated frailty as a potential risk factor of recurrence. Methods: This retrospective multicenter study included 266 patients aged \u2265 60 years who underwent mesh cruroplasty and LNF for giant sliding HH (> 5\u00a0cm) with severe reflux esophagitis (Demeester score > 100) between March 2016 and March 2022, stratified into non-recurrence (n = 241) and recurrence (n = 25) HH. Results: The mean age was 66.92 \u00b1 4.3 years vs. 67.79 \u00b1 3.7 years in the non-recurrence and recurrence group, respectively. Twenty-five (9.4%) patients developed recurrent HH, with a median size of 5.2\u00a0cm (4.1\u20136.0\u00a0cm), and the median time from surgery to recurrence was 16 months (13\u201320 months). Frailty was significantly correlated with recurrence, with moderately and severely frail patients demonstrating higher recurrence rates (44% vs. 17%, p = 0.02). Multivariate analysis confirmed that frailty was an independent predictor of recurrence (odds ratio [OR], 1.4; 95% CI, 1.003\u20131.982; p = 0.04). Time to recurrence included mild frailty (75% recurrence rate within 16 months), moderate frailty (90.9% recurrence within 12 months), and severe frailty (80% recurrence within 9 months). Conclusions: Frailty was an independent predictor of HH recurrence. Integrating frailty assessment into preoperative workflows could optimize patient selection and outcomes. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Elderly\",\r\n \" Frailty\",\r\n \" Gastroesophageal reflux disease\",\r\n \" Giant HH\",\r\n \" Mesh cruroplasty\",\r\n \" Nissen fundoplication\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 7,\r\n \"title\": \"Hendi, Nada Ibrahim (57956145200); AbuSammour, Yaser (59518440100); Khaled, Mohamed (59955541900); Mohamed, Ahmed S. (59955542000); Amin, Ahmed Mostafa (58353250400); Fallaha, Mohamed Saleh (59954964900); Kamel, Basma (59393146500); Helmy, Yehia Nabil Abdalla (59955106800); Hassan, Mohamed Ali Saeed (59955106900); Meshref, Mostafa Mahmoud (57222069701)\",\r\n \"authors\": \"Efficacy of transcranial direct current stimulation on seizure control in patients with refractory epilepsy: a systematic review and meta-analysis of randomized controlled trials\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105008696602&doi=10.1007%2Fs10143-025-03657-0&partnerID=40&md5=b667dfd6d4e9faa981b4f08e70ae4d22\",\r\n \"affiliations\": \"Faculty of Medicine, Ain Shams University, Cairo, Egypt; Faculty of Medicine, Al-Balqa Applied University, Salt, Jordan; Faculty of Medicine, Alexandria, Egypt; Faculty of Medicine, Merit University, Sohag, Egypt; Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Mansoura, Egypt; Zagazig University, Faculty of Medicine, Zagazig, Egypt; Faculty of Medicine, Cairo, Egypt; Supervisor of Epilepsy Units, Al-Azhar University Hospital, New Damietta, Egypt\",\r\n \"abstract\": \"Drug-resistant epilepsy is a challenging condition that affects around 30% of all patients with epilepsy. Evidence regarding treatment options is limited, especially for surgery and invasive techniques. However, non-invasive techniques constitute a promising alternative for these patients. This meta-analysis aims to evaluate the effectiveness of transcranial direct current stimulation on seizure frequency management in patients with drug-resistant epilepsy. We searched the literature in PubMed, Scopus, and Web of Science up to December 2023. We included randomized controlled trials that compared transcranial direct current stimulation with sham stimulation. Our main outcomes of interest were a percentage reduction in seizure frequency and epileptiform discharge frequency. A total of 10 studies with 269 patients were included. Monthly seizure frequency was significantly reduced by an average of -45.39%and -39.34% at week 4 and week 8, respectively. There was a significant reduction in IED in favor of tDCS at week 2 (SMD = -0.87, 95% CI = [\u2212 1.49, \u2212 0.25], P = 0.006), 4 weeks (SMD = -1.17, 95% CI = [\u2212 1.67, \u2212 0.66], P < 0.00001, Moderate quality of evidence) and 8 weeks (SMD = -1.11, 95% CI = [\u2212 1.69, \u2212 0.53], P = 0.0002) of follow-up. There were no serious adverse events associated with the stimulation. Transcranial direct current stimulation was associated with a reduction in both seizure frequency and epileptiform discharges with minimal side effects. Further studies with larger sample sizes and consensus protocol guidelines are needed to verify its long-term safety and effectiveness. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Drug-resistant epilepsy\",\r\n \" Non-invasive neurostimulation\",\r\n \" Seizure frequency\",\r\n \" tDCS\",\r\n \" Transcranial direct current stimulation\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 8,\r\n \"title\": \"Moghib, Khaled (58870319800); Altalab, Gergis (59907492700); Jader, Arwa (59328331500); Ghanm, Thoria Ibrahim Essa (59475851200); Hijazy, Mesan (59938241100); Tarawneh, Dana Y. (59937527300); Hannat, Ramish (59538277400); Salomon, Izere (59242048100); Edress, Ahmed Ibrahim (59937705900); Arafeh, Muhannad Wael Abu (59937706000); Uwishema, Olivier (57221675021); Limantoro, Joshua (58684568300); Luna, Antonio Medina (59936987200); Bozkurt, Ismail (56634449200)\",\r\n \"authors\": \"Comparison between spinal fusion vs. nonoperative treatment for lumbar degenerative pathology: a systematic review and meta-analysis\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105007747034&doi=10.1007%2Fs10143-025-03671-2&partnerID=40&md5=e34180d6768d4c1b9bddd3fb8fa968c7\",\r\n \"affiliations\": \"Faculty of Medicine, Cairo, Egypt; Medical Research Group of Egypt, Negida Academy, Arlington, United States; Faculty of Medicine, Merit University, Sohag, Egypt; Department of Neurosurgery, University of Kufa, Kufa, Iraq; Faculty of Medicine, Mansoura, Egypt; Al-Azhar University of Gaza, Gaza, Palestine; School of Medicine, Amman, Jordan; Services Institute of Medical Sciences Lahore, Lahore, Pakistan; University of Rwanda, Butare, Rwanda; Department of Neurosurgery, Tanta University, Tanta, Egypt; Hadassah Medical Center, Jerusalem, Palestine; Department of Research and Education, Oli Health Magazine Organization, Kigali, Rwanda; Faculty of Medicine, Universitas Udayana, Bali, Indonesia; Universidad de Monterrey, San Pedro Garza Garcia, Mexico; Department of Neurosurgery, Ankara Numune Hospital, Ankara, Turkey; Department of Neurosurgery, Y\u00fcksek \u0130htisas \u00dcniversitesi, Ankara, Turkey\",\r\n \"abstract\": \"Background: Lumbar fusion is widely used to treat chronic lumbar degenerative pathology; however, its effectiveness and safety compared with nonoperative management remain controversial. Objectives: This systematic review and meta-analysis aimed to evaluate and compare the effectiveness and safety of spinal fusion and conservative management in treating lumbar degenerative pathology. Method: A systematic review and meta-analysis were conducted following the PRISMA guidelines. The PubMed, Scopus, Cochrane Central, Web of Science, and Embase databases were searched in October 2024. Eligible studies included randomized controlled trials (RCTs) and observational studies reporting pain reduction and functional disability outcomes. The primary outcomes were changes in the Oswestry Disability Index (ODI) and Visual Analog Scale (VAS) scores for back and leg pain. Data were analyzed using a random-effects model in RevMan 5.4.1, with subgroup and sensitivity analyses performed to address heterogeneity. Results: Fourteen studies comprising 13 RCTs and one cohort study, involving 2,399 participants, were included. Spinal fusion showed significant improvements in ODI scores compared to conservative treatment (MD = -6.3; 95% CI [-12.02, -0.57]; p = 0.03), indicating reduced disability. VAS back pain scores also favored spinal fusion (MD = -3.02; 95% CI [-5, 1.04]; p = 0.003), with long-term outcomes showing consistent benefits (MD = -2.26; 95% CI [-3.16, 1.37]; p < 0.00001). However, spinal fusion did not significantly reduce leg pain compared to non-operative options (MD = -2.27; 95% CI [-8.37, 3.83]; p = 0.47). Conclusion: Spinal fusion offers statistically significant benefits in reducing disability and back pain compared with conservative treatments for lumbar degenerative pathology. However, it does not confer substantial advantages to leg pain and carries a high surgical risk. These findings emphasize the importance of individualized treatment selection based on patient characteristics and clinical indications. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Lumbar degenerative pathology\",\r\n \" Meta-analysis\",\r\n \" Non-operative management\",\r\n \" Oswestry disability index\",\r\n \" Spinal fusion\",\r\n \" Systematic review\",\r\n \" Visual analog scale\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 9,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Elias, Abd Al Kareem (57349114100); Adam, Abdelmonem A.M. (59693047600); Ali, Mohamed A. (57693482500); Ahmed, Saad Mohamed Ali (59781389000); Khyrallh, Ahmed (57199997926); Alsayed, Mohammed H. (57932903000); Awad, Esmail Tharwat Kamel (57338443100); Ibrahim, Emad A. (59781844800); Labib, Mohamed Fathy (57221263028); Teama, Sobhy Rezk Ahmed (58023821600); Badawy, Mahmoud Hassib Morsi (59781389100); Abo Alsaad, Mohamed Ibrahim (58743979200); Ali, Abouelatta Kh (59692860600); Elbelkasi, Hamdi (58744062800); Zaid, Mahmoud Ali Abou (59781038500); Shamy, Ibtsam Abdel Maksoud Mohamed El (59781612100); El-Houseiny, Boshra Ali (59781266900); Azawy, Mahmoud El (59781151100); Elhoofy, Ahmed (57203280920); Khedr, Ali Hussein (57953744900); Nawar, Abdelrahman Mohamed Hasanin (59781844900); Arafa, Ahmed Salah (57209472931); Abdelaziz, Ahmed Mesbah (58894628000); Abdelwanis, Abdelfatah H. (58303777800); Khairy, Mostafa Mohamed (57816377300); Yehia, Ahmed Mohamed (57210598249); Taher, Ahmed Kamal El (59781728100)\",\r\n \"authors\": \"Early readmission after adrenalectomy for pheochromocytoma. A retrospective study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105004457585&doi=10.1007%2Fs00423-025-03719-3&partnerID=40&md5=4baa336b0edf1dbc7768ba69ab1a87ec\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; Department of General Surgery, Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Cairo, Egypt; Merit University, Sohag, Egypt; Misr University for Science and Technology, 6th October, Egypt; Mataryia Teaching Hospital (GOTHI), Cairo, Egypt; General Surgery Department, El Mahala Hepatic Institute, Al Gharbia, Egypt; Faculty of Medicine, Cairo, Egypt; Department of Surgery, Faculty of Medicine, Helwan, Egypt; Ain Shams University, Cairo, Egypt\",\r\n \"abstract\": \"Purpose: Adrenalectomy for pheochromocytoma (PHEO) presents a significant challenge due to the high incidence of early hospital readmission (ER). This study evaluated the incidence and risk factors of ER for PHEO within 30 days of adrenalectomy. Methods: A retrospective analysis of 346 patients > 18 years with unilateral PHEO who underwent adrenalectomy between September 2012 and September 2024. The patients were categorised into ER (n = 49) and no ER (n = 297) groups. Logistic regression analyses were performed to predict risk factors for ER. Results: The most common causes of ER were postoperative maintained hypotension (42.9%), bleeding (6.1%), ileus (24.5%), wound infection (4.1%), hyperkalemia (8.2%), pneumonia (2%), intra-abdominal abscess (2%), acute MI (4.1%), and colonic injury (6.1%). Most postoperative complications were Clavien-Dindo grade II (n = 40, 81.6%). Two perioperative deaths (4%) occurred in the ER group. Logistic regression showed that low body mass index (OR 0.849, 95% CI, 0.748\u20130.964; p = 0.012), tumor size < 5\u00a0cm (OR 0.096, 95% CI, 0.030\u20130.310; p < 0.001), and low ASA (OR 0.435, 95% CI, 0.249\u20130.761; p = 0.003) were associated with risk reduction for ER while malignancy (OR 5.302, 95% CI, 1.214\u201323.164; p = 0.027), open approach(OR 12.247, 95% CI, 5.227\u201328.694; p < 0.001), and intraoperative complications (OR 19.149, 95% CI, 7.091\u201351.710; p < 0.001) were associated with risk increase of ER. Conclusion: Postoperatively maintained hypotension and ileus were the most common causes of ER. Low body mass index, tumour size < 5\u00a0cm, and low ASA were risk reductions for ER, while malignancy, open approach, and intraoperative complications were the independent risk increase factors. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Laparoscopic adrenalectomy\",\r\n \" Open adrenalectomy\",\r\n \" Pheochromocytoma\",\r\n \" Postoperative complications\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 10,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Chiaretti, Massimo (6603417473); Kryvoruchko, Igor A. (59374914600); Pesce, Antonio L. (54920280600); Kechagias, Aristotelis (22985131100); Elias, Abd Al Kareem (57349114100); Adam, Abdelmonem A.M. (59693047600); Ali, Mohamed A. (57693482500); Ali Ahmed, Saad Mohamed (59693227300); Khyrallh, Ahmed (57199997926); Alsayed, Mohammed H. (57932903000); Tharwat Kamel Awad, Esmail (59693406500); Elshafey, Mohammed Hassan (57212769328); Abo Alsaad, Mohamed Ibrahim (58743979200); Ali, Abouelatta Kh (59692860600); Elbelkasi, Hamdi (58744062800); Abou Zaid, Mahmoud Ali (59692860700); Youssef, Hoda A.A. (58465990500); Al-Zamek, Mona Mohammad Farid (59693774200); Fiad, Alaa A. (51863395700); Elshahidy, Tamer Mohamed Mahmoud (57219158772); Elballat, Mahmoud R. (59205549400); el-Taher, Ahmed Kamal (57221777128); Mohamed, Mohamed Mahmoud Mokhtar (57789094800); AboZeid, Ahmed Khaled (59205349300); Mansour, Mohamed Ibrahim (57219159269); Yassin, Mahmoud Abdou (57217355675); Arafa, Ahmed Salah (57209472931); Lotfy, Mohamed Ahmed (57221813392); Mousa, Bassam (57710406600); Atef, Baher (57437326000); Naguib, Sameh Mohamed (57204030809); Heggy, Ibrahim A. (59018529000); Elnemr, Mohamed M. (57219125086); Zaitoun, Mohamed Abdallah (57223230279); AbdAllah, Ehab Shehata (59693590100); Moussa, Mohamad S. (57208822751); Hamed, Abd Elwahab M. (58986714100); Elsayed, Rasha S. (58310525400)\",\r\n \"authors\": \"Mucosal advancement flap versus ligation of the inter-sphincteric fistula tract for management of trans-sphincteric perianal fistulas in the elderly: a retrospective study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105000028490&doi=10.1007%2Fs00384-025-04846-5&partnerID=40&md5=75d5faf0bbb9fca981eefb0a0d574f1a\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; Department of General Surgery and Organ Transplantation, Sapienza Universit\u00e0 di Roma, Rome, Italy; Department of Surgery No. 2, Kharkiv National Medical University, Kharkiv, Ukraine; Azienda Unit\u00e0 Sanitaria Locale di Ferrara, Ferrara, Italy; Department of Surgery, Athens General Hospital, Athens, Greece; Department of General Surgery, Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Cairo, Egypt; General Surgery Department, Merit University, Sohag, Egypt; Misr University for Science and Technology, 6th October, Egypt; Mataryia Teaching Hospital (GOTHI), Cairo, Egypt; General Surgery Department, El Mahala Hepatic Insistute, Tanta, Egypt; Faculty of Medicine, Cairo, Egypt\",\r\n \"abstract\": \"Purpose: There is no consensus on the standard approach for trans-sphincteric perianal fistulas (TPAF) in the elderly population. The most commonly used sphincter-saving procedures are ligation of the inter-sphincteric fistula tract (LIFT) and mucosal advancement flap (MAF). We aimed to evaluate the incidence and risk factors for recurrence and incontinence in elderly patients with TPAF using both approaches. Methods: This retrospective study included 257 patients who underwent LIFT (136 patients) or MAF (121 patients) for de novo and cryptoglandular TPAF between July 2018 and July 2021. Recurrent fistulas were clinically and radiologically detected using MRI. Postoperative incontinence was evaluated using the Wexner score and anorectal manometry. Logistic regression analysis was used to detect the risks of recurrence and incontinence. Results: The median ages of the patients were 68 (64, 74) and 68 (65, 74) years in the LIFT and MAF groups, respectively. Higher recurrence rates were observed after LIFT (17 (12.5%)) than after MAF (13 (10.7%)), but the difference was not statistically significant (P = 0.662). Postoperative incontinence was observed in 18 patients (13.2%) and seven patients (5.8%) in the LIFT and MAF groups, respectively (P = 0.044). The predictors for fistula recurrence were smoking (OR, 75.52; 95% CI, 1.02 to 5611.35; P = 0.049), length of tract (OR, 17.3; 95% CI, 1.49 to 201.13; P = 0.023), and CD classification (OR, 7.08; 95% CI, 1.51 to 33.14; P = 0.013). A low Charlson comorbidity index score (\u2264 5) (OR, 0.68; 95% CI, 0.47 to 0.99; P = 0.046) and high postoperative mean squeeze anal pressure (OR, 0.97; 95% CI, 0.95 to 0.99; P = 0.001) were significant factors associated with reduced risk of incontinence. In particular, LIFT was associated with a significantly higher risk of incontinence than MAF (OR, 2.089; 95% CI, 1.006 to 4.33; P = 0.04). Conclusions: The healing rates of MAF and LIFT procedures did not differ significantly; however, continence was significantly better after MAF. MAF should be added to the guidelines as a good option for the treatment of TPAF in elderly patients. Trial registration: The study was registered as a clinical trial www.clinicaltrials.gov (NCT06616662). \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Elderly\",\r\n \" Incontinence\",\r\n \" Ligation inter-sphincteric fistula surgery\",\r\n \" Mucosal advancement flap\",\r\n \" Observational study\",\r\n \" Recurrence\",\r\n \" Trans-sphincteric perianal fistula\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 11,\r\n \"title\": \"Yousef, Reda G. (57225078967); El-Metwally, Souad A. (36682085000); Al Ward, Maged Mohammed Saleh (57222123911); Alsfouk, Aisha A. (57208242449); Husein, Dalal Z. (55917450100); Soliman, Omar A. (57697503400); Elkaeed, Eslam B. (56884768800); Elkady, Hazem (57203864016); Metwaly, Ahmed M. (56153972200); Eissa, Ibrahim H. (57189457618)\",\r\n \"authors\": \"Discovery of new thieno[2,3-d]pyrimidine-based dual VEGFR-2 and EGFR inhibitors for enhanced therapeutic efficacy in breast cancer\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105004639860&doi=10.1016%2Fj.molstruc.2025.142586&partnerID=40&md5=e9044583a40ba4b557f498324b102aca\",\r\n \"affiliations\": \"Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Basic Sciences, Higher Technological Institute, Tenth of Ramadan City, Egypt; Department of Medicinal Chemistry, Al-Razi University, Sana'a, Yemen; Department of Pharmaceutical Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Department of Chemistry, Faculty of Science, Kharga, Egypt; Department of Clinical Pharmacy, Alexandria University, Alexandria, Egypt; Department of Human Genetics, Alexandria University, Alexandria, Egypt; Department of Pharmaceutical Sciences, Almaarefa University, Riyadh, Saudi Arabia; Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"A series of novel thieno[2,3-d]pyrimidine derivatives have been designed as dual inhibitors targeting VEGFR-2 and EGFR. The compounds were tested for in vitro cytotoxicity against human breast cancer (MDA-231, MCF-7), in addition to the non-carcinogenic lung fibroblast (WI-38), and epithelial (WISH) cell lines. Among the synthesized compounds, compound 14 demonstrated notable cytotoxicity with IC<inf>50<\/inf> values of 8.13 \u00b1 0.6 \u00b5M (MDA-231), 11.72 \u00b1 0.9 \u00b5M (MCF-7), and 53.66 \u00b1 3.1 \u00b5M (WI-38), comparable to sorafenib, a known anticancer agent. In addition, compound 14 showed potent inhibition of EGFR (IC<inf>50<\/inf> = 5.42 \u00b1 0.28 nM) and VEGFR-2 (IC<inf>50<\/inf> = 50.31 \u00b1 2.0 nM), suggesting its potential as a dual-target kinase inhibitor. The wound healing assay revealed that compound 14 inhibited cell migration in MDA-231 cells with a quantitative closure of 37.78% compared to the control (58.95%). Further analysis of cell death mechanisms indicated that compound 14 induced significant apoptosis in MDA-231 cells, with a marked increase in early (20.07%) and late (66.76%) apoptosis stages, alongside a decrease in viable cells (8.92%). Cell cycle analysis demonstrated a G1 phase arrest with a significant reduction in S-phase cells. Gene expression analysis revealed that compound 14 upregulated pro-apoptotic BAX (4.19 \u00b1 0.18) and downregulated anti-apoptotic Bcl-2 (0.44 \u00b1 0.04), leading to a high BAX\/Bcl-2 ratio (9.52 \u00b1 0.83). Moreover, caspase-8 and caspase-9 expression levels were significantly elevated, indicating the activation of intrinsic and extrinsic apoptotic pathways. Molecular docking and 200 ns dynamic simulations revealed stable binding of compound 14 to VEGFR-2 and EGFR, with docking scores surpassing those of sorafenib and comparable to erlotinib. Density Functional Theory (DFT) calculations highlighted the stability and reactivity of compound 14, while in silico ADMET analysis of the thieno[2,3-d]pyrimidines predicted favorable safety profiles, notably low risks of carcinogenicity and chronic toxicity. These findings suggest that thieno[2,3-d]pyrimidine derivatives, particularly compound 14, possess promising anticancer properties and warrant further investigation as potential therapeutic agents in cancer treatment. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Apoptosis\",\r\n \" Breast cancer\",\r\n \" Dual inhibitors\",\r\n \" EGFR\",\r\n \" MD simulations\",\r\n \" Thieno [2,3-d]pyrimidines\",\r\n \" VEGFR-2\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 12,\r\n \"title\": \"Badawy, Mohamed A.S. (60081641500); Br\u00e4se, Stefan J. (7005396290); Ali, Taha F.S. (56765352500); Abdel-Aziz, Mohamed A. (57200642898); Abdel-Rahman, Hamdy M. (8783095600)\",\r\n \"authors\": \"Biologically Active Benzimidazole Hybrids as Cancer Therapeutics: Recent Advances\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105020159742&doi=10.3390%2Fph18101454&partnerID=40&md5=c14cf11882bbc987c821caa490f80418\",\r\n \"affiliations\": \"Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruher Institut f\u00fcr Technologie, Karlsruhe, Germany; Karlsruher Institut f\u00fcr Technologie, Karlsruhe, Germany; Faculty of Pharmacy, Minya, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutical Chemistry, School of Pharmacy, Asyut, Egypt\",\r\n \"abstract\": \"Cancer is a highly significant medical concern, as it is the second most prevalent cause of mortality after cardiovascular diseases. It arises due to dysregulated cell cycle control, leading to a gradual decline in cellular differentiation and unrestricted cellular proliferation. Therefore, the primary objective for researchers is to develop a cancer treatment that addresses drug resistance while providing effective therapeutic benefits and minimizing side effects. Benzimidazole has garnered significant attention because it serves as an auxiliary isostere of nucleotides, which are found in several natural and biologically active molecules. Benzimidazole compounds possess a privileged pharmacophore that exhibits various pharmacological actions. Several benzimidazole derivatives exhibit dual or multiple anticancer properties through diverse mechanisms, focusing on specific compounds or employing strategies that are not gene specific. Furthermore, many drugs based on benzimidazole have previously been approved to treat cancer. This comprehensive review encompasses the most important reports on various benzimidazole hybrids, highlighting their anticancer significance, mechanism of action, and structure-activity relationships from 2005 up to 2025. These provide valuable knowledge for designing effective anticancer drugs. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"anticancer agents\",\r\n \" benzimidazole derivatives\",\r\n \" docking\",\r\n \" mechanisms of action\",\r\n \" structure\u2013activity relationship\",\r\n \" target proteins\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 13,\r\n \"title\": \"Moghib, Khaled (58870319800); Dawoud, Ali L.Abbas (59908104100); Altalab, Gergis (59907492700); Syed, Mohamed Salah (59907284400); Salomon, Izere (59242048100); Musse, Halima Abdirashid Y. (59907901900); Doubie, Ossama Ahmed Mohamed (59906883100); Elsekhary, Ahmed I. (59544159300); Al-Dalaeen, Raneem Awni (59907902000); Kandil, Gamal Eldin Hady (57192254385)\",\r\n \"authors\": \"Evaluating hyperbaric oxygen therapy as an adjunct to corticosteroids in sudden sensorineural hearing loss: a systematic review and meta-analysis\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105005805673&doi=10.1007%2Fs00405-025-09372-2&partnerID=40&md5=a7d6abac0489ddb13b2463e05822cb4e\",\r\n \"affiliations\": \"Faculty of Medicine, Cairo, Egypt; Medical Research Group of Egypt, Negida Academy, Arlington, United States; Faculty of Medicine, Al-Azhar University, Cairo, Egypt; Faculty of Medicine, Merit University, Sohag, Egypt; Faculty of Medicine, Ain Shams University, Cairo, Egypt; University of Rwanda, Butare, Rwanda; Faculty of Medicine, Cairo, Egypt; Zagazig University, Faculty of Medicine, Zagazig, Egypt; School of Medicine, Amman, Jordan; Department of Otorhinolaryngology, Cairo University, Giza, Egypt\",\r\n \"abstract\": \"Background: Sudden sensorineural hearing loss (SSNHL) is a medical emergency characterized by unexplained hearing loss, usually one-sided, of at least 30 dB across three or more contiguous frequencies within 72\u00a0h. This condition significantly impairs daily communication and has serious consequences for mental health, social relationships, and the overall quality of life. Hyperbaric oxygen therapy (HBOT) is being investigated as a potential adjuvant treatment for SSNHL alongside systemic steroids. Objectives: This systematic review and meta-analysis aimed to evaluate the efficacy of HBOT combined with systemic corticosteroids compared with corticosteroids alone in patients with SSNHL. Method: We searched PubMed, Cochrane, Scopus, Web of Science, and Google Scholar to identify 14 studies that matched our inclusion criteria of randomized controlled trials (RCTs) published in English, which evaluated HBOT alone or with corticosteroids in adults (\u2265 18 years) diagnosed with SSNHL based on the AAO-HNS criteria, reporting pure-tone audiometry (PTA)-based outcomes. The analysis included 794 participants and evaluated outcomes such as improvements in Pure Tone Audiometry (PTA) thresholds, rates of hearing recovery, and adverse events. Results: Results indicated that the combined therapy of HBOT and systemic corticosteroids significantly improved low-frequency hearing thresholds (SMD: 0.83, 95% CI: 0.66\u20131.00, p < 0.0001) and increased the odds of complete recovery (OR: 2.05, 95% CI: 1.41\u20132.98, p = 0.0002). However, significant heterogeneity (I\u00b2 = 96.7%) and variations in the treatment protocols were observed. Adverse events, including vertigo, have been reported but are generally mild. Conclusion: This meta-analysis suggests that combining systemic corticosteroids with HBOT may improve hearing recovery in ISSNHL, particularly at lower frequencies within the first three months. However, high heterogeneity and the lack of statistical significance in the random-effects model call for cautious interpretation. Well-designed RCTs with standardized protocols and clear patient selection criteria are needed to confirm these findings. Future research should focus on identifying subgroups most likely to benefit and optimizing treatment protocols. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Hyperbaric oxygen therapy\",\r\n \" Idiopathic sudden sensorineural hearing loss\",\r\n \" Sensorineural hearing loss\",\r\n \" Steroid therapy\",\r\n \" Sudden hearing loss\",\r\n \" Systemic corticosteroids\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 14,\r\n \"title\": \"Roshdi, Mostafa (60116218000); Mohamed, Mamdouh F.A. (57193728428); Beshr, Eman A.M. (36658017300); Aziz, Hossameldin A. (57209291308); Gebril, Sahar M. (57217824102); Br\u00e4se, Stefan J. (7005396290); Mohassab, Aliaa M. (57196023547)\",\r\n \"authors\": \"Design, Synthesis, In Silico Docking, Multitarget Bioevaluation and Molecular Dynamic Simulation of Novel Pyrazolo[3,4-d]Pyrimidinone Derivatives as Potential In Vitro and In Vivo Anti-Inflammatory Agents\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105017182700&doi=10.3390%2Fph18091326&partnerID=40&md5=7915fb4df8b2bb2e9a954c549933ba02\",\r\n \"affiliations\": \"Department of Medicinal Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Medicinal Chemistry, Merit University, Sohag, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kharga, Egypt; Department of Medicinal Chemistry, Minia National University, New Minia, Egypt; Department of Histology and Cell Biology, Faculty of Medicine, Sohag, Egypt; Institute of Biological and Chemical Systems, Karlsruher Institut f\u00fcr Technologie, Karlsruhe, Germany\",\r\n \"abstract\": \"Background: A novel series of pyrazolo[3,4-d]pyrimidinone derivatives were synthesized, characterized, and examined for their anti-inflammatory effects. Results: The findings indicated that compounds 5d, 5j, 5k, and 5m demonstrated significant anti-inflammatory effects through the selective inhibition of the COX-2 isozyme, with IC<inf>50<\/inf> values ranging from 0.27 to 2.34 \u03bcM, compared to celecoxib (IC<inf>50<\/inf> = 0.29 \u03bcM). Compound 5k emerged as the most potent, exhibiting a selectivity index (SI) of 95.8 for COX-2 relative to COX-1. In vivo tests additionally validated that compounds 5j and 5k demonstrated significant anti-inflammatory efficacy, exhibiting greater suppression percentages of generated paw edema than indomethacin, comparable to celecoxib, while preserving excellent safety profiles with intact gastric tissue. Mechanistic studies demonstrated that the anti-inflammatory efficacy of the target compounds was associated with a substantial decrease in serum levels of TNF-\u03b1 and IL-6. Moreover, molecular modeling investigations corroborated the in vitro findings. Compound 5k displayed a binding free energy \u0394G of \u221210.57 kcal\/mol, comparable to that of celecoxib, which showed a \u0394G of \u221210.19 kcal\/mol. The intensified binding contacts in the COX-2 isozyme indicated the augmented inhibitory efficacy of 5k. Conclusions: Compound 5k exhibited dual activity by inhibiting the COX-2 isozyme and suppressing the pro-inflammatory cytokines TNF-\u03b1 and IL-6, therefore providing a remarkable anti-inflammatory effect with increased therapeutic potential. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"anti-inflammatory\",\r\n \" COX-1\",\r\n \" COX-2\",\r\n \" IL-6\",\r\n \" pyrazolo[3,4-d]pyrimidine\",\r\n \" TNF-\u03b1\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 15,\r\n \"title\": \"Abdel-Hafez, Gehan A. (57411646000); Klopotowska, Dagmara (16637423800); Filip-Psurska, Beata (55504444900); Aboraia, Ahmed Safwat M. (11140453400); Wietrzyk, Joanna (7004261658); Aboul-Fadl, Tarek (6701571958); Youssef, Adel F. (7101875923)\",\r\n \"authors\": \"Hybrid nucleobase-heterocycle-2-oxindole scaffolds as innovative cell cycle modulators with potential anticancer activity\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105013751832&doi=10.1039%2Fd5ra04997k&partnerID=40&md5=617152363993bef444a163f0f3d0a766\",\r\n \"affiliations\": \"Department of Medicinal Chemistry, Merit University, Sohag, Egypt; Department of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences, Wroclaw, Poland; Department of Medicinal Chemistry, Faculty of Pharmacy, Asyut, Egypt\",\r\n \"abstract\": \"A series of hybrid molecules 6a-6d-13a-13d combining pyrazolo[3,4-d]pyrimidine or aminopurine frameworks with an oxindole moiety were designed as multitarget anticancer agents. Several compounds, especially 8b and 12a-12d, showed potent antiproliferative effects against three human cancer cell lines: A498 (kidney carcinoma), HepG-2 (hepatocellular carcinoma), and MDA-MB-231 (breast adenocarcinoma). Compounds 6b, 7b, 8b, and 12a-12c exhibited remarkable CDK6 inhibition (pIC<inf>50<\/inf> of up to 7.17), outperforming palbociclib, and VEGFR-2 inhibition comparable to sorafenib. These compounds also inhibited xanthine oxidase. Notably, 12a and 12c induced sub-G1 cell cycle arrest in HepG2 cells. Molecular modeling confirmed stable binding to CDK6 and VEGFR-2, while in silico ADMET profiling suggested favorable pharmacokinetics. These results support 8b and 12a-12c as strong leads for further multitarget cancer therapy development. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 16,\r\n \"title\": \"Ebied, Manal S. (55177240200); Korycka-Machala, Ma\u0142gorzata (6507875571); Shaldam, Moataz Ahmed (57189222976); Mohamed, Thabit Gamal (56512028900); Kawka, Malwina (57140427700); Dziadek, Bozena R. (6508131689); Kuzio\u0142a, Magdalena (6504171099); Atef Abdelsattar Ibrahim, Hoda (58854531900); Lei, Xinsheng (56223952500); Elshamy, Abdelsamed Ibrahim (57194089832); Dziadek, Jaroslaw (6603688174); Sabt, Ahmed (57202765042)\",\r\n \"authors\": \"Exploring antitubercular activity of new coumarin derivatives targeting enoyl acyl carrier protein reductase (InhA): Synthesis, biological evaluation and computational studies\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105000737827&doi=10.1016%2Fj.molstruc.2025.142074&partnerID=40&md5=e50c24f33b2ffada5997fba278120689\",\r\n \"affiliations\": \"Chemistry of Natural Compounds Department, National Research Centre, Giza, Egypt; Department of Chemistry, Northern Border University, Arar, Saudi Arabia; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish of Sciences, Lodz, Poland; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafr el-sheikh, Egypt; Department of Pharmacy, University of G. d'Annunzio Chieti and Pescara, Chieti, Italy; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Molecular Microbiology, University of Lodz, Lodz, Poland; Polish Academy of Sciences, Warsaw, Poland; Department of Pediatric Medicine, Faculty of Medicine, Cairo, Egypt; School of Pharmacy, Fudan University, Shanghai, China\",\r\n \"abstract\": \"Tuberculosis poses a significant global health challenge, resulting in substantial health, economic, and social issues worldwide. The development of new antitubercular agents is critically important and can be enhanced by targeting various druggable sites for inhibition. The enoyl acyl carrier protein reductase (InhA) enzyme plays a vital role in the survival of Mycobacterium tuberculosis. In this research, a variety of coumarin-derived thiazolidinone and thiazole derivatives were synthesized using a molecular hybridization approach, and their efficacy was subsequently assessed against the wild-type strain Mycobacterium tuberculosis H37Rv. Among the synthesized compounds, compound 5 exhibited the highest potency against wild-type M. tuberculosis, with a minimum inhibitory concentration (MIC) of 20 \u03bcg\/mL, while demonstrating low cytotoxicity towards mouse fibroblasts at concentrations twice that of the MIC. Furthermore, compound 5 significantly inhibited mycobacterial biofilm formation. This promising compound was also evaluated for its inhibitory effect on InhA, revealing potent activity with an IC<inf>50<\/inf> value of 0.191 \u00b5g, surpassing that of the reference drug triclosan. Molecular docking and dynamics simulations indicated that compound 5 exhibited strong in-silico binding, occupying the active site of InhA and interacting with the NAD+ molecule, while also demonstrating stable dynamics in relation to InhA. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Antitubercular\",\r\n \" Biological evaluation\",\r\n \" Coumarin derivatives\",\r\n \" InhA enzyme\",\r\n \" Molecular dynamics\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 17,\r\n \"title\": \"Abdel Hakiem, Ahmed F. (55372700500); Soliman, Aya M. (58672477400); Haredy, Ahmed M. (56895997900); Boushra, John M. (57381892800); Aboraia, Ahmed Safwat M. (11140453400)\",\r\n \"authors\": \"Ratiomeric Luminescent Monitoring of Cardiovascular Agents Exploiting Phosphorus and Nitrogen Co-Doped Carbon Quantum Dots as Nano-Sensors: Bioavailability Study in Rabbit Males\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105013232853&doi=10.1002%2Fbio.70243&partnerID=40&md5=0d49dd631de69af7b0c0c015da7a34a2\",\r\n \"affiliations\": \"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Qena, Egypt; Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Asyut, Egypt; School of Chemistry, UNSW Sydney, Sydney, Australia; Department of Pharmaceutical Chemistry, Nile Valley University, Fayoum, Egypt\",\r\n \"abstract\": \"Phosphorus and nitrogen co-doped carbon quantum dots (PNCQDs) were utilized as facile fluorescent probes for accurate monitoring of naftidrofuryl oxalate (NAFT) and rivaroxaban (RIVA). These luminescent templates have shown two emission ratiomeric bands at 335 and 444 nm upon excitation at 273 nm. Successive titration of the carbon dots with NAFT solution showed enhanced fluorescence at 335 nm band, leaving the other band unchanged, while by consecutive addition of RIVA increments to the PNCQDs\u2013NAFT complex, a fluorescence quenching occurred only to the same band. All measurements were performed in phosphate buffer; pH 7.40 (3.00 \u00d7 10\u22123 M) for \u2248 2 min reaction time. The method was validated according to the International Conference on Harmonization (ICH) guidelines with percentage relative standard deviation values (%RSD) not more than 2.90%. The studied analytes have shown excellent sensitivity with limits of quantitation (LOQ) of 1.50 \u00d7 10\u22123 and 3.00 \u00d7 10\u22123 \u03bcg\/mL for NAFT and RIVA, respectively, as well as outstanding selectivity towards a wide range of interfering species. Recovery percentages of 97.00\u201398.00 were obtained upon application to tablets and spiked plasma samples. The developed method was successfully employed in estimating the pharmacokinetics of both analytes in male rabbits. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"application to pharmaceuticals and spiked plasma samples\",\r\n \" carbon quantum dots\",\r\n \" naftidrofuryl oxalate and rivaroxaban\",\r\n \" pharmacokinetic study\",\r\n \" spectrofluorimetric determination\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 18,\r\n \"title\": \"Metwaly, Ahmed M. (56153972200); Elkady, Hazem (57203864016); Elgammal, Walid E. (57211620104); Yousef, Reda G. (57225078967); Husein, Dalal Z. (55917450100); Soliman, Omar A. (57697503400); Hagras, Mohamed (57194203232); Alsfouk, Bshra Ali A. (57208926635); Elkaeed, Eslam B. (56884768800); Eissa, Ibrahim H. (57189457618)\",\r\n \"authors\": \"Innovative Nicotinamide-Dihydrothiadiazole Compounds for Targeting VEGFR-2: Design, Synthesis, and Mechanistic Exploration in Breast Cancer Treatment\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105009774969&doi=10.1002%2Fslct.202501319&partnerID=40&md5=e0572197060a2f71616b5dbdb1f5f4b9\",\r\n \"affiliations\": \"Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Cairo, Egypt; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Faculty of Science, Cairo, Egypt; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Chemistry, Faculty of Science, Kharga, Egypt; Department of Clinical Pharmacy, Alexandria University, Alexandria, Egypt; Department of Human Genetics, Alexandria University, Alexandria, Egypt; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Department of Pharmaceutical Sciences, Almaarefa University, Riyadh, Saudi Arabia\",\r\n \"abstract\": \"In this study, a series of nicotinamide-dihydrothiadiazole hybrids were synthesized and evaluated for their anticancer potential through VEGFR-2 inhibition. Among the synthesized compounds, 7c demonstrated a very promising VEGFR-2 inhibitory activity (IC\u2085\u2080 = 0.098\u00a0\u00b1\u00a00.05\u00a0\u00b5M), comparable to the reference drug sorafenib (IC\u2085\u2080 = 0.1\u00a0\u00b1\u00a00.05\u00a0\u00b5M). In vitro cytotoxicity studies revealed that 7c exhibited significant anticancer activity against MDA-MB-231 (IC\u2085\u2080 = 6.92\u00a0\u00b1\u00a00.4\u00a0\u00b5M) and MCF-7 (IC\u2085\u2080 = 9.18\u00a0\u00b1\u00a00.7\u00a0\u00b5M) breast cancer cell lines, with minimal toxicity toward normal cells (WI-38 and WISH). Mechanistic studies indicated that 7c induces G0\/G1 phase arrest and apoptosis, as evidenced by increased late apoptotic populations (45.58%) and upregulation of caspase-3, Bax, and a significant reduction in Bcl-2. Computational analyses, encompassing molecular docking and 200\u00a0ns molecular dynamics (MD) simulations, demonstrated the stable interaction of 7c with VEGFR-2, highlighting its excellent binding affinity. Additionally, Swiss ADMET predictions highlighted the favorable pharmacokinetic and safety profiles of 7c, including non-mutagenic and noncarcinogenic properties, moderate absorption, and high plasma protein binding (>90%). These findings establish nicotinamid-dihydrothiadiazole hybrids, particularly 7c, as promising VEGFR-2 inhibitors with dual mechanisms of angiogenesis inhibition and apoptosis induction. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Breast cancer\",\r\n \" Dihydrothiadiazol\",\r\n \" MD simulation\",\r\n \" Nicotinamide\",\r\n \" VEGFR-2 inhibitors\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 19,\r\n \"title\": \"Tawfeek, Mohammed M.Mahdy (58506347900); Tohamy, Dalia M. (57212882341); Abdel Hamid Ahmed, Hanan M. (60133082200); Rashad, Mai Hamdy (59410526200); Nashaat Ali Rady, Ahmed M. (60132854900)\",\r\n \"authors\": \"Accelerated corneal cross-linking combined with topical voriconazole versus topical amphotericin B For the treatment of fungal keratitis with corneal melting\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105018186772&doi=10.4103%2Fejos.ejos_65_24&partnerID=40&md5=6ff878dac3ea9cfc08b77e58201547fa\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; Department of Ophthalmology, Assiut University, Asyut, Egypt; Department of Ophthalmology, The General Organization for Teaching Hospitals and Institutes, Cairo, Bab El Khalk, Egypt; Department of Microbiology, Suez University, Suez, Egypt; Department of Ophthalmology, Merit University, Sohag, Egypt; Department of Ophthalmology, Kazan Federal University, Cairo, Egypt\",\r\n \"abstract\": \"Objective This work aims to compare the safety and efficacy of accelerated corneal cross-linking (A-CXL) combined with topical voriconazole (VCZ) versus A-CXL combined with topical amphotericin B for the treatment of fungal keratitis (FK) with corneal melting. Patients and methods This is a retrospective comparative clinical cohort study. Total 40 eyes with clinically suspected and lab-confirmed FK with corneal melting were included. These eyes were classified randomly into two groups each of 20 eyes; group (A) was treated by repeated sessions of A-CXL plus topical VCZ and group (B) was treated by repeated sessions of A-CXL combined with topical amphotericin B. The end point of this study was complete corneal healing with negative culture on lab examination. Identification of organisms was done by lab study before and after treatment. Corneal healing was evaluated by corneal examination and anterior segment optical coherence tomography. Results Visual acuities improved from a mean decimal value of 0.063\u20130.25 in group (A) and from 0.08 to 0.125 in group (B) at the end of the follow-up period (12 months). Group (A) showed more improvement especially after the 3rd month compared with group (B), P less than 0.05. Corneal infiltration size reduced from mean of 32.4\u20131.15 mm in group (A), while it was reduced from 31.2 to 12.5 mm in group (B) at the end of the follow-up period. Reduction in infiltration size in group (A) was significantly reduced more than group (B), P value less than 0.001 highly significant. The success rate of treatment in group (A) was very highly significant (P<0.001) and in group (B) was weak significant (P=0.045). Comparison between the two groups showed highly significant difference (P=0.006). On the other hand, treatment failure was 0 in group (A) and eight cases in group (B) with highly significant difference (P<0.001). Conclusion The success of A-CXL in the treatment of FK is summarized by its known effect of reversal of corneal melting and anti-infective properties. A-CXL combined with topical VCZ was found to be more effective in treating FK with corneal melting than A-CXL combined with amphotericin B with better visual outcomes. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"accelerated corneal cross-linking (A-CXL)\",\r\n \" amphotericin B\",\r\n \" corneal melting\",\r\n \" fungal keratitis\",\r\n \" voriconazole (VCK)\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 20,\r\n \"title\": \"Fahmy, Seham (59968735300); Wadee, Amir N. (25422836600); Elshinnawy, Ahmed M. (57207305722); Eraky, Zeezy S. (58640374000); Taher, Marwa (59969025400); Anwar, Alaa (59969315300)\",\r\n \"authors\": \"Influence of Electro-Acupuncture on Diplopia in Patients With Oculomotor and Abducens Nerves Palsy\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105009412623&doi=10.1002%2Fpri.70074&partnerID=40&md5=b27b93af014a57033e9cceb3ded45b08\",\r\n \"affiliations\": \"Faculty of Physical Therapy, Cairo, Egypt; Military Medical Academy, Cairo, Egypt; Department of Basic Sciences, Faculty of Physical Therapy, Giza, Egypt; Faculty of Physical Therapy, Alexandria, Egypt; Department of Physical Therapy for Neuromuscular Disorders and Its Surgery, Merit University, Sohag, Egypt; Department of Physical Therapy for Internal Medicine and Elderly, Faculty of Physical Therapy, Cairo, Egypt; Egyptian Chinese University, Cairo, Egypt; Egyptian Chinese University, Cairo, Egypt\",\r\n \"abstract\": \"Background: Diplopia (DP) can have a significant negative impact on one's quality of life, many clinical investigations lend credence to the notion that acupuncture could be used to treat DP symptoms, randomized controlled trials are lacking, and only clinical observational studies have assessed the effectiveness of acupuncture in managing DP. Purpose: To examine the influence of electro-acupuncture on diplopia in patients with oculomotor and abducens nerve palsy. Methods: Forty eyes diagnosed with diplopia were randomly classified into study group (A) that received electro acupuncture therapy and standard prophylactic medications for 4\u00a0weeks at points selected for treating double vision, and control group (B) who received standard prophylactic medications only. The Hess screen test was used to measure degrees of deviation. Results: There were statistically significant differences in the post-test (p\u00a0=\u00a00.38 and 0.003 respectively) in favor of the study group. Discussion: In conclusion, integration between acupuncture therapies and standard prophylactic medications yields better results in treating DP. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"acupuncture\",\r\n \" diplopia\",\r\n \" hess screen test\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 21,\r\n \"title\": \"Elgammal, Walid E. (57211620104); Elkady, Hazem (57203864016); Yousef, Reda G. (57225078967); Eldehna, Wagdy M. (56318690700); Husein, Dalal Z. (55917450100); Amin, Fatma G. (57223365717); Alsfouk, Bshra Ali A. (57208926635); Elkaeed, Eslam B. (56884768800); Eissa, Ibrahim H. (57189457618); Metwaly, Ahmed M. (56153972200)\",\r\n \"authors\": \"New nicotinamide-thiadiazol hybrids as VEGFR-2 inhibitors for breast cancer therapy: design, synthesis and in silico and in vitro evaluation\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105004724157&doi=10.1039%2Fd5ra01223f&partnerID=40&md5=8d31c1f4e1740e553f198cda7bf03e06\",\r\n \"affiliations\": \"Faculty of Science, Cairo, Egypt; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafr el-sheikh, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria, Egypt; Department of Chemistry, Faculty of Science, Kharga, Egypt; Department of Physics, Faculty of Science, Alexandria, Egypt; Department of Pharmaceutical Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Department of Pharmaceutical Sciences, Almaarefa University, Riyadh, Saudi Arabia; Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"Vascular endothelial growth factor receptor-2 (VEGFR-2) is a key regulator of tumor angiogenesis and has become an important target in anticancer drug development. In this study, novel nicotinamide-thiadiazol hybrids were synthesized and evaluated for their anti-breast cancer potential through VEGFR-2 inhibition. The compounds were assessed in vitro for their cytotoxicity against MDA-MB-231 and MCF-7 cell lines. Among the nicotinamide-thiadiazol hybrids, 7a exhibited the most potent anticancer activity, with IC<inf>50<\/inf> values of 4.64 \u00b1 0.3 \u03bcM in MDA-MB-231 and 7.09 \u00b1 0.5 \u03bcM in MCF-7, showing comparable efficacy to sorafenib. VEGFR-2 inhibition assays confirmed strong inhibitory potential with an IC<inf>50<\/inf> of 0.095 \u00b1 0.05 \u03bcM. In vitro cell cycle analysis indicated that 7a induced S-phase arrest, while apoptosis assays demonstrated a substantial increase in late apoptotic cells (44.01%). Other in vitro mechanistic studies further confirmed the activation of the intrinsic apoptotic pathway, as evidenced by caspase-3 activation (8.2-fold), Bax upregulation (6.9-fold), and Bcl-2 downregulation (3.68-fold). Computational studies, including molecular docking and 200 ns molecular dynamics (MD) simulations, confirmed the stable interaction of 7a with VEGFR-2, showing binding affinities comparable to sorafenib. Further validation through MM-GBSA, ProLIF, PCAT, and FEL analyses reinforced its strong binding capability. Additionally, ADMET predictions suggested favorable pharmacokinetic properties, including good absorption, high plasma protein binding, and non-CYP2D6 inhibition. Moreover, toxicity analysis classified 7a as non-mutagenic and non-carcinogenic, with a lower predicted toxicity than sorafenib. Finally, density functional theory (DFT) calculations highlighted the structural stability and reactivity of 7a, further supporting its potential as a VEGFR-2 inhibitor. These findings suggest that 7a is a promising VEGFR-2 inhibitor with significant anticancer potential, favorable pharmacokinetics, and an improved safety profile. Further preclinical studies and structural modifications are warranted to optimize its therapeutic potential. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 22,\r\n \"title\": \"Younis, Inas Youssef (57204181603); Sedeek, Mohamed S. (57211455880); Essa, Ahmed Fathi (57211229061); Elgamal, Abdelbaset M. (57219921996); Eltanany, Basma M. (57196477994); Goda, Zeinab M. (57223340333); Pont, Laura (55966943100); Benavente, Fernando (6602224284); Mohsen, Engy (57203284031)\",\r\n \"authors\": \"Exploring geographic variations in quinoa grains: Unveiling anti-Alzheimer activity via GC\u2013MS, LC-QTOF-MS\/MS, molecular networking, and chemometric analysis\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85208654067&doi=10.1016%2Fj.foodchem.2024.141918&partnerID=40&md5=e54ef600e34e0fd150288ab4dfad418e\",\r\n \"affiliations\": \"Faculty of Pharmacy, Cairo, Egypt; Department of Pharmacognosy, Field of Pharmacy, Ras Sedr, Egypt; Chemistry of Natural Compounds Department, National Research Centre, Giza, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt; Chemistry of Natural and Microbial Products Department, National Research Centre, Giza, Egypt; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo, Egypt; Department of Chemical Engineering and Analytical Chemistry, Universitat de Barcelona, Barcelona, Spain; Generalitat de Catalunya, Barcelona, Spain\",\r\n \"abstract\": \"Quinoa is an ancient Andean crop with a significant interest due to its nutritional and health benefits. This work provides a comprehensive metabolite profiling of five commercially available quinoa grains from diverse geographical origins. GC\u2013MS analysis of primary metabolites identified sugars, sugar derivatives, and lipids as the predominant classes. LC-QTOF-MS\/MS metabolomics and molecular networking facilitated the identification of 151 secondary metabolites, including 20 flavonoids, 14 saponins, and 20 lipids, which were reported for the first time in quinoa. In the AChE inhibition assay, USA white quinoa exhibited the highest activity. Chemometric analyses indicated that flavonoids and saponins were crucial for distinguishing quinoa grains. Notably, flavonoid glycosides and saponins were positively correlated with AChE inhibition. This study represents the first MS-based metabolomics investigation using molecular networking and chemometrics to explore the metabolome heterogeneity of commercial quinoa grains, underscoring their potential as a promising natural source for combating Alzheimer's disease. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Anti-Alzheimer\",\r\n \" Anticholinesterase activity\",\r\n \" Chemometrics\",\r\n \" GC\u2013MS\",\r\n \" LC-QTOF-MS\/MS\",\r\n \" Molecular networking\",\r\n \" Quinoa\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 23,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Zaki, Randa Mohammed (54792413400); Hefny, Ahmed A. (57195534027); Afzal, Obaid (53870994800); Shahataa, Mary Girgis (57190442518); Abo El-Ela, Fatma I. (56461520900); Salem, Heba Farouk (16426683200); Gamal, Amr Gamal (57204454409)\",\r\n \"authors\": \"Corrigendum to \u201cIn vitro and in vivo evaluation of isoxsuprine loaded invasomes for efficient treatment of diabetes-accelerated atherosclerosis\u201d [J. Drug Deliv. Sci. Technol. 96 (2024) 105686] (Journal of Drug Delivery Science and Technology (2024) 96, (S1773224724003551), (10.1016\/j.jddst.2024.105686))\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85214000878&doi=10.1016%2Fj.jddst.2024.106597&partnerID=40&md5=7b940d0025ddcc64420f5101b16f0565\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Faculty of Pharmacy, Beni Suef, Egypt; School of Pharmacy, University of Waterloo, Waterloo, Canada; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutical Chemistry, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Pharmacology, Faculty of Medicine, Beni Suef, Egypt; Department of Pharmacology, Faculty of Veterinary Medicine, Beni Suef, Egypt; Faculty of Pharmacy, Beni Suef, Egypt\",\r\n \"abstract\": \"The authors regret < Acknowledgements: This study was supported via Prince Sattam Bin Abdulaziz University Project number (PSAU\/2024\/R\/1445) >. The authors would like to apologise for any inconvenience caused. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 24,\r\n \"title\": \"Eissa, Manar A. (57204365848); Farag, Mohamed Ali (7006035865); Saleh, Dalia Osama (37018567000); Shabana, Marwa E. (57195197565); Abou El-Ezz, Rania F. (55550010300); El-Kersh, Dina M. (57194212137)\",\r\n \"authors\": \"Metabolome classification of Tongkat Ali (Eurycoma longifolia jack) and its commercial products via UHPLC-QTOF-MS-MS and its protective effect against 5-flurouracil-Induced testicular toxicity in male rats\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85206981774&doi=10.1016%2Fj.jep.2024.118904&partnerID=40&md5=09b20f7846548406e3a53f36bb632b6d\",\r\n \"affiliations\": \"Department of Pharmacology and Toxicology, Merit University, Sohag, Egypt; Faculty of Pharmacy, Cairo, Egypt; Department of Pharmacology, National Research Centre, Giza, Egypt; Department of Pathology, National Research Centre, Giza, Egypt; Pharmacognosy Department, Faculty of Pharmacy, Cairo, Egypt; Pharmacognosy Department, Faculty of Pharmacy, El Shorouk, Egypt; University of Mississippi School of Medicine, Jackson, United States\",\r\n \"abstract\": \"Ethnopharmacological relevance: Tongkat Ali (Eurycoma longifolia Jack) is a chief herbal medicine that is well recognized for its aphrodisiac properties, available in various commercial products worldwide. Aim of the study: The aim of this work is to identify the different classes of secondary metabolites present in Tongkat Ali commercial products versus authenticated root, and to assess its root extract mitigative effect against 5-flurouracil (5FU)-induced testicular toxicity. Materials and methods: High-resolution UHPLC-QTOF-MS\/MS metabolites analysis was utilized on the ethanolic Tongkat Ali extract (TAE) parallel to three Mlayasian commercial products, followed by a multivariate data analysis to understand the variability among UHPLC-MS metabolites datasets. Adult male rats were treated with 5-Fluorouracil (5FU) \u00b1 Tongkat Ali extract. Semen parameters, serum testosterone, LH, and FSH, and testicular oxidative stress biomarkers like malondialdehyde (MDA) levels, Nuclear factor kappa B (NF-\u03baB) and erythroid 2\u2013related factor 2 (Nrf2) were analyzed. Results: The main categories of secondary metabolites identified through UHPLC-MS\/MS profiling were quassinoids, alkaloids, fatty acids, lignans and coumarins. Long Jack Plus\u00ae ELP-2 clustered alongside authentic roots ELR on the negative side, while Naturelle\u00ae ELP-1 and Nu-Prep-LEAKI\u00ae ELP-3 were positioned on the opposite side. The OPLS-DA model was used to identify markers for preparations from authentic roots, with commercial products enriching in ailanthone epoxide. In vivo results showed that 5FU reduced sperm parameters by 42%, while TAE improved sperm quality by 35\u201343% and 58\u201374% at dose of 400 and 800 mg\/kg, respectively. Testosterone, reduced by 74% with 5FU, increased 2.3- to 3.2-fold with TAE. TAE also reduced MDA by 31\u201362%, NF-\u03baB by 32\u201355% and increased Nrf2 by 1\u20132 folds. Conclusion: The manuscript presents a comparative metabolomics study and in vivo investigation into the potential of Tongkat Ali root to improve testicular function in male rats intoxicated with 5FU, an area not previously explored. Further research is required to understand the mechanisms. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Eurycoma longifolia\",\r\n \" Metabolomics\",\r\n \" Testicular toxicity\",\r\n \" Tongkat ali\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 25,\r\n \"title\": \"Elkaeed, Eslam B. (56884768800); Elkady, Hazem (57203864016); Khattab, Ahmed M. (58255139900); Yousef, Reda G. (57225078967); Al-Ghulikah, Hanan A. (55234967400); Husein, Dalal Z. (55917450100); Ibrahim, Ibrahim M. (57208274428); Elkady, Mohamed A. (59574718100); Metwaly, Ahmed M. (56153972200); Eissa, Ibrahim H. (57189457618)\",\r\n \"authors\": \"Integrated in silico and in vitro exploration of the anti-VEGFR-2 activities of a semisynthetic xanthine alkaloid inhibiting breast cancer\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85216376157&doi=10.1371%2Fjournal.pone.0316146&partnerID=40&md5=5556204c1daff01a033e0fc2373d4abc\",\r\n \"affiliations\": \"Department of Pharmaceutical Sciences, Almaarefa University, Riyadh, Saudi Arabia; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Chemistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Department of Chemistry, Faculty of Science, Kharga, Egypt; Department of Biophysics, Faculty of Science, Giza, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"This study presents T-1-NBAB, a new compound derived from the natural xanthine alkaloid theobromine, aimed at inhibiting VEGFR-2, a crucial protein in angiogenesis. T-1-NBAB\u2019s potential to interacts with and inhibit the VEGFR-2 was indicated using in silico techniques like molecular docking, MD simulations, MM-GBSA, PLIP, essential dynamics, and bi-dimensional projection experiments. DFT experiments was utilized also to study the structural and electrostatic properties of T-1-NBAB. Computational analysis was performed to predict the ADME-Tox profiles of T-1-NBAB. After semisynthesis, the in vitro results showed that T-1-NBAB effectively inhibits VEGFR-2, with an IC<inf>50<\/inf> of 0.115 \u03bcM, compared to sorafenib\u2019s 0.0591 \u03bcM. In vitro tests also demonstrated significant activity of T-1-NBAB against breast cancer cell lines MCF7 and T47D, with IC<inf>50<\/inf> values of 16.88 \u03bcM and 61.17 \u03bcM, respectively, and high selectivity. Importantly, T-1-NBAB induced early and late apoptosis in MCF7 cells, indicating its potential as a strong anticancer agent. Additionally, T-1-NBAB reduced the migration and healing abilities of MCF7 cells, suggesting it could be a promising anti-angiogenic agent. Overall, these findings suggest that T-1-NBAB is a promising lead compound for further research as a potential treatment for breast cancer. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 26,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Hussain, Abdulzahra Abdulsamad (16417168400); Chiaretti, Massimo (6603417473); Kryvoruchko, Igor A. (60080182100); Kechagias, Aristotelis (22985131100); Elias, Abd Al Kareem (57349114100); Adsam, Abdelmonem A.M. (60161847100); Ali, Mohamed A. (57693482500); Ahmed, Saad Mohamed Ali (59781389000); Khyrallh, Ahmed (57199997926); Alsayed, Mohammed H. (57932903000); Awad, Esmail Tharwat Kamel (57338443100); Ibrahim, Emad A. (59781844800); Labib, Mohamed Fathy (57221263028); Teama, Sobhy Rezk Ahmed (58023821600); Sobhy Shaaban, Mohamed (58024021400); Elshafey, Mohammed Hassan (57212769328); Seleem, Abdelhafez (57657407600); Radwan, Amr (60162192000); Abdelkader, Hamada Rashad Mohamed (57349786500); Othman, Ahmed Fayez (60162192100); Algalaly, Nasreldin Mohammed (60161847200); Mostafa, Mostafa Mahmoud Salama (58838861600); Abouelseoud, Mohammed Abbas Abdou (60161937500); Alsaad, Mohamed Ibrahim Abo (58987233100); Ali, Abouelatta Kh (59692860600); Elbelkasi, Hamdi (58744062800); Zaid, Mahmoud Ali Abou (59781038500); Mohamed, Basma Ahmed (58213524000); Ibrahim, Islam Mohamed (60161759800); Metwally, Ahmed Gamal Eldin (60161847300); El Azawy, Mahmoud (57223313146); Khalil, Amr (60162027100); Abu-Elela, Sameh T. (57119989900); el-Taher, Ahmed Kamal (57221777128); Yassin, Mahmoud Abdou (57217355675); Lotfy, Mohamed Ahmed (57221813392); Mousa, Bassam (57710406600); Atef, Baher (57437326000); Elnemr, Mohamed M. (57219125086); Abdelaziz, Ahmed Mesbah (58894628000); Wasefy, Tamer (57748757500); Mansour, Mohamed Ibrahim (57219159269); Nawar, Abdelrahman Mohamed Hasanin (59781844900)\",\r\n \"authors\": \"Updates in surgery for colorectal cancer: incidence and risk factors for acute anastomotic leak\u2014a retrospective study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105020191628&doi=10.1007%2Fs13304-025-02411-x&partnerID=40&md5=6b5a21ccce129028fef516746ebfc7ce\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; The University of Sheffield, Sheffield, United Kingdom; University of Alkafeel, Najaf, Iraq; Department of General Surgery and Organ Transplantation, Sapienza Universit\u00e0 di Roma, Rome, Italy; Department of Surgery No. 2, Kharkiv National Medical University, Kharkiv, Ukraine; Department of Surgery, Athens General Hospital, Athens, Greece; Department of General Surgery, Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Cairo, Egypt; General Surgery Department-Faculty of Medicine, Merit University, Sohag, Egypt; Misr University for Science and Technology, 6th October, Egypt; Mataryia Teaching Hospital (GOTHI), Cairo, Egypt; General Surgery Department, El Mahala Hepatic Institute, Al Gharbia, Egypt; Faculty of Medicine, Cairo, Egypt; Department of General Surgery, Helwan University, Helwan, Egypt; Department of Surgical Oncology, Al-Ahrar Teaching Hospital, Zagazig, Egypt; General Surgery Department, Faculty of Medicine, Ismailia, Egypt\",\r\n \"abstract\": \"This study aimed to analyze the incidence and risk factors of acute anastomotic leak (AL) in patients with colorectal cancer (CRC) during and after the COVID-19 pandemic. Active COVID-19 was evaluated as a risk factor of acute AL. A retrospective multicenter analysis was performed on 390 patients with CRC between April 2020 and October 2024. Patients were divided into acute AL (n = 27) and no acute AL (no AL) (n = 363) groups. In the acute AL group, there were 24 (88.8%) men and three (11.2%) women, with a median age of 63 (65\u201367) years. Twenty-seven patients in both groups had a previous COVID-19 infection and 15 patients (55.5%) who complained of COVID-19 had AL. The incidence of clinical AL was 6.9% (27\/390), of which 11.1% (3\/27) and 88.9% (24\/27) were grade B and C, respectively. 24\/27 (88.9%) had free AL with peritonitis requiring surgical re-intervention. Multivariate analysis showed that active COVID-19 infection (OR = 176, 95% CI 14.27\u20132172.57, p < 0.001) and serum albumin level < 3\u00a0g\/dl (OR = 16.249, 95% CI 1.033\u2013255.544, p = 0.04) were associated risk predictors of AL, while the laparoscopic approach (OR = 0.032, 95% CI 0.002\u20130.434, p = 0.01) and splenic flexure mobilization (OR = 0.022, 95% CI 0.003\u20134.844, p = 0.02) were protective. The incidence of AL after CRC surgery did not increase during or after the COVID-19 pandemic. Active COVID-19 and serum albumin levels < 3\u00a0g\/dl were associated risk factors for AL, while the laparoscopic approach and splenic flexure mobilization were protective. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Anastomotic leak\",\r\n \" Colorectal cancer\",\r\n \" COVID-19\",\r\n \" Risk factors\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 27,\r\n \"title\": \"Marcus, Wagih H. (60019494800); Ruby, Hassan A. (59140891400); Awwad, Amira E. (60161863900); Mahrous, Mahrous H. (59735314700); Abouelwafa, Ebraheem (58046250400); Badawy, Mohamed A.S. (60081641500); El-Shiekh, Riham Adel (57194776386); Zaki, Eman S.A. (57196458897); Mahmoud, Mahmoud Abdelmouti (59461776200)\",\r\n \"authors\": \"Modulatory effects of bioactive natural compounds on pruritic pathways: mechanistic basis and therapeutic prospects\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105020176140&doi=10.1007%2Fs10787-025-01999-1&partnerID=40&md5=1b47c808e5ad2236df5e28139c5b445b\",\r\n \"affiliations\": \"Faculty of Pharmacy, Cairo, Egypt; Pharmacognosy Department, Faculty of Pharmacy, 6th October, Egypt; Faculty of Pharmacy, Mansoura, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Faculty of Pharmacy, Cairo, Egypt; Department of Pharmacology, Faculty of Pharmacy, Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"Chronic pruritus, characterized by persistent itching, is a significant health issue that adversely affects individuals\u2019 quality of life, particularly in palliative care environments. Conventional treatments frequently do not yield sufficient relief and may lead to undesirable side effects, which has spurred interest in exploring alternative therapeutic options. A thorough literature search was conducted across several databases such as PubMed, Web of Science, Scopus, and EKB, with an emphasis on studies involving in vitro, animal models, and clinical trials utilizing terms like \u201cplant,\u201d \u201cextract,\u201d and \u201cpruritus.\u201d All studies were considered regardless of their publication date and were limited to English-language articles. This review highlights the promise of various medicinal plants, including chamomile, Aloe vera, calendula, curcumin, lavender, licorice, and peppermint, as adjunctive therapies for pruritus. These plants possess a range of pharmacological properties, such as anti-inflammatory, antioxidant, and skin-soothing effects, which are relevant to the complex nature of pruritus. Their favorable safety profiles and natural origins enhance their appeal in holistic and patient-centered care models. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Medicinal plants\",\r\n \" Pruritus\",\r\n \" Complementary medicine\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 28,\r\n \"title\": \"Abdelfattah, Shadwa (59709418900); Mady, Fatma Mohammed (36169550300); Sarhan, Hatem Abdelmonsef A. (21740157800); Khalifa, Hazim O. (56797844900); Hashem, Hamada (60139420900); Hassan, Hesham M. (58026884300); Alkhammash, Abdullah (59195595800); Hadiya, Safy (57204194075); Ibrahem, Reham Ali (57214752474); Qelliny, Milad Reda (57209500528)\",\r\n \"authors\": \"Topical delivery of meropenem via spanlastic carbopol gel: in-vitro studies and in-vivo application in pressure ulcers\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105018681892&doi=10.3389%2Ffphar.2025.1672677&partnerID=40&md5=93f27fc1e556fcb860b61b9d2b3bf17c\",\r\n \"affiliations\": \"Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, Minia National University, New Minia, Egypt; Department of Veterinary Medicine, United Arab Emirates University, Al Ain, United Arab Emirates; Department of Pharmaceutical Chemistry, University Sohag, Sohag, Egypt; Department of Pathology, College of Medicine, Abha, Saudi Arabia; Department of Pharmacology, Shaqra University, Shaqra, Saudi Arabia; Assiut International Center of Nanomedicine, Assiut University, Asyut, Egypt; Department of Microbiology and Immunology, Faculty of Pharmacy, Minya, Egypt\",\r\n \"abstract\": \"Introduction: Spanlastics, a type of elastic nanovesicle, represents a promising drug delivery system capable of encapsulating both hydrophilic and lipophilic drug compounds. These carriers are biodegradable, biocompatible, and non-immunogenic. Meropenem (MRP), a broad-spectrum carbapenem antibiotic, is widely used to treat severe infections in both adults and children before the causative pathogens are identified. However, meropenem\u2019s aqueous formulations are highly unstable and must be administered within 24 h of preparation. This study aimed to develop a meropenem-loaded spanlastic formulation (MRP-SP) for topical application, aiming to enhance both the drug\u2019s stability and skin permeability. Methods: Spanlastics were prepared using Span 60 and Brij 35 via the ethanol injection method. The MRP-SP formulation was extensively characterized through particle size analysis, polydispersity index (PDI), zeta potential, encapsulation efficiency, in vitro drug release, scanning electron microscopy, microbiological assays, and in vivo topical efficacy studies. Results and Discussion: The optimized formulation (Batch F5), composed of Span 60 and Brij 35 in a 1:4 M ratio, exhibited a particle size of 462 nm, spherical morphology, 69.5% drug encapsulation efficiency, and 20% drug release within 6 h. The gel form of the same batch showed a comparable release profile. Antibacterial testing revealed that MRP-SP reduced the minimum inhibitory concentration by 2.4-fold against Pseudomonas aeruginosa compared to free MRP. Additionally, MRP-SP significantly downregulated the expression of mexA, a key resistance gene. In vivo, the topical application of MRP-SP demonstrated superior therapeutic activity in treating ulcerative skin lesions in non-diabetic mice, as evidenced by wound closure percent (89% at 10 days), wound area (49% at 10 days), and histopathological improvements. Overall, the meropenem-loaded spanlastic formulation shows strong potential as an effective topical therapy for bacterial skin infections. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"edge activator\",\r\n \" meropenem\",\r\n \" mexA expression\",\r\n \" pressure ulcers\",\r\n \" spanlastics\",\r\n \" transdermal\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 29,\r\n \"title\": \"Ali, Rania Abd Elmonem (60095945200); El Ghait, Amal Taha Abou (60096097600); Ali, Safaa S. (57195993926); Radwan, Eman M. (57190883689); Meligy, Fatma Y. (55043152000)\",\r\n \"authors\": \"NRF2 PATHWAY INVOLVEMENT IN THE CENTRAL NERVOUS SYSTEM\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105015705001&doi=10.58240%2F1829006X-2025.21.6-170&partnerID=40&md5=ce11aaf361f4def6b250752b1c73aaca\",\r\n \"affiliations\": \"Histology and Cell Biology Department, Faculty of Medicine, Qena, Egypt; Histology and Cell Biology Department, Sphinx University, New Assuit, Egypt; Histology and Cell Biology Department, Faculty of Medicine, Asyut, Egypt; Department of Histology and Cell Biology, Merit University, Sohag, Egypt; Department of Medical Biochemistry, Faculty of Medicine, Asyut, Egypt; Department of Biochemistry, Sphinx University, New Assuit, Egypt; Department of Restorative Dentistry and Basic Medical Sciences, University of Petra, Amman, Jordan\",\r\n \"abstract\": \"The nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a fundamental role in cellular defense against oxidative and electrophilic stress. Within the central nervous system (CNS), where neurons and glial cells are highly susceptible to oxidative damage, Nrf2 has emerged as a master regulator of antioxidant and detoxification responses. Activation of Nrf2 upregulates a wide array of genes involved in maintaining redox balance, including heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and enzymes responsible for glutathione synthesis. These adaptive responses help protect neurons from oxidative injury and support overall brain homeostasis. Dysregulation of Nrf2 signaling is increasingly recognized as a critical factor in the pathogenesis of neurodegenerative disorders such as Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, amyotrophic lateral sclerosis, and multiple sclerosis, as well as in acute neurological injuries like ischemic stroke and traumatic brain injury. Pharmacological strategies to activate Nrf2, including synthetic compounds such as dimethyl fumarate and natural agents like sulforaphane, have shown promising neuroprotective effects in both experimental and clinical settings. This review provides a comprehensive discussion on the structure and regulation of the Nrf2 pathway, its physiological role in the CNS, its involvement in neurological diseases, and therapeutic approaches targeting Nrf2 signaling. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"antioxidant response\",\r\n \" central nervous system\",\r\n \" Keap1\",\r\n \" neurodegeneration\",\r\n \" neuroprotection\",\r\n \" Nrf2\",\r\n \" oxidative stress\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 30,\r\n \"title\": \"Atwan, Hany (58124357400); Mondy, Madleen (60078456000); Altalab, Gergis (59907492700); Elgendy, Mena (60078735600)\",\r\n \"authors\": \"Post-craniotomy headache and botulinum toxin A: A systematic review of case reports and case series\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105014653155&doi=10.1177%2F25158163251371150&partnerID=40&md5=3d1ecb4f41f14456b7d636dc1b8afb4a\",\r\n \"affiliations\": \"Faculty of Medicine, Asyut, Egypt; Faculty of Medicine, Merit University, Sohag, Egypt; College of Medicine, 6th October, Egypt\",\r\n \"abstract\": \"Background: Post-craniotomy headache (PCH) is a common, often debilitating complication with limited treatment options and unclear pathophysiology. While botulinum toxin A (BoNT-A) is effective for various headache disorders, its use in PCH is underexplored. This systematic review examines case reports and series on BoNT-A's efficacy and safety for PCH. Methods: A systematic search of PubMed, Scopus, and Web of Science was conducted in February 2025 using relevant keywords. Case reports and series on BoNT-A treatment for PCH were included, while unrelated studies, reviews, and incomplete abstracts were excluded. Data on patient characteristics, treatment protocols, efficacy, and adverse events were extracted. Results: Five case series published up to 2025 report on 15 patients from France, Canada, and the United States. Each study enrolled only three or four patients, all with persistent PCH unresponsive to standard analgesics. BoNT-A regimens differed widely, ranging from 15 to 165 U, and included single versus repeated sessions, as well as injection sites such as the temporalis muscle, incision margins, and cranial suture lines, highlighting the lack of a standardized protocol. Eleven patients achieved 75\u2013100% pain relief within 10\u201315 days, with therapeutic effects persisting for several weeks to over 5 years. Many also demonstrated improvements in daily functioning and a reduction in analgesic consumption. No serious adverse events were reported, supporting BoNT-A as a safe and promising treatment for PCH. Conclusion: BoNT-A is a well-tolerated and effective option for patients with refractory PCH, offering substantial pain relief and functional improvement. However, given the reliance on small-scale studies, larger clinical trials are needed to confirm its efficacy and establish standardized treatment protocols. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"botulinum toxin A (BoNT-A)\",\r\n \" headache\",\r\n \" neurosurgical complications\",\r\n \" post-Craniotomy\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 31,\r\n \"title\": \"Hamad, Ahmed Abdulhafez (57193447791); Mohammed, Bassam Shaaban (57211554238); Abdelsalam Ouf, Abdelsalam Mohamed (58777897900); Darwish, Ibrahim Ali (6701813769); Ashkar, Abdulsalam (59541306200); Haredy, Ahmed M. (56895997900)\",\r\n \"authors\": \"Sustainable Fluorescence-off Based Analytical Approach for the Quantification of Linagliptin Using a Biocompatible Sensor; Erythrosine B Dye\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105009942276&doi=10.1007%2Fs10895-025-04418-4&partnerID=40&md5=6f3b6da20c4309229ef62c167172c13e\",\r\n \"affiliations\": \"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Shibin El Kom, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Menofia, Egypt; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Chemistry, College of Pharmacy, Riyadh, Saudi Arabia; Department of Health Sciences, Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d, Vercelli, Italy; Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"A fluorescence quenching strategy was conceptualized to establish an environmentally compatible analytical system for trace-level detection of Linagliptin (LGP), an anti-diabetic pharmaceutical compound. This research delineates a biochemical sensing mechanism relying on an electrostatic coupling between LGP and Erythrosine B (EB), a biologically certified fluorophore, within optimized acidic parameters. The molecular association induced a concentration-dependent reduction in EB\u2019s intrinsic emission intensity at \u03bb<inf>em<\/inf> 554\u00a0nm, attributed to the generation of a non-luminescent LGP-EB supramolecular assembly. Methodical optimization of operational parameters governing the recognition process\u2014including pH modulation, stoichiometric ratios, and temporal stability\u2014yielded a linear response across 0.30\u20132.50\u00a0\u00b5g\/mL, with detection and quantification capacities reaching 0.0286\u00a0\u00b5g\/mL and 0.0943\u00a0\u00b5g\/mL, respectively. Validation studies confirmed adherence to International Council for Harmonization (ICH) criteria, exhibiting \u2264 1.9% relative standard deviation in precision assessments and 98.9\u2013100.8% recovery rates in spiked samples. The technique\u2019s efficacy was verified across multiple matrices, encompassing raw drug substances, pharmaceutical formulations, and simulated biological media. Ecological compatibility was rigorously evaluated through modern sustainability metrics aligned with green analytical chemistry principles. Implementation of the White Analytical Chemistry (WAC) protocol via the RGB 12 algorithm designated the methodology as \u201cenvironmentally considerate,\u201d reflecting minimal reagent consumption and energy requirements. Concurrent analysis using the BAGI (Biocompatible Analytical Greenness Index) tool produced exceptional scores in ecological safety and methodological adaptability, confirming its proficiency in harmonizing analytical precision with sustainable practices. This dual-focused approach addresses critical needs in pharmaceutical quality control while advancing eco-responsible analytical methodologies. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Ecological impact evaluation\",\r\n \" Electrostatic biosensing\",\r\n \" Fluorescence-quenching analytical platform\",\r\n \" Sustainable detection using biocompatible EB dye\",\r\n \" Trace-level LGP analysis\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 32,\r\n \"title\": \"Mabrouk, M. I. (57724297900); Abdalbary, Sahar Ahmed (57188714822); Abdelmonem, Asmaa Foad (58073411200); Abdelhakiem, Nadia Mohamed (57221741774); Ahmed, Alaa Anwar (59958664500); Gelany, Fathia Mostafa (59957590200); Abd El Rahim, Ahmed A. (59958664600)\",\r\n \"authors\": \"The impact of aerobic and balance exercises on anxiety and dizziness in post-COVID-19 patients: a randomised clinical trial\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105008828911&doi=10.5114%2Fpq%2F190527&partnerID=40&md5=830f3bac000b4a08deb73b2cc2c038eb\",\r\n \"affiliations\": \"Department of Physiotherapy, Applied Science Private University, Amman, Jordan; Department of Orthopaedics, Faculty of Physical Therapy, Beni Suef, Egypt; Department of Biomechanics, Faculty of Physical Therapy, Giza, Egypt; Department of Neuromuscular Disorders and its Surgery, Deraya University, New Minia, Egypt; Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Cairo, Egypt; Department of Growth and Development Disorders in Children and its Surgery, Merit University, Sohag, Egypt; Department of Basic Sciences, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Introduction. Examine how aerobic exercises, relaxation techniques, and balance exercises affect patients\u2019 anxiety and dizziness post-COVID-19 patients. Methods. Thirty participants post-COVID-19, complaining of anxiety and dizziness, aged 45\u201365 years, of both sexes, selected from the outpatient clinic of our hospital, were enrolled in the study after a COVID-19 infection. Treatment sessions were 3 times weekly for 4 weeks, and the patients were treated separately in group therapy. The 15 patients in group A were given aerobic, balancing, and relaxation techniques. The 15 patients in the control group (group B) were given only relaxation exercises. Assessments of the two groups were completed both before and after the course of treatment by the Hamilton Anxiety Scale (HAMA) and the Berg Balance Scale. Respiratory function was also assessed using maximum voluntary ventilation. Results. There were significant differences between the two groups after the treatment. The mean values of the HAMA after treatment were 17.2 \u00b1 1.7 and 21.7 \u00b1 1.4 in groups A and B, respectively. After treatment, the mean values of the Berg Balance Scale were 26.7 \u00b1 5.7 and 22.2 \u00b1 3.6 in groups A and B, respectively. The mean values of maximum voluntary ventilation were 117.2 \u00b1 16.7 and 108.1 \u00b1 16.3 in groups A and B, respectively. Both groups showed a significant decrease in anxiety and dizziness and a significant increase in maximum voluntary ventilation at the end of the 4 weeks of the training program. Participants in group A showed a significantly greater decrease in anxiety and dizziness and a significantly greater increase in maximum voluntary ventilation (p < 0.05) after the training program. Conclusions. Ultimately, it can be said that aerobic exercises, balance exercises, and relaxation techniques can raise maximal voluntary breathing and lessen anxiety and dizziness in post-COVID patients. Therefore, it might be regarded as a successful, secure, cost-effective, and efficient supplementary treatment method for lowering anxiety and vertigo in COVID-19 patients. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"aerobic exercises\",\r\n \" anxiety disorder\",\r\n \" balance exercises\",\r\n \" dizziness\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 33,\r\n \"title\": \"Hashem, Hamada (59345170800); Abdelfattah, Shadwa (59709418900); Hassan, Hesham M. (58026884300); Al-Emam, Ahmed (57163602000); Alqarni, Mohammed Ahmed (57221053161); Alotaibi, Ghallab Hamoud Sinhat (57371627300); Radwan, Ibrahim Taha (57205102710); Kaur, Kirandeep (57214547228); Rao, Devendra Pratap (35119371500); Br\u00e4se, Stefan J. (7005396290); Alkhammash, Abdullah (59195595800)\",\r\n \"authors\": \"Discovery of a novel 4-pyridyl SLC-0111 analog targeting tumor-associated carbonic anhydrase isoform IX through tail-based design approach with potent anticancer activity\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105003065163&doi=10.3389%2Ffchem.2025.1571646&partnerID=40&md5=ac6f74b8db08f95e35c85ac1ae2d5319\",\r\n \"affiliations\": \"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pathology, College of Medicine, Abha, Saudi Arabia; Department of Pharmaceutical Chemistry, Taif University, Taif, Saudi Arabia; Department of Pharmacology, Shaqra University, Shaqra, Saudi Arabia; Supplementary General Sciences Department, Faculty of Oral & Dental Medicine, New Cairo, Egypt; Department of Chemistry, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Bathinda, India; Department of Chemistry, Dayanand Anglo-Vedic (PG) College, Kanpur, India; Institute of Biological and Chemical Systems, Karlsruher Institut f\u00fcr Technologie, Karlsruhe, Germany\",\r\n \"abstract\": \"Introduction: Carbonic anhydrase IX (CA IX) is a tumor-associated enzyme involved in cancer progression and survival. Targeting CA IX with selective inhibitors like SLC-0111 has shown therapeutic potential. This study aimed to develop a novel 4-pyridyl analog (Pyr) of SLC-0111 with enhanced anticancer activity. Methods: Pyr was synthesized using a tail-based design and characterized by NMR. Its cytotoxicity was tested against cancer and normal cell lines. CA inhibition, cell cycle effects, apoptosis induction, and protein expression changes were evaluated. Molecular docking and ADMET predictions assessed binding and drug-like properties. Results and Discussion: Pyr showed selective cytotoxicity toward cancer cells and potent CA IX inhibition. It induced G0\/G1 arrest, apoptosis, and modulated p53, Bax, and Bcl-2 levels. Docking confirmed strong CA IX binding, and ADMET analysis indicated good oral bioavailability. These results support Pyr as a promising anticancer candidate. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"apoptosis\",\r\n \" carbonic anhydrase\",\r\n \" cytotoxicity\",\r\n \" SLC-0111\",\r\n \" sulphonamide\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 34,\r\n \"title\": \"Alsfouk, Aisha A. (57208242449); Al Ward, Maged Mohammed Saleh (57222123911); Al-Qadhi, Mustafa A. (58480352000); El-Metwally, Souad A. (36682085000); Yousef, Reda G. (57225078967); Elkaeed, Eslam B. (56884768800); Husein, Dalal Z. (55917450100); Amin, Fatma G. (57223365717); Elkady, Hazem (57203864016); Metwaly, Ahmed M. (56153972200); Eissa, Ibrahim H. (57189457618)\",\r\n \"authors\": \"Anti-breast cancer potential of thieno-pyrimidine derivatives as VEGFR-2 inhibitors\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105000333613&doi=10.1080%2F17568919.2025.2479422&partnerID=40&md5=544ac45cf53862532fd550ade7a3f84b\",\r\n \"affiliations\": \"Department of Pharmaceutical Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Department of Medicinal Chemistry, Al-Razi University, Sana'a, Yemen; Department of Medicinal Chemistry, Sana'a University, Sana'a, Yemen; Department of Basic Sciences, Higher Technological Institute, Tenth of Ramadan City, Egypt; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Pharmaceutical Sciences, Almaarefa University, Riyadh, Saudi Arabia; Department of Chemistry, Faculty of Science, Kharga, Egypt; Department of Physics, Faculty of Science, Alexandria, Egypt; Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"Background: Thieno-pyrimidine derivatives have emerged as promising candidates for VEGFR-2 inhibition. This study aimed to design, synthesize, and evaluate novel thieno-pyrimidine derivatives for their anti-cancer potential. Methods: A series of thieno-pyrimidine compounds were synthesized and screened for in vitro cytotoxicity against MDA-231 and MCF-7 cell lines. The most active compound, 6b, was further analyzed for VEGFR-2 kinase inhibition, wound healing, apoptosis induction, and cell cycle arrest. Molecular docking, 200 ns molecular dynamics simulations, MM-GBSA, ProLIF PCAT, and FEL analyses were conducted to assess binding stability. DFT calculations evaluated electronic properties, while in silico ADMET profiling predicted pharmacokinetics and toxicity. Results: Compound 6b exhibited potent cytotoxicity with IC<inf>50<\/inf> values of 5.91 \u00b5M (MDA-231) and 7.16 \u00b5M (MCF-7). It demonstrated VEGFR-2 inhibition is comparable to sorafenib (IC<inf>50<\/inf>: 53.63 \u00b1 3.14 nM). Wound healing assays showed significant inhibition of MDA-231 migration. Flow cytometry confirmed apoptosis induction (57.20% early apoptosis) and G1 phase arrest. Gene expression analysis revealed upregulation of pro-apoptotic markers and downregulation of Bcl-2. Computational studies confirmed stable VEGFR-2 binding, and ADMET predictions indicated a favorable safety profile. Conclusion: Compound 6b exhibits strong VEGFR-2 inhibition, potent anti-cancer effects, and a favorable toxicity profile, highlighting its potential for further therapeutic development. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"apoptosis\",\r\n \" breast cancer\",\r\n \" DFT\",\r\n \" MD simulations\",\r\n \" Thieno-pyrimidine\",\r\n \" VEGFR-2\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 35,\r\n \"title\": \"Elrosasy, Amr M. (58299324200); Maher, Ahmed (58727943900); Ramadan, Abdelraouf (57848892900); Hamam, Nada G. (59383277100); Soliman, Mohamed Mohsen (57907443800); Kamal, Sara K. (58782392400); Milik, Beshoy Emad (59411337900); Shahat, Abdullah Ali (59410954800); Kamel, Menna Nabil (59411148500); Ali, Ahmed Abdeltawab (59411148600); Hassan, Loay Abdelnabi (59410954900); Zabady, Ahmed Hamdy (59394731500); Abo-Zeid, Mohamed Gamal (58866318400); Abdelmottaleb, Wael A. (57219122953); Nassar, Sameh M. (57283577300)\",\r\n \"authors\": \"A Network Meta-Analysis of Vasodilator Therapies in Pulmonary Hypertension Patients Undergoing Mitral Valve Replacement Surgery: Insights for Optimizing Hemodynamics\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85209142273&doi=10.1007%2Fs40261-024-01404-9&partnerID=40&md5=2912cab415c2c136f4f140d7d6de4461\",\r\n \"affiliations\": \"Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Merit University, Sohag, Egypt; Faculty of Science, Damanhour, Egypt; Faculty of Medicine, Tanta, Egypt; Department of Medicine, New York Medical College, Valhalla, United States; Department of Cardiology, West Virginia University, Morgantown, United States\",\r\n \"abstract\": \"Background and Objective: Pulmonary hypertension (PH) is a progressive hemodynamic condition associated with significant morbidity and mortality, especially in patients undergoing cardiac surgery. Therefore, the objective of this network meta-analysis (NMA) is to compare the efficacy of various pulmonary vasodilators in perioperative control of PH among patients undergoing mitral valve replacement surgery (MVRS), aiming to address the existing knowledge gap and improve perioperative outcomes. Methods: Electronic databases including PubMed, Cochrane Central Registry of Controlled Trials, Scopus, Embase, and Web of Science (WOS) from inception to 17 September 2024. Only randomized controlled trials (RCTs) evaluating vasodilators in PH patients undergoing MVRS were included. We used netmeta package in RStudio to analyze the outcome data with their corresponding mean difference (MD) and confidence intervals (CI). Results: Seventeen RCTs including 862 patients were analyzed. Prostacyclin, nitric oxide (NO), and sodium nitroprusside (SN) significantly reduced mean pulmonary arterial pressure with effect sizes [MD, 95% confidence interval (CI)] of (11.77, \u2212\u00a018.78; \u2212\u00a04.76; \u2212\u00a08.3, \u2212\u00a015.9; \u2212\u00a00.6; \u2212\u00a011.02, \u2212\u00a020.1; \u2212\u00a03.8, respectively). While no treatment showed significant efficacy on pulmonary capillary wedge pressure, systolic pulmonary arterial pressure, or heart rate, nitroglycerin, NO, and prostacyclin, showed significant increases in cardiac index with effect sizes (MD, 95% CI) of (1, 0.3; 1.7; 1.2 0.8; 1.6; 1.2 0.8; 1.6, respectively). Additionally, NO, prostacyclin, SN, and nitroglycerin demonstrated significant reductions in systemic vascular resistance (SVR), with effect sizes of. (\u2212\u00a00.54, \u2212\u00a00.82; \u2212\u00a00.26, \u2212\u00a00.37, \u2212\u00a00.65; \u2212\u00a00.09; \u2212\u00a00.47, \u2212\u00a00.77; \u2212\u00a00.16; \u2212\u00a00.14, \u2212\u00a00.24; \u2212\u00a00.03, respectively). Conclusions: This NMA highlights prostacyclin, nitroglycerin, NO, and SN as consistently effective in improving hemodynamics for patients with PH undergoing MVRS, and provides valuable insights for surgeons to choose the suitable vasodilator for these surgeries. However, limitations and the need for further RCTs are acknowledged. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 36,\r\n \"title\": \"Salama, Eman S. (59367999800); Hussein, Mostafa (35554674300); Fetih, Ahmed Nabil (6506295698); Abul-Fadl, Azza Mohamed A.M. (35483215100); Elghazally, Shimaa A. (57208304065)\",\r\n \"authors\": \"High-risk pregnancy and risk of breastfeeding failure\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85206494443&doi=10.1186%2Fs42506-024-00172-w&partnerID=40&md5=a26cf7c44f9b7da29e06fe7ab1f4424d\",\r\n \"affiliations\": \"Department of Obstetrics and Gynecology, Merit University, Sohag, Egypt; Department of Obstetrics and Gynecology, Faculty of Medicine, Asyut, Egypt; Certified Lactation Consultant, Faculty of Medicine, Benha, Egypt; Department of Public Health and Community Medicine, Faculty of Medicine, Asyut, Egypt\",\r\n \"abstract\": \"Background: There is growing evidence that supports the role of breastfeeding in reducing the burden of non-communicable diseases (NCDs). There are considerable gaps in breastfeeding outcomes in mothers with chronic diseases due to a lack of knowledge and support in the postpartum period. Mothers who have NCDs and pregnancy complications are at risk of breastfeeding failure. Aim: To compare breastfeeding outcomes in mothers with NCDs with healthy mothers and determine the underlying challenges that lead to poor outcomes. Methods: A prospective cohort study was conducted among 150 women (50 with high-risk pregnancies (HRP) and 100 with normal pregnancies (NP)). They were recruited from those attending the immunization and outpatient clinics at Sohag General Hospital. Mothers were recruited at 34\u00a0weeks gestation and were followed up at 2\u00a0weeks, 6\u00a0weeks, and 6\u00a0months after delivery. A pretested and validated questionnaire was used to collect detailed epidemiological, personal, health-related status, medications, hospitalizations, reproductive history, current delivery, and previous breastfeeding experiences. On follow-up they were assessed for breastfeeding practices, their health and health and growth of their children, and\u00a0social support. Results: Delivery by cesarean section and postpartum bleeding were commoner among HRP patients. Initiation of breastfeeding in the 1st hour of delivery was significantly lower among women with HRP than those with normal pregnancies (48.0% versus 71.0%, p = 0.006). The most common reason for not initiating breastfeeding among the NP group was insufficient milk (34.5%), while in the HRP group, it was the mother\u2019s illness (80.8%). Skin-to-skin contact with the baby after birth was significantly less practiced in the HRP than in the NP group (38.0% vs 64.0% at p = 0.003). Herbs (such as cumin, caraway, cinnamon, aniseed, and chamomile) were the most common pre-lacteal feeds offered (63.0% in NP vs 42.0% in HRP). Artificial milk was more used in HRP than NP (24.0% vs 4.0%). Breast engorgement was 3 times more common in the HRP compared to the NP group (61.5% vs19.6%). Stopping breastfeeding due to breast problems was 2.5 times higher in the HRP than in the NP group (38.5% vs. 15.2%, p = 0.003). Nipple fissures were twice as common among the NP than among the HRP group ((73.0%) vs. (38.5%), p = 0.026). Exclusive breastfeeding during the period of follow-up was lower in the HRP than in the NP group (40.0% vs 61.0%, p < 0.05) and formula feeding was twice as common in the HRP as in the NP group (34.0% vs. 18.0%, p = 0.015). Child illness was significantly higher among women with HRP than those with NP (66.0% vs 48.0%, p = 0.037). Conclusions: Women with HRP are at a high risk of poor breastfeeding outcomes with increased lactation problems and formula feeding rates. Encouraging women especially those with HRP to achieve optimal breastfeeding practices is a simple intervention that can be included in daily practice and may have a positive impact on mothers\u2019 health. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Casarean section\",\r\n \" Exclusive breastfeeding\",\r\n \" High-risk pregnancy\",\r\n \" Noncommunicable diseases\",\r\n \" Pregnancy\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 37,\r\n \"title\": \"Abd-Elkareem, M. (57193520825); Alnasser, Sulaiman Mohammed Abdullah (57202385164); Meshal, Alotaibi (58065801700); Abdullah, Raghda Ismail (58691072300); Ali, Ahmed U. (57213590141)\",\r\n \"authors\": \"The effect of Norethisterone acetate on the uterus of albino rats: histological, histochemical and ultrastructure study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85202867267&doi=10.1186%2Fs12917-024-04219-0&partnerID=40&md5=929c1639751a8d892cf79f70f7157177\",\r\n \"affiliations\": \"Department of Cell and Tissues, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Pharmacology and Toxicology, Qassim University, Al-Mulida, Saudi Arabia; College of Pharmacy, University of Hafr Al-Batin, Hafar al Batin, Saudi Arabia; Department of Anatomy, College of Veterinary Medicine, Kharga, Egypt; Department of Pharmaceutics, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Background: Norethisterone acetate (NETA), also known as norethindrone acetate is a progestogens medication that is widely used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders as abnormal uterine bleeding and endometriosis. There is a lack of detailed histological information regarding the effects of NETA on the uterine structure. So, the present study focuses on the uterine histological, histochemical and ultrastructure changes following the exposure to NETA in the albino rats. To do this aim, fourteen adult female albino rats were used. They were randomly divided into two equally groups: Control group and NETA treated group. Albino rats of control group were administered daily food, water and orally distilled water only, while rats of NETA treated group were administered daily orally 20\u00a0\u00b5g of NETA dissolved in 2\u00a0ml distilled water, food, and water. The experiment was continued for three weeks. Results: The findings of the present work indicated that the use of NETA has negative effects on the endometrial epithelium (proliferation, autophagy and apoptosis), glands (necrotic, apoptotic or pseudosecretory glands) and stromal and myometrial reactions (granulocytes, connective tissue remodeling, apoptosis, myocytes hypertrophy). Conclusion: This work revealed that NETA has desynchronized progestogenic effect on the uterine tissues of the albino rat and thereby prevent implantation and pregnancy. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Apoptosis\",\r\n \" Endometrium\",\r\n \" Norethisterone acetate\",\r\n \" Rat\",\r\n \" Uterine glands\",\r\n \" Uterus\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 38,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Podda, Mauro Guido (7004555508); Chiaretti, Massimo (6603417473); Kechagias, Aristotelis (22985131100); Lled\u00f3, Jos\u00e9 Bueno (24462324800); Kalmoush, Abd Elfattah (57727380200); Mustafa, Fawzy M. (58227729800); Nassar, Mohammed Shaaban (57727355400); Labib, Mohamed Fathy (57221263028); Teama, Sobhy Rezk Ahmed (58023821600); Elshafey, Mohammed Hassan (57212769328); Elbelkasi, Hamdi (58744062800); Alsaad, Mohamed Ibrahim Abo (58987233100); Sallam, Ahmed M. (57203144124); Ashour, Hassan Rabea Galal (57203575895); Mansour, Mohamed Ibrahim (57219159269); Mostafa, Abdelshafy (58744089300); Elshahidy, Tamer Mohamed Mahmoud (57219158772); Yehia, Ahmed Mohamed (57210598249); Rushdy, Tamer (57211491570); Ramadan, Alaaedin (57924392600); Hamed, Abd Elwahab M. (58986714100); Yassin, Mahmoud Abdou (57217355675); Metwalli, Abd Elrahman M. (57219157262)\",\r\n \"authors\": \"Comparative study of laparoscopic ventral mesh rectopexy versus perineal stapler resection for external full-thickness rectal prolapse in elderly patients: enhanced outcomes and reduced recurrence rates\u2014a retrospective cohort study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85190433927&doi=10.1007%2Fs10151-024-02919-1&partnerID=40&md5=84dd70c3073512e2c46a7de80bc969b1\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; Department of Surgical Sciences, Azienda Ospedaliero Universitaria di Cagliari, Cagliari, Italy; Sapienza Universit\u00e0 di Roma, Rome, Italy; Department of Surgery, Hospital Universitari i Polit\u00e8cnic La Fe, Valencia, Spain; General Surgery Department, Faculty of Medicine, Cairo, Egypt; General Surgery Department, Mataryia Teaching Hospital (GOTHI), Cairo, Egypt; General Surgery Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Background: In elderly patients with external full-thickness rectal prolapse (EFTRP), the exact differences in postoperative recurrence and functional outcomes between laparoscopic ventral mesh rectopexy (LVMR) and perineal stapler resection (PSR) have not yet been investigated. Methods: We conducted a retrospective multicenter study on 330 elderly patients divided into LVMR group (n = 250) and PSR (n = 80) from April 2012 to April 2019. Patients were evaluated before and after surgery by Wexner incontinence scale, Altomare constipation scale, and patient satisfaction questionnaire. The primary outcomes were incidence and risk factors for EFTRP recurrence. Secondary outcomes were postoperative incontinence, constipation, and patient satisfaction. Results: LVMR was associated with fewer postoperative complications (p < 0.001), lower prolapse recurrence (p < 0.001), lower Wexner incontinence score (p = 0.03), and lower Altomare\u2019s score (p = 0.047). Furthermore, LVMR demonstrated a significantly higher surgery\u2013recurrence interval (p < 0.001), incontinence improvement (p = 0.019), and patient satisfaction (p < 0.001) than PSR. Three and 13 patients developed new symptoms in LVMR and PSR, respectively. The predictors for prolapse recurrence were LVMR (associated with 93% risk reduction of recurrence, OR\u00a00.067, 95%\u00a0CI 0.03\u20130.347, p = 0.001), symptom duration (prolonged duration was associated with an increased risk of recurrence, OR\u00a01.131, 95%\u00a0CI 1.036\u20131.236, p = 0.006), and length of prolapse (increased length was associated with a high recurrence risk (OR = 1.407, 95% CI = 1.197\u20131.655, p < 0.001). Conclusions: LVMR is safe for EFTRP treatment in elderly patients with low recurrence, and improved postoperative functional outcomes. Trial registration: Clinical Trial.gov (NCT05915936), retrospectively registered on June 14, 2023. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Elderly\",\r\n \" Functional outcomes\",\r\n \" Laparoscopic ventral mesh rectopexy\",\r\n \" Perineal stapler resection\",\r\n \" Rectal prolapse\",\r\n \" Recurrence\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 39,\r\n \"title\": \"Abd-Eldayem, Ahmed Mohammed (57195596545); Makram, Sohayla Mahmoud (58187419600); Messiha, Basim Anwar Shehata (56431085800); Abd-Elhafeez, Hanan H. (57216658260); Abdel-Reheim, Mustafa Ahmed (57194939309)\",\r\n \"authors\": \"Cyclosporine-induced kidney damage was halted by sitagliptin and hesperidin via increasing Nrf2 and suppressing TNF-\u03b1, NF-\u03baB, and Bax\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85188816578&doi=10.1038%2Fs41598-024-57300-x&partnerID=40&md5=c75662b2e217bf46fb74f9ebaff4557d\",\r\n \"affiliations\": \"Department of Medical Pharmacology, Faculty of Medicine, Asyut, Egypt; Department of Pharmacology, Merit University, Sohag, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Cell and Tissues, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Pharmaceutical Sciences, Shaqra University, Shaqra, Saudi Arabia\",\r\n \"abstract\": \"Cyclosporine A (CsA) is employed for organ transplantation and autoimmune disorders. Nephrotoxicity is a serious side effect that hampers the therapeutic use of CsA. Hesperidin and sitagliptin were investigated for their antioxidant, anti-inflammatory, and tissue-protective properties. We aimed to investigate and compare the possible nephroprotective effects of hesperidin and sitagliptin. Male Wistar rats were utilized for induction of CsA nephrotoxicity (20\u00a0mg\/kg\/day, intraperitoneally for 7\u00a0days). Animals were treated with sitagliptin (10\u00a0mg\/kg\/day, orally for 14\u00a0days) or hesperidin (200\u00a0mg\/kg\/day, orally for 14\u00a0days). Blood urea, serum creatinine, albumin, cystatin-C (CYS-C), myeloperoxidase (MPO), and glucose were measured. The renal malondialdehyde (MDA), glutathione (GSH), catalase, and SOD were estimated. Renal TNF-\u03b1 protein expression was evaluated. Histopathological examination and immunostaining study of Bax, Nrf-2, and NF-\u03baB were performed. Sitagliptin or hesperidin attenuated CsA-mediated elevations of blood urea, serum creatinine, CYS-C, glucose, renal MDA, and MPO, and preserved the serum albumin, renal catalase, SOD, and GSH. They reduced the expressions of TNF-\u03b1, Bax, NF-\u03baB, and pathological kidney damage. Nrf2 expression in the kidney was raised. Hesperidin or sitagliptin could protect the kidney against CsA through the mitigation of oxidative stress, apoptosis, and inflammation. Sitagliptin proved to be more\u00a0beneficial than hesperidin. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Cyclosporine\",\r\n \" Hesperidin\",\r\n \" Nephrotoxicity\",\r\n \" NF-\u03baB\",\r\n \" Nrf2\",\r\n \" Sitagliptin\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 40,\r\n \"title\": \"Sayed, Alaa El Din H. (59100118600); Abou-Khalil, Nasser Sayed (57160296500); Alghriany, Alshaimaa A.I. (57224211446); Abd El-Ghaffar, Sary Kh (10440451100); Hussein, Asmaa A.A. (36641259100)\",\r\n \"authors\": \"Prefeeding of Clarias gariepinus with Spirulina platensis counteracts petroleum hydrocarbons-induced hepato- and nephrotoxicity\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85188748429&doi=10.1038%2Fs41598-024-57420-4&partnerID=40&md5=8f55d74ead1dda7f511a3350842b5a78\",\r\n \"affiliations\": \"Molecular Biology Research & Studies Institute, Assiut University, Asyut, Egypt; Faculty of Science, Asyut, Egypt; Department of Medical Physiology, Faculty of Medicine, Asyut, Egypt; Department of Basic Medical Sciences, Merit University, Sohag, Egypt; Department of Clinical Pathology, Faculty of Veterinary Medicine, Asyut, Egypt; School of Veterinary Medicine, Asyut, Egypt\",\r\n \"abstract\": \"Petroleum aromatic hydrocarbons are considered one of the most dangerous aquatic pollutants due to their widespread across water bodies, persistence, and extension to the food chain. To our knowledge, there hasn\u2019t been any research investigating the hepatorenoprotective effects of Spirulina platensis (SP) against toxicity induced by these environmental toxicants in fish. Thus, we decided to explore its potential safeguarding against benzene and toluene exposure in adult Clarias gariepinus. To achieve this objective, fish were divided into five groups (60 per group; 20 per replicate). The first group served as a control. The second and third groups were intoxicated with benzene and toluene at doses of 0.762 and 26.614\u00a0ng\/L, respectively for 15\u00a0days. The fourth and fifth groups (SP + benzene and SP + toluene, respectively) were challenged with benzene and toluene as previously mentioned following dietary inclusion of SP at a dose of 5\u00a0g\/kg diet for 30\u00a0days. The marked increase in liver metabolizing enzymes, glucose, total protein, albumin, globulin, albumin\/globulin ratio, and creatinine confirmed the hepato- and nephrotoxic impacts of benzene and toluene. These outcomes were coupled with cytopathological affections and excessive collagen deposition. The incorporation of SP in ration formulation, on the contrary, restored the previously mentioned toxicological profile due to its antioxidant and cytoprotective attributes. Regardless of SP intervention, the renal tissues still displayed histo-architectural lesions, because of insufficient dose and timeframe. Additional research will be required to identify the ideal SP remediation regimen. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Fish\",\r\n \" Kidney\",\r\n \" Liver\",\r\n \" Microalga\",\r\n \" Petroleum hydrocarbons\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 41,\r\n \"title\": \"Alghriany, Alzahraa A. (58702438700); Ali, Ahmed U. (57213590141); Khallaf, Iman S.A. (57213352391); Hassan, Abeer S. (57196119456); Sayed, Marwa A. (57217417384); Fikry, Ahmed Mortada (57216749226)\",\r\n \"authors\": \"Clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction as a palatal dressing material compared to Alveogyl: randomized clinical trial\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85184543720&doi=10.1038%2Fs41598-024-53511-4&partnerID=40&md5=26fa0954907d0b3ccbc152cb2cfd592e\",\r\n \"affiliations\": \"Department of Oral Medicine, Faculty of Dentistry, Asyut, Egypt; Department of Pharmaceutics, Merit University, Sohag, Egypt; Pharmacognosy and Natural Products Department, Faculty of Pharmacy, Shibin El Kom, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Qena, Egypt; Department of Industrial Pharmacy, Faculty of Pharmacy, Asyut, Egypt\",\r\n \"abstract\": \"This study assessed the clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction (OPMF) solid dispersion as a palatal dressing material, compared with Alveogyl, in a randomized clinical trial. After harvesting free gingival grafts for 18 patients in three groups, the donor site in group I received OPMF; group II received Alveogyl; and group III received placebo dough material. The visual analog scale (VAS) pain score in group I showed the lowest value in week one without a significant difference. In week 2, there was a substantial decrease in pain in group I compared to group III. Week 4 showed reduced pain scores in all groups without significant differences. The results of the number of analgesic pills revealed, after 1\u00a0week, the lowest number of pills consumed in group I, with a considerable difference compared to group III. Healing process results showed that group I had the highest healing values in each interval, with a significant difference between group I and group III at 1 and 2\u00a0weeks. Color matching parameter showed slight differences between the groups\u2019 readings in favor of group I in all intervals without a statistically significant difference. The results suggest OPMF as a palatal dressing material that facilitates hemostasis, pain relief, and palatal wound healing. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 42,\r\n \"title\": \"Ragab, Sohair M.M. (56747567100); ALmohaimeed, Hailah M. (57219174113); Alghriany, Alshaimaa A.I. (57224211446); Abou-Khalil, Nasser Sayed (57160296500); Abd-Allah, Elham A. (57804727300)\",\r\n \"authors\": \"Protective effect of Moringa oleifera leaf ethanolic extract against uranyl acetate-induced testicular dysfunction in rats\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85181886558&doi=10.1038%2Fs41598-023-50854-2&partnerID=40&md5=9dc1afdd272e6742db34d2480fc06892\",\r\n \"affiliations\": \"Department of Zoology and Entomology, Faculty of Science, Asyut, Egypt; Department of Basic Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Department of Zoology and Entomology, Faculty of Science, Asyut, Egypt; Department of Basic Medical Sciences, Merit University, Sohag, Egypt; Department of Medical Physiology, Faculty of Medicine, Asyut, Egypt; Department of Zoology, Faculty of Science, Kharga, Egypt\",\r\n \"abstract\": \"Uranyl acetate (UA) is used in civilian and military applications, predisposing it to wide dispersion in ecosystems. Using high-performance liquid chromatography, gas chromatography\u2013mass spectrometry, and 2,2-Diphenyl-1-picrylhydrazyl scavenging radical analysis, we confirmed that Moringa oleifera leaf ethanolic extract (MLEE) is rich in biologically active phytochemicals. Thus, this study aims to investigate the possible defensive effect of MLEE against UA-induced testicular dysfunction. To achieve this, rats were divided randomly and evenly into three groups for 14 days. The control group received no treatment, while the UA group received a single intraperitoneal injection of UA at a dose of 5\u00a0mg\/kg BW dissolved in saline on the 12th day of the experiment, followed by no treatment the following day. The MLEE + UA group received daily oral administration of MLEE (300 mg\/kg BW) dissolved in distilled water before exposure to UA intoxication. The disruption observed in the pituitary\u2013gonadal axis of UA-intoxicated rats was characterized by a significant decrease in luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol 17beta levels. Additionally, there was a notable increase in malondialdehyde and a decrease in catalase, superoxide dismutase, reduced glutathione, and nitric oxide, accompanied by an up-regulation in the immuno-expression of nuclear factor-kappa B, indicating a disturbance in the redox balance. The TUNEL assay confirmed a substantial rise in apoptotic cell numbers in the UA group. Testicular histopathological changes, excessive collagen deposition, and reduced glycogen content were evident following UA exposure. However, supplementation with MLEE effectively countered these mentioned abnormalities. MLEE is proposed to combat the toxicological molecular targets in the UA-affected testis by restoring the balance between oxidants and antioxidants while obstructing the apoptotic cascade. MLEE contains an abundance of redox-stabilizing and cytoprotective phytochemicals that have the potential to counteract the mechanistic pathways associated with UA exposure. These findings encourage further research into other plausible protective aspects of Moringa oleifera against the UA challenge. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 43,\r\n \"title\": \"Saleem, Tahia Hashem (35608413200); Rizk, Mohamed Ahmed (53664349900); Abdelhafez, Nashwa F. (58791219900); Sabra, Ahmed (58791691300); Radwan, Eman M. (57190883689)\",\r\n \"authors\": \"Upregulation of BRCA1 and 2 protein expression is associated with dysregulation in amino acids profiles in breast cancer\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85181244493&doi=10.1007%2Fs11033-023-09028-6&partnerID=40&md5=19bc729367097e716fb5547ed885191a\",\r\n \"affiliations\": \"Department of Medical Biochemistry, Faculty of Medicine, Asyut, Egypt; Faculty of Medicine, Asyut, Egypt; Anesthesia and Intensive Care Unit, Faculty of Medicine, Asyut, Egypt; Department of Medical Biochemistry, Merit University, Sohag, Egypt; Department of Biochemistry, Sphinx University, New Assuit, Egypt\",\r\n \"abstract\": \"Background: The prevalence of breast cancer (BC) is high among cancers in Egypt, ranking it the most common cause of cancer mortality in women. BRCA1 and BRCA2 tumor suppressors proteins have a specific relationship with BC. Plasma free amino acids levels (PFAAs) have been reported to exhibit altered profiles among cancer patients. Thus, the present study aims to examine the alteration of the PFAAs profiles and investigate their association with BRCA1 and 2 circulating levels in Egyptian females diagnosed with BC and in females with family history of BC to establish potential early detection strategies for BC. Methods and results: This study included 26 BC patients, 22 females with family history of BC (relatives) in addition to 38 healthy females as control group. Quantitative measurement of PFAAs was determined by the ion exchange separation method through high performance liquid chromatography. BRCA1 and BRCA2 concentrations were determined using ELISA. Our results showed PFAAs profiles in BC patients and in females with BC family history with significant upregulation in mean plasma levels of Alanine, Phenylalanine, Glutamate and Cysteine and downregulation of Taurine, Threonine, Serine, Glycine, Valine, Methionine and Histidine levels compared to controls. Also, a significant positive correlation was observed between plasma BRCA1 and Valine levels while a significant negative correlation was observed between BRCA2 and Lysine plasma levels. Conclusion: PFAAs profile can potentially be used in early screening for BC patients and for susceptible females. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Amino acids\",\r\n \" BRCA\",\r\n \" Breast cancer\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 44,\r\n \"title\": \"Khalil, Eman M. (58218941100); Madney, Yasmin M. (57193872234); Hassan, Mahmoud (55669885400); Fahmy, Alzhraa M. (57384219700); Alshammari, Saud O. (57204353584); Alshammari, Qamar A. (57204352937); Abou-Taleb, Heba A. (57197775199); Taha, Ahmed Abdelrahem (57188559442); Elgendy, Marwa O. (56926529900); Ali, Hamada Ashry Abd El Wahed (57200288809)\",\r\n \"authors\": \"Maternal and Fetal Outcome of COVID-19 Infection among Pregnant Women\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85207685199&doi=10.3390%2Fmedicina60101676&partnerID=40&md5=8f72fbf67267ab7e08ec13e966742534\",\r\n \"affiliations\": \"Faculty of Medicine, Beni Suef, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Internal Medicine, Faculty of Medicine, Beni Suef, Egypt; Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Beni Suef, Egypt; Department of Pharmacognosy and Alternative Medicine, Northern Border University, Arar, Saudi Arabia; Department of Pharmacology and Toxicology, Northern Border University, Arar, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Clinical Pharmacy, Faculty of Pharmacy, Beni Suef, Egypt\",\r\n \"abstract\": \"Background and Objectives: Pregnant women face an increased risk of experiencing negative consequences due to COVID-19 infection. Our study aimed to identify outcomes for both mothers and fetuses associated with COVID-19 during each trimester, as well as to identify post-COVID symptoms in this population. Materials and Methods: Among the total population, 14 females were infected during the first trimester, 25 during the second, and 66 during the third trimester. Weekly follow-ups were conducted until delivery. Seventy-five females (71.4%; 95% CI:26.9\u2013115.9%) were admitted to the hospital secondary to COVID-19 infection. Maternal hospitalization was independently associated with COVID-19 severity (adjusted odds ratio (aOR) = 3.9; 95% CI: 1.6\u20139.2 at p = 0.002 relative to the reference group (mild infection)) and the presence of dyspnea at initial assessment (aOR = 6.9; 95% CI: 1.7\u201328.2 at p = 0.007 relative to nondyspneic patients). Results: The duration of hospitalization (mean \u00b1 SD) was higher in the third trimester than the first and second trimesters (10.1 \u00b1 0.8 vs. 4.0 \u00b1 1.2 days and 10.1 \u00b1 0.8 vs. 6.2 \u00b1 1.4 days, respectively, at p < 0.05). The number of maternal deaths in the third trimester was higher than in the first and second trimesters (16 (24.2%) vs. no deaths and 16 (24.2%) vs. 1 (4%) deaths, respectively, at p < 0.05). In terms of fetal outcomes, a good fetal condition was more likely if the mother was infected during the first trimester (92.9%) than the second (80%) or third trimesters (66.7%), but the difference was not significant. The percentage of preterm deliveries was insignificantly higher in the second trimester (16%) than the first (7.1%) and third (4.5%) trimesters. Conclusions: The most common post-COVID symptoms included persistent loss of smell, dry eyes, post-partum depression, knee pain, and myalgia. Post-COVID symptoms were more prevalent in patients infected during the third trimester. The adverse outcomes of COVID-19 infection for both mother and fetus were more severe in cases where the infection occurred during the third trimester compared to the second and first trimesters. Therefore, it is crucial to adhere to precautionary measures against COVID-19, prioritize vaccination, and provide comprehensive care for pregnant mothers. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"COVID-19\",\r\n \" fetus\",\r\n \" post-COVID syndrome\",\r\n \" pregnancy\",\r\n \" SARS-CoV-2\",\r\n \" three trimesters\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 45,\r\n \"title\": \"Hamdy, Aya (58046302000); Hassanein, Khaled M.A. (36863873500); Ali, Magda Mahmoud (7404486251); Ali, Ahmed U. (57213590141); Khallaf, Iman S.A. (57213352391); Abdelhakiem, Mohammed Ahmed Hamdy (56922161200)\",\r\n \"authors\": \"Evaluation of the subconjunctival injection of Hesperidin with or without olive oil on the healing of alkali burn corneal ulcer in rabbits\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85206880190&partnerID=40&md5=150d2f9fdd95b6eeb941a42481f1718c\",\r\n \"affiliations\": \"Department of Surgery, Faculty of Veterinary Medicine, Asyut, Egypt; Faculty of Veterinary Medicine, Asyut, Egypt; Department of Pharmaceutics, Merit University, Sohag, Egypt; Department of Pharmacognosy and Natural Products, Faculty of Pharmacy, Shibin El Kom, Egypt\",\r\n \"abstract\": \"Corneal ulcers represent an anxious problem in animals and humans. The alkali burn corneal ulcer is severe and may be associated with damage to most of the corneal structure. The healing of the corneal ulcer is mainly complicated by the impairment of vision. The striving to find a new therapy that promotes the healing of corneal injuries with the maintenance of the power of vision is the main aim of most studies. The current study was conducted to evaluate the effect of hesperidin with or without olive oil after its deposition under the bulbar con-junctiva on the healing of induced alkali burn corneal ulcers. For carrying out the study, 18 New Zealand albino rabbits were included. They were divided into three equal groups. Group I (control) received 0.5 ml of normal saline 0.9% under the bulbar conjunctiva 5 times at one-week intervals. Group II (H) received 0.5 ml of hesperi-din nanovesicles subconjunctivally 5 times at one-week intervals. Group III (HO) received 0.5 ml of nanovesicles of hesperidin with olive oil under the bulbar conjunctiva 5 times one week apart. The right eye of animals was subjected to induction of corneal ulcer using 1% NaOH before the commencement of treatment. The left eye was used as a negative control one. The animals were examined clinically (lacrimation, neovascularization, pus formation, corneal perforation, measurement of corneal ulcer), and with fluorescein test staining every week just before each treatment. The animals were examined on days 1, 8, 15, 22, 29, 36 post corneal ulcer induction. At the end of the experiment, the treated and nontreated eye samples were collected for histopathological and electron microscopy examination. The results showed an improvement in the total clinical score in groups H and HO especially in the fifth week, while the control group displayed increasing in the inflammatory process of the injured eye throughout the time of experiment. There was a significant difference between both of H and HO groups and the control group in the third, fourth, and fifth weeks. The results of the histopathological and electron microscopy revealed the superiority of hesperidin with olive oil over hesperidin alone in promoting the healing of corneal ulcers (p= 0.045). The current study concluded that the subconjunctival injection of hes-peridin with or without olive oil has a beneficial and promoting effect in the healing and regeneration of alkali burn corneal ulcers in rabbits. Moreover, subconjunctival injections can ensure long-term drug maintenance compared to topical methods, which in turn saves time and effort. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Corneal ulcer\",\r\n \" Hesperidin\",\r\n \" Olive oil\",\r\n \" Rabbits\",\r\n \" Subcon-junctival injection\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 46,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Mohamed, Mohamed S. (57211757868); Zayed, Gamal M.S. (36865467400); Abdelaty, Lamiaa N. (57214763588); Makki, Mahmoud A.E. (57188804969); Abdel-Aleem, Hazem L. (58225883900); El-Mokhtar, Mohamed Ahmed (57190683185); Hetta, Helal F. (55939372100); Abdullah, Nidaa (59345080100); Saddik, Mohammed S. (57214806788)\",\r\n \"authors\": \"HPMC-Zein Film-forming Gel Loaded with 5-Fluorouracil Coupled with CO2 Laser Dermabrasion for Managing Stable Vitiligo\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85205073412&doi=10.1208%2Fs12249-024-02937-0&partnerID=40&md5=4c8066c8fc4e92f1987201d50aa36bf5\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Cairo, Egypt; Department of Clinical Pharmacy, Faculty of Pharmacy, 6th October, Egypt; Department of Dermatology and Andrology, Faculty of Medicine, Cairo, Egypt; Gilbert and Rose-Marie Chagoury School of Medicine, Byblos, Lebanon; Immunology and Biotechnology, University of Tabuk, Tabuk, Saudi Arabia; Department of Medical Sterilization, Ohud Hospital, Medina, Saudi Arabia; Faculty of Pharmacy, Sohag, Egypt; College of Pharmacy, Al-Ayen Iraqi University, AUIQ, An Nasiriyah, Iraq\",\r\n \"abstract\": \"Vitiligo is a significant dermatological challenge affecting 0.5 to 2% of the global population. Despite the various existing medical approaches, current vitiligo treatments are far from ideal. The present study aimed to prepare and evaluate a film-forming gel of 5 fluorouracil (5FU) using different ratios of hydroxypropyl methylcellulose (HPMC) and Zein for treating vitiligo. The prepared film-forming gels were fully characterized in terms of morphology, Fourier-transform infrared spectroscopy, drug content, pH, drying time, in-vitro drug release, and clinical investigation. A 32-full factorial design was used to study the impact of varying concentrations of HPMC (X1) and Zein (X2) on the percentage of 5FU released (Y1) from the prepared film-forming gels. Scanning electron microscopy (SEM) revealed a cross-linked network structure between polymers. An increase in HPMC concentration (2\u20134%) correlated with higher 5FU release, whereas increased Zein concentration (1\u20132%) resulted in reduced 5FU release. Furthermore, patients treated with 5FU film-forming gel after dermabrasion with fractional CO2 (FCO2) laser exhibited a significant decrease in JAK3 gene expression and higher effectiveness than those treated with FCO2 laser alone. Our results suggest that the film-forming gel of 5FU is promising as an effective formulation for treating vitiligo. Graphical Abstract: (Figure presented.) \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"5-Fluorouracil (5FU)\",\r\n \" dermabrasion\",\r\n \" film-forming gel\",\r\n \" JAK3 expression\",\r\n \" vitiligo\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 47,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Araujo-Castro, Marta (57195685068); Chiaretti, Massimo (6603417473); Podda, Mauro Guido (7004555508); Aiolfi, Alberto (6508362055); Kryvoruchko, Igor A. (59374914600); Manangi, Mallikarjuna (57219159683); Shelat, Vishalkumar G. (16744511800); Kalmoush, Abd Elfattah (57727380200); Labib, Mohamed Fathy (57221263028); Elshafey, Mohammed Hassan (57212769328); Ibrahim, Sameh Mohamed Mahmoud (59206142600); Abo Alsaad, Mohamed Ibrahim (58743979200); Elbelkasi, Hamdi (58744062800); Mansour, Mohamed Ibrahim (57219159269); Elshahidy, Tamer Mohamed Mahmoud (57219158772); Heggy, Ibrahim A. (59018529000); Elsayed, Rasha S. (58310525400); Fiad, Alaa A. (51863395700); Yehia, Ahmed Mohamed (57210598249); Yassin, Mahmoud Abdou (57217355675); Elballat, Mahmoud R. (59205549400); Hebeishy, Mohamed H. (59205743000); AboZeid, Ahmed Khaled (59205349300); Saleh, Mohamed Adel Ahmed (58588452500); Hamed, Abd Elwahab M. (58986714100); Abdelghani, Amr A. (57913319900); Mousa, Bassam (57710406600)\",\r\n \"authors\": \"Side-specific factors for intraoperative hemodynamic instability in laparoscopic adrenalectomy for pheochromocytoma: a comparative study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85197632427&doi=10.1007%2Fs00464-024-10974-w&partnerID=40&md5=e193b8c99221a7ded81664b912442fbc\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; Neuroendocrinology & amp; Adrenal Unit of the Endocrinology & amp; Nutrition Department, Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain; Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria, Madrid, Spain; Department of General Surgery and Organ Transplantation, Sapienza Universit\u00e0 di Roma, Rome, Italy; Department of Surgical Sciences, Universit\u00e0 degli Studi di Cagliari, Cagliari, Italy; Surgery Department #2, Kharkiv National Medical University, Kharkiv, Ukraine; Bangalore Medical College and Research Institute, Bengaluru, India; General Surgery, Tan Tock Seng Hospital, Singapore City, Singapore; General Surgery Department, Faculty of Medicine, Cairo, Egypt; Armed Forces College of Medicine, Cairo, Egypt; General Surgery Department-Faculty of Medicine, Merit University, Sohag, Egypt; Mataryia Teaching Hospital (GOTHI), Cairo, Egypt\",\r\n \"abstract\": \"Background: Adrenalectomy for pheochromocytoma (PHEO) is challenging because of the high risk of intraoperative hemodynamic instability (HDI). This study aimed to compare the incidence and risk factors of intraoperative HDI between laparoscopic left adrenalectomy (LLA) and laparoscopic right adrenalectomy (LRA). Methods: We retrospectively analyzed two hundred and seventy-one patients aged > 18\u00a0years with unilateral benign PHEO of any size who underwent transperitoneal laparoscopic adrenalectomy at our hospitals between September 2016 and September 2023. Patients were divided into LRA (N = 122) and LLA (N = 149) groups. Univariate and multivariate logistic regression analyses were used to predict intraoperative HDI. In multivariate analysis for the prediction of HDI, right-sided PHEO, PHEO size, preoperative comorbidities, and preoperative systolic blood pressure were included. Results: Intraoperative HDI was significantly higher in the LRA group than in the LLA (27% vs. 9.4%, p < 0.001). In the multivariate regression analysis, right-sided tumours showed a higher risk of intraoperative HDI (odds ratio [OR] 5.625, 95% confidence interval [CI], 1.147\u201327.577, p = 0.033). The tumor size (OR 11.019, 95% CI 3.996\u201330.38, p < 0.001), presence of preoperative comorbidities [diabetes mellitus, hypertension, and coronary heart disease] (OR 7.918, 95% CI 1.323\u201347.412, p = 0.023), and preoperative systolic blood pressure (OR 1.265, 95% CI 1.07\u20131.495, p = 0.006) were associated with a higher risk of HDI in both LRA and LLA, with no superiority of one side over the other. Conclusion: LRA was associated with a significantly higher intraoperative HDI than LLA. Right-sided PHEO was a risk factor for intraoperative HDI. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Adrenalectomy\",\r\n \" Hemodynamic instability\",\r\n \" Laparoscopic adrenalectomy\",\r\n \" Pheochromocytoma\",\r\n \" Transperitoneal\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 48,\r\n \"title\": \"Ahmed, Marwa A. (59607360600); Kamel, Esam Omar (57211744749); Abd-Eldayem, Ahmed Mohammed (57195596545)\",\r\n \"authors\": \"Role of cAMP\/pCREB and GSK-3\u03b2\/NF-\u03baB p65 signaling pathways in the renoprotective effect of mirabegron against renal ischemia-reperfusion injury in rats\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85191467946&doi=10.1016%2Fj.ejphar.2024.176617&partnerID=40&md5=601ce2f3570ecf5f4293122bbd5ae6a8\",\r\n \"affiliations\": \"Department of Pharmacology, Faculty of Medicine, Asyut, Egypt; Department of Histology and Cell Biology, Faculty of Medicine, Cairo, Egypt; Department of Pharmacology, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Acute kidney injury and other renal disorders are thought to be primarily caused by renal ischemia-reperfusion (RIR). Cyclic adenosine monophosphate (cAMP) has plenty of physiological pleiotropic effects and preserves tissue integrity and functions. This research aimed to examine the potential protective effects of the \u03b2<inf>3<\/inf>-adrenergic receptors agonist mirabegron in a rat model of RIR and its underlying mechanisms. Male rats enrolled in this work were given an oral dose of 30 mg\/kg mirabegron for two days before surgical induction of RIR. Renal levels of kidney injury molecule-1 (KIM-1), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-\u03b1), Interleukin-10 (IL-10), cAMP, cAMP-responsive element binding protein (pCREB), and glycogen synthase kinase-3 beta (GSK-3\u03b2) were assessed along with blood urea nitrogen and serum creatinine. Additionally, caspase-3 and nuclear factor-kappa B (NF-\u03baB) p65 were explored by immunohistochemical analysis. Renal specimens were inspected for histopathological changes. RIR led to renal tissue damage with elevated blood urea nitrogen and serum creatinine levels. The renal KIM-1, MCP-1, TNF-\u03b1, and GSK-3\u03b2 were significantly increased, while IL-10, cAMP, and pCREB levels were reduced. Moreover, upregulation of caspase-3 and NF-\u03baB p65 protein expression was seen in RIR rats. Mirabegron significantly reduced kidney dysfunction, histological abnormalities, inflammation, and apoptosis in the rat renal tissues. Mechanistically, mirabegron mediated these effects via modulation of cAMP\/pCREB and GSK-3\u03b2\/NF-\u03baB p65 signaling pathways. Mirabegron administration could protect renal tissue and maintain renal function against RIR. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"cAMP\",\r\n \" CREB\",\r\n \" GSK-3\u03b2\",\r\n \" Mirabegron\",\r\n \" Renal ischemia\/reperfusion\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 49,\r\n \"title\": \"Salem, Heba Farouk (16426683200); Aboud, Heba M. (55558016900); Abdellatif, Mostafa M. (58947107100); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Nose-to-Brain Targeted Delivery of Donepezil Hydrochloride via Novel Hyaluronic Acid-Doped Nanotransfersomes for Alzheimer's Disease Mitigation\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85188219286&doi=10.1016%2Fj.xphs.2024.02.014&partnerID=40&md5=9389508de3cc2a93a5868220e3496569\",\r\n \"affiliations\": \"Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Alzheimer's disease is the most serious neurodegenerative disorder characterized by cognitive and memorial defects alongside deterioration in behavioral, thinking and social skills. Donepezil hydrochloride (DPZ) is one of the current two FDA-approved cholinesterase inhibitors used for the management of Alzheimer's disease. The current study aimed to formulate hyaluronic acid-coated transfersomes containing DPZ (DPZ-HA-TFS) for brain delivery through the intranasal pathway to surpass its oral-correlated GIT side effects. DPZ-HA-TFS were produced using a thin film hydration method and optimized with a 24 factorial design. The influence of formulation parameters on vesicle diameter, entrapment, cumulative release after 8 h, and ex vivo nasal diffusion after 24 h was studied. The optimal formulation was then evaluated for morphology, stability, histopathology and in vivo biodistribution studies. The optimized DPZ-HA-TFS formulation elicited an acceptable vesicle size (227.5 nm) with 75.83% entrapment efficiency, 37.94% cumulative release after 8 h, 547.49 \u00b5g\/cm2 permeated through nasal mucosa after 24 h and adequate stability. Histopathological analysis revealed that the formulated DPZ-HA-TFS was nontoxic and tolerable for intranasal delivery. Intranasally administered DPZ-HA-TFS manifested significantly superior values for drug targeting index (5.08), drug targeting efficiency (508.25%) and direct nose-to-brain transport percentage (80.32%). DPZ-HA-TFS might be deemed as a promising intranasal nano-cargo for DPZ cerebral delivery to tackle Alzheimer's disease safely, steadily and in a non-invasive long-term pattern. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Alzheimer's disease\",\r\n \" Donepezil hydrochloride\",\r\n \" Hyaluronic acid\",\r\n \" Intranasal\",\r\n \" Pharmacokinetics\",\r\n \" Transfersomes\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 50,\r\n \"title\": \"Ali, Ahmed U. (57213590141); Khallaf, Iman S.A. (57213352391); Hassan, Abeer S. (57196119456); Sayed, Marwa A. (57217417384); Hamdy, Aya (58046302000); Ali, Magda Mahmoud (7404486251); Hassanein, Khaled M.A. (36863873500); Badry, Mahmoud El (59307289800); Abdelhakiem, Mohammed Ahmed Hamdy (56922161200)\",\r\n \"authors\": \"Effect of Olive Oil on Hesperidin Nanovesicles in Treatment of Induced Corneal Ulcers in Rabbits, Morphological and Histopathologic Study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85202744131&doi=10.22037%2Fijps.v20i2.44223&partnerID=40&md5=55f6c1c4c5959027482cb0649bb67420\",\r\n \"affiliations\": \"Faculty of Pharmacy, Merit University, Sohag, Egypt; Department of pharmacognosy and natural products Faculty of Pharmacy, Menoufia University, Shibin El Kom, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Qena, Egypt; Department of Industrial Pharmacy, Faculty of Pharmacy, Asyut, Egypt; Department of Surgery, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Clinical Pathology, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Asyut, Egypt; Assiut International Center of Nanomedicine, Assiut University, Asyut, Egypt\",\r\n \"abstract\": \"Hesperidin (HSP) and Olive oil possess many biological activities that are required for the safe and effective treatment of corneal ulcers. However, the poor aqueous solubility of HSP hinders its topical utilization. This work aims at enhancing the dissolution of HSP and combining the powerful effectiveness of Olive oil in treating corneal ulcers. HSP was isolated from orange peel and described by spectroscopic methods (1H NMR and 13C NMR), then HSP nanovesicles were prepared with and without Olive oil using the ethanol injection method. Nanovesicles were applied topically to rabbits\u2019 eyes in which alkali burn corneal ulcers were induced. After five weeks, histopathological studies were performed. No ulcers were determined after topical application of HSP, and the inclusion of Olive oil returned the eye to its normal conditions. Thus, this study clarified the potential role of the HSP - Olive oil combination in managing corneal ulcers. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Corneal ulcer\",\r\n \" Hesperidin\",\r\n \" Histopathology\",\r\n \" nanovesicles\",\r\n \" Olive oil\",\r\n \" rabbits\",\r\n \" Topical application\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 51,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Zaki, Randa Mohammed (54792413400); Hefny, Ahmed A. (57195534027); Afzal, Obaid (53870994800); Shahataa, Mary Girgis (57190442518); Abo El-Ela, Fatma I. (56461520900); Salem, Heba Farouk (16426683200); Gamal, Amr Gamal (57204454409)\",\r\n \"authors\": \"In vitro and in vivo evaluation of isoxsuprine loaded invasomes for efficient treatment of diabetes\u2010accelerated atherosclerosis\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85190945098&doi=10.1016%2Fj.jddst.2024.105686&partnerID=40&md5=1a45ab8e1f24a245e4866367d9adcbe2\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Faculty of Pharmacy, Beni Suef, Egypt; School of Pharmacy, University of Waterloo, Waterloo, Canada; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutical Chemistry, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Pharmacology, Faculty of Medicine, Beni Suef, Egypt; Department of Pharmacology, Faculty of Veterinary Medicine, Beni Suef, Egypt; Faculty of Pharmacy, Beni Suef, Egypt\",\r\n \"abstract\": \"Hyperglycemia in diabetes mellitus exacerbates vascular disarray in atherosclerosis by damaging endothelial cells and vascular smooth muscles. It's a major contributor to deaths from cardiovascular disease. Isoxsuprine (IXS) is an oral beta-adrenergic agonist that improves arterial blood flow due to its vasodilatation effect and boosts insulin secretion. However, oral IXS has low efficacy, low bioavailability and patient incompliance due to its high dose frequency, short biological half-life and fast clearance. The goal of this research was to develop a nasal formulation of IXS-loaded invasomes to sustain IXS's release and improve its permeation and efficacy as a potential diabetes-accelerated atherosclerosis treatment. Different IXS-loaded invasomes formulations were developed using design expert software to study the effects of ethanol, phospholipid, and cineole concentrations. Based on the desirability index, the formulation with 1 % ethanol, 0.5 % cineole, and 2.48 % phospholipid was chosen as the optimum formulation. The optimum IXS-loaded invasomes formulation showed an encapsulation efficiency of 72.03 % and a particle size of 210.26 nm. Production of nasal IXS-loaded invasomes formulation increased the permeation of IXS with a ratio of 2.25 and sustained its release. The optimum IXS-loaded invasomes formulation was non-cytotoxic and showed a good binding mode with serum proteins. When optimum IXS-loaded invasomes formulation was evaluated in vivo against a rat model of experimental diabetes and atherosclerosis, it showed anti-diabetic and anti-atherosclerotic effects. It substantially increased the levels of HDL by 45.11 % and substantially decreased the levels of glucose, LDL, triglycerides, and cholesterol by 41.35 %, 89.76 %, 51.01 %, and 60.18 %, respectively. Histopathology also showed that atherosclerotic lesions got improved in rats given optimum IXS-loaded invasomes formulation. In conclusion, nasal administration of IXS-loaded invasomes could be a potential diabetes-accelerated atherosclerosis treatment. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Atherosclerosis\",\r\n \" Cineole\",\r\n \" Diabetes mellitus\",\r\n \" Invasomes\",\r\n \" Isoxsuprine\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 52,\r\n \"title\": \"Eissa, Manar A. (57204365848); Hashim, Yumi Zuhanis Has Yun (9435676000); Badawi, Noha M. (57201151660)\",\r\n \"authors\": \"Unlocking the potential of chitosan-based polymeric nanoparticles for the treatment of neurological disorders\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85189696053&doi=10.22038%2FNMJ.2024.74564.1812&partnerID=40&md5=4b6a7ff463667035ad70dce7c072c8dd\",\r\n \"affiliations\": \"Department of Pharmacology and Toxicology, Merit University, Sohag, Egypt; International Institute for Halal Research and Training, International Islamic University Malaysia, Kuala Lumpur, Malaysia; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, El Shorouk, Egypt\",\r\n \"abstract\": \"Neurological disorders are the diseases associated with the central and peripheral nervous system. They are among the most serious and prevalent diseases nowadays. However, most of the pharmacological agents used to treat neurological disorders demonstrate severe toxicities and side effects, along with failure to achieve the desired outcomes due to their inability to cross the blood-brain barrier (BBB). Therefore, efforts have been made to develop potential drug carriers that can enhance the penetration of various therapeutic agents across the BBB. Due to the remarkable selectivity of nanoparticles and their ability to penetrate the BBB, they have attracted enormous interest as a viable solution to overcome these challenges. Polymeric nanoparticles used as drug delivery systems, in particular, demonstrated multiple advantages over traditional drug delivery systems in the treatment of neurological and psychological disorders due to several beneficial properties. This minireview article discusses the current literature on the use of chitosan nanoparticles in particular as promising carriers for delivering therapeutic agents to the brain for the treatment of different neurological diseases. The article emphasizes the advantages of using chitosan over other natural and synthetic polymers, and illustrates the methods of preparation of chitosan nanoparticles, in addition to the characterization of chitosan-based nanoparticles. The article also discusses the specific application of chitosan-based nanoparticles for brain targeting with the aim of the treatment of neurological disorders. Furthermore, challenges and future prospects were also discussed. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Chitosan\",\r\n \" Drug delivery systems\",\r\n \" Nanocapsules\",\r\n \" Neurological disorders\",\r\n \" Polymer\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 53,\r\n \"title\": \"Zaher, Ahmed M. (55816802700); Anwar, Walaa S. (58082428700); Makboul, Makboul A. (6508060541); Abdel-Rahman, Iman A.M. (57217534275)\",\r\n \"authors\": \"Potent anticancer activity of (Z)-3-hexenyl-\u03b2-D-glucopyranoside in pancreatic cancer cells\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85173799800&doi=10.1007%2Fs00210-023-02755-4&partnerID=40&md5=24454a2103bfba08d1085f12ecfd0782\",\r\n \"affiliations\": \"Faculty of Pharmacy, Asyut, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Qena, Egypt\",\r\n \"abstract\": \"This current study reports, for the first time, on the potent cytotoxicity of (Z)-3-hexenyl-\u03b2-<inf>D<\/inf>-glucopyranoside, as well as its cellular and molecular apoptotic mechanisms against Panc1 cancer cells. The cytotoxicity of three compounds, namely (Z)-3-hexenyl-\u03b2-<inf>D<\/inf>-glucopyranoside (1), gallic acid (2), and pyrogallol (3), which were isolated from C. rotang leaf, was investigated against certain cancer and normal cells using the MTT assay. The cellular apoptotic activity and Panc1 cell cycle impact of compound (1) were examined through flow cytometry analysis and Annexin V-FITC cellular apoptotic assays. Additionally, RT-PCR was employed to evaluate the effect of compound (1) on the Panc1 apoptotic genes Casp3 and Bax, as well as the antiapoptotic gene Bcl-2. (Z)-3-hexenyl-\u03b2-<inf>D<\/inf>-glucopyranoside demonstrated the highest cytotoxic activity against Panc1 cancer cells, with an IC<inf>50<\/inf> value of 7.6\u00a0\u00b5M. In comparison, gallic acid exhibited an IC<inf>50<\/inf> value of 21.8\u00a0\u00b5M, and pyrogallol showed an IC<inf>50<\/inf> value of 198.2\u00a0\u00b5M. However, (Z)-3-hexenyl-\u03b2-<inf>D<\/inf>-glucopyranoside displayed minimal or no significant cytotoxic activity against HepG2 and MCF7 cancer cells as well as WI-38 normal cells, with IC<inf>50<\/inf> values of 45.8\u00a0\u00b5M, 108.7\u00a0\u00b5M, and 194. \u00b5M, respectively. (Z)-3-hexenyl-\u03b2-<inf>D<\/inf>-glucopyranoside (10\u00a0\u00b5M) was demonstrated to induce cellular apoptosis and cell growth arrest at the S phase of the cell cycle in Panc1 cells. These findings were supported by RT-PCR analysis, which revealed the upregulation of apoptotic genes (Casp3 and Bax) and the downregulation of the antiapoptotic gene Bcl-2. This study emphasizes the significant cellular potency of (Z)-3-hexenyl-\u03b2-<inf>D<\/inf>-glucopyranoside in specifically inducing cytotoxicity in Panc1 cells. Graphical Abstract: (Figure presented.). \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"(Z)-3-hexenyl-\u03b2-D-glucopyranoside\",\r\n \" Bax\",\r\n \" Bcl-2\",\r\n \" Casp3\",\r\n \" Panc1\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 54,\r\n \"title\": \"El-Hawary, Seham Salah Dine (6505933617); Hassan, Marwa H.A. (56468563000); Hudhud, Ahmed O. (58122425100); Al-Karmalawy, Ahmed A. (57210596269); Mustafa, Muhamad (56588496500); Hamed, El Sayed A.E. (57091344200); Abdelmohsen, Usama Ramadan (36056037900); Mohammed, Rabab (54963341500)\",\r\n \"authors\": \"LC-HRMS Profiling and Cytotoxic Potential of Actinomycetes Associated with the Red Sea Soft Coral Sarcophyton glaucum: In vitro and In silico Studies\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85186913430&doi=10.1002%2Fcbdv.202301617&partnerID=40&md5=a5320dd53683a0fd35c937d7271b1a34\",\r\n \"affiliations\": \"Faculty of Pharmacy, Cairo, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt; Department of Pharmaceutical Chemistry, Horus University - Egypt, New Damietta, Egypt; Faculty of Pharmacy, 6th October, Egypt; Institut des Biomol\u00e9cules Max Mousseron, Montpellier, France; Department of Medicinal Chemistry, Deraya University, New Minia, Egypt; National Institute of Oceanography and Fisheries, Cairo, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Minya, Egypt; Department of Pharmacognosy, Deraya University, New Minia, Egypt\",\r\n \"abstract\": \"In the current study, the actinomycetes associated with the red sea-derived soft coral Sarcophyton glaucum were investigated in terms of biological and chemical diversity. Four different media, M1, ISP2, Marine Agar (MA), and Actinomycete isolation agar (AIA) were used for the isolation of three strains of actinomycetes that were identified as Streptomyces sp. UR 25, Micromonospora sp. UR32 and Saccharomonospora sp. UR 19. LC-HRMS analysis was used to investigate the chemical diversity of the isolated actinobacteria. The LC-HRMS data were statistically processed using MetaboAnalyst 5.0 viz to differentiate the extract groups and determine the optimal growth culturing conditions. Multivariate data statistical analysis revealed that the Micromonospora sp. extract cultured on (MA) medium is the most distinctive extract in terms of chemical composition. While, the Streptomyces sp. UR 25 extracts are differ significantly from Micromonospora sp. UR32 and Saccharomonospora sp. UR 19. Biological investigation using in vitro cytotoxic assay for actinobacteria extracts revealed the prominent potentiality of the Streptomyces sp. UR 25 cultured on oligotrophic medium against human hepatoma (HepG2), human breast adenocarcinoma (MCF-7) and human colon adenocarcinoma (CACO2) cell lines (IC<inf>50<\/inf>=3.3, 4.2 and 6.8 \u03bcg\/mL, respectively). SwissTarget Prediction speculated that among the identified compounds, 16-deethyl, indanomycin (8) could have reasonable affinity on HDM2 active site. In this respect, molecular docking study was performed for compound (8) to reveal a substantial affinity on HDM2 active site. In addition, molecular dynamics simulations were carried out at 200 ns for the most active compound (8) compared to the co-crystallized inhibitor DIZ giving deeper information regarding their thermodynamic and dynamic properties as well. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Actinomycetes\",\r\n \" docking\",\r\n \" Micromonospora\",\r\n \" Molecular dynamics and MM-GBSA calculations\",\r\n \" Streptomyces, Saccharomonospora, multivariate\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 55,\r\n \"title\": \"Waly, Hanan S.A. (55623917400); Abdelfattah, Mostafa Galal (57209069196); Abou-Khalil, Nasser Sayed (57160296500); Ragab, Sohair M.M. (56747567100)\",\r\n \"authors\": \"Role of Eruca sativa L. seeds in boosting the reproductive performance of male Japanese quails (Coturnix c. japonica)\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85178966399&doi=10.1111%2Fjpn.13912&partnerID=40&md5=513750a3cbf4f5fb4a4d2f0751befd66\",\r\n \"affiliations\": \"Department of Zoology and Entomology, Faculty of Science, Asyut, Egypt; Department of Poultry Production, Faculty of Agriculture, Asyut, Egypt; Department of Medical Physiology, Faculty of Medicine, Asyut, Egypt; Department of Basic Medical Sciences, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Herein we attempt to shed light on the potential improving effect of Eruca sativa seeds (ESS) on the reproductive aspects of male Japanese quails. To accomplish this objective, two groups of quails were supplemented with ESS powder at doses of 5 and 10 g\/kg feed from 7 days to 140 days of age, in addition to the control group, which did not receive treatment. Forty males were reared singly in cages to evaluate sperm characters and 32 males were raised with 64 females to evaluate fertility and sperm penetrability. Sixty-six phytochemical compounds were found according to gas chromatography\u2013mass spectrometry analysis of ESS. The most plentiful ones are 13-docosenoic acid methyl ester, 9-octadecenoic acid methyl ester, and linoleic acid methyl ester. Both 5 g\/kg and 10 g\/kg doses of ESS showed similar effectiveness in enhancing various reproductive parameters, including gonadal index, sperm characteristics, fertility, libido, and cloacal gland attributes. However, some aspects like sperm concentration and testosterone levels exhibited a dose-dependent response. There is no significant change in mortality rate of supplemented groups compared to the control one. ESS also caused a reduction in feed intake and an enhancement in feed conversion ratio without affecting final body weight and body weight gain. This suggests potential nutritional benefits beyond reproductive health. The low-dose-fed group showed a significant reduction in total cholesterol and malondialdehyde compared to the high-dose-fed and unfed groups. The higher dose notably increased total antioxidant capacity compared to the lower dose and control group. Despite the positive effects on male reproductive parameters, there wasn't a significant impact on hatchability percentage, indicating that while male fertility improved, it might not have directly affected the viability of the eggs. Overall, the study suggests that ESS could be a safe and promising addition to the diet of male Japanese quails to enhance their reproductive capabilities without adverse effects. The findings could have implications for poultry farming by potentially improving breeding efficiency and health outcomes in quails. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"antioxidants\",\r\n \" cloacal gland\",\r\n \" Eruca sativa seeds\",\r\n \" male Japanese quails\",\r\n \" physiology\",\r\n \" semen\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 56,\r\n \"title\": \"Eissa, Manar A. (57204365848); Abdullah, Raihan (59482494900); Sharif, Mohd Faez (57205264279); Nasir, Mohd Hamzah (57212019419)\",\r\n \"authors\": \"Repeated Blood Sampling from an Adult Danio Rerio\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85212742742&doi=10.1201%2F9781003402893-6&partnerID=40&md5=693beeae245dd58652fbf18084dc87e9\",\r\n \"affiliations\": \"Merit University, Sohag, Egypt; International Islamic University Malaysia, Kuala Lumpur, Malaysia\",\r\n \"abstract\": \"Zebrafish (Danio rerio) has emerged as an enormously powerful and popular model for biomedical and preclinical research over the past few years. This is largely attributed to the significant genetics and physiological homology with higher vertebrates, especially humans, and the emerging opportunities for genetic manipulation and live in vivo imaging. Furthermore, the body fluids of zebrafish, including blood, plasma, and interstitial and cerebrospinal fluids, can also provide an insightful data on health and disease status. The high similarity between zebrafish and human plasma proteins makes zebrafish an excellent alternative model organism for studying hematologic and metabolic diseases in the quest for a new therapy. The analysis of the metabolites and the blood parameters of zebrafish is essential, as it might provide important details about the physiological condition of the fish. Besides, the longitudinal analysis of individual zebrafish provides a better insight of metabolic dynamics than the single point blood analysis. Despite the advantages of employing zebrafish for metabolic and blood research studies, it can be difficult to collect blood samples from these tiny aquatic creatures, owing to the fact that a 4-cm-long adult zebrafish only has about 0.05-0.07 ml of blood. As a result, several techniques for routine blood collecting from adult zebrafish have been developed. These techniques include decapitation, lateral incision in the dorsal aorta, tail-clipping, and heart puncture. Some of these techniques have been deemed as invasive or even harmful, whereas others are non-invasive and safe to employ for repeated blood samples from the same fish. The various blood collection techniques are briefly compared in this chapter, along with their benefits and drawbacks. It is important to keep in mind that some blood sampling techniques are not better than others; instead, the best techniques should be chosen based on the objectives of the study and the bare minimum quantity of blood needed for analysis. This chapter will also introduce a new and low-cost instrument that can be used for repeated blood sampling from adult zebrafish for blood glucose monitoring, with a survival rate of 93%. The fabricated instrument comprised a pulled microcapillary glass needle with an outer tip diameter of about 20 \u00b5m. The needle is inserted at the caudal vein, where 5-7 \u00b5l of blood were drawn at 30 minutes to 1-hour time intervals. This proposed device can be simply fabricated in new labs for drawing blood from zebrafish with high survival rate and at minimal cost. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 57,\r\n \"title\": \"Abdelkader, Hamdy (20336654000); Alfatease, Adel M. (57193644396); Fathalla, Zeinab M.A. (57188965212); Shoman, Mai E. (24559439600); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Meloxicam-amino acids salts\/ion pair complexes with advanced solubility, dissolution, and gastric safety\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85207516201&doi=10.1080%2F10837450.2024.2417766&partnerID=40&md5=3f3c10254743230e854087158d6ce316\",\r\n \"affiliations\": \"Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Amino acids have attracted attention as a potential functional excipient for optimizing biopharmaceutics characteristics of poorly soluble drugs. The amino acids are a diverse class with many functional groups, natural compounds, biocompatible, and low-molecular-weight substances. Two amino acids serine and arginine were investigated with meloxicam. Meloxicam has extremely low solubility; being NSAIDs, gastric upset, and ulcer are common side effects. Solid dispersions were produced by precipitation and physical mixing techniques. The produced combinations underwent in\u00a0vitro dissolution, docking, DSC, FTIR, XRD, solubility, and gastric ulcer formation studies. Docking indicated ion pair\/salt formation between the basic amino acid arginine and meloxicam. Both solubility and dissolution rates were increased by up to 3000-fold and 12-fold, respectively. DSC, FTIR an XRD supported these findings. Rats treated with meloxicam showed loss of surface gastric epithelium integrity and ulceration. The animal group received meloxicam: arginine showed intact gastric mucosa with the surface epithelium and gastric glands well organized and nearly similar to the untreated control. Arginine with the guanidine group that was capable of preserving gastric mucosa after repeated administration for 10 days. This study highlighted the role of arginine as a functional excipient that did not only improve solubility and dissolution rates but ameliorated the long-standing gastric side effects attributed to meloxicam. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"dissolution, arginine\",\r\n \" gastric ulcer\",\r\n \" ion pair\",\r\n \" Meloxicam\",\r\n \" salt\",\r\n \" serine\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 58,\r\n \"title\": \"Seddik, Mark Monir (59348874900); Rahmy, Awny Fouad (57189642973); Wadee, Amir N. (25422836600); Ahmad, Ahmad Mahdi (57204148188)\",\r\n \"authors\": \"Effects of different aerobic exercise protocols on regional body fatness and serum lipids in women with obesity: A randomized trial; Wp\u0142yw r\u00f3\u017cnych protoko\u0142\u00f3w \u0107wicze\u0144 aerobowych na rozmieszczenie tkanki t\u0142uszczowej i poziom lipid\u00f3w w surowicy u kobiet z oty\u0142o\u015bci\u0105: Badanie randomizowane\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85205283362&doi=10.56984%2F8ZG020AYN5&partnerID=40&md5=0420f6d5cb4090c1e7d3407e3d3e43de\",\r\n \"affiliations\": \"Department of Physical Therapy for Internal Medicine and Geriatrics, Badr University in Assuit, Asyut, Egypt; Department of Physical Therapy for Cardiovascular, Faculty of Physical Therapy, Giza, Egypt; Faculty of Physical Therapy, Merit University, Sohag, Egypt; Department of Basic Science for Physical Therapy, Faculty of Physical Therapy, Giza, Egypt; Faculty of Physical Therapy, Alexandria, Egypt\",\r\n \"abstract\": \"Aim. This study aimed to compare the effects of high-volume high-intensity interval training (HV-HIIT), low-volume high-intensity interval training (LV-HIIT), and moderate-intensity continuous training (MICT) on regional body fatness and serum lipids in adult obese women. Methods. Forty-six women with obesity and dyslipidemia completed this study. They were randomly allocated to HV-HIIT protocol (n = 15) that consisted of 4 \u00d7 4-minute intervals at 85%-95% HRmax, LV-HIIT protocol (n = 14) that consisted of 4 \u00d7 2-minute intervals at 85%-95% HRmax, and MICT protocol (n = 17) that consisted of continuous training for 30 minutes at 65%-75% HRmax. All protocols were performed three days\/week for eight weeks. The measurements included anthropometric characteristics [i.e., body mass index (BMI) and waist circumference (WC)], dual-energy x-ray absorptiometry (DXA) (i.e. for measurement of sub-total fat, leg fat, trunk fat, arm fat, lean mass, fat-free mass, and bone mineral content), self-paced maximal cycle test (i.e., for HRmax determination), and serum lipids [i.e., total cholesterol (TC), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and triglycerides (TG)]. Results. HV-HIIT induced significantly more improvements in HRmax, sub-total fat, leg fat, trunk fat, arm fat, TC, and HDL than other exercise protocols (p < 0.05). Both LV-HIIT and MICT were similar (p > 0.05) in reducing TC; however, LV-HIIT was better than MICT in improving HDL (P < 0.05). Conclusion. HV-HIIT could lead to the greatest improvements in regional body fatness, TC, and HDL. LV-HIIT could lead to higher improvements in HDL than MICT. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"aerobic exercise\",\r\n \" high-intensity interval training\",\r\n \" obese\",\r\n \" regional body fatness\",\r\n \" serum lipids\",\r\n \" women\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 59,\r\n \"title\": \"Hammam, Radwa Fayek (57216980347); Alshimy, Ahmed Magdy (58537265300); Mosaad, Andrew Anis Fakhrey (59335461700); Ibrahim, Maha Gamal (59336291800)\",\r\n \"authors\": \"Effect of foot muscle energy technique in patients with diabetic neuropathy: a randomized controlled trial\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85204419092&doi=10.5114%2Fpq%2F174937&partnerID=40&md5=2bdb224ce33f7fcec548d73899e1ef8b\",\r\n \"affiliations\": \"Faculty of Physical Therapy, Cairo, Egypt; Faculty of Physical Therapy, Al-Ryada University for Science and Technology, Sadat City, Egypt; Faculty of Physical Therapy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Introduction. This study investigated the effect of foot muscle energy technique (MET) on nerve conduction velocity (NCV) and isometric muscle strength in patients with type 2 diabetic neuropathy (DN). Methods. Forty-four patients were randomly assigned to either the MET group (group A) or the conventional physical therapy program group (group B). Electrophysiological measurements, including peroneal and tibial motor NCV studies, and isometric muscle strength using a toe strength dynamometer, were conducted. The assessment period ranged from April to November 2022, with measurements taken before the first session and after 4 weeks of treatment. Results. Significant improvements were observed in post-treatment peroneal motor NCV (p < 0.001), tibial motor NCV (p < 0.001), and isometric muscle strength (p < 0.001) in group A, but not in group B. Conclusions. MET enhances motor NCV and isometric muscle strength in patients with type 2 DN. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"diabetic neuropathy\",\r\n \" foot muscle energy technique\",\r\n \" isometric muscle strength\",\r\n \" motor nerve conduction velocity study\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 60,\r\n \"title\": \"Alqarni, Abdulmalik M. (57204497870); Haredy, Ahmed M. (56895997900); Abdelrahman, Kamal S. (57218117868); Soltan, Osama M. (57216819679); Abdel-Aal, Mohamed A.A. (57209617417); Alrofaidi, Mohammad A. (58026863900); Aalamri, Abdulwahab (58581035300); Osman, Mhdia Elhadi D. (58096090300); Alamri, Ahmed Awadh Saleh (58820661300); Hamad, Ahmed Abdulhafez (57193447791)\",\r\n \"authors\": \"Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85182687259&doi=10.1002%2Fbio.4661&partnerID=40&md5=6781acdc003e8a35569903896bb8aa65\",\r\n \"affiliations\": \"Department of Pharmaceutical Chemistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Chemistry, Al Baha University, Al Aqiq, Saudi Arabia; Department of Pharmacology and Toxicology, University of Ha'il, Ha'il, Saudi Arabia; Department of Clinical Pharmacy, University of Ha'il, Ha'il, Saudi Arabia; Medical Services, Ministry of Interior, Riyadh, Saudi Arabia; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"The suggested study adheres to a particular protocol to ensure that the process is environmentally friendly and sustainable. It is worth mentioning that several tools have been adopted as prospective measures of the method greenness. Fortunately, the established analytical method is identified as white by the white analytical chemistry (WAC) concept, which uses the red\/ green\/blue color scheme (RGB 12 tool) to combine ecological and functional factors for the first time in studying of the cited drug. Amlodipine (AMD), a cardiovascular treating agent, belongs to the dihydropyridine class of oral calcium channel-blocking agents. This article presents a novel, simple, green, one-pot-processed, fast, and ultrasensitive fluorimetric approach for monitoring and assessment of AMD using molecular-size-dependent fluorescence augmentation of the light scattering-driven signal of eosin, a biological stain at a wavelength of 415 nm. This enhancement was directly proportional to the size of the produced complex. The linearity range was from 30 to 900 ng mL\u22121, with corresponding sensitivity limits (detection and quantitation levels) of 9.2 and 28 ng mL\u22121, respectively. The planned approach was also successfully used to track AMD content in bulk, dosage forms, and bio-fluids (human plasma and urine). The developed method's eco-friendliness was established by different eco-rating metric tools. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"amlodipine\",\r\n \" biological dye probe\",\r\n \" content homogeneity testing\",\r\n \" green and white analytical chemistry\",\r\n \" molecular-size-dependent system\",\r\n \" sustainability profile\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 61,\r\n \"title\": \"Botla, Afaf Mohamed Mahmoud (57207855357); Mustafa, Jehan H. (58561282900); Abd-Elmonem, Amira M. (57203746938); Sayed, Mohamed D. (58561283000); Shehata, Mai M.A. (57801091200)\",\r\n \"authors\": \"Effect of laser acupuncture on monosymptomatic nocturnal enuresis in adolescent females: A randomized controlled trial\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85169670238&doi=10.1002%2Fpri.2048&partnerID=40&md5=192f9fcaf9a0e9e9ca6b21e180efe761\",\r\n \"affiliations\": \"Department of Physical Therapy for Women\u2019s Health, Faculty of Physical Therapy, Giza, Egypt; Department of Physical Therapy for Women's Health, Merit University, Sohag, Egypt; Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Giza, Egypt; Department of Urology, Faculty of Medicine, Sohag, Egypt\",\r\n \"abstract\": \"Background and aim: Nocturnal enuresis (NE) is prevalent in children and adolescents and affects their social life later. Therefore, the objective of this study was to ascertain laser acupuncture (LA) therapy's effect on NE in adolescent females. Methods: Sixty adolescent females diagnosed with chronic monosymptomatic nocturnal enuresis (MNE) were randomly divided into two equal groups: The intervention group (received LA and desmopressin) and the control group (received desmopressin only) (n\u00a0=\u00a030 each). Treatment was delivered and LA was used three times a week for 12\u00a0successive weeks. Abdominal ultrasonography and voiding calendar were used to assess bladder capacity and maximum voiding volume (MVV), respectively. The frequency of bed wetness was assessed throughout the trial period in a diary. Results: Statistically significant differences were reported in the intervention group. Bladder capacity significantly increased in the intervention group (LA and desmopressin) than in the control group. Conclusions: The results of this study suggest the beneficial influences of LA on MNE, despite the very poor quality of the literature's available evidence. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"adolescent\",\r\n \" desmopressin\",\r\n \" laser acupuncture\",\r\n \" monosymptomatic nocturnal enuresis\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 62,\r\n \"title\": \"Zaher, Ahmed M. (55816802700); Salama, Fawzy Mahmoud (7005616732); El-Tayeh, Noha A. (54890792000); El-Naggar, Sara H. (57224613149); Sultan, Raoof (57216129507); Gaafar, Ali Al Saied (57210886120)\",\r\n \"authors\": \"INFLUENCES OF ENVIRONMENTAL FACTORS ON THE ACTIVE METABOLITES AND CERTAIN BIOACTIVITIES OF DESERT DATE LEAF AND FRUIT (BALANITES AEGYPTIACA L. DELILE) GROWN IN EGYPT\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85181312499&doi=10.21608%2FBFSA.2023.327683&partnerID=40&md5=7afddcc97c394dc1328fddd8ac0888e0\",\r\n \"affiliations\": \"Faculty of Pharmacy, Asyut, Egypt; Faculty of Science, Asyut, Egypt; Department of Botany & Microbiology, Faculty of Science, Qena, Egypt; Botany and Microbiology Department, Faculty of Science, Kharga, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Balanites aegyptiaca (L.) Delile is a medicinal wild tree, naturally distributed in wide regions of Africa and South Asia. The fruits are commercially available in Egypt as antidiabetic natural products. The current study aimed to determine the effects of environmental factors on the metabolites and the bioactivities of fruit and leaf extracts. The main ecological differences between the sites of collection, Wadi El-Gemal and Baris Oasis, are temperature, aridity, humidity, and location. The fruit extract of Baris Oasis showed higher saponin content and saponin metabolites (LC-MS analysis) than the fruit extract of Wadi El-Gemal. Baris Oasis fruit extract showed twice the inhibition of \u03b1-Glucosidase than Wadi El-Gemal fruit extract. Twelve phenolics and flavonoids were detected in Baris Oasis leaf extract, while ten compounds were detected in Wadi El-Gemal leaf extract using HPLC. The higher quality and quantity of flavonoids and phenolics of Baris Oasis leaf extract than Wadi El-Gemal leaf extract, have significant effects on the antioxidant and acetylcholinesterase inhibitory activities. In conclusion, elevation of temperature and aridity have significant positive effects on the synthesis and accumulation of B. aegyptiaca saponins, phenolics and flavonoids. The bioactivities of the fruit and leaf extracts are directly proportional to the variation in metabolites due to abiotic stresses. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Balanites aegyptiaca L\",\r\n \" Ecological Factors\",\r\n \" Flavonoids\",\r\n \" Phenolics\",\r\n \" Saponins\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 63,\r\n \"title\": \"Elmileegy, Ibtisam M.H. (57459044600); Waly, Hanan S.A. (55623917400); Alghriany, Alshaimaa A.I. (57224211446); Abou-Khalil, Nasser Sayed (57160296500); Mahmoud, Sara M.M. (58206942200); Negm, Eman Ahmed (56246401100)\",\r\n \"authors\": \"Gallic acid rescues uranyl acetate induced-hepatic dysfunction in rats by its antioxidant and cytoprotective potentials\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85177592727&doi=10.1186%2Fs12906-023-04250-y&partnerID=40&md5=b688dec9ca86c9a4b129d9ce2cb5c0de\",\r\n \"affiliations\": \"Department of Medical Physiology, Faculty of Medicine, Asyut, Egypt; Department of Zoology and Entomology, Faculty of Science, Asyut, Egypt; Department of Zoology and Entomology, Faculty of Science, Asyut, Egypt; Department of Basic Medical Sciences, Merit University, Sohag, Egypt; Department of Physiology, Faculty of Veterinary Medicine, Asyut, Egypt\",\r\n \"abstract\": \"Background: The liver was identified as a primary target organ for the chemo-radiological effects of uranyl acetate (UA). Although the anti-oxidant and anti-apoptotic properties of gallic acid (GA) make it a promising phytochemical to resist its hazards, there is no available data in this area of research. Methods: To address this issue, eighteen rats were randomly and equally divided into three groups. One group was received carboxymethyl cellulose (vehicle of GA) and kept as a control. The UA group was injected intraperitoneally with UA at a single dose of 5\u00a0mg\/kg body weight. The third group (GA + UA group) was treated with GA orally at a dose of 100\u00a0mg\/kg body weight for 14 days before UA exposure. UA was injected on the 15th day of the experiment in either the UA group or the GA + UA group. The biochemical, histological, and immunohistochemical findings in the GA + UA group were compared to both control and UA groups. Results: The results showed that UA exposure led to a range of adverse effects. These included elevated plasma levels of aspartate aminotransferase, lactate dehydrogenase, total protein, globulin, glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very-low-density lipoprotein and decreased plasma levels of high-density lipoprotein cholesterol. The exposure also disrupted the redox balance, evident through decreased plasma total antioxidant capacity and hepatic nitric oxide, superoxide dismutase, reduced glutathione, glutathione-S-transferase, glutathione reductase, and glutathione peroxidase and increased hepatic oxidized glutathione and malondialdehyde. Plasma levels of albumin and alanine aminotransferase did not significantly change in all groups. Histopathological analysis revealed damage to liver tissue, characterized by deteriorations in tissue structure, excessive collagen accumulation, and depletion of glycogen. Furthermore, UA exposure up-regulated the immuno-expression of cleaved caspase-3 and down-regulated the immuno-expression of nuclear factor-erythroid-2-related factor 2 in hepatic tissues, indicating an induction of apoptosis and oxidative stress response. However, the pre-treatment with GA proved to be effective in mitigating these negative effects induced by UA exposure, except for the disturbances in the lipid profile. Conclusions: The study suggests that GA has the potential to act as a protective agent against the adverse effects of UA exposure on the liver. Its ability to restore redox balance and inhibit apoptosis makes it a promising candidate for countering the harmful effects of chemo-radiological agents such as UA. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Apoptosis\",\r\n \" Gallic acid\",\r\n \" Liver\",\r\n \" Nrf2\",\r\n \" Physiology\",\r\n \" Uranyl acetate\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 64,\r\n \"title\": \"Emeish, Walaa F.A. (57199862558); Abd-Elhafeez, Hanan H. (57216658260); Alghamdi, Abdullah A.A. (57410884000); Ahmed, Madeha Ahmed (58421192500); Khalifa, Mahmoud Osman (57226469231); El-Mansi, Ahmed A. (57202830660); Abou-Elhamd, Alaa S. (35483139100); Khormi, Mohsen Ali (57210917357); Alkashif, Khalid (58691331400); Soliman, Soha A. (55940843600)\",\r\n \"authors\": \"Morphological changes in intraepithelial and stromal telocytes in Cyprinus carpio in response to salinity stress\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85176465051&doi=10.1038%2Fs41598-023-43279-4&partnerID=40&md5=f5555e65e5044d74bb51c07071b0afdd\",\r\n \"affiliations\": \"Department of Fish Diseases, Faculty of Veterinary Medicine, Qena, Egypt; Department of Cell and Tissues, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Biology, Al Baha University, Al Aqiq, Saudi Arabia; Department of Histology, Faculty of Veterinary Medicine, Sohag, Egypt; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Aswan, Egypt; Department of Molecular Bone Biology, Graduate School of Biomedical Sciences, Nagasaki, Japan; Department of Biology, King Khalid University, Abha, Saudi Arabia; Respiratory Therapy Department, Jazan University, Jizan, Saudi Arabia; Department of Biology, Jazan University, Jizan, Saudi Arabia; Department of Physiology, Merit University, Sohag, Egypt; Faculty of Veterinary Medicine, Qena, Egypt\",\r\n \"abstract\": \"Telocytes establish connections and communicate with various types of cells and structures. Few experimental studies have been performed on telocytes. In this study, we investigated the effect of salinity stress on telocytes in relation to osmoregulatory, immune, and stem cells. After exposing the common carp to 0.2 (control), 6, 10, or 14 ppt salinity, we extracted and fixed gill samples in glutaraldehyde, processed and embedded the samples in resin, and prepared semi-thin and ultrathin sections. Two types of telocytes were identified: intraepithelial and stromal telocytes. Intraepithelial telocytes were found to form part of the cellular lining of the lymphatic space and shed secretory vesicles into this space. Stromal telocytes were observed to shed their secretory vesicles into the secondary circulatory vessels. Both intraepithelial and stromal telocytes were enlarged and exhibited increased secretory activities as salinity increased. They exerted their effects via direct contact and paracrine signaling. The following changes were observed in samples from fish exposed to high salinity levels: chloride cells underwent hypertrophy, and their mitochondria became cigar-shaped; pavement cells were enlarged, and their micro-ridges became thin and elongated; stromal telocytes established contact with stem cells and skeletal myoblasts; skeletal muscle cells underwent hypertrophy; and macrophages and rodlet cells increased in number. In conclusion, our findings indicate that intraepithelial and stromal telocytes respond to salinity stress by activating cellular signaling and that they play major roles in osmoregulation, immunity, and regeneration. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 65,\r\n \"title\": \"Ali, Ahmed U. (57213590141); Sayed, Marwa A. (57217417384); Hassan, Abeer S. (57196119456); Elkabsh, Mai M. (57215670490); Shahat, Mohammed (57195246596); Abdelhakiem, Mohammed Ahmed Hamdy (56922161200); Kamel, Amira A. (57208054498); Abd-Eldayem, Ahmed Mohammed (57195596545); El-Badry, Mahmoud (6602674566); Amer, Enas Mahmoud (55921618900)\",\r\n \"authors\": \"Serum levels of tumor necrosis factor (TNF-\u03b1) and vaginal gene expression of toll-like receptor 2 (TLR2) & microtubule-associated protein 1 light chain 3 (LC3) after treatment of vulvovaginal candidiasis with sertaconazole nitrate spanlastics\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85176284661&doi=10.1016%2Fj.jddst.2023.105016&partnerID=40&md5=53f9b8f3bba53f15ebad3dfb64ef9d2c\",\r\n \"affiliations\": \"Department of Pharmaceutics, Merit University, Sohag, Egypt; Department of Industrial Pharmacy, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Qena, Egypt; Faculty of Veterinary Medicine, Asyut, Egypt; Department of Obstetrics and Gynecology, Faculty of Medicine, Asyut, Egypt; Department of Surgery, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Asyut, Egypt; Department of Pharmacology, Faculty of Medicine, Asyut, Egypt; Faculty of Pharmacy, Asyut, Egypt; Assiut International Center of Nanomedicine, Assiut University, Asyut, Egypt; Faculty of Science, Asyut, Egypt\",\r\n \"abstract\": \"The irritating infection known as vulvovaginal candidiasis (VVC) affects women all over the world. Around 75% of women will acquire at least one attack throughout their lives. In addition to its demonstrated antifungal properties, sertaconazole nitrate (SCN) also exhibits anti-inflammatory effects, which are of significant importance in the therapeutic management of (VVC). Despite its benefits, SCN suffers from poor solubility, which affects its biological activity. This project's objective is to construct SCN spanlstics in order to enhance its solubility as well as its antifungal and anti-inflammatory activities. SCN spanlastics were created utilizing the ethanol injection technique, after which they were characterized. Chitosan (2.5%) w\/w gels containing 2 % w\/w of SCN in the form of spanlastics were prepared, and then the in vitro antifungal activity of the prepared chitosan gel and commercial SCN cream (Dermofix) was performed. After a complete gynecological examination, vaginal swabs were obtained from patients suspected of VVC and then cultured on Sabouraud dextrose agar for phenotypic identification. VVC was then induced in nonpregnant ovariectomized female rats using isolated and identified Candida albicans (C. albicans) species. In order to detect the difference between chitosan gel containing SCN spanlastics and the commercial (Dermofix) cream, serum levels of pro-inflammatory cytokine Tumor necrosis factor (TNF- \u03b1) were detected. After sacrificing the rats, gene expression of toll-like receptor 2 (TLR2) & microtubule-associated protein 1 light chain 3 (LC3) in vaginal tissue and immunohistochemical expression of interleukin-6 (IL-6) as an inflammatory chemokine were performed in all groups. Results revealed that SCN was successfully entrapped into spanlastics, the particle size ranged from 1.6 \u00b1 0.050 to 5.7 \u00b1 0.900 \u03bcm in diameter; in-vitro dissolution of SCN was significantly enhanced from chitosan gel compared to that from Dermofix cream, the inhibition zone of prepared chitosan gel containing SCN spanlastics was significantly larger compared to that of Dermofix cream. Our results revealed that the anti-inflammatory effect of SCN in the form of spanlastics was significantly greater than that of commercial (Dermofix) cream. Finally, we recommend the use of SCN spanlastics as the best antifungal and anti-inflammatory formulation in cases of vaginal candidiasis. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"And vulvovaginal candidiasis\",\r\n \" Factorial design\",\r\n \" Immunohistochemistery\",\r\n \" Inhibition zone\",\r\n \" Sertaconazole nitrate\",\r\n \" Spanlastics\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 66,\r\n \"title\": \"Alrefaie, Zienab A. (53982701300); Bashraheel, Jana (58143165200); Hammad, Hossam A. (58143483100); Ali, Soad Shaker (35783844900); Alahmadi, Ahlam Abdulaziz (57207757871)\",\r\n \"authors\": \"Hippocampal mitochondrial Ca++ in experimentally induced Alzheimer's disease, link to calpains and impact of vitamin D3 supplementation\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85176232603&doi=10.1016%2Fj.jsps.2023.101834&partnerID=40&md5=28af53baf0adae99f24de728f63c83ba\",\r\n \"affiliations\": \"Department of Medical Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Department of Histology, Merit University, Sohag, Egypt; Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia\",\r\n \"abstract\": \"Objective: Vitamin D impact on hippocampal mitochondrial Ca++ and calpains was not previously investigated in Alzheimer's disease (AD). The current work aimed to assess the alteration in hippocampal mitochondrial Ca++, ATP & ADP and hippocampal calpains' level in (AlCl<inf>3<\/inf>)-induced AD model, and the effect of 2 regimens of vitamin D supplementation on these alterations. Methods: Forty male Wistar rats were randomized into 4 groups; control, AD (AlCl<inf>3<\/inf>100 mg\/kg, p.o. daily for 42 days), AD and vitamin D co-treated group (AlCl<inf>3<\/inf> as in AD group with vitamin D<inf>3<\/inf> 400 IU\/kg\/day, p.o. for 42 days) and AD, followed by vitamin D<inf>3<\/inf> group (AlCl<inf>3<\/inf> was given as in AD group for 42 days, then vitamin D<inf>3<\/inf> for two weeks). AD was assessed by hippocampal levels of A\u03b2<inf>42<\/inf>, p-tau and spatial memory assessment in Morris water maze. Hippocampal mitochondrial Ca++, ATP and ADP levels besides to calpain-1 & 2 and cytochrome C were assessed in addition to CA1 histological examination. Results: AD animals showed impaired mitochondrial function as denoted by high Ca++ and decreased ATP and ADP and elevated calpain-1 & 2 and cytochrome C. Hippocampal CA1 region showed increased degenerated neurons and reduced thickness of its pyramidal layer. Vitamin D administration minimized the hippocampal mitochondrial impairement induced by AD and mitigated histological alterations even when supplemented post AD establishment. Conclusion: Vitamin D administration to AD rats breaks the deleterious loop in the hippocampus that involves increased Ca++, calpain activation, mitochondrial failure, neuronal degeneration and AD disease progression. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"AD\",\r\n \" Calpain-1 & 2\",\r\n \" Hippocampus\",\r\n \" Mitochondrial Ca++\",\r\n \" Vitamin D\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 67,\r\n \"title\": \"Eissa, Manar A. (57204365848); Gohar, Eman Y. (24331652000)\",\r\n \"authors\": \"Aromatase enzyme: Paving the way for exploring aromatization for cardio-renal protection\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85175622863&doi=10.1016%2Fj.biopha.2023.115832&partnerID=40&md5=17ee3279c9b2d13333ceb5540f4573f2\",\r\n \"affiliations\": \"Department of Pharmacology and Toxicology, Merit University, Sohag, Egypt; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States\",\r\n \"abstract\": \"Documented male-female differences in the risk of cardiovascular and chronic kidney diseases have been largely attributed to estrogens. The cardiovascular and renal protective effects of estrogens are mediated via the activation of estrogen receptors (ER\u03b1 and ER\u03b2) and G protein-coupled estrogen receptor, and involve interactions with the renin-angiotensin-aldosterone system. Aromatase, also called estrogen synthase, is a cytochrome P-450 enzyme that plays a pivotal role in the conversion of androgens into estrogens. Estrogens are biosynthesized in gonadal and extra-gonadal sites by the action of aromatase. Evidence suggests that aromatase inhibitors, which are used to treat high estrogen\u2013related pathologies, are associated with the development of cardiovascular events. We review the potential role of aromatization in providing cardio-renal protection and highlight several meta-analysis studies on cardiovascular events associated with aromatase inhibitors. Overall, we present the potential of aromatase enzyme as a fundamental contributor to cardio-renal protection. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Aromatase inhibitors\",\r\n \" Cardiovascular\",\r\n \" Estrogen synthase\",\r\n \" Kidney\",\r\n \" Meta-analysis\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 68,\r\n \"title\": \"Tawfeek, Mohammed M.Mahdy (58506347900); Ahmed, Hanan Mohamed Abdel Hamid (58076476500); Bor\u2019i, Ashraf (57056277100); Rady, Ahmed M.Nashaat Ali (58536630100)\",\r\n \"authors\": \"Repeated sessions of PACK-CXL WA for the treatment of resistant bacterial keratitis: a retrospective study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85165639487&doi=10.1186%2Fs12886-023-03080-3&partnerID=40&md5=12c1b2ad54931c7eefc70d7fb290a186\",\r\n \"affiliations\": \"Zagazig University, Zagazig, Egypt; The General Organization for Teaching Hospitals and Institutes, Cairo, Bab El Khalk, Egypt; Zagazig University, Zagazig, Egypt; Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Objective: The aim of this work is to evaluate the safety and efficacy of repeated sessions of photo-activated chromophore for keratitis-cross linking (PACK-CXL) window absorption (WA) for the treatment of resistant bacterial keratitis (BK). Patients and methods: This is a retrospective clinical cohort study. Thirty eyes with clinically suspected and lab-confirmed bacterial keratitis, resistant to appropriate antibiotic therapy- which was modified by sensitivity reports- for 2 weeks with failure of epithelialization for 4 weeks after the standard anti-microbial therapy (SAT) together with one setting of PACK-CXL WA were included. If after the first session of PACK-CXL, there is a start of improvement in the form of reduction of the size of corneal ulcer and stromal infiltrates together with the start of epithelialization on clinical examination and AS-OCT, another session of PACK-CXL WA was performed after one week, and so on, till the complete healing and resolution of bacterial keratitis and confirmation by negative bacterial culture. Identification of the micro-organisms was done by lab study before and after treatment. Corneal healing was evaluated by corneal examination and anterior segment OCT (AS-OCT). Results: Thirty eyes of 30 patients were recruited in this study. They were 16 males and 14 females, their mean age was 44.3 \u00b1 5.38 years. The mean ulcer size was 3.96 \u00b1 1.87 (mm3), while the mean size of stromal infiltrates was 4.52 \u00b1 2.24 (mm3). PACK-CXL WA treatment was performed an average of 2.87 times for the 30 eyes. Complete healing and resolution (Successful treatment) was observed in 27 eyes (90%) of cases and failure of epithelialization was observed only in 3 eyes (10%). Complete corneal healing was reported in the second month postoperatively in 90% of eyes. Conclusion and recommendation: PACK-CXL WA may be a promising, non-invasive treatment option for resistant bacterial keratitis. It may have a synergistic effect with standard antimicrobial treatment (SAT). Also, it can overcome the antibiotics resistance that has become rapidly spreading worldwide. Repeated sessions of PACK-CXL WA may be more effective for the treatment of resistant bacterial keratitis till complete epithelialization and resolution of BK than a single session with few complications. However, further prospective and comparative studies to support the results are needed. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Bacterial keratitis\",\r\n \" Corneal cross linking\",\r\n \" PACK-CXL\",\r\n \" Repeated\",\r\n \" Window absorption\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 69,\r\n \"title\": \"Ali, Ahmed U. (57213590141); Abd-Elkareem, M. (57193520825); Kamel, Amira A. (57208054498); Abou-Khalil, Nasser Sayed (57160296500); Hamad, D. (58253979300); Nasr, Nasr Eldin Hussein (57223125614); Hassan, Maha Abdelazeem (7401625373); El-Faham, Tahani H. (6603115454)\",\r\n \"authors\": \"Impact of porous microsponges in minimizing myotoxic side effects of simvastatin\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85151948834&doi=10.1038%2Fs41598-023-32545-0&partnerID=40&md5=918616d161450de4668a2eb133016d1d\",\r\n \"affiliations\": \"Department of Pharmaceutics, Merit University, Sohag, Egypt; Department of Cell and Tissues, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Asyut, Egypt; Department of Medical Physiology, Faculty of Medicine, Asyut, Egypt; Faculty of Science, Asyut, Egypt; Technical Manager at Al Esraa Pharmaceutical Optima, Badr, Egypt; Faculty of Pharmacy, Asyut, Egypt\",\r\n \"abstract\": \"Simvastatin (SV) is a poorly soluble drug; its oral administration is associated with a significant problem: Myopathy. The present study aims to formulate SV microsponges that have the potential to minimize the myotoxicity accompanying the oral administration of the drug. SV microsponges were prepared by exploiting the emulsion solvent evaporation technique. The % entrapment efficiency (%EE) of the drug approached 82.54 \u00b1 1.27%, the mean particle size of SV microsponges ranged from 53.80 \u00b1 6.35 to 86.03 \u00b1 4.79\u00a0\u00b5m in diameter, and the % cumulative drug release (%CDR) of SV from microsponges was significantly higher than that from free drug dispersion much more, the specific surface area of the optimized microsponges formulation was found to be 16.6 m2\/g revealed the porosity of prepared microsponges. Histological and glycogen histochemical studies in the skeletal muscles of male albino rats revealed that microsponges were safer than free SV in minimizing myotoxicity. These findings were proven by Gene expression of Mitochondrial fusion and fission (Mfn1) & (Fis1) and (Peroxisome proliferator-activated receptor gamma co-activator 1\u03b1) PGC-1\u03b1. Finally, our study ascertained that SV microsponges significantly decreased the myotoxicity of SV. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 70,\r\n \"title\": \"Anwar, Walaa S. (58082428700); Abdel-Maksoud, Fatma M. (56976406600); Sayed, Ahmed M. (57201406179); Abdel-Rahman, Iman A.M. (57217534275); Makboul, Makboul A. (6508060541); Zaher, Ahmed M. (55816802700)\",\r\n \"authors\": \"Correction: Potent hepatoprotective activity of common rattan (Calamus rotang L.) leaf extract and its molecular mechanism (BMC Complementary Medicine and Therapies, (2023), 23, 1, (24), 10.1186\/s12906-023-03853-9)\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85148409806&doi=10.1186%2Fs12906-023-03881-5&partnerID=40&md5=458e4a1bc3246986303ccd25626af2e4\",\r\n \"affiliations\": \"Faculty of Pharmacy, Asyut, Egypt; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Asyut, Egypt; Laboratory of Biochemistry, Faculty of Science, Asyut, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Qena, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Following the publication of the original article [1], it was noted that due to a typesetting error Dr. Walaa S. Anwar and Dr. Makboul A. Makboul were incorrectly affiliated to Merit University. Correct affiliation for Dr. Walaa S. Anwar and Dr. Makboul A. Makboul should be Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, 71515 Assiut, Egypt. The affiliations have been updated above and the original article [1] has been corrected. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 71,\r\n \"title\": \"Anwar, Walaa S. (58082428700); Abdel-Maksoud, Fatma M. (56976406600); Sayed, Ahmed M. (57201406179); Abdel-Rahman, Iman A.M. (57217534275); Makboul, Makboul A. (6508060541); Zaher, Ahmed M. (55816802700)\",\r\n \"authors\": \"Potent hepatoprotective activity of common rattan (Calamus rotang L.) leaf extract and its molecular mechanism\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85146988559&doi=10.1186%2Fs12906-023-03853-9&partnerID=40&md5=677d0e2b27a4ea02f1dca6779efa64e4\",\r\n \"affiliations\": \"Department of Pharmacognosy, Merit University, Sohag, Egypt; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Asyut, Egypt; Laboratory of Biochemistry, Faculty of Science, Asyut, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Qena, Egypt\",\r\n \"abstract\": \"Background: Calamus rotang L. (CR) is an Indian shrub. The leaves and other organs of the plant are traditionally used in India for treatment of various diseases. The in vitro antioxidant property of the leaves extract was previously established. Thus, the current study aimed to evaluate the antioxidant and hepatoprotective effects of CR ethyl acetate extract at a dose of 350\u00a0mg\/kg on CCl<inf>4<\/inf> induced hepatotoxic rats through different mechanisms. Methods: Histopathological examination of the treated rats\u2019 group in comparison with positive and negative controls were performed. Quantitative measuring of the proinflammatory cytokines (TNF \u03b1), inflammatory regulators (Arginase, PPAR \u03b1) and the antiapoptotic protein Bcl-2 in comparison with positive and negative control groups was achieved using immunohistochemical examination. HPLC profiling of the polyphenol contents and molecular docking of the identified compounds against BH3 proapoptotic protein were correspondingly studied to evaluate the potential antiapoptotic property. Results: The CR extract greatly protects the liver tissue through the suppression of TNF \u03b1, arginase and PPAR \u03b1 induced by CCl<inf>4<\/inf> as well as its enhancement of the antiapoptotic Bcl-2 protein. Fourteen polyphenols of different classes were identified in CR extract and tested via molecular docking for their potential antiapoptotic activities against BH3 protein. Naringin, rutin, 7-hydroxy flavone, and ellagic acid compounds exhibit the highest affinity and potential inhibition of pro-apoptotic protein BH3 via molecular docking study. Conclusions: The ethyl acetate fraction of the leaves of C. rotang is rich in polyphenols that exhibited potent hepatoprotective effect on CCl<inf>4<\/inf> induced hepatotoxic rats through its antioxidant, anti-inflammatory, anti-steatosis and antiapoptotic properties. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Apoptosis\",\r\n \" Calamus rotang\",\r\n \" Hepatoprotective\",\r\n \" HPLC\",\r\n \" Metabolite profiling\",\r\n \" Molecular docking\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 72,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Hussain, Abdulzahra Abdulsamad (16417168400); Podda, Mauro Guido (7004555508); Aiolfi, Alberto (6508362055); Kryvoruchko, Igor A. (59374914600); Kalmoush, Abd Elfattah (57727380200); Labib, Mohamed Fathy (57221263028); Mustafa, Fawzy M. (58227729800); Elbelkasi, Hamdi (58744062800); Hamdy, Ahmed Farouk Aziz (7005577041); Abo Alsaad, Mohamed Ibrahim (58743979200); Sallam, Ahmed M. (57203144124); Zaitoun, Mohamed Abdallah (57223230279); Negm, Mohamed Ibrahim (55903490500); Mostafa, Abdelshafy (58744089300); Yassin, Mahmoud Abdou (57217355675); Elshahidy, Tamer Mohamed Mahmoud (57219158772); Elsayed, Ashraf Abdel Monem (57349226400); Mansour, Mohamed Ibrahim (57219159269); Elaidy, Mostafa M. (57211668955); Moursi, Adel Mahmoud (57223158475); Yehia, Ahmed Mohamed (57210598249); Ashour, Hassan Rabea Galal (57203575895); Metwalli, Abd Elrahman M. (57219157262); Abdelhady, Waleed Ahmed (57223158353); Abdelghani, Amr A. (57913319900); AbdAllah, Ehab Shehata (59693590100); Ramadan, Alaaedin (57924392600); Rushdy, Tamer (57211491570)\",\r\n \"authors\": \"Intraoperative endomanometric laparoscopic Nissen fundoplication improves postoperative outcomes in large sliding hiatus hernias with severe gastroesophageal reflux disease: a retrospective cohort study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85178544499&doi=10.1097%2FJS9.0000000000000659&partnerID=40&md5=6481e516010ce4198fdfbfd6d6625cb2\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; General Surgery Department, Merit University, Sohag, Egypt; General Surgery Department, Al-Azher University, Damietta, Egypt; General Surgery Department, Mataryia Teaching Hospital, Egypt; National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; Department of Surgical Sciences, Universit\u00e0 degli Studi di Cagliari, Cagliari, Italy; Department of Biomedical Science for Health, Universit\u00e0 degli Studi di Milano, Milan, Italy; Department of Surgery, Kharkiv National Medical University, Kharkiv, Ukraine; Department of General Surgery, Homerton University Hospital NHS Foundation Trust, London, United Kingdom\",\r\n \"abstract\": \"Background: Laparoscopic Nissen fundoplication (LNF) is the gold standard surgical intervention for gastroesophageal reflux disease (GERD). LNF can be followed by recurrent symptoms or complications affecting patient satisfaction. The aim of this study is to assess the value of the intraoperative endomanometric evaluation of esophagogastric competence and pressure combined with LNF in patients with large sliding hiatus hernia (> 5 cm) with severe GERD (DeMeester score > 100). Materials and methods: This is a retrospective, multicenter cohort study. Baseline characteristics, postoperative dysphagia and gas bloat syndrome, recurrent symptoms, and satisfaction were collected from a prospectively maintained database. Outcomes analyzed included recurrent reflux symptoms, postoperative side effects, and satisfaction with surgery. Results: Three hundred sixty patients were stratified into endomanometric LNF (180 patients, LNF +) and LNF alone (180 patients, LNF). Recurrent heartburn (3.9 vs. 8.3%) and recurrent regurgitation (2.2 vs. 5%) showed a lower incidence in the LNF + group (P = 0.012). Postoperative score III recurrent heartburn and score III regurgitations occurred in 0 vs. 3.3% and 0 vs. 2.8% cases in the LNF + and LNF groups, respectively (P = 0.005). Postoperative persistent dysphagia and gas bloat syndrome occurred in 1.75 vs. 5.6% and 0 vs. 3.9% of patients (P = 0.001). Score III postoperative persistent dysphagia was 0 vs. 2.8% in the two groups (P = 0.007). There was no redo surgery for dysphagia after LNF + . Patient satisfaction at the end of the study was 93.3 vs. 86.7% in both cohorts, respectively (P = 0.05). Conclusions: Intraoperative high-resolution manometry and endoscopic were feasible in all patients, and the outcomes were favorable from an effectiveness and safety standpoint. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"anti-reflux surgery\",\r\n \" fundoplication\",\r\n \" gastroesophageal reflux disease\",\r\n \" high-resolution manometry\",\r\n \" lower esophageal sphincter\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 73,\r\n \"title\": \"Hamad, Ahmed Abdulhafez (57193447791); Mohammed, Bassam Shaaban (57211554238); Hassan, Yasser F. (57212006840); Batubara, Afnan S. (57239981200); Haredy, Ahmed M. (56895997900)\",\r\n \"authors\": \"Facile decoration of one-pot fluorescence probe-patterned reaction for sensing and ultrasensitive determination of tradjenta, a new type 2 diabetes oral therapy\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85158141319&doi=10.1016%2Fj.saa.2023.122808&partnerID=40&md5=272157593bdbd4387c4fc5c86cb82dab\",\r\n \"affiliations\": \"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo, Egypt; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Shibin El Kom, Egypt; Department of Pharmaceutical Chemistry, Umm Al-Qura University, Makkah, Saudi Arabia; Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Type 2 diabetes can be cured by using tradjenta (also known as Linagliptin), a new therapeutic drug that is an inhibitor of the dipeptidyl peptidase-4 enzyme. Tradjenta is administered orally alone or in combination with metiguanide or empagliflozin. An easy and specific fluorimetric analysis of Tradjenta was developed and demonstrated in the present investigation. The Hantzsch reaction method, which generates a fluorescent dihydropyridine derivative, is the basis of this assay. In a Toerell-Stenhagen buffered solution, the unsubstituted amine group of Tradjenta interacted with 2,4-Pentadione\/Oxomethane. Spectrofluorimetry was utilized for this investigation at an excitation\/emission wavelength of 421\/480 nm. When comparing the Tradjenta concentration to the tracked fluorimetric signal, the method revealed linearity over the concentration range of 0.05 to 1.2 \u00b5g\/mL. By strictly altering system parameters and analyzing the validation factors following International Council for Harmonisation (ICH) requirements, the outcomes were achieved. Finally, the proposed approach was successfully applied to assay the drug not only in its raw form and prescribed formulations but also to evaluate the tablet's uniformity of content. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Dosage form\",\r\n \" Fluorimetric assay\",\r\n \" Hantzsch derivatization reaction\",\r\n \" Method greenness evaluation\",\r\n \" Tradjenta\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 74,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Aldosari, Basmah N. (35081654900); Zaki, Randa Mohammed (54792413400); Afzal, Obaid (53870994800); Tulbah, Alaa S. (56182231200); Shahataa, Mary Girgis (57190442518); Abo El-Ela, Fatma I. (56461520900); Salem, Heba Farouk (16426683200); Gamal, Amr Gamal (57204454409)\",\r\n \"authors\": \"Formulation and Therapeutic Evaluation of Isoxsuprine-Loaded Nanoparticles against Diabetes-Associated Stroke\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85172484963&doi=10.3390%2Fpharmaceutics15092242&partnerID=40&md5=f40a351c739cc14faeddc8941a8b8e4c\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, College of Pharmacy, Riyadh, Saudi Arabia; Department of Pharmaceutics, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutical Chemistry, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Pharmaceutics, Umm Al-Qura University, Makkah, Saudi Arabia; Department of Pharmacology, Faculty of Medicine, Beni Suef, Egypt; Department of Pharmacology, Faculty of Veterinary Medicine, Beni Suef, Egypt; Faculty of Pharmacy, Beni Suef, Egypt\",\r\n \"abstract\": \"Ischemic stroke is the second-leading cause of death. Hyperglycemia, which is characteristic of diabetes mellitus, contributes to the development of endothelial dysfunction and increases the risk of stroke. Isoxsuprine is an efficient beta-adrenergic agonist that improves blood flow to the ischemic aria and stops the infarct core from growing. However, low bioavailability, a short biological half-life, and first-pass hepatic metabolism reduce the therapeutic efficacy of oral isoxsuprine. Therefore, the authors focused on developing isoxsuprine-loaded liposomes containing ethanol and propylene glycol (ILEP) formulation as nasal drops for the treatment of ischemic stroke in diabetic patients. Different ILEP formulations were optimized using Design Expert software, and the selected formulation was examined in vivo for its anti-stroke effect using a rat model of diabetes and stroke. The optimized ILEP, composed of 15% propylene glycol, 0.16% cholesterol, 10% ethanol, and 3.29% phospholipid, improved the sustainability, permeation, and targeting of isoxsuprine. Furthermore, the in vivo studies verified the improved neurological behavior and decreased dead shrunken neurons and vascular congestion of the rats treated with the optimized ILEP formulation, demonstrating its anti-stroke activity. In conclusion, our study found that treatment with an optimized ILEP formulation prevented the initiation and severity of stroke, especially in diabetic patients. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"diabetes mellitus\",\r\n \" isoxsuprine\",\r\n \" liposomes\",\r\n \" propylene glycol\",\r\n \" stroke\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 75,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Fathalla, Zeinab M.A. (57188965212); Naguib, Demiana M. (57193580045); Alfatease, Adel M. (57193644396); Abdelkader, Hamdy (20336654000)\",\r\n \"authors\": \"Chitosan\/Solid-Lipid Nanoparticles Hybrid Gels for Vaginal Delivery of Estradiol for Management of Vaginal Menopausal Symptoms\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85172452190&doi=10.3390%2Fph16091284&partnerID=40&md5=91408e0358c34a1a6f36c364c09cea1b\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia\",\r\n \"abstract\": \"Hormonal replacement therapy is the mainstay treatment to improve quality of life and reduce mortality. With the increasing number of young women with early menopause, women now live longer (increased life expectancy). However, poor patient compliance with oral estrogen therapy has emerged. Intravaginal estrogen therapy can provide significant benefits with minimal risk for postmenopausal women with symptoms of the lower urinary tract and vaginal area but who do not want to take oral estrogen. In this study, estradiol-loaded solid lipid nanoparticles (SLPs) were prepared from compritol ATO 888 and precirol ATO 5, and two different stabilizers (Pluronic F127 and Tween 80) were studied. Selected SLPs (F3 and F6) were coated with different concentrations of the mucoadhesive and sustained-release polymer chitosan. Furthermore, gelation time, viscosity, mucoadhesion, ex vivo permeation, and in vitro irritation for vaginal irritation were studied. Particle sizes ranged between 450\u2013850 nm, and EE% recorded 50\u201383% for the six SLPs depending on the type and amount of lipids used. Cumulative % drug release was significantly enhanced and was recorded at 51% to 83%, compared to that (less than 20%) for the control suspension of estradiol. Furthermore, extensive thermal gelation and mucoadhesion were recorded for chitosan-coated SLPs. Up to 2.2-fold increases in the permeation parameters for SLPs gels compared to the control suspension gel were recorded, revealing a slight to moderate irritation on Hela cell lines. These findings demonstrated chitosan-coated estradiol SLPs as novel and promising vaginal mucoadhesive hybrid nanogels. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"estradiol\",\r\n \" irritation\",\r\n \" menopause\",\r\n \" permeability\",\r\n \" vaginal deliver\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 76,\r\n \"title\": \"Abdelkader, Hamdy (20336654000); Abdel-Aleem, Jelan A. (55390544500); Mousa, Heba Salah (36495289200); Elgendy, Marwa O. (56926529900); Alfatease, Adel M. (57193644396); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Captopril Polyvinyl Alcohol\/Sodium Alginate\/Gelatin-Based Oral Dispersible Films (ODFs) with Modified Release and Advanced Oral Bioavailability for the Treatment of Pediatric Hypertension\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85172229896&doi=10.3390%2Fph16091323&partnerID=40&md5=4a9bbb6fd6ceae004dbb5de35ed0694d\",\r\n \"affiliations\": \"Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia; Department of Industrial Pharmacy, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Qena, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Clinical Pharmacy, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Hypertension can begin in childhood; elevated blood pressure in children is known as pediatric hypertension. Contrary to adult hypertension, there is a scarcity of commercial medications suitable for the treatment of pediatric hypertension. The aim of this study was to develop orally dispersible films (ODFs) loaded with captopril for the treatment of hypertension in children. Captopril-loaded ODFs were composed of different blends of synthetic polymers, such as polyvinyl alcohol (PVA) and polyvinyl pyrrolidone, and natural polymers, such as sodium alginate (SA) and gelatin. The ODFs were characterized based on their mechanical and thermal properties, drug content, surface morphology, in vitro disintegration, in vitro release, and bioavailability. A novel HPLC method with precolumn derivatization was developed to precisely and selectively determine captopril levels in plasma. A low concentration of PVA and a high concentration of SA generated ODFs with faster hydration and disintegration rates. SA-based films exhibited fast disintegration properties (1\u20132 min). The optimized modified-release film (F2) showed significant (p < 0.05) enhancement in bioavailability (AUC = 1000 ng min\/mL), with a value 1.43 times that of Capoten\u00ae tablets (701 ng min\/mL). While the plasma concentration peaking was in favor of the immediate-release tablet, T<inf>max<\/inf> was significantly prolonged by 5.4 times for the optimized ODF (3.59 h) compared with that of the tablets (0.66 h). These findings indicate uniform and sustained plasma concentrations, as opposed to the pulsatile and rapid plasma peaking of captopril from the immediate-release tablets. These findings suggest that the modified release of oral films could offer more favorable plasma profiles and better control of hypertension than the conventional release tablets. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"captopril\",\r\n \" hypertension\",\r\n \" oral films\",\r\n \" oral mucosa\",\r\n \" pediatric\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 77,\r\n \"title\": \"El Gazzar, Walaa Bayoumie (57194634097); Sliem, Rania E. (58250376200); Bayoumi, Heba (57219487533); Nasr, Hend Elsayed (57270493600); Shabanah, Manar (58208705100); Elalfy, Amira Kamal El Din Mohammed (57271026700); Radwaan, Shaimaa E. (58249675400); Gebba, Mohammed A. (58242198500); Mansour, Heba Mahmoud (58459297600); Badr, Amul M. (57205124942); Amer, Marwa Fathy (57202005616); Ashour, Sara Salama (57417715200); Morsi, Heba Mohamed Abdelhafiz (55273576200); Aboelkomsan, Elshaimaa Ahmed Fahmy (58567581300); Baioumy, Bodour (57271026800); Sayed, Alaa El Din H. (59100118600); Farag, Amina Ali (57316248600)\",\r\n \"authors\": \"Melatonin Alleviates Intestinal Barrier Damaging Effects Induced by Polyethylene Microplastics in Albino Rats\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85170241988&doi=10.3390%2Fijms241713619&partnerID=40&md5=fdcf4f10a9262ee8d52b891038c7a207\",\r\n \"affiliations\": \"Department of Anatomy, Hashemite University, Zarqa, Jordan; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Benha, Egypt; Faculty of Science, Benha, Egypt; Department of Histology and Cell Biology, Faculty of Medicine, Benha, Egypt; Faculty of Medicine, Mansoura, Egypt; Faculty of Veterinary Medicine Benha University, Toukh, Egypt; Department of Anatomy and Embryology, Merit University, Sohag, Egypt; Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences and Drug Manufacturing, 6th October, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Cairo, Egypt; Department of Pathology, New Giza University, Giza, Egypt; Faculty of Science, Asyut, Egypt; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha, Egypt\",\r\n \"abstract\": \"There have been concerns about the potential health risks posed by microplastics (MP). The detection of MP in a variety of food products revealed that humans are ingesting MP. Nevertheless, there is a paucity of data about their impacts, as well as their uptake, on intestinal barrier integrity. This study examined the toxic effects of oral administration of two doses of polyethylene microplastics (PE-MP) (3.75 or 15 mg\/kg\/day for 5 weeks; mean particle size: 4.0\u20136.0 \u00b5m) on the intestinal barrier integrity in rats. Moreover, the effect of melatonin treatment with MP exposure was also assessed. The PE-MP particle uptake, histopathological changes, Alcian blue staining, Muc2 mRNA, proinflammatory cytokines (IL-1\u03b2 and TNF-\u03b1), and cleaved caspase-3, as well as tight junction proteins (claudin-1, myosin light-chain kinase (MLCK), occludin, and zonula occludens-1 (ZO-1)) were assessed. Oral administration of PE-MP resulted in apparent jejunal histopathological alterations; significantly decreased mucin secretion, occludin, ZO-1, and claudin-1 expression; and significantly upregulated MLCK mRNA, IL-1\u03b2 concentration, and cleaved caspase-3 expression. Melatonin reversed these altered parameters and improved the PE-MP-induced histopathological and ultrastructure changes. This study highlighted the PE-MP\u2019s toxic effect on intestinal barrier integrity and revealed the protective effect of melatonin. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"intestinal barrier\",\r\n \" melatonin\",\r\n \" polyethylene microplastics\",\r\n \" proinflammatory cytokines\",\r\n \" tight junction proteins\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 78,\r\n \"title\": \"Abd El-Emam, Mahran Mohamed (57435232000); Mostafa, Mahmoud E. (57619859800); Farag, Amina Ali (57316248600); Youssef, Heba S. (58227767200); El-Demerdash, Azza Salah Eldin (57190969352); Bayoumi, Heba (57219487533); Gebba, Mohammed A. (58242198500); El-Halawani, Sawsan M. (56106760100); Saleh, Abdulrahman M. (57222647990); Badr, Amira M. (57208267192); El Sayed, Shorouk (57200595854)\",\r\n \"authors\": \"The Potential Effects of Quercetin-Loaded Nanoliposomes on Amoxicillin\/Clavulanate-Induced Hepatic Damage: Targeting the SIRT1\/Nrf2\/NF-\u03baB Signaling Pathway and Microbiota Modulation\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85169148621&doi=10.3390%2Fantiox12081487&partnerID=40&md5=7a8824802d4ba792e2724d082015701c\",\r\n \"affiliations\": \"Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Zagazig, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha, Egypt; Department of Physiology, Faculty of Medicine, Benha, Egypt; Department of Microbiology, Animal Health Research Institute, Giza, Egypt; Department of Histology and Cell Biology, Faculty of Medicine, Benha, Egypt; Faculty of Veterinary Medicine Benha University, Toukh, Egypt; Department of Anatomy and Embryology, Merit University, Sohag, Egypt; Department of Biotechnology, Mansoura University, Urology and Nephrology Center, Mansoura, Egypt; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Faculty of Pharmacy, College of Pharmacy, Riyadh, Saudi Arabia; Department of Microbiology, Faculty of Veterinary Medicine, Zagazig, Egypt\",\r\n \"abstract\": \"Amoxicillin\/clavulanate (Co-Amox), a commonly used antibiotic for the treatment of bacterial infections, has been associated with drug-induced liver damage. Quercetin (QR), a naturally occurring flavonoid with pleiotropic biological activities, has poor water solubility and low bioavailability. The objective of this work was to produce a more bioavailable formulation of QR (liposomes) and to determine the effect of its intraperitoneal pretreatment on the amelioration of Co-Amox-induced liver damage in male rats. Four groups of rats were defined: control, QR liposomes (QR-lipo), Co-Amox, and Co-Amox and QR-lipo. Liver injury severity in rats was evaluated for all groups through measurement of serum liver enzymes, liver antioxidant status, proinflammatory mediators, and microbiota modulation. The results revealed that QR-lipo reduced the severity of Co-Amox-induced hepatic damage in rats, as indicated by a reduction in serum liver enzymes and total liver antioxidant capacity. In addition, QR-lipo upregulated antioxidant transcription factors SIRT1 and Nrf2 and downregulated liver proinflammatory signatures, including IL-6, IL-1\u03b2, TNF-\u03b1, NF-\u03baB, and iNOS, with upregulation in the anti-inflammatory one, IL10. QR-lipo also prevented Co-Amox-induced gut dysbiosis by favoring the colonization of Lactobacillus, Bifidobacterium, and Bacteroides over Clostridium and Enterobacteriaceae. These results suggested that QR-lipo ameliorates Co-Amox-induced liver damage by targeting SIRT1\/Nrf2\/NF-\u03baB and modulating the microbiota. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Co-Amox-induced hepatotoxicity\",\r\n \" gut dysbiosis\",\r\n \" quercetin antioxidant activity\",\r\n \" quercetin liposomes\",\r\n \" SIRT1, Nrf2 and NF-\u03baB targeting\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 79,\r\n \"title\": \"Hamad, Ahmed Abdulhafez (57193447791); Haredy, Ahmed M. (56895997900)\",\r\n \"authors\": \"Designing a unique molecular size-dependent approach for determining levamisole via synergizing Rayleigh Scattering response of Cilefa Pink B dye; application to bulk, dosage forms, and biofluids; method greenness evaluation\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85149708638&doi=10.1016%2Fj.talo.2023.100196&partnerID=40&md5=f40329077ba274da24704607dfda8ad8\",\r\n \"affiliations\": \"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo, Egypt; Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Levamisole is an anti-helminthic agent employed medically to treat worm-causative disease, also used as an immune system modifying agent in rheumatic arthritis and as assistant therapy for treating the cancers of the head, colorectal, and neck regions. The first innovative size-dependent approach for levamisole drug analysis is described in this study. It is both efficient and environmentally benign. The drug was evaluated and validated using a green, one-pot, and direct size-dependent technique in this approach. An instant complex was created by combining levamisole and Cilefa Pink B in a mildly acidic medium. The fluorimetric investigation was based on the augmentation effect of levamisole on the Rayleigh scattering response amplitude of a biological dye (Cilefa Pink B) at 424 nm. which was related to produced complex's molecular size. Linearity ranged from 0.08 to 2.0 \u00b5g mL\u22121, with sensitivity limits of 0.023 and 0.069 \u00b5g mL\u22121, respectively. Analytical modulation of Levamisole-Cilefa Pink B complexes was done for all system parameters. In addition, the system was found to meet ICH criteria. Moreover, this technique successfully recovered the substance in the prescribed medicinal dosage forms. The created fluorimetric technique was also successfully employed to track the drug of interest in human biofluids, which was a significant accomplishment. Finally, an eco-scale was applied to recognize the designed method's environmental friendliness. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Biofluids\",\r\n \" Cilefa pink B\",\r\n \" Eco-rating\",\r\n \" Levamisole\",\r\n \" Resonance Rayleigh Scattering\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 80,\r\n \"title\": \"Alwafi, Hanadi Abdullah (57218902404); Ali, Soad Shaker (35783844900); Kotha, Sunil Babu (57189875766); Abuljadayel, Layla Waleed (56495355300); Ibrahim, Maha (57846148000); Elahi, Ibrahim Rashad Noor (57845485300); Alwafi, Hebah Abdullah (56613610900); Finkelman, Matthew David (24558635500); El-Shitany, Nagla Abd Aziz (24179446000)\",\r\n \"authors\": \"Imbalanced salivary electrolytes, COVID-19 severity, and dysgeusia\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85164596577&doi=10.22514%2Fsv.2023.005&partnerID=40&md5=79fcb076909caa317f49d2f6b3d6e3ac\",\r\n \"affiliations\": \"Department of Preventive Dentistry, Riyadh Elm University, Riyadh, Saudi Arabia; Department of Histology and Cell Biology, Faculty of Medicine, Asyut, Egypt; Department of Histology, Merit University, Sohag, Egypt; Department of Pediatric and Preventive Dentistry, Datta Meghe Institute of Higher Education & Research (Deemed to be University), Wardha, India; Department of Dental Public Health, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Hematology, MSF for Medical Research and Development, Jeddah, Saudi Arabia; Consultant of Preventive Medicine and Public Health, Directorate of Health Affairs for Public Health Division, Jeddah, Saudi Arabia; General surgery resident, Security Forces Hospital, Dammam, Saudi Arabia; Department of Public Health and Community Service, Tufts University School of Dental Medicine, Boston, United States; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta, Egypt; Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia\",\r\n \"abstract\": \"Early studies of patients who progressed to severe coronavirus disease 2019 (COVID-19) reported various serum electrolyte disturbances. Hyposalivation and dysgeusia are two of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection oral symptoms. This study investigated how SARS-CoV-2 infection affects saliva volume, pH, zinc, and inorganic components (sodium, potassium, calcium). The association between these salivary properties and dysgeusia was also investigated in patients with mild and severe COVID-19. Saliva volume, pH, zinc, sodium, potassium, and calcium were measured in 142 healthy persons (control) and 158 COVID-19 patients (72 mild and 86 severe). This study showed that saliva volume, pH, zinc, sodium, potassium, and calcium levels reduced dramatically during COVID-19. Likewise, these saliva characteristics were significantly lower in severe COVID-19 individuals than in mild COVID-19 cases. In addition, there was no correlation between dysgeusia and salivary composition, volume, or pH. All salivary indicators were reduced in the COVID-19 group reporting the loss of taste and smell and the group who perceived neither. These data suggested that COVID-19 is associated with many salivary abnormalities, including hyposalivation, decreased pH, and electrolyte imbalances. These were more pronounced in severe COVID-19 cases. According to the current study, saliva characteristics could be utilized for early diagnosis, quarantine, and therapy in COVID-19 patients. As a result, the virus transmission can be stopped, and the optimum therapeutic results might be obtained. COVID-19-associated dysgeusia was unrelated to the reduction of these changes. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"COVID-19\",\r\n \" Dysgeusia\",\r\n \" Electrolytes\",\r\n \" pH\",\r\n \" Saliva\",\r\n \" Severity\",\r\n \" Volume\",\r\n \" Zinc\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 81,\r\n \"title\": \"Tawfeek, Mohammed M.Mahdy (58506347900); Ahmed, Hanan Mohamed Abdel Hamid (58076476500); Bor\u2019i, Ashraf (57056277100); Rady, Ahmed M.Nashaat Ali (58536630100)\",\r\n \"authors\": \"SMILE lenticule versus amniotic membrane graft (AMG) augmented with platelet-rich plasma (PRP) for the treatment of perforated corneal ulcer\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85146743649&doi=10.1007%2Fs10792-023-02631-3&partnerID=40&md5=8511b357762d9f1016360022a53fdf1f\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; The General Organization for Teaching Hospitals and Institutes, Cairo, Bab El Khalk, Egypt; Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Purpose: To evaluate the safety and efficacy of stromal lenticule obtained from small-incision lenticule extraction (SMILE) surgery versus amniotic membrane graft (AMG) augmented with platelet-rich plasma (PRP) for the treatment of perforated corneal ulcers and compare the results between the two groups. Patients and methods: This is a comparative retrospective study that included 40 eyes with medium-sized corneal perforations, which were classified into two equal groups of 20 eyes each; group (A) was treated with SMILE lenticule graft and group (B) was treated with AMG augmented with PRP. Pre- and postoperative evaluations were carried out using both slit-lamp (SL) examination and anterior segment optical coherence tomography (AS-OCT), including closure of perforation, complete healing, and best corrected visual acuity (BCVA). Results: Complete closure of the perforation was achieved in both groups. However, healing was faster in the SMILE lenticule group than in the AMG with PRP group (P < 0.05). Complete healing was achieved in\u00a0both groups: 100% in SMILE lenticule group and 95% in AMG with PRP group (P > 0.05). Both groups had few insignificant complications (30% in each), which were managed. Conclusion: Both methods achieved adequate healing of corneal perforations within few weeks without significant complications. However, the stromal lenticule obtained from small-incision lenticule extraction (SMILE) surgery tended to be safer with faster healing than AMG with PRP. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"AMG\",\r\n \" Perforated corneal ulcer\",\r\n \" PRP\",\r\n \" Stromal lenticule obtained from small-incision lenticule extraction (SMILE) surgery\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 82,\r\n \"title\": \"El-Hefnawy, Sally Mohammed (57184192200); El-Naidany, Sherin Sobhy (56353251000); Alhanafy, Alshimaa Mahmoud (57039017800); Badr, Nehad (57751681100); Ellaithy, Manal Abd El Monem (57225945510)\",\r\n \"authors\": \"Prognostic impact of serum vascular endothelial growth factor and VEGF gene polymorphism (rs2010963) in breast cancer patients\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85151439426&doi=10.1016%2Fj.humgen.2023.201168&partnerID=40&md5=068b2b239c13be9a8984e8927f2f03a1\",\r\n \"affiliations\": \"Medical Biochemistry and Molecular Biology Department, Menoufia University Faculty of Medicine, Shibin El Kom, Egypt; Department of Clinical Oncology and Nuclear Medicine, Menoufia University Faculty of Medicine, Shibin El Kom, Egypt; Public Health and Community Medicine Department, Menoufia University Faculty of Medicine, Shibin El Kom, Egypt; Medical Biochemistry & Molecular Biology Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Back ground: Vascular Endothelial Growth Factor (VEGF) mediates breast carcinogenesis. Several studies shown that, VEGF is associated with increased breast cancer risk. However its prognostic significance and expression in different molecular subtypes remain unclear. The current study aimed to evaluate the diagnostic and prognostic role of serum VEGF and VEGF rs2010963 polymorphism in Egyptian women with breast cancer. Aim: The current study aimed to evaluate the diagnostic and prognostic role of serum VEGF and VEGF rs2010963 polymorphism in Egyptian women with breast cancer. Subjects and methods: This study was held in Menoufia University Hospital and included 275 participants, 150 women with invasive breast cancer and 125 women as healthy controls. Serum VEGF was assayed by ELISA technique and genotyping of VEGF rs2010963 polymorphism was analyzed by real time PCR. Results: The frequency of GG, CG genotypes and G allele were higher in breast cancer group when compared to the control group (p value = 0.001). In breast cancer patients there was significant relation between VEGF gene (C\/G) polymorphism and patient age, tumor and nodal stage, molecular subtype and higher level of serum of CA15\u20133, CEA and VEGF for patients with GG genotype (P \u2264 0.05). Multivariate Cox regression analysis of factors affecting survival showed that advanced tumor stage, presence of metastasis, serum level of VEGF and GG rs 2010963VEGF gene polymorphism were independent factors affecting patient survival (P \u2264 0.05). Conclusion: rs2010963 VEGF gene polymorphism and serum VEGF could be considered as potential risk factors for breast cancer, Patients with breast cancer presenting the GG genotype have the highest serum VEGF levels, large tumor size, advanced tumor stage and shorter survival than CC carriers. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Breast cancer\",\r\n \" Genotype\",\r\n \" PCR\",\r\n \" Prognostic gene\",\r\n \" VEGF\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 83,\r\n \"title\": \"Aboelkhair, Noran Talaat (57218158329); Mashal, Samya S. (58142476600); El-Hefnawy, Sally Mohammed (57184192200); Alhanafy, Alshimaa Mahmoud (57039017800); Khodeer, Seham Ahmed (54583660200); Montaser, Belal Abdelmohsen M. (57192925452)\",\r\n \"authors\": \"The role of long non-coding RNA UCA1 and MALAT1 in bladder cancer patients\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85150016528&doi=10.1016%2Fj.humgen.2023.201164&partnerID=40&md5=8c47510cf884724729dabd126a2f9058\",\r\n \"affiliations\": \"Menoufia University Faculty of Medicine, Shibin El Kom, Egypt; Department of Biochemistry and Molecular Biology, Menoufia University, Shibin El Kom, Egypt; Medical Biochemistry and Molecular Biology Department, Merit University, Sohag, Egypt; Department of Clinical Oncology and Nuclear Medicine, Menoufia University Faculty of Medicine, Shibin El Kom, Egypt\",\r\n \"abstract\": \"Background: Bladder cancer (BC) is considered the most prevalent tumor of the urinary tract, and incidence rates are rising globally. Long noncoding RNAs (lncRNAs) can serve as biomarkers to help the diagnosis and anticipation of recurrence in cancer patients as they are implicated in carcinogenesis and tumor progression. This study targeted to investigate the expression of lncRNA as urothelial cancer associated 1 (UCA1) as well as metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the diagnosis of BC. Subjects and methods: The study included 70 BC patients, 70 benign urinary tract diseases and 70 controls. The UCA1 and MALAT1 expressions were studied utilizing quantitative real-time polymerase chain reaction. Results: The UCA1 and MALAT1 expression were significantly increased in patients with BC than patients with chronic cystitis and controls (p < 0.001). The sensitivity and specificity for the diagnosis of BC for UCA1(87.14%, 97.14% respectively) and MALAT1 (92.86%, 90% respectively). Multivariate logistic regression analysis showed that UCA1 and MALAT1 were risk factors for the development of BC where the odds ratio (OR) for UCA1 was 1.262 (CI 1.004\u20131.587) and MALAT1 was 2.201(CI 1.036\u20134.676). Conclusion: UCA1 and MALAT1 could be potential diagnostic biomarkers with good specificity and sensitivity in bladder cancer. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Bladder cancer\",\r\n \" Long non-coding RNAs\",\r\n \" MALAT1\",\r\n \" UCA1\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 84,\r\n \"title\": \"Ali, Ahmed U. (57213590141); Khallaf, Iman S.A. (57213352391); Kamel, Amira A. (57208054498); Badran, Aya Y. (57209326769); Gomaa, Ahmed Shawky (57211605576); El-Faham, Tahani H. (6603115454); Mortagi, Yasmin Ismail M. (55753556700)\",\r\n \"authors\": \"Corrigendum to \u201cImpact of quercetin spanlastics on livin and caspase-9 expression in the treatment of psoriasis vulgaris\u201d [J. Drug Deliv. Sci. Technol. 76(2022) 103809] (Journal of Drug Delivery Science and Technology (2022) 76, (S1773224722007201), (10.1016\/j.jddst.2022.103809))\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85150049707&doi=10.1016%2Fj.jddst.2023.104314&partnerID=40&md5=48f77b52606ee13eb1467a24ce05a58e\",\r\n \"affiliations\": \"Department of Pharmaceutics, Merit University, Sohag, Egypt; Pharmacognosy and Natural Products Department, Faculty of Pharmacy, Shibin El Kom, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Asyut, Egypt; Department of Dermatology, Faculty of Medicine, Asyut, Egypt; Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutics, Sinai University, El-Arish, Egypt\",\r\n \"abstract\": \"The authors regret that the affiliation of the authors Aya Y. Badran and Ahmed S. Gomaa was incomplete. The correct affiliation is as follows: dDepartment of Dermatology, Venereology, Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt. The authors would like to apologise for any inconvenience caused. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 85,\r\n \"title\": \"Mansoury, Manal M.S. (57215721450); Almukadi, Haifa S. (57220247407); Turkistani, Arwa Mohammed Shukri (57901832200); Khattab, Hala A.H. (55892011600); Ali, Soad Shaker (35783844900); Hassanein, Emad H.M. (57201654198); Alahmadi, Bassam Abdulaziz (57188537067); Al-Jaouni, Soad K. (6508203673); El-Shitany, Nagla Abd Aziz (24179446000)\",\r\n \"authors\": \"Apocynin attenuates methotrexate-induced mucositis by regulating NF-\u03baB, PPAR-\u03b3 and Bax\/Bcl-2\/Puma signals\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85161260342&doi=10.36721%2FPJPS.2023.36.2.REG.457-466.1&partnerID=40&md5=cf048486d8aae9ed35adab776cfa05fc\",\r\n \"affiliations\": \"Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; Faculty of Home Economics, Helwan, Egypt; Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Histology, Merit University, Sohag, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo, Egypt; Department of Biology, Taibah University, Medina, Saudi Arabia; Department of Pediatric Hematology-Oncology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta, Egypt\",\r\n \"abstract\": \"Oxidative stress, inflammation, and apoptosis are the primary inducers of Methotrexate (MTX)-induced mucositis. This research aimed to determine whether apocynin (APO) could protect against MTX-induced mucositis. The antioxidants, anti-inflammatory, and anti-apoptotic actions of APO in this model will be evaluated. The experiment was performed on 32 rats. A single dose (20 mg\/kg) of MTX was injected i.p. to induce intestinal mucositis. APO was given orally once per day at a dose of 100mg\/kg (five days prior to and five days following an MTX injection). APO safeguarded the histological structure of the duodenal mucosa, as observed by the conserved histology of goblet cells (villi and crypts). APO mitigated oxidative stress by reducing intestin MDA and raising GSH, SOD and GST, also suppressing NF-\u03baB mRNA expression. Intestinal content of proinflammatory cytokines was reduced in APO-treated MTX rats, with downregulation of proinflammatory iNOS and upregulation of anti-inflammatory PPAR-\u03b3 proteins. The intestinal mucosa of rats treated with APO and MTX displayed weekly positive immune staining for cleaved caspase-3. APO upregulate the anti-apoptotic Bcl2 mRNA and down regulate the proapoptotic Bax and Puma mRNA in the duodenal mucosa. The results indicate the possibility of using APO as a novel therapeutic agent to prevent MTX-induced mucositis. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"apocynin\",\r\n \" apoptosis\",\r\n \" Methotrexate\",\r\n \" NF-\u03baB\",\r\n \" PPAR-\u03b3\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 86,\r\n \"title\": \"El-Hawary, Seham Salah Dine (6505933617); Hassan, Marwa H.A. (56468563000); Hudhud, Ahmed O. (58122425100); Abdelmohsen, Usama Ramadan (36056037900); Mohammed, Rabab (54963341500)\",\r\n \"authors\": \"Elicitation for activation of the actinomycete genome's cryptic secondary metabolite gene clusters\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85149138552&doi=10.1039%2Fd2ra08222e&partnerID=40&md5=d3b17befb93d035b8e13e3fdd02abbe5\",\r\n \"affiliations\": \"Faculty of Pharmacy, Cairo, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Minya, Egypt; Department of Pharmacognosy, Deraya University, New Minia, Egypt\",\r\n \"abstract\": \"This review summarizes the recent advances in the elicitation approaches used to activate the actinomycete genome's cryptic secondary metabolite gene clusters and shows the diversity of natural products obtained by various elicitation methods up to June 2022, such as co-cultivation of actinomycetes with actinomycetes, other non-actinomycete bacteria, fungi, cell-derived components, and\/or algae. Chemical elicitation and molecular elicitation as transcription factor decoys, engineering regulatory genes, the promoter replacement strategy, global regulatory genes, and reporter-guided mutant selection were also reported. For researchers interested in this field, this review serves as a valuable resource for the latest studies and references. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 87,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Shoman, Mai E. (24559439600); Makram, Tarek Saad (6506095690); Abdel-Aleem, Jelan A. (55390544500); Abdelkader, Hamdy (20336654000)\",\r\n \"authors\": \"Exploration of the Safety and Solubilization, Dissolution, Analgesic Effects of Common Basic Excipients on the NSAID Drug Ketoprofen\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85149123402&doi=10.3390%2Fpharmaceutics15020713&partnerID=40&md5=1aa2abd67af0566e2779b734f341e3ee\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, 6th October, Egypt; Department of Industrial Pharmacy, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia\",\r\n \"abstract\": \"Since its introduction to the market in the 1970s, ketoprofen has been widely used due to its high efficacy in moderate pain management. However, its poor solubility and ulcer side effects have diminished its popularity. This study prepared forms of ketoprofen modified with three basic excipients: tris, L-lysine, and L-arginine, and investigated their ability to improve water solubility and reduce ulcerogenic potential. The complexation\/salt formation of ketoprofen and the basic excipients was prepared using physical mixing and coprecipitation methods. The prepared mixtures were studied for solubility, docking, dissolution, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), in vivo evaluation for efficacy (the writhing test), and safety (ulcerogenic liability). Phase solubility diagrams were constructed, and a linear solubility (AL type) curve was obtained with tris. Docking studies suggested a possible salt formation with L-arginine using Hirshfeld surface analysis. The order of enhancement of solubility and dissolution rates was as follows: L-arginine > L-lysine > tris. In vivo analgesic evaluation indicated a significant enhancement of the onset of action of analgesic activities for the three basic excipients. However, safety and gastric protection indicated that both ketoprofen arginine and ketoprofen lysine salts were more favorable than ketoprofen tris. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"basic amino acids\",\r\n \" gastric ulcer\",\r\n \" ketoprofen\",\r\n \" L-arginine\",\r\n \" L-lysine\",\r\n \" tris\",\r\n \" writhing\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 88,\r\n \"title\": \"Elsayed, Mohamed (59088212000); Mohamed, Mohamed Ahmed (58862493900); Ali, Mohammad F. (58861249800); Dabash, Ghada R. (58862246700); El Din Taha, Taher Salah (58862738600); Abdelrahim, Reham M. (58861499200)\",\r\n \"authors\": \"Effect of Muscle Energy Technique versus Graston Technique on nonspecific neck pain; Efecto de la t\u00e9cnica de energ\u00eda muscular versus la t\u00e9cnica de Graston sobre el dolor de cuello inespec\u00edfico\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85184026792&doi=10.6018%2Fsportk.599011&partnerID=40&md5=7a02af723be740482f75d1e743760220\",\r\n \"affiliations\": \"Badr University Hospital, Helwan, Egypt; Department of Basic Sciences, Sphinx University, New Assuit, Egypt; Department of Physical Therapy for Internal Medicine and Surgery, Faculty of Physical Therapy, 6th October, Egypt; Department of Orthopedic Physical Therapy, Faculty of Physical Therapy, Beni Suef, Egypt; Department of Physical Therapy, Buraydah Private Colleges, Buraidah, Saudi Arabia; Woman\u2019s Health Department, Modern University for Technology and Information, Cairo, Egypt; Sohag Educational Administration, Sohag, Egypt; Merit University, Sohag, Egypt; Basic Sciences Department, Modern University for Technology and Information, Cairo, Egypt\",\r\n \"abstract\": \"Background: Numerous researches have been carried out in order to determine the most effective physical therapy strategy for treating nonspecific neck pain (NSNP). Purpose: To contrast between the outcomes of Graston Technique (GT) and Muscle Energy Technique (MET) on both pain intensity and functional disability in patients with NSNP. Methods: Forty-two (30 males and 12 females) patients with NSNP divided randomly into three groups: Group A: received Graston Technique and traditional physiotherapy treatment (TPT), Group B: received muscle energy technique and TPT, and Group C: received TPT only. Intervention lasted for 12 sessions (3 per week). At the start and finish of the fourth week, a visual analogue scale was used to quantify pain intensity and a neck disability index (NDI) questionnaire was used to measure functional disability. Results: There were significant mean effects of time (pre\/post) and intervention group (Graston, MET, conventional) and significant interaction on pain and disability (p<0.05). MET group had higher changes in the pain than both Graston and control groups (p<0.05). However, no significant differences among groups in the functional change. Conclusion: GT and MET had similar effects on the function in patients with NSNP, but MET had higher effects on reducing pain. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Graston Technique\",\r\n \" Instrument-assisted soft tissue mobilization\",\r\n \" Muscle energy technique\",\r\n \" Neck disability\",\r\n \" Non-specific neck pain\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 89,\r\n \"title\": \"Abdelkader, Hamdy (20336654000); El-Wahab, Asmaa Abd (58573421200); El-Gendy, Ahmed Osama (55582023600); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Formulation and optimization of lipid- and Poloxamer-tagged niosomes for dermal delivery of terbinafine: preparation, evaluation, and in\u00a0vitro antifungal activity\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85170706310&doi=10.1080%2F10837450.2023.2255889&partnerID=40&md5=568b4bab5fece8b1a95eda55dc6aef8c\",\r\n \"affiliations\": \"Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia; Faculty of Pharmacy, Beni Suef, Egypt; Department of Microbiology and Immunology, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Fungal skin diseases are recognized as a global burden disease that affect human quality adjusted life. Terbinafine belongs to allylamine and broad-spectrum antifungal drugs but considered practically insoluble. Different lipids\/surfactant with two different molar ratios were investigated with Span 40-based niosomes; characterized for size, morphology, loading capacity (EE%), in\u00a0vitro release, kinetics, and antifungal activities. Vesicle sizes (0.19\u20131.23\u00a0\u00b5m), EE% (25\u201399%), zeta potential (> \u221232 mV), and in\u00a0vitro release rates were dependent on both lipid types and ratios. Higher ratios of Poloxamer 407 preferably formed mixed micelles rather than forming noisome bilayers. Both Compritol and Precirol were deemed to be potential alternatives to cholesterol as bilayer membrane stabilizers. Terbinafine-loaded Compritol and Precirol stabilized niosomes were successfully prepared and demonstrated superior antifungal activities in\u00a0vitro (inhibition zones) using Candida albicans ATCC 60913. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Compritol\",\r\n \" membrane additives\",\r\n \" niosomes\",\r\n \" Precirol\",\r\n \" Terbinafine\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 90,\r\n \"title\": \"Al-Ghamdi, Maryam A. (55796092800); Huwait, Etimad A. (36646153400); El-Sawi, Nagwa M. (8344020000); Ali, Soad Shaker (35783844900); Sayed, Ahmed M. (57201406179)\",\r\n \"authors\": \"Thymoquinone ameliorates acrylamide-induced reproductive toxicity in female rats: An experimental study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85147446723&doi=10.18502%2Fijrm.v21i1.12668&partnerID=40&md5=2bfb3fc1d0bb40fa628e24246283d60d\",\r\n \"affiliations\": \"Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Experimental Biochemistry Unit, King Fahd Medical Research Center, Jeddah, Saudi Arabia; Vitamin D Pharmacogenomics Research Group, King Abdulaziz University, Jeddah, Saudi Arabia; Laboratory of Biochemistry, Faculty of Science, Sohag, Egypt; Faculty of Medicine, Merit University, Sohag, Egypt; Laboratory of Biochemistry, Faculty of Science, Asyut, Egypt\",\r\n \"abstract\": \"Background: Acrylamide (AA) is a carcinogenic compound that causes severe reproductive impairments and represents a high environmental risk factor. Thymoquinone (TQ) has a unique antioxidant activity and has been widely used as a protective agent against various types of toxicity. Objective: To evaluate the protective effects of TQ against AA-induced reproductive toxicity in female rats. Materials and Methods: In this experimental study, 40 female albino rats (120-150 gr, 8-10 wk) were sorted into 4 groups, (n = 10\/each), vehicle group (received a daily oral administration of 0.5 ml saline [9%]); AA group (received a daily oral administration with freshly prepared AA, 20 mg\/kg body weight) for 21 days which is less than the lethal dose LD<inf>50<\/inf> of AA in rats (20 mg\/kg body weight); AA+TQ group (received a daily oral administration of TQ, 10 mg\/kg body weight) after AA intoxication for 21 days, and TQ group (received a daily oral administration of TQ only, 10 mg\/kg body weight) for 21 consecutive days. Reproductive hormones, carcinogenic biomarkers, and oxidative stress markers were measured. The histological assessment showed the protective effect of TQ against AA-induced ovarian injury. Network pharmacology analysis and molecular docking approach were carried out to determine the binding affinity of TQ with cyclooxygenase 2. Results: TQ administration significantly enhanced the functional capacity of the ovary at hormones, oxidative biomarkers, and tumor markers at a significant level of p < 0.001. Besides, TQ protects the ovary of AA-treated rats from the severe degeneration effect. Conclusion: TQ showed a promising protective effect against AA-induced reproductive toxicity in female rats. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Acrylamide\",\r\n \" Cyclooxygenase 2\",\r\n \" Inflammation\",\r\n \" Oxidative stress\",\r\n \" Rats\",\r\n \" Thymoquinone\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 91,\r\n \"title\": \"Alfatease, Adel M. (57193644396); Shoman, Mai E. (24559439600); Abourehab, Mohammed A.S. (56641727000); Abou-Taleb, Heba A. (57197775199); Abdelkader, Hamdy (20336654000)\",\r\n \"authors\": \"A Novel Curcumin Arginine Salt: A Solution for Poor Solubility and Potential Anticancer Activities\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85145736868&doi=10.3390%2Fmolecules28010262&partnerID=40&md5=7a90640c950a0a78313a93598f31efbc\",\r\n \"affiliations\": \"Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia; Department of Medicinal Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics, Umm Al-Qura University, Makkah, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Curcumin is a natural polyphenolic compound with well-known anticancer properties. Poor solubility and permeability hamper its use as an anticancer pharmaceutical product. In this study, L-arginine, a basic amino acid and a small hydrophilic molecule, was utilized to form a salt with the weak acid curcumin to enhance its solubility and potentiate the anticancer activities of curcumin. Two methods were adopted for the preparation of curcumin: L-arginine salt, namely, physical mixing and coprecipitation. The ion pair or salt was characterized for docking, solubility, DSC, FTIR, XRD, in vitro dissolution, and anticancer activities using MCF7 cell lines. The molecular docking suggested a salt\/ion-pair complex between curcumin and L-arginine. Curcumin solubility was increased 335- and 440-fold by curcumin in L-arginine, physical, and co-precipitated mixtures, respectively. Thermal and spectral analyses supported the molecular docking and formation of a salt\/ion pair between curcumin and L-arginine. The cytotoxicity of curcumin L-arginine salt significantly improved (p < 0.05) by 1.4-fold, as evidenced by the calculated IC<inf>50%<\/inf>, which was comparable to Taxol (the standard anticancer drug but with common side effects). \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"breast cancer\",\r\n \" curcumin\",\r\n \" cytotoxicity\",\r\n \" L-arginine\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 92,\r\n \"title\": \"Abdelkader, Hamdy (20336654000); Alfatease, Adel M. (57193644396); Fathalla, Zeinab M.A. (57188965212); Shoman, Mai E. (24559439600); Abou-Taleb, Heba A. (57197775199); Abourehab, Mohammed A.S. (56641727000)\",\r\n \"authors\": \"Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85141846223&doi=10.3390%2Fpharmaceutics14112283&partnerID=40&md5=50b4997f120eae0a4b9b3cbb21414230\",\r\n \"affiliations\": \"Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, Umm Al-Qura University, Makkah, Saudi Arabia\",\r\n \"abstract\": \"Curcumin is one of the most researched phytochemicals by pharmacologists and formulation scientists to unleash its potential therapeutic benefits and tackle inherent biopharmaceutic problems. In this study, the native \u03b2-cyclodextrin (CD) and three derivatives, namely, Captisol (sulfobutyl ether \u03b2-CD), hydroxypropyl \u03b2-cyclodextrin, and hydroxyethyl \u03b2-cyclodextrin were investigated for inclusion complexes with curcumin using two preparation methods (physical mixing and solvent evaporation). The prepared complexes were studied for docking, solubility, FTIR, DSC, XRD, and dissolution rates. The best-fitting curcumin: cyclodextrins (the latter of the two CDs) were evaluated for cytotoxicity using human breast cell lines (MCF-7). Dose-dependent cytotoxicity was recorded as IC50% for curcumin, curcumin: hydroxyethyl \u03b2-cyclodextrin, and curcumin: hydroxypropyl \u03b2-cyclodextrin were 7.33, 7.28, and 19.05 \u00b5g\/mL, respectively. These research findings indicate a protective role for the curcumin: hydroxypropyl \u03b2-cyclodextrin complex on the direct cell lines of MCF-7. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"curcumin\",\r\n \" cyclodextrins\",\r\n \" cytotoxicity\",\r\n \" hydroxyethyl \u03b2-cyclodextrin\",\r\n \" MCF-7\",\r\n \" solubility\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 93,\r\n \"title\": \"Abbas, Noha S. (57203950222); Mohamed, Yahya Abduh Salim (55759946600); Derayea, Sayed Mohamed (55530732800); Omar, Mahmoud Ahmed (15733097700); Saleh, Gamal A. (7003720153)\",\r\n \"authors\": \"Micellar Thin Layer Chromatography and Computer-Aided Analysis of Empagliflozin, Linagliptin and Metformin HCl Ternary Mixture\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85133901721&doi=10.1093%2Fchromsci%2Fbmac008&partnerID=40&md5=bce81491bd112003774b0e1e2f346cb2\",\r\n \"affiliations\": \"Egyptian Ministry of Health and Population, Cairo, Egypt; Department of Pharmaceutical Medicinal and Organic Chemistry, Sana'a University, Sana'a, Yemen; Department of Analytical Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Pharmacognosy and Pharmaceutical Chemistry, Taibah University, Medina, Saudi Arabia; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutical Analytical Chemistry, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"The present work was performed in order to study the mechanism of micellar thin layer chromatography (MTLC) and to develop a new simple and sensitive simultaneous MTLC method for separation of empagliflozin, Linagliptin and metformin hydrochloride ternary mixture. The study was done using three different surfactants; sodium dodecyl sulphate (SDS), benzalkonium chloride (BAC) and polysorbate 80 (tween 80). Chromatographic procedure was performed using micellar mobile phase that composed of aqueous solution of each surfactant and methanol (6: 4 v\/v) and micellar TLC determination at \u03bbmax 237 nm. Separation using SDS (anionic surfactant) and BAC (cationic surfactant) depends on ionization potential (AMI-IP), partition coefficient (logP (o\/w)) and hydrogen bond donor atoms (a-don), whereas separation using tween 80 depends mainly on the lipophilicity (R<inf>M0<\/inf>), solvation energy (E-sol) and Van der Waals energy (E-vdw). Quantitative structure\u2013retention relationships study was carried out, modeled, evaluated and validated using molecular operating environment software. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 94,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Sayed, Ahmed M. (57155946600); Refaat, Hesham (57224139658); Alsenani, Faisal (57198490138); Alaaeldin, Eman (55693863500); Mokhtar, Fatma Alzahraa (26323715100); Abdelmohsen, Usama Ramadan (36056037900); Shady, Nourhan Hisham (57194451949)\",\r\n \"authors\": \"Network Pharmacological Analysis of the Red Sea Sponge Hyrtios erectus Extract to Reveal Anticancer Efficacy of Corresponding Loaded Niosomes\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85140582940&doi=10.3390%2Fmd20100628&partnerID=40&md5=fb359e45f7d1774fcc99fb17f0155278\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmacognosy, Almaaqal University, Basra, Iraq; Department of Pharmacognosy, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics, Deraya University, New Minia, Egypt; Department of Pharmacognosy, Umm Al-Qura University, Makkah, Saudi Arabia; Department of Pharmacognosy, AlSalam University in Egypt, Tanta, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Minya, Egypt; Department of Pharmacognosy, Deraya University, New Minia, Egypt\",\r\n \"abstract\": \"In this study, the LC-HRMS-assisted chemical profiling of Hyrtios erectus sponge led to the annotation of eleven major compounds (1\u201311). H. erectus-derived crude extract (HE) was tested in vitro for its antiproliferative activity against three human cancer cell lines, Hep-G2 (human liver cancer cell line), MCF-7 (breast cancer cell line), and Caco-2 (colon cancer cell line), before and after encapsulation within niosomes. Hyrtios erectus extract showed moderate in vitro antiproliferative activities towards the studied cell lines with IC<inf>50<\/inf> values 18.5 \u00b1 0.08, 15.2 \u00b1 0.11, and 13.4 \u00b1 0.12, respectively. The formulated extract-containing niosomes (size 142.3 \u00b1 10.3 nm, PDI 0.279, and zeta potential 22.8 \u00b1 1.6) increased the in vitro antiproliferative activity of the entrapped extract significantly (IC<inf>50<\/inf> 8.5 \u00b1 0.04, 4.1 \u00b1 0.07, and 3.4 \u00b1 0.05, respectively). A subsequent computational chemical study was performed to build a sponge\u2013metabolite\u2013targets\u2013cancer diseases network, by focusing on targets that possess anticancer activity toward the three cancer types: breast, colon, and liver. Pubchem, BindingDB, and DisGenet databases were used to build the network. Shinygo and KEGG databases in addition to FunRich software were used for gene ontology and functional analysis. The computational analysis linked the metabolites to 200 genes among which 147 genes related to cancer and only 64 genes are intersected in the three cancer types. The study proved that the co-occurrence of compounds 1, 2, 3, 7, 8, and 10 are the most probable compounds possessing cytotoxic activity due to large number of connections to the intersected cytotoxic genes with edges range from 9-14. The targets possess the anticancer effect through Pathways in cancer, Endocrine resistance and Proteoglycans in cancer as mentioned by KEGG and ShinyGo 7.1 databases. This study introduces niosomes as a promising strategy to promote the cytotoxic potential of H. erectus extract. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"cytotoxicity\",\r\n \" enrichment analysis\",\r\n \" Hyrtios\",\r\n \" marine sponge\",\r\n \" metabolic\",\r\n \" network pharmacology\",\r\n \" niosomes\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 95,\r\n \"title\": \"Ali, Ahmed U. (57213590141); Khallaf, Iman S.A. (57213352391); Kamel, Amira A. (57208054498); Badran, Aya Y. (57209326769); Gomaa, Ahmed Shawky (57211605576); El-Faham, Tahani H. (6603115454); Mortagi, Yasmin Ismail M. (55753556700)\",\r\n \"authors\": \"Impact of quercetin spanlastics on livin and caspase-9 expression in the treatment of psoriasis vulgaris\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85138773433&doi=10.1016%2Fj.jddst.2022.103809&partnerID=40&md5=5eee84ca1a9117fc78822be158914297\",\r\n \"affiliations\": \"Department of Pharmaceutics, Merit University, Sohag, Egypt; Pharmacognosy and Natural Products Department, Faculty of Pharmacy, Shibin El Kom, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Asyut, Egypt; Department of Dermatology, Andrology, Asyut, Egypt; Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutics, Sinai University, El-Arish, Egypt\",\r\n \"abstract\": \"Psoriasis is a chronic immune-mediated disease presented by erythematic lesions. It is an incurable disease; however, topical treatment attempts to stop the uncontrolled proliferation of skin cells. Quercetin (Qc) is a natural compound plentiful in several natural plant species and plays a vital role in treating psoriasis; however, it has poor aqueous solubility and penetrability. Consequently, our work aims to enhance Qc's dissolution and anti-psoriatic activity. In this work, Qc was isolated from Psidium guajava leaves, and spanlastics were prepared using the ethanol injection method. The % encapsulation efficiency (%EE) of Qc ranged from 76.40 \u00b1 1.42 to 98.29 \u00b1 0.2,4, and the Particle size (P.size) varied between 414.66 \u00b1 1.94 to 748.33 \u00b1 5.19 nm. In vitro release studies of Qc from spanlastic preparations were significantly higher than those from free drug dispersion. Selected Qc spanlastics formulation was included in Sodium carboxymethylcellulose (SCMC) 3.5% gel for biological application. Clinical improvement after eight weeks of treatment was powerfully distinguished. By the end of 8 weeks of treatment, Psoriasis Area and Severity Index (PASI) score decreased from 5.19 \u00b1 1.14 at baseline to 2.26 \u00b1 1.1. Qc is famous for its apoptotic-inducing activity, livin is one of the Inhibitors of apoptosis proteins (IAPs), and its function is mediated through the inhibition of caspase activation. Quantitative real-time polymer chain reaction (qrt- PCR) declared that the expression of livin (p = 0.002) was lowered while that of caspase-9 (P < 0.001) was elevated in comparison to those before treatment with QC spanlastics; thus, Qc spanlastics are promising easily prepared formulation for the treatment of psoriasis. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Ethanol injection method\",\r\n \" Factorial design\",\r\n \" Livin and caspase)\",\r\n \" Psoriasis\",\r\n \" Quercetin\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 96,\r\n \"title\": \"Elsayed, Mahmoud M.A. (57218323683); Aboelez, Moustafa O. (57191738528); Mohamed, Mohamed S. (57211757868); Mahmoud, Reda A. (57223227945); El-Shenawy, Ahmed Ahmed (57192806043); Mahmoud, Essam A. (57221280023); Al-Karmalawy, Ahmed A. (57210596269); Santali, Eman Y. (39762585800); Alshehri, Sameer (57204084546); Elsadek, Mahmoud Elkot Mostafa (57666064900); A. El Hamd, Mohamed (55265969200); El Hakim Ramadan, Abd (57217825641)\",\r\n \"authors\": \"Tailoring of Rosuvastatin Calcium and Atenolol Bilayer Tablets for the Management of Hyperlipidemia Associated with Hypertension: A Preclinical Study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85137405032&doi=10.3390%2Fpharmaceutics14081629&partnerID=40&md5=007fdf515ede585f0fc02a6d29b7c269\",\r\n \"affiliations\": \"Faculty of Pharmacy, Sohag, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag, Egypt; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Cairo, Egypt; Faculty of Veterinary Medicine, Zagazig, Egypt; Department of Pharmaceutical Medicinal Chemistry, Horus University - Egypt, New Damietta, Egypt; Department of Pharmaceutical Chemistry, Taif University, Taif, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Taif University, Taif, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutical Sciences, Shaqra University, Shaqra, Saudi Arabia; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Qena, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Port Said, Egypt\",\r\n \"abstract\": \"Hyperlipidemia is still the leading cause of heart disease in patients with hypertension. The purpose of this study is to make rosuvastatin calcium (ROS) and atenolol (AT) bilayer tablets to treat coexisting dyslipidemia and hypertension with a single product. ROS was chosen for the immediate-release layer of the constructed tablets, whereas AT was chosen for the sustained-release layer. The solid dispersion of ROS with sorbitol (1:3 w\/w) was utilized in the immediate-release layer while hydroxypropyl methylcellulose (HPMC), ethylcellulose (EC), and sodium bicarbonate were incorporated into the floating sustained-release layer. The concentrations of HPMC and EC were optimized by employing 32 full factorial designs to sustain AT release. The bilayer tablets were prepared by the direct compression method. The immediate-release layer revealed that 92.34 \u00b1 2.27% of ROS was released within 60 min at a pH of 1.2. The second sustained-release layer of the bilayer tablets exhibited delayed release of AT (96.65 \u00b1 3.36% within 12 h) under the same conditions. The release of ROS and AT from the prepared tablets was found to obey the non-Fickian diffusion and mixed models (zero-order, Higuchi and Korsmeyer\u2013Peppas), respectively. Preclinical studies using rabbit models investigated the impact of ROS\/AT tablets on lipid profiles and blood pressure. A high-fat diet was used to induce obesity in rabbits. Bilayer ROS\/AT tablets had a remarkable effect on decreasing the lipid profiles, slowing weight gain, and lowering blood pressure to normal levels when compared to the control group. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"atenolol\",\r\n \" bilayer tablets\",\r\n \" factorial design\",\r\n \" hyperlipidemia\",\r\n \" hypertension\",\r\n \" preclinical studies\",\r\n \" rosuvastatin calcium\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 97,\r\n \"title\": \"Farrag, Sherien A. (57760120000); Rageh, Azza H. (21233802300); Askal, Hassan F. (6601931305); Saleh, Gamal A. (7003720153)\",\r\n \"authors\": \"Biocompatible magnetite nanoparticles coated with ionic liquid-based surfactant as a hydrophilic sorbent for dispersive solid phase microextraction of cephalosporins prior to their quantitation by HPTLC\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85132552851&doi=10.1016%2Fj.jchromb.2022.123339&partnerID=40&md5=9eabf66dd1f12b5403aacd2a346673fb\",\r\n \"affiliations\": \"Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Asyut, Egypt; Faculty of Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Extraction of highly hydrophilic compounds from biological fluids including urine or plasma samples is a dilemma due to high hydrophilicity of the matrix itself. The main aim of the current work is to explore the competence of ionic liquid (IL)-based surfactant-coated mineral oxide nanoparticles (NPs) in dispersive solid-phase microextraction (d-SPME) of highly hydrophilic analytes taking cefoperazone (CPZ) as a model analyte for the study. The IL-based surfactant coated Fe<inf>3<\/inf>O<inf>4<\/inf> NPs is utilized as an innovative adsorbent for the separation and pre-concentration of CPZ after intramuscular injection (I.M) in rabbits. The utilized magnetite NPs were synthesized via simple and reliable co-precipitation procedure, which doesn't require any air-free environment and depends on a single iron (III) salt. Characterization of the as-synthesized NPs was achieved by X-ray powder diffraction (XRD), Fourier transform infrared (FT-IR) and energy dispersive X-ray (EDX). Surface area measurements show that Fe<inf>3<\/inf>O<inf>4<\/inf> NPs have large surface area of 75 m2 g\u22121. The developed approach utilizes the unique properties of the IL-based surfactant including multiple polar interaction types provided by the polar head in addition to merits of Fe<inf>3<\/inf>O<inf>4<\/inf> nanoparticles, which include large adsorptive capacity and magnetic properties, to improve separation, save time, and achieve satisfactory recovery. Comprehensive study was developed for the factors, that affect the adsorption capacity such as pH, NPs amount, IL-based surfactant concentration, ionic strength, adsorption time, and desorption conditions. Moreover, the adsorption data was fitted to Langmuir and second-order kinetic models as reflected by the reasonable determination coefficients of 0.9319 and 0.9726, respectively. Under the optimized conditions, the developed approach achieves good correlation coefficient of 0.9975, and 0.9981 over linearity range of 0.7\u201312.0 and 4.0\u201350.0 \u00b5g mL\u22121 for both CPZ standard solutions and spiked rabbit plasma, respectively. It also provides good sensitivity expressed by the low values of limit of detection (LOD) of 0.2 and 1.2 \u00b5g mL\u22121 and limit of quantitation (LOQ) of 0.7 and 4.0 \u00b5g mL\u22121 for both the standard solutions and spiked plasma, respectively. The developed approach was also applied successfully for monitoring CPZ in rabbit plasma samples with satisfactory recovery % (83\u2013110). In addition, a detailed pharmacokinetic study is performed where pharmacokinetic parameters of CPZ in rabbit plasma samples were calculated. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Cefoperazone\",\r\n \" Dispersive solid phase microextraction\",\r\n \" High-performance thin layer chromatography\",\r\n \" In-vivo analysis\",\r\n \" Ionic liquid based-surfactant\",\r\n \" Magnetic Fe3O4 NPs\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 98,\r\n \"title\": \"Al\u2013Farhan, Badriah Saad (57224940566); Gahlan, Ahmed A. (57215860803); Haredy, Ahmed M. (56895997900); Fargaly, O. A. (57737325800)\",\r\n \"authors\": \"Cathodic Stripping Voltammetric Determination of Lisinopril in Dosage Forms and Biological Fluids\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85131814084&doi=10.21608%2Fejchem.2021.104642.4835&partnerID=40&md5=50e2b72d7f3e65025889a32c3dc27a02\",\r\n \"affiliations\": \"Department of Chemistry, King Khalid University, Abha, Saudi Arabia; Department of Chemistry, Faculty of Science, Cairo, Egypt; Department of Chemistry, Al Baha University, Al Aqiq, Saudi Arabia; Pharmaceutical Analytical Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Lisinopril (LSP) in pharmaceutical dosage forms and biological fluids was studied using the square wave cathodic stripping voltammetric method (SWCSV) at a carbon paste electrode (CPE). To maximize the method's circumstances, many parameters were defined. The linear concentration range of 3.53 \u2013 44.17 ng\/mL was effectively determined at ideal conditions of 0.08 M Britton-Robinson buffers (pH = 9.00) at accumulation times 15, 30 sec., and 2.64 \u2013 44.17 ng\/mL at 60 sec. With good results, the standard addition method was employed to determine LSP in pure solutions, tablets, and biological fluids. The proposed method is compared to the previously published standard method. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Biological Fluids\",\r\n \" Cathodic Stripping Voltammetric\",\r\n \" Dosage Forms\",\r\n \" Lisinopril\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 99,\r\n \"title\": \"Alshora, Doaa Hasan (56998666500); Ibrahim, Mohamed Abbas (58516410900); Zayed, Gamal M.S. (36865467400); Al Rwashed, Mohammed A. (57468461600); Abou-Taleb, Heba A. (57197775199); Ali, Marwa Farouk (57211363599)\",\r\n \"authors\": \"The role of sodium lauryl sulfate on formulation of directly compressed tablets containing simvastatin and aspirin: Effect on drugs dissolution and gastric mucosa\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85125307281&doi=10.1016%2Fj.jsps.2022.02.006&partnerID=40&md5=b4809242634e1f989119228327b835d2\",\r\n \"affiliations\": \"Department of Pharmaceutics, College of Pharmacy, Riyadh, Saudi Arabia; Faculty of Pharmacy, Cairo, Egypt; Al-Azhar University, Cairo, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Faculty of Medicine, Asyut, Egypt\",\r\n \"abstract\": \"According to the American College of Cardiology\/American Heart Association (ACC\/AHA), both aspirin and statin are used in the primary prevention of cardiovascular diseases. Aspirin (ASA) is contraindicated if there is gastrointestinal bleeding because it will exaggerate the condition. In this study, the effect of surfactant; sodium lauryl sulfate (SLS), in enhancing the in vitro dissolution of simvastatin (SIM) and ASA, as well as gastric irritation and upset, was studied. Oral tablets containing both ASA and SIM with and without the SLS were manufactured using the direct compression technique. The prepared tablets were characterized with respect to hardness, friability, uniformity of dosage units, in vitro disintegration, and dissolution. The effect of the addition of SLS in reducing the in vivo irritation and protection of gastric mucosa were also investigated. The results showed that the compressed tablets possessed sufficient hardness, acceptable friability, and are uniform with respect to disintegration, drugs contents, and tablet weight. The results showed that SIM alone exhibited a gastroprotective effect on the induced irritation. In addition, the incorporation of the SLS in the tablets containing SIM and ASA significantly enhanced the dissolution rates of both drugs and significantly decreased the gastric irritation and the ulcer index. The ulcer index of aspirin was decreased from 2.3 for tablets manufactured without SLS to 0.8 for tablets containing SLS. In a conclusion, the addition of pH modifier surfactant; SLS could enhance the dissolution rate of poorly soluble acidic drugs, reduce gastric upset and irritation without any effect on the main characters of the tablets. Moreover, the addition of SLS is very useful in improving the therapeutic activities and reducing the side effects of ASA and SIM for patients who require long-term administration of these drugs. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Aspirin\",\r\n \" Cytokines\",\r\n \" In vitro dissolution\",\r\n \" Simvastatin\",\r\n \" SLS\",\r\n \" Tablets\",\r\n \" Ulcer index\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 100,\r\n \"title\": \"Inam, Sana (57215504323); Irfan, Muhammad Abeer (35069404400); Lali, Noor Ul Ain (57665753700); Syed, Haroon Khalid (35734013600); Asghar, Sajid (35751888600); Khan, Ikram Ullah (57194341390); Khan, Salahuddin Ud Din (57218916034); Iqbal, Muhammad Shahid (57213578076); Zaheer, Imran (57193592227); Khames, Ahmed (24076276400); Abou-Taleb, Heba A. (57197775199); Abourehab, Mohammed A.S. (56641727000)\",\r\n \"authors\": \"Development and Characterization of Eudragit\u00ae EPO-Based Solid Dispersion of Rosuvastatin Calcium to Foresee the Impact on Solubility, Dissolution and Antihyperlipidemic Activity\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85129394271&doi=10.3390%2Fph15040492&partnerID=40&md5=66ce124d72536b9cbe097504c0d55cf7\",\r\n \"affiliations\": \"Department of Pharmaceutics, Government College University Faisalabad, Faisalabad, Pakistan; Department of Medicine, Fatima Jinnah Medical University, Lahore, Pakistan; Department of Biochemistry, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia; Department of Clinical Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Pharmacology, Shaqra University, Shaqra, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Taif University, Taif, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, Umm Al-Qura University, Makkah, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Minia University, Minya, Egypt\",\r\n \"abstract\": \"Poor solubility is the major challenge involved in the formulation development of new chemical entities (NCEs), as more than 40% of NCEs are practically insoluble in water. Solid dispersion (SD) is a promising technology for improving dissolution and, thereby, the bioavailability of poorly soluble drugs. This study investigates the influence of a pH-sensitive acrylate polymer, EPO, on the physicochemical properties of rosuvastatin calcium, an antihyperlipidemic drug. In silico docking was conducted with numerous polymers to predict drug polymer miscibility. The screened-out polymer was used to fabricate the binary SD of RoC in variable ratios using the co-grinding and solvent evaporation methods. The prepared formulations were assessed for physiochemical parameters such as saturation solubility, drug content and in vitro drug release. The optimized formulations were further ruled out using solid-state characterization (FTIR, DSC, XRD and SEM) and in vitro cytotoxicity. The results revealed that all SDs profoundly increased solubility as well as drug release. However, the formulation RSE-2, with a remarkable 71.88-fold increase in solubility, presented 92% of drug release in the initial 5 min. The molecular interaction studied using FTIR, XRD, DSC and SEM analysis evidenced the improvement of in vitro dissolution. The enhancement in solubility of RoC may be important for the modulation of the dyslipidemia response. Therefore, pharmacodynamic activity was conducted for optimized formulations. Our findings suggested an ameliorative effect of RSE-2 in dyslipidemia and its associated complications. Moreover, RSE-2 exhibited nonexistence of cytotoxicity against human liver cell lines. Convincingly, this study demonstrates that SD of RoC can be successfully fabricated by EPO, and have all the characteristics that are favourable for superior dissolution and better therapeutic response to the drug. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"anti-hyperlipidemic activity\",\r\n \" docking\",\r\n \" Eudragit\u00ae EPO\",\r\n \" improved solubility\",\r\n \" rosuvastatin calcium\",\r\n \" solid dispersion\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 101,\r\n \"title\": \"Elsayed, Mahmoud M.A. (57218323683); Aboelez, Moustafa O. (57191738528); Elsadek, Bakheet E.M. (36500633700); Sarhan, Hatem Abdelmonsef A. (21740157800); Khaled, Khaled Ali (7003878192); Belal, Amany (55749719800); Khames, Ahmed (24076276400); Hassan, Yasser A.H. (57201672273); Abdel-Rheem, Amany A. (57666064800); Elkaeed, Eslam B. (56884768800); Raafat, Mohamed (56660952500); Elsadek, Mahmoud Elkot Mostafa (57666064900)\",\r\n \"authors\": \"Tolmetin Sodium Fast Dissolving Tablets for Rheumatoid Arthritis Treatment: Preparation and Optimization Using Box-Behnken Design and Response Surface Methodology\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85129365237&doi=10.3390%2Fpharmaceutics14040880&partnerID=40&md5=8151930432ecac5ea27e07844029300f\",\r\n \"affiliations\": \"Faculty of Pharmacy, Sohag, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutical Chemistry, Taif University, Taif, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Taif University, Taif, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Mansoura, Egypt; Department of Pharmaceutical Sciences, Almaarefa University, Riyadh, Saudi Arabia; Department of Pharmacology and Toxicology, Umm Al-Qura University, Makkah, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Tolmetin sodium (TLM) is a non-steroidal anti-inflammatory drug (NSAIDs). TLM is used to treat inflammation, skeletal muscle injuries, and discomfort associated with bone disorders. Because of the delayed absorption from the gastro intestinal tract (GIT), the currently available TLM dosage forms have a rather protracted start to the effect, according to pharmacokinetic studies. The aim of this study was to create a combination for TLM fast dissolving tablets (TLM-FDT) that would boost the drug\u2019s bioavailability by increasing pre-gastric absorption. The TLM-FDTs were developed using a Box-Behnken experimental design with varied doses of crospovidone (CP), croscarmellose sodium (CCS) as super-disintegrants, and camphor as a sublimating agent. In addition, the current study used response surface approach to explore the influence of various formulation and process factors on tablet qualities in order to verify an optimized TLM-FDTs formulation. The optimized TLM-FDTs formula was subsequently evaluated for its in vivo anti-inflammatory activity. TLM-FDTs have good friability, disintegration time, drug release, and wetting time, as well as fast disintegration and dissolution behavior. Significant increase in drug bioavailability and reliable anti-inflammatory efficacy were also observed, as evidenced by considerable reductions in paw thickness in rats following carrageenan-induced rat paw edema. For optimizing and analyzing the effect of super-disintegrants and sublimating agents in the TLM-FDTs formula, the three-factor, three-level full factorial design is a suitable tool. TLM-FDTs are a possible drug delivery system for enhancing TLM bioavailability and could be used to treat rheumatoid arthritis. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Box-Behnken experimental design\",\r\n \" fast disintegrating tablets\",\r\n \" response surface methodology\",\r\n \" tolmetin sodium\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 102,\r\n \"title\": \"Elkomy, Mohammed H. (56176656800); Abou-Taleb, Heba A. (57197775199); Eid, Hussein M. (57189066350); Yassin, Heba A. (57219433769)\",\r\n \"authors\": \"Fabrication and In Vitro\/In Vivo Appraisal of Metronidazole Intra-Gastric Buoyant Sustained-Release Tablets in Healthy Volunteers\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85129179993&doi=10.3390%2Fpharmaceutics14040863&partnerID=40&md5=d57014567b8cdc54c8d02cee061a815a\",\r\n \"affiliations\": \"Department of Pharmaceutics, Jouf University, Sakakah, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics, El Saleheya El Gadida University, El Saleheya El Gadida, Egypt\",\r\n \"abstract\": \"Helicobacter pylori is thought to be the most common cause of peptic and duodenal ulcers. Eradication of this organism is now considered one of the lines of treatment of gastric and duodenal ulcers. This can be achieved via local delivery of antibacterial agents in high concentrations. Accordingly, our objective was to fabricate and evaluate sustained release floating tablets for metronidazole to extend the gastric residence period and control the release rate of metronidazole. Floating tablets containing cellulose derivatives and Avicel were prepared using direct compression. The rate of metronidazole release from the floating tablets (K = 6.278 mg min\u22121\/2 ) was significantly lower than that from conventional tablets (K = 10.666 mg min\u22121\/2 ), indicating sustained drug release, according to the Higuchi model, for more than 6 h in an acidic medium of 0.1 N HCl. In vivo study in healthy volunteers revealed significantly improved bioavailability; increased Tmax, AUC, and MRT; and significantly lower absorption rate constant after a single oral dose of 150 mg metronidazole as floating tablets. In addition, the significant increase in MRT indicated an in vivo sustained drug release. The floating tablets provided several benefits, including ease of preparation, absence of effervescent ingredients, and reliance on a pH-independent gel-forming agent to deliver metronidazole in a sustained manner. In conclusion, the prepared tablets could be promising for enhancing both local and systemic metronidazole efficacy. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"drug delivery system\",\r\n \" floating tablets\",\r\n \" HPLC assay of metronidazole\",\r\n \" in vitro and in vivo evaluation of metronidazole\",\r\n \" sustained-release system\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 103,\r\n \"title\": \"Tammam, Azza S. (57203940949); Gahlan, Ahmed A. (57215860803); Taher, Mahmoud Ahmed (57192438437); Haredy, Ahmed M. (56895997900)\",\r\n \"authors\": \"Hantzsch condensation reaction as a spectrofluorometric method for determination of alogliptin, an antidiabetic drug, in pure form, tablet form, and human and rat plasma\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85124583213&doi=10.1002%2Fbio.4178&partnerID=40&md5=a2904a0be0d71017bee5eb7b799b4aa8\",\r\n \"affiliations\": \"Department of Chemistry, Faculty of Science, Cairo, Egypt; Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"To analyze alogliptin in its pharmaceutical dosage forms and human plasma, a sensitive, inexpensive, simple, and precise spectrofluorimetric method was developed and tested. This method was also used to investigate the drug\u2019s pharmacokinetic behaviour in the blood of rats. This was based on the Hantzsch reaction, which produces yellowish luminous products that can be detected spectrofluorometrically at 480 and 415 nm for emission and excitation, respectively, when the primary amine group in the examined drug reacts with acetylacetone and formaldehyde. Several experimental parameters that affect the reaction product's development and stability were explored and improved. The curve of fluorescence and concentration for alogliptin was linear in the concentration range 0.05\u20133.60 \u03bcg ml\u22121. The proposed approach was validated according to International Council for Harmonization criteria. The method was successfully utilized to evaluate the examined drug in dose formulations and spiked human plasma with high accuracy. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"alogliptin\",\r\n \" antidiabetic drug\",\r\n \" Hantzsch\",\r\n \" human\",\r\n \" pure\",\r\n \" rat plasma\",\r\n \" spectrofluorometric method\",\r\n \" tablet\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 104,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Mustafa, Wesam W. (57397853700); Makram, Tarek Saad (6506095690); Abdelaty, Lamiaa N. (57214763588); Salem, Hesham S. (7102055199); Abdelkader, Hamdy (20336654000)\",\r\n \"authors\": \"Vardenafil Oral Dispersible Films (ODFs) with Advanced Dissolution, Palatability, and Bioavailability\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85125665512&doi=10.3390%2Fpharmaceutics14030517&partnerID=40&md5=d3379221f5dbbc524def6cd9abb94955\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Chemical and Pharmaceutical Sciences, Kingston University, Kingston Upon Thames, United Kingdom; Al-Mustafa University, Baghdad, Iraq; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, 6th October, Egypt; Department of Clinical Pharmacy, Faculty of Pharmacy, 6th October, Egypt; Department of Pharmaceutical Chemistry, Deraya University, New Minia, Egypt; Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt\",\r\n \"abstract\": \"Oral, quick response, and on demand, also known as a spontaneous oral treatment for erectile dysfunction, is highly needed by both patients and physicians. Vardenafil is selective (fewer side effects) and more effective in difficult\u2010to\u2010treat conditions than sildenafil. This study aims at fostering the dual objectives of using biomolecules such as artificial sweetening agents to solubilize and mask the bitterness of vardenafil loaded on biodegradable polymeric materials (PVA, MC, SA, and PVP K30) to fabricate oral, fast\u2010dissolving films (vardenafil ODFs) in the mouth without the need for water to ingest the dosage form. Furthermore, coprecipitated\u2010dispersed mixtures of vardenafil and three sweeteners (sorbitol, acesulfame K, and sucralose) were prepared and characterized using FTIR, DSC, and solubility studies. Moreover, eight different vardenafil ODFs were prepared using the solvent\u2010casting method. Modified gustatory sensation test, in vitro disintegration, and release studies were performed. In addition, the optimized ODF (F8) was compared with the commercial film\u2010coated tablets pharmacokinetically (relative bioavailability, onset, and duration of actions were estimated). The results indicated that the three sweetening agents had comparable solubilizing capacity. However, both sucralose\u2010 and acesulfame K\u2010based ODFs have a more enhanced sweet and palatable taste than sorbitol\u2010sweetened ODF. The SA\u2010 and PVP K30\u2010based ODFs showed significantly faster disintegration times and release rates than MC. In conclusion, PVA has good film\u2010forming properties, but a higher ratio of PVA adversely affected the disintegration and release characteristics. The % relative bioavailability for ODF was 126.5%, with a superior absorption rate constant (Ka) of 1.2\u2010fold. The Cmax and estimated Tmax were compared to conventional film-coated tablets. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Acesulfame\",\r\n \" Oral dispersible films\",\r\n \" Sorbitol\",\r\n \" Spontaneity\",\r\n \" Sucralose\",\r\n \" Vardenafil\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 105,\r\n \"title\": \"Haredy, Ahmed M. (56895997900); Derayea, Sayed Mohamed (55530732800); Gahlan, Ahmed A. (57215860803); Omar, Mahmoud Ahmed (15733097700); Saleh, Gamal A. (7003720153)\",\r\n \"authors\": \"Graphene oxide modified glassy carbon electrode for determination of linagliptin in dosage form, biological fluids, and rats' feces using square wave voltammetry\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85122196668&doi=10.1016%2Fj.arabjc.2021.103663&partnerID=40&md5=42cb0ea9deb0ca919f59798443c74b39\",\r\n \"affiliations\": \"Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt; Department of Analytical Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Chemistry, Faculty of Science, Cairo, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmacognosy and Pharmaceutical Chemistry, Taibah University, Medina, Saudi Arabia\",\r\n \"abstract\": \"An applicable square wave anodic adsorptive stripping voltammetric (SWAdASV) technique was utilized for linagliptin determination. A glassy carbon electrode was modified with graphene oxide to increase the electrode reactivity. The method is cheap, accurate, precise, and selective, with a good linearity range and a low detection limit. The proposed method was the first one to determine linagliptin in the feces, which is the main route for excreting the drug from the body. The electrode was characterized using various techniques, including Scanning Electron Microscope (SEM), Fourier-transform infrared (FTIR), and X-ray powder diffraction (XRD), and the oxidation mechanism of the drug was examined. The proposed method has a linear range of 9.45\u2013103.96 ng mL\u22121. The detection limit was 4.0 ng mL\u22121. The modified electrode was employed efficiently to determine the drug in tablet formulations, spiked human urine, plasma, and rats' feces with high recoveries. The proposed method's results were statistically compared with those of another previously published method. \u00a9 2021 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Graphene oxide modified glassy carbon electrode\",\r\n \" Human biological fluids\",\r\n \" Linagliptin\",\r\n \" Rats' Feces\",\r\n \" Square-wave voltammetry\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 106,\r\n \"title\": \"Mahmoud, Samah (57995805700); Gaber, Yasser (36621001600); Khattab, Rania Abdelmonem (55620838000); Bakeer, Walid I. (37115255400); Dishisha, Tarek (55258477100); Ramadan, Mohamed Abdelhalim (59796543400)\",\r\n \"authors\": \"The inhibitory effect of dextranases from Bacillus velezensis and Pseudomonas stutzeri on Streptococcus mutans biofilm\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85143517796&doi=10.18502%2Fijm.v14i6.11260&partnerID=40&md5=907ce8a030b922b0acfe553a4338029f\",\r\n \"affiliations\": \"Department of Microbiology and Immunology, Faculty of Pharmacy, Beni Suef, Egypt; Department of Microbiology and Immunology, Merit University, Sohag, Egypt; Department of Microbiology and Immunology, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics and Pharmaceutical Technology, Mutah University, Karak, Jordan; Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"Background and Objectives: Dental caries is a breakdown of the teeth enamel due to harmful bacteria, lack of oral hygiene, and sugar consumption. The acid-producing bacterium Streptococcus mutans is the leading cause of dental caries. Dextra-nase is an enzyme that can degrade dextran to low molecular weight fractions, which have many therapeutic and industrial applications. The purpose of the present study was to isolate a novel dextranase-producing bacteria from a source (molasses). The cell-free extracts containing dextranases were tested as antibiofilm agents. Materials and Methods: Dextranase-producing bacteria were identified using phenotypic and genotypic methods such as 16S rRNA gene sequencing and enzymatic characterization. Results: The highest six dextranase-producing bacterial isolates were Bacillus species. The best conditions for dextranase productivity were obtained after 72 hours of culture time at pH 7. The addition of glucose to the medium enhanced the production of the enzymes. The cell-free extract of the six most active isolates showed remarkable activity against biofilm formation by Streptococcus mutans ATCC 25175. The highest inhibition activities reached 60% and 80% for Bacillus velezensis and Pseudomonas stutzeri, respectively. Conclusion: Therefore, our study added to the current dextranase-producing bacteria with potential as a source of dextra-nases. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Bacillus velezensis\",\r\n \" Biofilm\",\r\n \" Dextranase\",\r\n \" Molasses\",\r\n \" Streptococcus mutans\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 107,\r\n \"title\": \"Elkomy, Mohammed H. (56176656800); Eid, Hussein M. (57189066350); Elmowafy, Mohammed (55813135300); Shalaby, Khaled (36950469600); Zafar, Ameeduzzafar (36987334900); Abdelgawad, Mohamed A. (57189208661); Rateb, Mostafa Ezzat M. (16317169000); Ali, Mohammed R.A. (57188687759); Alsalahat, Izzeddin M.M. (36676946100); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85136056599&doi=10.1080%2F10717544.2022.2110997&partnerID=40&md5=dc05b9bd23fa66a25bbbee2361441381\",\r\n \"affiliations\": \"Department of Pharmaceutics, Jouf University, Sakakah, Saudi Arabia; Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutical Chemistry, Jouf University, Sakakah, Saudi Arabia; Engineering & Physical Sciences, University of the West of Scotland, Ayr, United Kingdom; Faculty of Pharmacy, Beni Suef, Egypt; Cardiff University School of Medicine, Cardiff, United Kingdom; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Diabetes mellitus is a life-threatening metabolic disease. At the moment, there is no effective treatment available to combat it. In this study, we aimed to develop berberine-loaded bilosomes (BER-BLS) to boost the oral bioavailability and therapeutic efficacy of berberine, a natural antidiabetic medication. The BER-BLS was fabricated using a thin-film hydration strategy and optimized using a central composite design (face-centered). The average vesicle size, entrapment efficiency, and surface charge of the optimized BER-BLS preparation were 196.5 nm, 89.7%, (\u2212) 36.4 mV, respectively. In addition, it exhibited higher stability and better-sustained release of berberine than the berberine solution (BER-SOL). BER-BLS and BER-SOL were administered to streptozocin-induced diabetic rats. The optimized BER-BLS formulation had a significant hypoglycemic impact, with a maximum blood glucose decrease of 41%, whereas BER-SOL only reduced blood glucose by 19%. Furthermore, the pharmacological effect of oral BER-BLS and BER-SOL corresponded to 99.3% and 31.7%, respectively, when compared to subcutaneous insulin (1 IU). A pharmacokinetic analysis found a 6.4-fold rise in the relative bioavailability of berberine in BER-BLS when compared to BER-SOL at a dosage of 100 mg\/kg body weight. Histopathological investigation revealed that BER-BLS is suitable for oral administration. Our data demonstrate that BLS is a potential nanocarrier for berberine administration, enhancing its oral bioavailability and antidiabetic activity. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Berberine\",\r\n \" bile salts\",\r\n \" bilosomes\",\r\n \" bioavailability\",\r\n \" diabetes mellitus\",\r\n \" optimization\",\r\n \" pharmacokinetics\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 108,\r\n \"title\": \"Kachanathu, Shaji John (55652551700); Abdulwahab, Sami S. (25957549200); Hafez, Ashraf Ramadan (55546986100); Aldaihan, Mishal M. (57656956700); Nuhmani, Shibili (55266417800); Rizvi, Moattar Raza (56352155800)\",\r\n \"authors\": \"A randomised controlled trial between hamstring muscle tightness and lumbar lordotic angle\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85132721515&doi=10.3920%2FCEP220001&partnerID=40&md5=9e6b0fd5c8a3aef112584b1e270f66c7\",\r\n \"affiliations\": \"College of Applied Medical Sciences, Riyadh, Saudi Arabia; Orthopedic Physical Therapy, Merit University, Sohag, Egypt; College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; Manav Rachna International Institute of Research and Studies, Faridabad, India\",\r\n \"abstract\": \"Shortening of the hamstring muscles is a common problem in both symptomatic and asymptomatic individuals. Low back pain and injury caused by postural deficits might be caused by an imbalance of this muscle. The various degrees of hamstring muscle stiffness and its impact on trunk postures are relatively unknown. The goal of this study was to see how different hamstring muscle length (HML) ranges influenced lumbar lordotic angle (LLA). Sixty asymptomatic healthy male and female subjects with a mean age of 40.4\u00b19.2 years and a body mass index of 25.5\u00b1 2.2 kg\/m2 participated in this study. Subjects were randomly assigned to one of three groups (n=20) with hamstring muscle lengths of 111-120 degrees, 121-130 degrees, or 131-140 degrees, respectively by using a random number generator. The LLA was estimated on a lateral lumbosacral radiograph using the Kinovea application, and hamstring muscle length was measured using the active knee extension test at the university\u2019s rehabilitation centre within a week of subject selection. The Pearson correlation test was used to examine the relationship between LLA and HML, and one-way ANOVA was used to compare the two groups. The correlation coefficients were expressed using 95% confidence intervals. A significant relationship between LLA and HML was observed in 111-120 degrees and 121-130 degrees groups (P<0.05), whereas, the HML >130 degrees group had no influence on LLA (P>0.05). The findings show that hamstring muscle tightness between 111 and 130 degrees has a negative impact on lumbar curvature mechanisms. As a result, hamstring muscle tightness less than 130 degrees should be addressed first in clinical stretching programs for patients. The findings also suggest that instead of focusing on HML, rehabilitation specialists should devote more time to other high-priority interventions, particularly in patients with hamstring muscle lengths greater than 130 degrees \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Cobb\u2019s angle\",\r\n \" Hamstrings tightness\",\r\n \" Lumbar lordotic angle\",\r\n \" Posture\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 109,\r\n \"title\": \"Yassin, Heba A. (57219433769); Ibrahim, Mohamed Abbas (58516410900); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Aceclofenac-Loaded Microspheres Prepared by Vesicular Ionotropic Gelation to Minimize Drug-induced Gastric Ulcers in Rats\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85132592647&doi=10.2174%2F1389200223666220321111214&partnerID=40&md5=87e2c884931228ca7d5dd0c2b802c254\",\r\n \"affiliations\": \"Department of Pharmaceutics, El Saleheya El Gadida University, El Saleheya El Gadida, Egypt; Department of Pharmaceutics, College of Pharmacy, Riyadh, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Background: Aceclofenac is a non-steroidal anti-inflammatory drug and a potent analgesic. However, its oral ingestion may cause gastrointestinal problems, including dyspepsia, abnormal pain, nausea, diarrhea, and ulcera-tive colitis. Objective: This study aimed to prepare vesicular-based enteric microspheres containing aceclofenac by ionotropic gelation technique to minimize gastric irritation in rats. Methods: The micron-size vesicles were prepared by the ionic-orifice gelation method. Three types of vesicular-based microcapsules containing aceclofenac were prepared by employing sodium alginate as the coating material in combination with Eudragit L100, Eudragit S100, and polyvinylpyrrolidone PVP K90. The drug to sodium alginate to polymer ratios were 1:0.5:0.5, 1:1:1, and 1:1.5:1.5, respectively. Gelation of sodium alginate was induced by the dropwise addition of calcium chloride solution (10 % w\/v). Aceclofenac-loaded microspheres were evaluated in terms of aceclofenac content and in vitro drug release, and FTIR, DSC, and XRD were used for physicochemical evaluation of some selected formulae. The effects of microencapsulation on aceclofenac-induced ulcerative activity in male Wistar rats were also investigated. Results: The results indicated no interaction between aceclofenac and microcapsules forming polymers. In addition, microcapsules formulations M1, M4, and M7 gave maximal protection in acidic pH and optimal release in alkaline pH. The histopathological studies revealed that the reduction of ulceration is evident from the macroscopic and mi-croscopic studies, which showed complete protection of the tissue morphology with no ulcers, indicating the effec-tiveness of the microcapsules system against aceclofenac-induced gastric ulceration in rats again. Conclusion: Ionotropic gelation seems to be a simple, efficient technique to prepare aceclofenac-loaded micro-spheres with a reduced risk of gastric ulceration. It is possible to overcome the problem of gastric damage while utilizing aceclofenac by avoiding the exposure of the drug to the ulcer-prone area of the gastrointestinal tract. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Aceclofenac\",\r\n \" enteric microspheres\",\r\n \" in vitro release\",\r\n \" induced gastric ulcer\",\r\n \" ionotropic gelation\",\r\n \" rheumatoid arthritis\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 110,\r\n \"title\": \"Mohammed, Sherine Ahmed (57204465191); Alm, Ahmed Salah (57677914400)\",\r\n \"authors\": \"Role of macrophages in liver cirrhosis: fibrogenesis and resolution\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85129813810&doi=10.5115%2Facb.21.046&partnerID=40&md5=e859ff89dc4b735129abb9db0c59c821\",\r\n \"affiliations\": \"Histology Department, Faculty of Medicine, Sohag, Egypt; Histology Department, Faculty of Medicine, Sohag, Egypt\",\r\n \"abstract\": \"At present, chronic liver disease accounts for approximately 2 million deaths per year worldwide. Liver injury induces a series of events causing inflammation. Chronic inflammation ends in liver fibrosis. A stage of fibrinolysis occurs on stopping insult. Kupffer cells play their role to initiate inflammatory responses, while infiltrating monocyte-derived macrophages have a role both in chronic inflammation and fibrosis and in fibrosis resolution. Ly-6C high expressing monocytes act during fibrogenesis, while Ly-6C low expressing monocytes are restorative macrophages which promote resolution of fibrosis after end of the injury. Recent studies have identified new phenotypes, such as metabolically activated M, oxidized, which may have a role in fatty liver diseases \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Fibrosis\",\r\n \" Liver cirrhosis\",\r\n \" Liver cirrhosis\",\r\n \" Macrophages\",\r\n \" Macrophages\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 111,\r\n \"title\": \"Saddik, Mohammed S. (57214806788); Elsayed, Mahmoud M.A. (57218323683); El-Mokhtar, Mohamed Ahmed (57190683185); Sedky, Haitham (57336971600); Abdel-Aleem, Jelan A. (55390544500); Abu-Dief, Ahmed M. (36969028400); Al-Hakkani, Mostafa F. (57205123273); Hussein, Hazem L. (57402916200); Al-Shelkamy, Samah A. (57210421025); Meligy, Fatma Y. (55043152000); Khames, Ali (57193826810); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85122446537&doi=10.3390%2Fpharmaceutics14010111&partnerID=40&md5=8198086e6dfdd6d778b03b4d805162e2\",\r\n \"affiliations\": \"Faculty of Pharmacy, Sohag, Egypt; Department of Medical Microbiology and Immunology, Faculty of Medicine, Asyut, Egypt; Faculty of Medicine, Asyut, Egypt; Department of Industrial Pharmacy, Faculty of Pharmacy, Asyut, Egypt; Department of Chemistry, Taibah University, Medina, Saudi Arabia; Faculty of Science, Sohag, Egypt; Department of Chemistry, Faculty of Science, Cairo, Egypt; Department of Chemistry, Faculty of Science, Kharga, Egypt; Department of Dermatology, Al-Azhar University, Cairo, Egypt; Department of Physics, Faculty of Science, Kharga, Egypt; Department of Histology, Faculty of Medicine, Asyut, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sohag, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Skin is the largest mechanical barrier against invading pathogens. Following skin injury, the healing process immediately starts to regenerate the damaged tissues and to avoid complications that usually include colonization by pathogenic bacteria, leading to fever and sepsis, which further impairs and complicates the healing process. So, there is an urgent need to develop a novel pharmaceutical material that promotes the healing of infected wounds. The present work aimed to prepare and evaluate the efficacy of novel azithromycin-loaded zinc oxide nanoparticles (AZM-ZnONPs) in the treatment of infected wounds. The Box\u2013Behnken design and response surface methodology were used to evaluate loading efficiency and release characteristics of the prepared NPs. The minimum inhibitory concentration (MIC) of the formulations was determined against Staphylococcus aureus and Escherichia coli. Moreover, the anti-bacterial and wound-healing activities of the AZM-loaded ZnONPs impregnated into hydroxyl propyl methylcellulose (HPMC) gel were evaluated in an excisional wound model in rats. The prepared ZnONPs were loaded with AZM by adsorption. The prepared ZnONPs were fully characterized by XRD, EDAX, SEM, TEM, and FT-IR analysis. Particle size distribution for the prepared ZnO and AZM-ZnONPs were determined and found to be 34 and 39 nm, respectively. The mechanism by which AZM adsorbed on the surface of ZnONPs was the best fit by the Freundlich model with a maximum load capacity of 160.4 mg\/g. Anti-microbial studies showed that AZM-ZnONPs were more effective than other controls. Using an experimental infection model in rats, AZM-ZnONPs impregnated into HPMC gel enhanced bacterial clearance and epidermal regeneration, and stimulated tissue formation. In conclusion, AZM-loaded ZnONPs are a promising platform for effective and rapid healing of infected wounds. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Azithromycin\",\r\n \" Metal nanoparticles\",\r\n \" Wound healing\",\r\n \" Zinc oxide nanoparticles\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 112,\r\n \"title\": \"Mohamed, Samira Mahmoud (57263883500); Mohammed, Doha Saber (37026811800); Abd Elhaliem, Nesreen Gamal (55734409700); Elbadry, Mahmoud I. (56814732100); Abu-Dief, E. E. (8927490800)\",\r\n \"authors\": \"Mangosteen Can Improve Steatohepatitis through Modulating Inflammatory and Autophagy\/Apoptosis Cell Injury: An Animal Model Study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85115168729&doi=10.3103%2FS0095452721050091&partnerID=40&md5=ea15ef8c81444a4a2e12418e087014ea\",\r\n \"affiliations\": \"Department of Histology, Faculty of Medicine, Sohag, Egypt; Department of Internal Medicine, Faculty of Medicine, Sohag, Egypt; Department of Histology, Faculty of Medicine, Sohag, Egypt\",\r\n \"abstract\": \"Abstract-Background:: Non-alcoholic fatty liver disease (NAFLD) is characterized by triglycerides deposition in hepatocytes causing their injury and leading to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Mangosteen (MG) is a tropical fruit that contains a lot of bioactive anti-oxidant, and anti-adipogenic compounds. Aim: To investigate the ability of MG to ameliorate NAFLD\/NASH and its role in the regulation of apoptosis and autophagy within the injured hepatocytes. Materials and Methods: A total number of 50 adult male mice were divided into 5 groups: GI were fed with standard diet, GII were fed with high fat diet (HFD), GIII were fed with HFD concomitant with MG by oral gavage for 16 weeks, GIV were fed with HFD for 16 weeks followed by MG for 2 weeks, and GV were fed with HFD for 16 weeks followed by standard diet (SD) for 2 weeks. Results: MG reduced body weight gain, liver weight coefficient, and plasma free fatty acids levels. There was a decrease in lipid accumulation with improved liver function. Most of the histopathological changes observed in NASH were ameliorated. Immunohistochemical results showed that MG increased autophagy process and suppressed hepatocyte apoptosis. There was a significant decrease in CD68 positive macrophages and a significant decrease in \u03b1-SMA expression. Conclusions: MG exerts effects by regulating hepatic lipid homeostasis, inflammation, apoptosis, and autophagy. Therefore, it could be a new approach to a dietary based method that suspends the onset and development of steatohepatitis, liver cirrhosis and HCC risk by the prevention and management of NAFLD\/\/NASH. \u00a9 2021 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"apoptosis\",\r\n \" autophagy\",\r\n \" mangosteen\",\r\n \" non-alcoholic fatty liver disease\",\r\n \" steatohepatitis\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 113,\r\n \"title\": \"Ahmed, Hala Rady (57222980979); Waly, Nancy Gamil Fawzy M. (57212513648); Abd El-Baky, Rehab Mahmoud (30067553600); Yahia, Ramadan (57216081885); Hetta, Helal F. (55939372100); Elsayed, Amr M. (57213973155); Ibrahem, Reham Ali (57214752474)\",\r\n \"authors\": \"Distribution of naturally -occurring NS5B resistance-associated substitutions in Egyptian patients with chronic Hepatitis C\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85104346974&doi=10.1371%2Fjournal.pone.0249770&partnerID=40&md5=fdc3696bb9445e91353ab9dcd326e3cc\",\r\n \"affiliations\": \"Department of Microbiology and Immunology, Faculty of Pharmacy, Minya, Egypt; Department of Microbiology and Immunology, Deraya University, New Minia, Egypt; Department of Medical Microbiology and Immunology, Faculty of Medicine, Asyut, Egypt; Department of Medical Microbiology and Immunology, Faculty of Medicine, Sohag, Egypt; Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Minya, Egypt\",\r\n \"abstract\": \"Background NS5B polymerase inhibitors represent the cornerstone of the present treatment of Hepatitis C virus infection (HCV). Naturally occurring substitution mutations to NS5B inhibitors have been recorded. The current study intended to demonstrate possible natural direct acting antiviral (DAA)\u2014mutations of the HCV NS5B region in HCV patients in Minia governorate, Egypt. Methods Samples were collected from 27 treatment-na\u00efve HCV patients and 8 non-responders. Out of 27 treatment-na\u00efve patients, 17 NS5B sequences (amino acids 221\u2013345) from treatment-na\u00efve patients and one sample of non-responders were successfully amplified. Nucleotide sequences have been aligned, translated into amino acids, and compared to drug resistance mutations reported in the literature. Results NS5B amino acid sequence analysis ensures several novel NS5B mutations existence (more than 40 substitution mutations) that have not been previously documented to be correlated with a resistant phenotype. It was found that K304R (82.4%), E327D and P300T (76.5% each) substitutions were the most distributed in the tested samples, respectively. S282T, the major resistance mutation that induces high sofosbuvir-resistance level in addition to other reported mutations (L320F\/C) and (C316Y\/N) were not recognized. Q309R mutation is a ribavirin-associated resistance, which was recognized in one strain (5.9%) of genotype 1g sequences. Besides, one substitution mutation (E237G) was identified in the successfully amplified non-responder sample. Conclusion Our study showed various combinations of mutations in the analyzed NS5B genes which could enhance the possibility of therapy failure in patients administered regimens including multiple DAA. \u00a9 2021 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n }\r\n]\r\n \r\n \/\/alert(publications.length)\r\n displayPublications(publications);\r\n updateResultsCount(publications.length);\r\n populateFilters();\r\n\r\n \/\/ Add event listeners\r\n document.getElementById('searchButton').addEventListener('click', performSearch);\r\n document.getElementById('searchInput').addEventListener('keyup', function (event) {\r\n if (event.key === 'Enter') {\r\n performSearch();\r\n }\r\n });\r\n\r\n document.getElementById('authorFilter').addEventListener('change', performSearch);\r\n document.getElementById('keywordFilter').addEventListener('change', performSearch);\r\n document.getElementById('yearFilter').addEventListener('change', performSearch);\r\n \/\/ Initialize the page\r\n \r\n \r\n\r\n\r\n \r\n\r\n \r\n\r\n \/\/ Display publications in the UI\r\n function displayPublications(publications) {\r\n const publicationsList = document.getElementById('publicationsList');\r\n publicationsList.innerHTML = '';\r\n\r\n if (publications.length === 0) {\r\n publicationsList.innerHTML = '<div class=\"no-results\">No publications found matching your criteria.<\/div>';\r\n return;\r\n }\r\n\r\n publications.forEach(pub => {\r\n const pubElement = document.createElement('div');\r\n pubElement.className = 'publication-card';\r\n\r\n pubElement.innerHTML = `\r\n <h2 class=\"publication-title\">${pub.authors}<\/h2>\r\n <p class=\"authors\">${pub.title}<\/p>\r\n <p class=\"affiliations\">${pub.affiliations}<\/p>\r\n <p class=\"abstract\">${truncateText(pub.abstract, 500)}<\/p>\r\n <div class=\"keywords\">\r\n ${pub.keywords.map(keyword => `<span class=\"keyword\">${keyword}<\/span>`).join('')}\r\n <\/div>\r\n <a 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\n\t\t\t\t\t\r\n\r\n\r\n\r\n\r\n \r\n \r\n \r\n Struggling Student System<\/title>\r\n <link rel=\"stylesheet\" href=\"\/lib\/bootstrap\/dist\/css\/bootstrap.min.css\" \/>\r\n <link rel=\"stylesheet\" href=\"\/css\/site.css?v=AKvNjO3dCPPS0eSU1Ez8T2wI280i08yGycV9ndytL-c\" \/>\r\n <link rel=\"stylesheet\" href=\"\/Informative_Exam_System.styles.css?v=BGdvP_FBOWiMWg-g4mzfuCD-pFWud7Q8bDVVE6HC9zc\" \/>\r\n <link rel=\"icon\" type=\"image\/png\" href=\"\/images\/MertLog12.png\" sizes=\"16x16\" style=\"border:1px;border-radius:50%\">\r\n <link href=\"\/css\/all.min.css\" rel=\"stylesheet\" \/>\r\n\r\n <link href=\"\/datatable\/datatables.min.css\" rel=\"stylesheet\" \/>\r\n\r\n <style>\r\n\r\n .ac {\r\n text-decoration: none;\r\n transition: 0.4s;\r\n border-radius: 5px;\r\n }\r\n\r\n \/* .ac:hover {\r\n box-shadow: 0 4px 8px 0 rgba(0, 0, 0, 0.2);\r\n background: maroon;\r\n } *\/\r\n .act {\r\n box-shadow: 0 4px 8px 0 rgba(0, 0, 0, 0.2);\r\n background-color: #1e81b0;\r\n color: white 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content=\"width=device-width, initial-scale=1.0\">\r\n <title>Research Publications Database<\/title>\r\n <style>\r\n * {\r\n box-sizing: border-box;\r\n margin: 0;\r\n padding: 0;\r\n font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif;\r\n }\r\n \r\n body {\r\n background-color: #f5f7fa;\r\n color: #333;\r\n line-height: 1.6;\r\n }\r\n \r\n .container {\r\n max-width: 1200px;\r\n margin: 0 auto;\r\n padding: 20px;\r\n }\r\n \r\n \r\n \r\n h1 {\r\n font-size: 2.5rem;\r\n margin-bottom: 10px;\r\n }\r\n \r\n .subtitle {\r\n font-size: 1.2rem;\r\n opacity: 0.9;\r\n }\r\n \r\n .search-section {\r\n background-color: white;\r\n padding: 25px;\r\n border-radius: 8px;\r\n box-shadow: 0 4px 8px rgba(0, 0, 0, 0.05);\r\n margin-bottom: 30px;\r\n }\r\n \r\n .search-box {\r\n display: flex;\r\n gap: 15px;\r\n margin-bottom: 20px;\r\n }\r\n \r\n input[type=\"text\"] {\r\n flex: 1;\r\n padding: 12px 15px;\r\n border: 1px solid #ddd;\r\n border-radius: 4px;\r\n font-size: 1rem;\r\n 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.publication-card {\r\n background-color: white;\r\n border-radius: 8px;\r\n padding: 25px;\r\n margin-bottom: 20px;\r\n box-shadow: 0 4px 8px rgba(0, 0, 0, 0.05);\r\n transition: transform 0.3s, box-shadow 0.3s;\r\n }\r\n \r\n .publication-card:hover {\r\n transform: translateY(-5px);\r\n box-shadow: 0 8px 16px rgba(0, 0, 0, 0.1);\r\n }\r\n \r\n .publication-title {\r\n font-size: 1.4rem;\r\n color: #A90506;\r\n margin-bottom: 10px;\r\n line-height: 1.4;\r\n }\r\n \r\n .authors {\r\n color: #2c3e50;\r\n margin-bottom: 15px;\r\n font-style: italic;\r\n }\r\n \r\n .abstract {\r\n margin-bottom: 15px;\r\n line-height: 1.6;\r\n color: #555;\r\n }\r\n \r\n .keywords {\r\n margin-bottom: 15px;\r\n }\r\n \r\n .keyword {\r\n display: inline-block;\r\n background-color: #A90506;\r\n color: white;\r\n padding: 5px 10px;\r\n border-radius: 20px;\r\n font-size: 0.85rem;\r\n margin-right: 8px;\r\n margin-bottom: 8px;\r\n }\r\n \r\n .details-link {\r\n display: inline-block;\r\n background-color: #A90506;\r\n color: white;\r\n padding: 8px 15px;\r\n border-radius: 4px;\r\n text-decoration: none;\r\n font-weight: 600;\r\n transition: background-color 0.3s;\r\n }\r\n \r\n .details-link:hover {\r\n background-color: #A90506;\r\n }\r\n \r\n .affiliations {\r\n font-size: 0.9rem;\r\n color: #777;\r\n margin-bottom: 15px;\r\n }\r\n \r\n .no-results {\r\n text-align: center;\r\n padding: 40px;\r\n color: #777;\r\n font-size: 1.2rem;\r\n }\r\n \r\n footer {\r\n text-align: center;\r\n margin-top: 40px;\r\n padding: 20px;\r\n color: #777;\r\n font-size: 0.9rem;\r\n border-top: 1px solid #eee;\r\n }\r\n \r\n @media (max-width: 768px) {\r\n .search-box {\r\n flex-direction: column;\r\n }\r\n \r\n .filters {\r\n flex-direction: column;\r\n }\r\n \r\n .publication-title {\r\n font-size: 1.2rem;\r\n }\r\n }\r\n <\/style>\r\n<\/head>\r\n<body data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1 data-rsssl=1>\r\n <div class=\"container\">\r\n <header>\r\n <h1 style=\"margin-top:25px\">Merit University - Scopus Indexed Publications<\/h1>\r\n \r\n <\/header>\r\n \r\n <section class=\"search-section\">\r\n <div class=\"search-box\">\r\n <input type=\"text\" id=\"searchInput\" placeholder=\"Search publications by title, author, keywords, or abstract...\">\r\n <button id=\"searchButton\">Search<\/button>\r\n <\/div>\r\n \r\n <div class=\"filters\">\r\n <div class=\"filter-group\">\r\n <label for=\"authorFilter\">Filter by Author<\/label>\r\n <select id=\"authorFilter\">\r\n <option value=\"\" style=\"height:3.25em\">All Authors<\/option>\r\n <\/select>\r\n <\/div>\r\n \r\n <div class=\"filter-group\">\r\n <label for=\"keywordFilter\">Filter by Keyword<\/label>\r\n <select id=\"keywordFilter\">\r\n <option value=\"\" style=\"height:3.25em\">All Keywords<\/option>\r\n <\/select>\r\n <\/div>\r\n \r\n <div class=\"filter-group\">\r\n <label for=\"yearFilter\" >Filter by Year<\/label>\r\n <select id=\"yearFilter\" >\r\n <option value=\"\" style=\"height:3.25em\">All Years<\/option>\r\n <option value=\"2025\">2025<\/option>\r\n <option value=\"2024\">2024<\/option>\r\n \r\n <\/select>\r\n <\/div>\r\n <\/div>\r\n \r\n <div class=\"results-info\">\r\n Showing <span id=\"resultsCount\">1<\/span> publications\r\n <\/div>\r\n <\/section>\r\n \r\n <section id=\"publicationsList\">\r\n \r\n <\/section>\r\n \r\n <footer>\r\n <p>Research Publications Database © 2025 | Merit University<\/p>\r\n <\/footer>\r\n <\/div>\r\n\r\n\r\n \r\n\r\n<\/body>\r\n<\/html>\r\n\r\n <\/main>\r\n <\/div>\r\n\r\n \r\n\r\n \r\n \r\n <script>\r\n \/\/ Sample data - in a real application, this would come from a database\r\n\r\n\r\n const publications = [\r\n {\r\n \"id\": 1,\r\n \"title\": \"Ashour, Marwa M.N. (60165514700); Abd-Eldayem, Ahmed Mohammed (57195596545); El-Shoura, Ehab A.M. (57203193884); Messiha, Basim Anwar Shehata (56431085800); Sharkawi, Souty Mouner Zaky (57202833715)\",\r\n \"authors\": \"Nicardipine protects against gentamicin-induced nephrotoxicity: Potential involvement of IL-23R, NRF2, and Beclin-1 perturbation\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105020395373&doi=10.1016%2Fj.lfs.2025.124042&partnerID=40&md5=77c1f64e45ed468f9748ca6571d5a879\",\r\n \"affiliations\": \"Department of Pharmacology, Merit University, Sohag, Egypt; Department of Medical Pharmacology, Faculty of Medicine, Asyut, Egypt; Department of Basic Sciences, Fahad Bin Sultan University, Tabuk, Saudi Arabia; Department of Clinical Pharmacy, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni Suef, Egypt\",\r\n \"abstract\": \"Aims: Gentamicin (GNT) remains a cornerstone in the treatment of severe Gram-negative infections; however, its clinical utility is constrained by dose-limiting nephrotoxicity. Emerging evidence implicates nicardipine (NIC), a dihydropyridine calcium channel blocker, in renoprotection via mechanisms distinct from its canonical vascular effects. In this study, we delineate an unprecedented nephroprotective mechanism of NIC in the context of GNT-induced renal injury, with a particular focus on its capacity to modulate oxidative stress, inflammatory signaling, autophagic, and apoptotic pathways. Materials and methods: Experimental groups comprised control rats, GNT-treated rats, NIC-treated rats, and animals that received NIC + GNT. Renal function was rigorously evaluated through measuring serum creatinine and blood urea nitrogen (BUN), alongside a multidimensional analysis encompassing oxidative stress indices, inflammatory mediators, histopathological alterations, and expression profiles of apoptosis- and autophagy-associated proteins. Mechanistic interrogation centered on nuclear factor erythroid 2-related factor 2 (NRF2), a master regulator of antioxidant defense; interleukin-23 receptor (IL-23R), a pivotal mediator of proinflammatory signaling; and Beclin-1, a crucial autophagy-related factor underlying NIC's renoprotective action. Key findings: Co-administration of NIC markedly ameliorated GNT-induced renal injury, as reflected by improved biochemical indices of kidney function, preservation of renal histoarchitecture, attenuation of caspase-3-mediated apoptosis, upregulation of NRF2-driven antioxidant responses, suppression of IL-23R\u2013dependent inflammatory signaling, and modulation of Beclin-1\u2013associated autophagic activity. Significance: These findings delineate a novel mechanistic axis by which NIC exerts coordinated antioxidant, anti-inflammatory, autophagic, and anti-apoptotic effects. This multifactorial cytoprotection highlights NIC's therapeutic potential for targeted intervention in aminoglycoside-induced nephrotoxicity. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Gentamicin\",\r\n \" IL-23R\",\r\n \" Inflammation\",\r\n \" Nephrotoxicity\",\r\n \" Nicardipine\",\r\n \" Oxidative stress\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 2,\r\n \"title\": \"Badawy, Mohamed A.S. (60081641500); Abdel-Aziz, Mohamed A. (57200642898); Abdel-Rahman, Hamdy M. (8783095600); Ali, Taha F.S. (56765352500)\",\r\n \"authors\": \"Targeting melanoma resistance: Novel oxindole and non-oxindole-based benzimidazole derivatives as potent dual inhibitors of BRAFV600E and ABL2 kinases\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105014804250&doi=10.1016%2Fj.ejmech.2025.118096&partnerID=40&md5=dc17a810259d997d1778ece1cb14d9c7\",\r\n \"affiliations\": \"Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutical Chemistry, School of Pharmacy, Asyut, Egypt\",\r\n \"abstract\": \"Melanoma is one of the deadliest forms of cancer. The disease is incurable for many due to its aggressive, metastatic characteristics and its elevated resistance. Herein, we design and synthesize two series of target compounds oxindole-based (7a-h) and non-oxindole-based (8a-h) benzimidazole. Selected compounds were evaluated against mutant BRAFV600E and ABL2 kinases upon evaluating for anti-tumor efficacy against a preliminary 60-tumor cell line panel at NCI, USA. The NCI selected six compounds (7c, 7d, 7g, 7h, 8b, and 8h) for evaluation at five doses. Compounds 8b and 8h exhibited the highest cytotoxic potency against SK-MEL-5 with IC<inf>50<\/inf> = 1.00 and 0.54 \u03bcM, respectively. Compounds 7c and 8h were the most potent to inhibit BRAFV600E with IC<inf>50<\/inf> = 0.072 and 0.088 \u03bcM, respectively. While compounds 7c and 8b showed the most potent inhibitory activity against ABL2 kinases (IC<inf>50<\/inf> = 0.143 and 0.236 \u03bcM, respectively). Compound 8h diminished P-glycoprotein expression by 0.2732. Molecular docking findings showed that compound 8b exhibits the highest binding affinity for the ABL2 kinase enzyme. Cytotoxicity assays in resistant melanoma cells showed IC<inf>50<\/inf> values of 12.3 \u03bcM (A375) and 20.1 \u03bcM (A375-R), demonstrating potency comparable to vemurafenib. Western blot analysis showed that 8h effectively inhibited p-CrkL (Abl2 signaling) and p-ERK1\/2 (BRAFV600E pathway) in A375-R melanoma cells. Compounds 8h, 7c, and 8b demonstrated the highest binding affinities for BRAFV600E. Compound 8h causes cell cycle arrest at the G1 phase, inhibiting progression to the S phase and subsequent phases (28.55 % compared to 39.02 %) and G2\/M phase (13.33 % compared to 16.35 %). Furthermore, the apoptotic efficacy of 8h demonstrated a significant increase in the percentage of late apoptotic cells, reaching 13.89 % in treated cells, in contrast to 0.15 % in untreated cells. In Silico ADME profiling indicated that the proposed compounds are suitable drug candidates. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"ABL2\",\r\n \" ADME\",\r\n \" Anticancer\",\r\n \" Benzimidazoles\",\r\n \" BRAFV600E\",\r\n \" Melanoma\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 3,\r\n \"title\": \"Abo-Zeid, Mohamed Gamal (58866318400); Elrosasy, Amr M. (58299324200); Alkousheh, Hazim (59373757700); Mohamed, Rashad G. (58959162200); AlEdani, Esraa M. (58691452900); Zabady, Ahmed Hamdy (59394731500); Alhammad, Norah S. (59675119700); Alhussainy, Nabeel Hussain (56558795600); Yousef, Hanaa Sayed Suliman (59674353200)\",\r\n \"authors\": \"A comprehensive evaluation of Naftifine's efficacy and safety in treating dermatophyte infections; systematic review and meta-analysis\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-86000309422&doi=10.1007%2Fs00403-025-04044-x&partnerID=40&md5=b3402bf145b5e89a82f531c507c4c3e9\",\r\n \"affiliations\": \"Faculty of Medicine, Tanta, Egypt; Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Hashemite University, Zarqa, Jordan; Mansoura Manchester Program for Medical Education, Faculty of Medicine, Mansoura, Egypt; University of Basrah, Basra, Iraq; Department of Microbiology, Faculty of Science, Damanhour, Egypt; Department of Dermatology, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia; Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Clinical Pharmacy & Pharmacy practice, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Dermatophyte infections, including tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch), are widespread fungal infections that significantly impact global health and quality of life. Naftifine, an allylamine antifungal agent, is noted for its potent fungicidal activity, targeting fungal cell membranes by inhibiting squalene epoxidase. Additionally, Naftifine has anti-inflammatory and antibacterial properties, enhancing its therapeutic potential. This systematic review and meta-analysis aims to comprehensively evaluate the efficacy and safety of Naftifine in treating tinea pedis, tinea corporis, and tinea cruris, focusing on clinical outcomes, cure rates, and adverse effects to provide a thorough understanding of its effectiveness in managing these infections. This meta-analysis followed the PRISMA guidelines and included randomized controlled trials (RCTs) assessing naftifine's efficacy and safety in treating tinea pedis, corporis, and cruris. A systematic search was conducted in major databases from inception until February 9th, 2024. Eligible studies were selected based on predefined inclusion criteria, and data were extracted and analyzed using RevMan software. Seven multicenter RCTs were included in the meta-analysis. Naftifine demonstrated superior efficacy compared to vehicle control in terms of complete cure rate (RR = 5.83, 95% CI [3.73 to 9.10]) with no significant heterogeneity (I2 = 0%), clinical improvement [RR = 1.55, 95% CI (1.21\u20132.00)], and treatment effectiveness [RR = 3.93, 95% CI (2.44\u20136.33)] for tinea pedis. Similarly, for tinea corporis and cruris, Naftifine demonstrated significant efficacy compared to vehicle control regarding complete cure rate, mycological cure rate, clinical improvement, and treatment effectiveness. However, there was no significant difference in adverse events between Naftifine and the vehicle across all three conditions. Naftifine is an effective topical treatment for tinea pedis, corporis, and cruris, with a favorable safety profile with no significant difference in adverse events compared to the vehicle. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Dermatophytes\",\r\n \" Naftifine\",\r\n \" Tinea corporis\",\r\n \" Tinea cruris\",\r\n \" Tinea pedis\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 4,\r\n \"title\": \"El-Masry, Yassin M. (57966931700); Zaghloul, T. I. (6602904235)\",\r\n \"authors\": \"Recombinant Bacillus subtilis-derived alkaline protease: a novel agent for skin depigmentation and hair follicle neogenesis\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85214437660&doi=10.1007%2Fs00403-024-03744-0&partnerID=40&md5=ee1745dabfda6afe3a2a5d2f7467c310\",\r\n \"affiliations\": \"Department of Medical Biochemistry, Merit University, Sohag, Egypt; Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria, Egypt\",\r\n \"abstract\": \"[No abstract available]\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 5,\r\n \"title\": \"Ahmed, Mohamed Abdelmoaty (60054729200); AbdelMoety, Ahmed (57214272287); Soliman, Asmaa Mohamed Ahmed (54780550200)\",\r\n \"authors\": \"Predicting cancer risk using machine learning on lifestyle and genetic data\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105013670024&doi=10.1038%2Fs41598-025-15656-8&partnerID=40&md5=9ba0fa0e98d3656f6c878713787f5501\",\r\n \"affiliations\": \"Faculty of Medicine, Merit University, Sohag, Egypt; Faculty of Engineering, Qena, Egypt; Department of Public Health and Community Medicine, Faculty of Medicine, Asyut, Egypt\",\r\n \"abstract\": \"Cancer remains one of the leading causes of mortality worldwide, where early detection significantly improves patient outcomes and reduces treatment burden. This study investigates the application of Machine Learning (ML) techniques to predict cancer risk based on a combination of genetic and lifestyle factors. A structured dataset of 1,200 patient records was used, comprising features such as age, gender, Body Mass Index (BMI), smoking status, alcohol intake, physical activity, genetic risk level, and personal history of cancer. A full end-to-end ML pipeline was implemented, encompassing data exploration, preprocessing, feature scaling, model training, and evaluation using stratified cross-validation and a separate test set. Nine supervised learning algorithms were evaluated and compared, including Logistic Regression (LR), Decision Tree (DT), Random Forest (RF), Support Vector Machines (SVMs), and several ensemble methods. Among these, Categorical Boosting (CatBoost) achieved the highest predictive performance, with a test accuracy of 98.75% and an F1-score of 0.9820, outperforming both traditional and other advanced models. Feature importance analysis confirmed the strong influence of cancer history, genetic risk, and smoking status on prediction outcomes. The findings highlight the effectiveness of boosting-based ensemble models in capturing complex interactions within health data and support their potential use in personalized cancer risk assessment. This research underscores the value of integrating genetic and modifiable lifestyle variables into predictive modeling to enhance early detection and preventive healthcare strategies. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Cancer prediction\",\r\n \" Genetic risk\",\r\n \" Lifestyle factors\",\r\n \" Machine learning\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 6,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Hussain, Abdulzahra Abdulsamad (16417168400); Aiolfi, Alberto (6508362055); Lled\u00f3, Jos\u00e9 Bueno (24462324800); Chiaretti, Massimo (6603417473); Kryvoruchko, Igor A. (59374914600); Kermansaravi, Mohammad (57192913150); Nimeri, Abdelrahman A. (12795619600); Elias, Abd Al Kareem (57349114100); Ahmed, Saad Mohamed Ali (59781389000); Awad, Esmail Tharwat Kamel (57338443100); Ali, Mohamed A. (57693482500); Khyrallh, Ahmed (57199997926); Alsayed, Mohammed H. (57932903000); Labib, Mohamed Fathy (57221263028); Teama, Sobhy Rezk Ahmed (58023821600); Seleem, Abdelhafez (57657407600); Elshafey, Mohammed Hassan (57212769328); Mostafa, Mostafa Mahmoud Salama (58838861600); Elbelkasi, Hamdi (58744062800); Zaid, Mahmoud Ali Abou (59781038500); Hamdy, Ahmed (57528237700); Abo Alsaad, Mohamed Ibrahim (58743979200); Youssef, Maged Z. (60004133100); Ali, Rasha Mohamed Motawea (60004778200); Shamy, Ibtsam Abdel Maksoud Mohamed El (59781612100); Arafa, Ahmed Salah (57209472931); Heggy, Ibrahim A. (59018529000); Naguib, Sameh Mohamed (57204030809); Wasefy, Tamer (57748757500); Abozaid, Mohamed Mehriz Naguib (57720672400); Elshahidy, Tamer Mohamed Mahmoud (57219158772); Mostafa, Abdelshafy (58744089300); Elnemr, Mohamed M. (57219125086); Nawar, Abdelrahman Mohamed Hasanin (59781844900); Khairy, Mostafa Mohamed (57816377300); Abdelaziz, Ahmed Mesbah (58894628000); Abdelwanis, Abdelfatah H. (58303777800); El Teliti, Ahmed M. (57203877548)\",\r\n \"authors\": \"Frailty predicts recurrence after laparoscopic Nissen fundoplication with mesh cruroplasty for giant sliding hiatal hernia with severe reflux esophagitis in elderly patients: a multicenter retrospective study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105011052336&doi=10.1007%2Fs10029-025-03416-6&partnerID=40&md5=644513a6324ef885f92734acdc7645cb\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; Department of General Surgery, Homerton University Hospital NHS Foundation Trust, London, United Kingdom; University of Alkafeel, Najaf, Iraq; Department of Biomedical Science for Health, Universit\u00e0 degli Studi di Milano, Milan, Italy; Hospital Universitari i Polit\u00e8cnic La Fe, Valencia, Spain; Department of General Surgery and Organ Transplantation, Sapienza Universit\u00e0 di Roma, Rome, Italy; Department of Surgery, Kharkiv National Medical University, Kharkiv, Ukraine; Department of Surgery, IUMS Minimally Invasive Surgery Research Center, Tehran, Iran; Department of Surgery, Harvard Medical School, Boston, United States; Department of General Surgery, Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Cairo, Egypt; Mataryia Teaching Hospital (GOTHI), Cairo, Egypt; General Surgery Department, El Mahala Hepatic Institute, Al Gharbia, Egypt; National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; General Surgery Department-Faculty of Medicine, Merit University, Sohag, Egypt; Department of General Surgery, Faculty of Medicine, 6th October, Egypt; Faculty of Medicine, Cairo, Egypt\",\r\n \"abstract\": \"Purpose: Giant sliding hiatal hernias (HH) are prevalent in the elderly population (EP) and often present with multiple comorbidities and a high surgical risk. Frailty has been increasingly recognized as a predictor of surgical outcomes in the EP. This study assessed the rate of recurrent sliding HH following mesh cruroplasty and laparoscopic Nissen fundoplication (LNF), and evaluated frailty as a potential risk factor of recurrence. Methods: This retrospective multicenter study included 266 patients aged \u2265 60 years who underwent mesh cruroplasty and LNF for giant sliding HH (> 5\u00a0cm) with severe reflux esophagitis (Demeester score > 100) between March 2016 and March 2022, stratified into non-recurrence (n = 241) and recurrence (n = 25) HH. Results: The mean age was 66.92 \u00b1 4.3 years vs. 67.79 \u00b1 3.7 years in the non-recurrence and recurrence group, respectively. Twenty-five (9.4%) patients developed recurrent HH, with a median size of 5.2\u00a0cm (4.1\u20136.0\u00a0cm), and the median time from surgery to recurrence was 16 months (13\u201320 months). Frailty was significantly correlated with recurrence, with moderately and severely frail patients demonstrating higher recurrence rates (44% vs. 17%, p = 0.02). Multivariate analysis confirmed that frailty was an independent predictor of recurrence (odds ratio [OR], 1.4; 95% CI, 1.003\u20131.982; p = 0.04). Time to recurrence included mild frailty (75% recurrence rate within 16 months), moderate frailty (90.9% recurrence within 12 months), and severe frailty (80% recurrence within 9 months). Conclusions: Frailty was an independent predictor of HH recurrence. Integrating frailty assessment into preoperative workflows could optimize patient selection and outcomes. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Elderly\",\r\n \" Frailty\",\r\n \" Gastroesophageal reflux disease\",\r\n \" Giant HH\",\r\n \" Mesh cruroplasty\",\r\n \" Nissen fundoplication\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 7,\r\n \"title\": \"Hendi, Nada Ibrahim (57956145200); AbuSammour, Yaser (59518440100); Khaled, Mohamed (59955541900); Mohamed, Ahmed S. (59955542000); Amin, Ahmed Mostafa (58353250400); Fallaha, Mohamed Saleh (59954964900); Kamel, Basma (59393146500); Helmy, Yehia Nabil Abdalla (59955106800); Hassan, Mohamed Ali Saeed (59955106900); Meshref, Mostafa Mahmoud (57222069701)\",\r\n \"authors\": \"Efficacy of transcranial direct current stimulation on seizure control in patients with refractory epilepsy: a systematic review and meta-analysis of randomized controlled trials\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105008696602&doi=10.1007%2Fs10143-025-03657-0&partnerID=40&md5=b667dfd6d4e9faa981b4f08e70ae4d22\",\r\n \"affiliations\": \"Faculty of Medicine, Ain Shams University, Cairo, Egypt; Faculty of Medicine, Al-Balqa Applied University, Salt, Jordan; Faculty of Medicine, Alexandria, Egypt; Faculty of Medicine, Merit University, Sohag, Egypt; Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Mansoura, Egypt; Zagazig University, Faculty of Medicine, Zagazig, Egypt; Faculty of Medicine, Cairo, Egypt; Supervisor of Epilepsy Units, Al-Azhar University Hospital, New Damietta, Egypt\",\r\n \"abstract\": \"Drug-resistant epilepsy is a challenging condition that affects around 30% of all patients with epilepsy. Evidence regarding treatment options is limited, especially for surgery and invasive techniques. However, non-invasive techniques constitute a promising alternative for these patients. This meta-analysis aims to evaluate the effectiveness of transcranial direct current stimulation on seizure frequency management in patients with drug-resistant epilepsy. We searched the literature in PubMed, Scopus, and Web of Science up to December 2023. We included randomized controlled trials that compared transcranial direct current stimulation with sham stimulation. Our main outcomes of interest were a percentage reduction in seizure frequency and epileptiform discharge frequency. A total of 10 studies with 269 patients were included. Monthly seizure frequency was significantly reduced by an average of -45.39%and -39.34% at week 4 and week 8, respectively. There was a significant reduction in IED in favor of tDCS at week 2 (SMD = -0.87, 95% CI = [\u2212 1.49, \u2212 0.25], P = 0.006), 4 weeks (SMD = -1.17, 95% CI = [\u2212 1.67, \u2212 0.66], P < 0.00001, Moderate quality of evidence) and 8 weeks (SMD = -1.11, 95% CI = [\u2212 1.69, \u2212 0.53], P = 0.0002) of follow-up. There were no serious adverse events associated with the stimulation. Transcranial direct current stimulation was associated with a reduction in both seizure frequency and epileptiform discharges with minimal side effects. Further studies with larger sample sizes and consensus protocol guidelines are needed to verify its long-term safety and effectiveness. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Drug-resistant epilepsy\",\r\n \" Non-invasive neurostimulation\",\r\n \" Seizure frequency\",\r\n \" tDCS\",\r\n \" Transcranial direct current stimulation\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 8,\r\n \"title\": \"Moghib, Khaled (58870319800); Altalab, Gergis (59907492700); Jader, Arwa (59328331500); Ghanm, Thoria Ibrahim Essa (59475851200); Hijazy, Mesan (59938241100); Tarawneh, Dana Y. (59937527300); Hannat, Ramish (59538277400); Salomon, Izere (59242048100); Edress, Ahmed Ibrahim (59937705900); Arafeh, Muhannad Wael Abu (59937706000); Uwishema, Olivier (57221675021); Limantoro, Joshua (58684568300); Luna, Antonio Medina (59936987200); Bozkurt, Ismail (56634449200)\",\r\n \"authors\": \"Comparison between spinal fusion vs. nonoperative treatment for lumbar degenerative pathology: a systematic review and meta-analysis\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105007747034&doi=10.1007%2Fs10143-025-03671-2&partnerID=40&md5=e34180d6768d4c1b9bddd3fb8fa968c7\",\r\n \"affiliations\": \"Faculty of Medicine, Cairo, Egypt; Medical Research Group of Egypt, Negida Academy, Arlington, United States; Faculty of Medicine, Merit University, Sohag, Egypt; Department of Neurosurgery, University of Kufa, Kufa, Iraq; Faculty of Medicine, Mansoura, Egypt; Al-Azhar University of Gaza, Gaza, Palestine; School of Medicine, Amman, Jordan; Services Institute of Medical Sciences Lahore, Lahore, Pakistan; University of Rwanda, Butare, Rwanda; Department of Neurosurgery, Tanta University, Tanta, Egypt; Hadassah Medical Center, Jerusalem, Palestine; Department of Research and Education, Oli Health Magazine Organization, Kigali, Rwanda; Faculty of Medicine, Universitas Udayana, Bali, Indonesia; Universidad de Monterrey, San Pedro Garza Garcia, Mexico; Department of Neurosurgery, Ankara Numune Hospital, Ankara, Turkey; Department of Neurosurgery, Y\u00fcksek \u0130htisas \u00dcniversitesi, Ankara, Turkey\",\r\n \"abstract\": \"Background: Lumbar fusion is widely used to treat chronic lumbar degenerative pathology; however, its effectiveness and safety compared with nonoperative management remain controversial. Objectives: This systematic review and meta-analysis aimed to evaluate and compare the effectiveness and safety of spinal fusion and conservative management in treating lumbar degenerative pathology. Method: A systematic review and meta-analysis were conducted following the PRISMA guidelines. The PubMed, Scopus, Cochrane Central, Web of Science, and Embase databases were searched in October 2024. Eligible studies included randomized controlled trials (RCTs) and observational studies reporting pain reduction and functional disability outcomes. The primary outcomes were changes in the Oswestry Disability Index (ODI) and Visual Analog Scale (VAS) scores for back and leg pain. Data were analyzed using a random-effects model in RevMan 5.4.1, with subgroup and sensitivity analyses performed to address heterogeneity. Results: Fourteen studies comprising 13 RCTs and one cohort study, involving 2,399 participants, were included. Spinal fusion showed significant improvements in ODI scores compared to conservative treatment (MD = -6.3; 95% CI [-12.02, -0.57]; p = 0.03), indicating reduced disability. VAS back pain scores also favored spinal fusion (MD = -3.02; 95% CI [-5, 1.04]; p = 0.003), with long-term outcomes showing consistent benefits (MD = -2.26; 95% CI [-3.16, 1.37]; p < 0.00001). However, spinal fusion did not significantly reduce leg pain compared to non-operative options (MD = -2.27; 95% CI [-8.37, 3.83]; p = 0.47). Conclusion: Spinal fusion offers statistically significant benefits in reducing disability and back pain compared with conservative treatments for lumbar degenerative pathology. However, it does not confer substantial advantages to leg pain and carries a high surgical risk. These findings emphasize the importance of individualized treatment selection based on patient characteristics and clinical indications. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Lumbar degenerative pathology\",\r\n \" Meta-analysis\",\r\n \" Non-operative management\",\r\n \" Oswestry disability index\",\r\n \" Spinal fusion\",\r\n \" Systematic review\",\r\n \" Visual analog scale\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 9,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Elias, Abd Al Kareem (57349114100); Adam, Abdelmonem A.M. (59693047600); Ali, Mohamed A. (57693482500); Ahmed, Saad Mohamed Ali (59781389000); Khyrallh, Ahmed (57199997926); Alsayed, Mohammed H. (57932903000); Awad, Esmail Tharwat Kamel (57338443100); Ibrahim, Emad A. (59781844800); Labib, Mohamed Fathy (57221263028); Teama, Sobhy Rezk Ahmed (58023821600); Badawy, Mahmoud Hassib Morsi (59781389100); Abo Alsaad, Mohamed Ibrahim (58743979200); Ali, Abouelatta Kh (59692860600); Elbelkasi, Hamdi (58744062800); Zaid, Mahmoud Ali Abou (59781038500); Shamy, Ibtsam Abdel Maksoud Mohamed El (59781612100); El-Houseiny, Boshra Ali (59781266900); Azawy, Mahmoud El (59781151100); Elhoofy, Ahmed (57203280920); Khedr, Ali Hussein (57953744900); Nawar, Abdelrahman Mohamed Hasanin (59781844900); Arafa, Ahmed Salah (57209472931); Abdelaziz, Ahmed Mesbah (58894628000); Abdelwanis, Abdelfatah H. (58303777800); Khairy, Mostafa Mohamed (57816377300); Yehia, Ahmed Mohamed (57210598249); Taher, Ahmed Kamal El (59781728100)\",\r\n \"authors\": \"Early readmission after adrenalectomy for pheochromocytoma. A retrospective study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105004457585&doi=10.1007%2Fs00423-025-03719-3&partnerID=40&md5=4baa336b0edf1dbc7768ba69ab1a87ec\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; Department of General Surgery, Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Cairo, Egypt; Merit University, Sohag, Egypt; Misr University for Science and Technology, 6th October, Egypt; Mataryia Teaching Hospital (GOTHI), Cairo, Egypt; General Surgery Department, El Mahala Hepatic Institute, Al Gharbia, Egypt; Faculty of Medicine, Cairo, Egypt; Department of Surgery, Faculty of Medicine, Helwan, Egypt; Ain Shams University, Cairo, Egypt\",\r\n \"abstract\": \"Purpose: Adrenalectomy for pheochromocytoma (PHEO) presents a significant challenge due to the high incidence of early hospital readmission (ER). This study evaluated the incidence and risk factors of ER for PHEO within 30 days of adrenalectomy. Methods: A retrospective analysis of 346 patients > 18 years with unilateral PHEO who underwent adrenalectomy between September 2012 and September 2024. The patients were categorised into ER (n = 49) and no ER (n = 297) groups. Logistic regression analyses were performed to predict risk factors for ER. Results: The most common causes of ER were postoperative maintained hypotension (42.9%), bleeding (6.1%), ileus (24.5%), wound infection (4.1%), hyperkalemia (8.2%), pneumonia (2%), intra-abdominal abscess (2%), acute MI (4.1%), and colonic injury (6.1%). Most postoperative complications were Clavien-Dindo grade II (n = 40, 81.6%). Two perioperative deaths (4%) occurred in the ER group. Logistic regression showed that low body mass index (OR 0.849, 95% CI, 0.748\u20130.964; p = 0.012), tumor size < 5\u00a0cm (OR 0.096, 95% CI, 0.030\u20130.310; p < 0.001), and low ASA (OR 0.435, 95% CI, 0.249\u20130.761; p = 0.003) were associated with risk reduction for ER while malignancy (OR 5.302, 95% CI, 1.214\u201323.164; p = 0.027), open approach(OR 12.247, 95% CI, 5.227\u201328.694; p < 0.001), and intraoperative complications (OR 19.149, 95% CI, 7.091\u201351.710; p < 0.001) were associated with risk increase of ER. Conclusion: Postoperatively maintained hypotension and ileus were the most common causes of ER. Low body mass index, tumour size < 5\u00a0cm, and low ASA were risk reductions for ER, while malignancy, open approach, and intraoperative complications were the independent risk increase factors. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Laparoscopic adrenalectomy\",\r\n \" Open adrenalectomy\",\r\n \" Pheochromocytoma\",\r\n \" Postoperative complications\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 10,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Chiaretti, Massimo (6603417473); Kryvoruchko, Igor A. (59374914600); Pesce, Antonio L. (54920280600); Kechagias, Aristotelis (22985131100); Elias, Abd Al Kareem (57349114100); Adam, Abdelmonem A.M. (59693047600); Ali, Mohamed A. (57693482500); Ali Ahmed, Saad Mohamed (59693227300); Khyrallh, Ahmed (57199997926); Alsayed, Mohammed H. (57932903000); Tharwat Kamel Awad, Esmail (59693406500); Elshafey, Mohammed Hassan (57212769328); Abo Alsaad, Mohamed Ibrahim (58743979200); Ali, Abouelatta Kh (59692860600); Elbelkasi, Hamdi (58744062800); Abou Zaid, Mahmoud Ali (59692860700); Youssef, Hoda A.A. (58465990500); Al-Zamek, Mona Mohammad Farid (59693774200); Fiad, Alaa A. (51863395700); Elshahidy, Tamer Mohamed Mahmoud (57219158772); Elballat, Mahmoud R. (59205549400); el-Taher, Ahmed Kamal (57221777128); Mohamed, Mohamed Mahmoud Mokhtar (57789094800); AboZeid, Ahmed Khaled (59205349300); Mansour, Mohamed Ibrahim (57219159269); Yassin, Mahmoud Abdou (57217355675); Arafa, Ahmed Salah (57209472931); Lotfy, Mohamed Ahmed (57221813392); Mousa, Bassam (57710406600); Atef, Baher (57437326000); Naguib, Sameh Mohamed (57204030809); Heggy, Ibrahim A. (59018529000); Elnemr, Mohamed M. (57219125086); Zaitoun, Mohamed Abdallah (57223230279); AbdAllah, Ehab Shehata (59693590100); Moussa, Mohamad S. (57208822751); Hamed, Abd Elwahab M. (58986714100); Elsayed, Rasha S. (58310525400)\",\r\n \"authors\": \"Mucosal advancement flap versus ligation of the inter-sphincteric fistula tract for management of trans-sphincteric perianal fistulas in the elderly: a retrospective study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105000028490&doi=10.1007%2Fs00384-025-04846-5&partnerID=40&md5=75d5faf0bbb9fca981eefb0a0d574f1a\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; Department of General Surgery and Organ Transplantation, Sapienza Universit\u00e0 di Roma, Rome, Italy; Department of Surgery No. 2, Kharkiv National Medical University, Kharkiv, Ukraine; Azienda Unit\u00e0 Sanitaria Locale di Ferrara, Ferrara, Italy; Department of Surgery, Athens General Hospital, Athens, Greece; Department of General Surgery, Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Cairo, Egypt; General Surgery Department, Merit University, Sohag, Egypt; Misr University for Science and Technology, 6th October, Egypt; Mataryia Teaching Hospital (GOTHI), Cairo, Egypt; General Surgery Department, El Mahala Hepatic Insistute, Tanta, Egypt; Faculty of Medicine, Cairo, Egypt\",\r\n \"abstract\": \"Purpose: There is no consensus on the standard approach for trans-sphincteric perianal fistulas (TPAF) in the elderly population. The most commonly used sphincter-saving procedures are ligation of the inter-sphincteric fistula tract (LIFT) and mucosal advancement flap (MAF). We aimed to evaluate the incidence and risk factors for recurrence and incontinence in elderly patients with TPAF using both approaches. Methods: This retrospective study included 257 patients who underwent LIFT (136 patients) or MAF (121 patients) for de novo and cryptoglandular TPAF between July 2018 and July 2021. Recurrent fistulas were clinically and radiologically detected using MRI. Postoperative incontinence was evaluated using the Wexner score and anorectal manometry. Logistic regression analysis was used to detect the risks of recurrence and incontinence. Results: The median ages of the patients were 68 (64, 74) and 68 (65, 74) years in the LIFT and MAF groups, respectively. Higher recurrence rates were observed after LIFT (17 (12.5%)) than after MAF (13 (10.7%)), but the difference was not statistically significant (P = 0.662). Postoperative incontinence was observed in 18 patients (13.2%) and seven patients (5.8%) in the LIFT and MAF groups, respectively (P = 0.044). The predictors for fistula recurrence were smoking (OR, 75.52; 95% CI, 1.02 to 5611.35; P = 0.049), length of tract (OR, 17.3; 95% CI, 1.49 to 201.13; P = 0.023), and CD classification (OR, 7.08; 95% CI, 1.51 to 33.14; P = 0.013). A low Charlson comorbidity index score (\u2264 5) (OR, 0.68; 95% CI, 0.47 to 0.99; P = 0.046) and high postoperative mean squeeze anal pressure (OR, 0.97; 95% CI, 0.95 to 0.99; P = 0.001) were significant factors associated with reduced risk of incontinence. In particular, LIFT was associated with a significantly higher risk of incontinence than MAF (OR, 2.089; 95% CI, 1.006 to 4.33; P = 0.04). Conclusions: The healing rates of MAF and LIFT procedures did not differ significantly; however, continence was significantly better after MAF. MAF should be added to the guidelines as a good option for the treatment of TPAF in elderly patients. Trial registration: The study was registered as a clinical trial www.clinicaltrials.gov (NCT06616662). \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Elderly\",\r\n \" Incontinence\",\r\n \" Ligation inter-sphincteric fistula surgery\",\r\n \" Mucosal advancement flap\",\r\n \" Observational study\",\r\n \" Recurrence\",\r\n \" Trans-sphincteric perianal fistula\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 11,\r\n \"title\": \"Yousef, Reda G. (57225078967); El-Metwally, Souad A. (36682085000); Al Ward, Maged Mohammed Saleh (57222123911); Alsfouk, Aisha A. (57208242449); Husein, Dalal Z. (55917450100); Soliman, Omar A. (57697503400); Elkaeed, Eslam B. (56884768800); Elkady, Hazem (57203864016); Metwaly, Ahmed M. (56153972200); Eissa, Ibrahim H. (57189457618)\",\r\n \"authors\": \"Discovery of new thieno[2,3-d]pyrimidine-based dual VEGFR-2 and EGFR inhibitors for enhanced therapeutic efficacy in breast cancer\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105004639860&doi=10.1016%2Fj.molstruc.2025.142586&partnerID=40&md5=e9044583a40ba4b557f498324b102aca\",\r\n \"affiliations\": \"Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Basic Sciences, Higher Technological Institute, Tenth of Ramadan City, Egypt; Department of Medicinal Chemistry, Al-Razi University, Sana'a, Yemen; Department of Pharmaceutical Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Department of Chemistry, Faculty of Science, Kharga, Egypt; Department of Clinical Pharmacy, Alexandria University, Alexandria, Egypt; Department of Human Genetics, Alexandria University, Alexandria, Egypt; Department of Pharmaceutical Sciences, Almaarefa University, Riyadh, Saudi Arabia; Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"A series of novel thieno[2,3-d]pyrimidine derivatives have been designed as dual inhibitors targeting VEGFR-2 and EGFR. The compounds were tested for in vitro cytotoxicity against human breast cancer (MDA-231, MCF-7), in addition to the non-carcinogenic lung fibroblast (WI-38), and epithelial (WISH) cell lines. Among the synthesized compounds, compound 14 demonstrated notable cytotoxicity with IC<inf>50<\/inf> values of 8.13 \u00b1 0.6 \u00b5M (MDA-231), 11.72 \u00b1 0.9 \u00b5M (MCF-7), and 53.66 \u00b1 3.1 \u00b5M (WI-38), comparable to sorafenib, a known anticancer agent. In addition, compound 14 showed potent inhibition of EGFR (IC<inf>50<\/inf> = 5.42 \u00b1 0.28 nM) and VEGFR-2 (IC<inf>50<\/inf> = 50.31 \u00b1 2.0 nM), suggesting its potential as a dual-target kinase inhibitor. The wound healing assay revealed that compound 14 inhibited cell migration in MDA-231 cells with a quantitative closure of 37.78% compared to the control (58.95%). Further analysis of cell death mechanisms indicated that compound 14 induced significant apoptosis in MDA-231 cells, with a marked increase in early (20.07%) and late (66.76%) apoptosis stages, alongside a decrease in viable cells (8.92%). Cell cycle analysis demonstrated a G1 phase arrest with a significant reduction in S-phase cells. Gene expression analysis revealed that compound 14 upregulated pro-apoptotic BAX (4.19 \u00b1 0.18) and downregulated anti-apoptotic Bcl-2 (0.44 \u00b1 0.04), leading to a high BAX\/Bcl-2 ratio (9.52 \u00b1 0.83). Moreover, caspase-8 and caspase-9 expression levels were significantly elevated, indicating the activation of intrinsic and extrinsic apoptotic pathways. Molecular docking and 200 ns dynamic simulations revealed stable binding of compound 14 to VEGFR-2 and EGFR, with docking scores surpassing those of sorafenib and comparable to erlotinib. Density Functional Theory (DFT) calculations highlighted the stability and reactivity of compound 14, while in silico ADMET analysis of the thieno[2,3-d]pyrimidines predicted favorable safety profiles, notably low risks of carcinogenicity and chronic toxicity. These findings suggest that thieno[2,3-d]pyrimidine derivatives, particularly compound 14, possess promising anticancer properties and warrant further investigation as potential therapeutic agents in cancer treatment. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Apoptosis\",\r\n \" Breast cancer\",\r\n \" Dual inhibitors\",\r\n \" EGFR\",\r\n \" MD simulations\",\r\n \" Thieno [2,3-d]pyrimidines\",\r\n \" VEGFR-2\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 12,\r\n \"title\": \"Badawy, Mohamed A.S. (60081641500); Br\u00e4se, Stefan J. (7005396290); Ali, Taha F.S. (56765352500); Abdel-Aziz, Mohamed A. (57200642898); Abdel-Rahman, Hamdy M. (8783095600)\",\r\n \"authors\": \"Biologically Active Benzimidazole Hybrids as Cancer Therapeutics: Recent Advances\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105020159742&doi=10.3390%2Fph18101454&partnerID=40&md5=c14cf11882bbc987c821caa490f80418\",\r\n \"affiliations\": \"Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruher Institut f\u00fcr Technologie, Karlsruhe, Germany; Karlsruher Institut f\u00fcr Technologie, Karlsruhe, Germany; Faculty of Pharmacy, Minya, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutical Chemistry, School of Pharmacy, Asyut, Egypt\",\r\n \"abstract\": \"Cancer is a highly significant medical concern, as it is the second most prevalent cause of mortality after cardiovascular diseases. It arises due to dysregulated cell cycle control, leading to a gradual decline in cellular differentiation and unrestricted cellular proliferation. Therefore, the primary objective for researchers is to develop a cancer treatment that addresses drug resistance while providing effective therapeutic benefits and minimizing side effects. Benzimidazole has garnered significant attention because it serves as an auxiliary isostere of nucleotides, which are found in several natural and biologically active molecules. Benzimidazole compounds possess a privileged pharmacophore that exhibits various pharmacological actions. Several benzimidazole derivatives exhibit dual or multiple anticancer properties through diverse mechanisms, focusing on specific compounds or employing strategies that are not gene specific. Furthermore, many drugs based on benzimidazole have previously been approved to treat cancer. This comprehensive review encompasses the most important reports on various benzimidazole hybrids, highlighting their anticancer significance, mechanism of action, and structure-activity relationships from 2005 up to 2025. These provide valuable knowledge for designing effective anticancer drugs. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"anticancer agents\",\r\n \" benzimidazole derivatives\",\r\n \" docking\",\r\n \" mechanisms of action\",\r\n \" structure\u2013activity relationship\",\r\n \" target proteins\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 13,\r\n \"title\": \"Moghib, Khaled (58870319800); Dawoud, Ali L.Abbas (59908104100); Altalab, Gergis (59907492700); Syed, Mohamed Salah (59907284400); Salomon, Izere (59242048100); Musse, Halima Abdirashid Y. (59907901900); Doubie, Ossama Ahmed Mohamed (59906883100); Elsekhary, Ahmed I. (59544159300); Al-Dalaeen, Raneem Awni (59907902000); Kandil, Gamal Eldin Hady (57192254385)\",\r\n \"authors\": \"Evaluating hyperbaric oxygen therapy as an adjunct to corticosteroids in sudden sensorineural hearing loss: a systematic review and meta-analysis\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105005805673&doi=10.1007%2Fs00405-025-09372-2&partnerID=40&md5=a7d6abac0489ddb13b2463e05822cb4e\",\r\n \"affiliations\": \"Faculty of Medicine, Cairo, Egypt; Medical Research Group of Egypt, Negida Academy, Arlington, United States; Faculty of Medicine, Al-Azhar University, Cairo, Egypt; Faculty of Medicine, Merit University, Sohag, Egypt; Faculty of Medicine, Ain Shams University, Cairo, Egypt; University of Rwanda, Butare, Rwanda; Faculty of Medicine, Cairo, Egypt; Zagazig University, Faculty of Medicine, Zagazig, Egypt; School of Medicine, Amman, Jordan; Department of Otorhinolaryngology, Cairo University, Giza, Egypt\",\r\n \"abstract\": \"Background: Sudden sensorineural hearing loss (SSNHL) is a medical emergency characterized by unexplained hearing loss, usually one-sided, of at least 30 dB across three or more contiguous frequencies within 72\u00a0h. This condition significantly impairs daily communication and has serious consequences for mental health, social relationships, and the overall quality of life. Hyperbaric oxygen therapy (HBOT) is being investigated as a potential adjuvant treatment for SSNHL alongside systemic steroids. Objectives: This systematic review and meta-analysis aimed to evaluate the efficacy of HBOT combined with systemic corticosteroids compared with corticosteroids alone in patients with SSNHL. Method: We searched PubMed, Cochrane, Scopus, Web of Science, and Google Scholar to identify 14 studies that matched our inclusion criteria of randomized controlled trials (RCTs) published in English, which evaluated HBOT alone or with corticosteroids in adults (\u2265 18 years) diagnosed with SSNHL based on the AAO-HNS criteria, reporting pure-tone audiometry (PTA)-based outcomes. The analysis included 794 participants and evaluated outcomes such as improvements in Pure Tone Audiometry (PTA) thresholds, rates of hearing recovery, and adverse events. Results: Results indicated that the combined therapy of HBOT and systemic corticosteroids significantly improved low-frequency hearing thresholds (SMD: 0.83, 95% CI: 0.66\u20131.00, p < 0.0001) and increased the odds of complete recovery (OR: 2.05, 95% CI: 1.41\u20132.98, p = 0.0002). However, significant heterogeneity (I\u00b2 = 96.7%) and variations in the treatment protocols were observed. Adverse events, including vertigo, have been reported but are generally mild. Conclusion: This meta-analysis suggests that combining systemic corticosteroids with HBOT may improve hearing recovery in ISSNHL, particularly at lower frequencies within the first three months. However, high heterogeneity and the lack of statistical significance in the random-effects model call for cautious interpretation. Well-designed RCTs with standardized protocols and clear patient selection criteria are needed to confirm these findings. Future research should focus on identifying subgroups most likely to benefit and optimizing treatment protocols. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Hyperbaric oxygen therapy\",\r\n \" Idiopathic sudden sensorineural hearing loss\",\r\n \" Sensorineural hearing loss\",\r\n \" Steroid therapy\",\r\n \" Sudden hearing loss\",\r\n \" Systemic corticosteroids\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 14,\r\n \"title\": \"Roshdi, Mostafa (60116218000); Mohamed, Mamdouh F.A. (57193728428); Beshr, Eman A.M. (36658017300); Aziz, Hossameldin A. (57209291308); Gebril, Sahar M. (57217824102); Br\u00e4se, Stefan J. (7005396290); Mohassab, Aliaa M. (57196023547)\",\r\n \"authors\": \"Design, Synthesis, In Silico Docking, Multitarget Bioevaluation and Molecular Dynamic Simulation of Novel Pyrazolo[3,4-d]Pyrimidinone Derivatives as Potential In Vitro and In Vivo Anti-Inflammatory Agents\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105017182700&doi=10.3390%2Fph18091326&partnerID=40&md5=7915fb4df8b2bb2e9a954c549933ba02\",\r\n \"affiliations\": \"Department of Medicinal Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Medicinal Chemistry, Merit University, Sohag, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kharga, Egypt; Department of Medicinal Chemistry, Minia National University, New Minia, Egypt; Department of Histology and Cell Biology, Faculty of Medicine, Sohag, Egypt; Institute of Biological and Chemical Systems, Karlsruher Institut f\u00fcr Technologie, Karlsruhe, Germany\",\r\n \"abstract\": \"Background: A novel series of pyrazolo[3,4-d]pyrimidinone derivatives were synthesized, characterized, and examined for their anti-inflammatory effects. Results: The findings indicated that compounds 5d, 5j, 5k, and 5m demonstrated significant anti-inflammatory effects through the selective inhibition of the COX-2 isozyme, with IC<inf>50<\/inf> values ranging from 0.27 to 2.34 \u03bcM, compared to celecoxib (IC<inf>50<\/inf> = 0.29 \u03bcM). Compound 5k emerged as the most potent, exhibiting a selectivity index (SI) of 95.8 for COX-2 relative to COX-1. In vivo tests additionally validated that compounds 5j and 5k demonstrated significant anti-inflammatory efficacy, exhibiting greater suppression percentages of generated paw edema than indomethacin, comparable to celecoxib, while preserving excellent safety profiles with intact gastric tissue. Mechanistic studies demonstrated that the anti-inflammatory efficacy of the target compounds was associated with a substantial decrease in serum levels of TNF-\u03b1 and IL-6. Moreover, molecular modeling investigations corroborated the in vitro findings. Compound 5k displayed a binding free energy \u0394G of \u221210.57 kcal\/mol, comparable to that of celecoxib, which showed a \u0394G of \u221210.19 kcal\/mol. The intensified binding contacts in the COX-2 isozyme indicated the augmented inhibitory efficacy of 5k. Conclusions: Compound 5k exhibited dual activity by inhibiting the COX-2 isozyme and suppressing the pro-inflammatory cytokines TNF-\u03b1 and IL-6, therefore providing a remarkable anti-inflammatory effect with increased therapeutic potential. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"anti-inflammatory\",\r\n \" COX-1\",\r\n \" COX-2\",\r\n \" IL-6\",\r\n \" pyrazolo[3,4-d]pyrimidine\",\r\n \" TNF-\u03b1\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 15,\r\n \"title\": \"Abdel-Hafez, Gehan A. (57411646000); Klopotowska, Dagmara (16637423800); Filip-Psurska, Beata (55504444900); Aboraia, Ahmed Safwat M. (11140453400); Wietrzyk, Joanna (7004261658); Aboul-Fadl, Tarek (6701571958); Youssef, Adel F. (7101875923)\",\r\n \"authors\": \"Hybrid nucleobase-heterocycle-2-oxindole scaffolds as innovative cell cycle modulators with potential anticancer activity\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105013751832&doi=10.1039%2Fd5ra04997k&partnerID=40&md5=617152363993bef444a163f0f3d0a766\",\r\n \"affiliations\": \"Department of Medicinal Chemistry, Merit University, Sohag, Egypt; Department of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences, Wroclaw, Poland; Department of Medicinal Chemistry, Faculty of Pharmacy, Asyut, Egypt\",\r\n \"abstract\": \"A series of hybrid molecules 6a-6d-13a-13d combining pyrazolo[3,4-d]pyrimidine or aminopurine frameworks with an oxindole moiety were designed as multitarget anticancer agents. Several compounds, especially 8b and 12a-12d, showed potent antiproliferative effects against three human cancer cell lines: A498 (kidney carcinoma), HepG-2 (hepatocellular carcinoma), and MDA-MB-231 (breast adenocarcinoma). Compounds 6b, 7b, 8b, and 12a-12c exhibited remarkable CDK6 inhibition (pIC<inf>50<\/inf> of up to 7.17), outperforming palbociclib, and VEGFR-2 inhibition comparable to sorafenib. These compounds also inhibited xanthine oxidase. Notably, 12a and 12c induced sub-G1 cell cycle arrest in HepG2 cells. Molecular modeling confirmed stable binding to CDK6 and VEGFR-2, while in silico ADMET profiling suggested favorable pharmacokinetics. These results support 8b and 12a-12c as strong leads for further multitarget cancer therapy development. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 16,\r\n \"title\": \"Ebied, Manal S. (55177240200); Korycka-Machala, Ma\u0142gorzata (6507875571); Shaldam, Moataz Ahmed (57189222976); Mohamed, Thabit Gamal (56512028900); Kawka, Malwina (57140427700); Dziadek, Bozena R. (6508131689); Kuzio\u0142a, Magdalena (6504171099); Atef Abdelsattar Ibrahim, Hoda (58854531900); Lei, Xinsheng (56223952500); Elshamy, Abdelsamed Ibrahim (57194089832); Dziadek, Jaroslaw (6603688174); Sabt, Ahmed (57202765042)\",\r\n \"authors\": \"Exploring antitubercular activity of new coumarin derivatives targeting enoyl acyl carrier protein reductase (InhA): Synthesis, biological evaluation and computational studies\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105000737827&doi=10.1016%2Fj.molstruc.2025.142074&partnerID=40&md5=e50c24f33b2ffada5997fba278120689\",\r\n \"affiliations\": \"Chemistry of Natural Compounds Department, National Research Centre, Giza, Egypt; Department of Chemistry, Northern Border University, Arar, Saudi Arabia; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish of Sciences, Lodz, Poland; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafr el-sheikh, Egypt; Department of Pharmacy, University of G. d'Annunzio Chieti and Pescara, Chieti, Italy; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Molecular Microbiology, University of Lodz, Lodz, Poland; Polish Academy of Sciences, Warsaw, Poland; Department of Pediatric Medicine, Faculty of Medicine, Cairo, Egypt; School of Pharmacy, Fudan University, Shanghai, China\",\r\n \"abstract\": \"Tuberculosis poses a significant global health challenge, resulting in substantial health, economic, and social issues worldwide. The development of new antitubercular agents is critically important and can be enhanced by targeting various druggable sites for inhibition. The enoyl acyl carrier protein reductase (InhA) enzyme plays a vital role in the survival of Mycobacterium tuberculosis. In this research, a variety of coumarin-derived thiazolidinone and thiazole derivatives were synthesized using a molecular hybridization approach, and their efficacy was subsequently assessed against the wild-type strain Mycobacterium tuberculosis H37Rv. Among the synthesized compounds, compound 5 exhibited the highest potency against wild-type M. tuberculosis, with a minimum inhibitory concentration (MIC) of 20 \u03bcg\/mL, while demonstrating low cytotoxicity towards mouse fibroblasts at concentrations twice that of the MIC. Furthermore, compound 5 significantly inhibited mycobacterial biofilm formation. This promising compound was also evaluated for its inhibitory effect on InhA, revealing potent activity with an IC<inf>50<\/inf> value of 0.191 \u00b5g, surpassing that of the reference drug triclosan. Molecular docking and dynamics simulations indicated that compound 5 exhibited strong in-silico binding, occupying the active site of InhA and interacting with the NAD+ molecule, while also demonstrating stable dynamics in relation to InhA. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Antitubercular\",\r\n \" Biological evaluation\",\r\n \" Coumarin derivatives\",\r\n \" InhA enzyme\",\r\n \" Molecular dynamics\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 17,\r\n \"title\": \"Abdel Hakiem, Ahmed F. (55372700500); Soliman, Aya M. (58672477400); Haredy, Ahmed M. (56895997900); Boushra, John M. (57381892800); Aboraia, Ahmed Safwat M. (11140453400)\",\r\n \"authors\": \"Ratiomeric Luminescent Monitoring of Cardiovascular Agents Exploiting Phosphorus and Nitrogen Co-Doped Carbon Quantum Dots as Nano-Sensors: Bioavailability Study in Rabbit Males\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105013232853&doi=10.1002%2Fbio.70243&partnerID=40&md5=0d49dd631de69af7b0c0c015da7a34a2\",\r\n \"affiliations\": \"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Qena, Egypt; Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Asyut, Egypt; School of Chemistry, UNSW Sydney, Sydney, Australia; Department of Pharmaceutical Chemistry, Nile Valley University, Fayoum, Egypt\",\r\n \"abstract\": \"Phosphorus and nitrogen co-doped carbon quantum dots (PNCQDs) were utilized as facile fluorescent probes for accurate monitoring of naftidrofuryl oxalate (NAFT) and rivaroxaban (RIVA). These luminescent templates have shown two emission ratiomeric bands at 335 and 444 nm upon excitation at 273 nm. Successive titration of the carbon dots with NAFT solution showed enhanced fluorescence at 335 nm band, leaving the other band unchanged, while by consecutive addition of RIVA increments to the PNCQDs\u2013NAFT complex, a fluorescence quenching occurred only to the same band. All measurements were performed in phosphate buffer; pH 7.40 (3.00 \u00d7 10\u22123 M) for \u2248 2 min reaction time. The method was validated according to the International Conference on Harmonization (ICH) guidelines with percentage relative standard deviation values (%RSD) not more than 2.90%. The studied analytes have shown excellent sensitivity with limits of quantitation (LOQ) of 1.50 \u00d7 10\u22123 and 3.00 \u00d7 10\u22123 \u03bcg\/mL for NAFT and RIVA, respectively, as well as outstanding selectivity towards a wide range of interfering species. Recovery percentages of 97.00\u201398.00 were obtained upon application to tablets and spiked plasma samples. The developed method was successfully employed in estimating the pharmacokinetics of both analytes in male rabbits. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"application to pharmaceuticals and spiked plasma samples\",\r\n \" carbon quantum dots\",\r\n \" naftidrofuryl oxalate and rivaroxaban\",\r\n \" pharmacokinetic study\",\r\n \" spectrofluorimetric determination\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 18,\r\n \"title\": \"Metwaly, Ahmed M. (56153972200); Elkady, Hazem (57203864016); Elgammal, Walid E. (57211620104); Yousef, Reda G. (57225078967); Husein, Dalal Z. (55917450100); Soliman, Omar A. (57697503400); Hagras, Mohamed (57194203232); Alsfouk, Bshra Ali A. (57208926635); Elkaeed, Eslam B. (56884768800); Eissa, Ibrahim H. (57189457618)\",\r\n \"authors\": \"Innovative Nicotinamide-Dihydrothiadiazole Compounds for Targeting VEGFR-2: Design, Synthesis, and Mechanistic Exploration in Breast Cancer Treatment\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105009774969&doi=10.1002%2Fslct.202501319&partnerID=40&md5=e0572197060a2f71616b5dbdb1f5f4b9\",\r\n \"affiliations\": \"Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Cairo, Egypt; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Faculty of Science, Cairo, Egypt; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Chemistry, Faculty of Science, Kharga, Egypt; Department of Clinical Pharmacy, Alexandria University, Alexandria, Egypt; Department of Human Genetics, Alexandria University, Alexandria, Egypt; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Department of Pharmaceutical Sciences, Almaarefa University, Riyadh, Saudi Arabia\",\r\n \"abstract\": \"In this study, a series of nicotinamide-dihydrothiadiazole hybrids were synthesized and evaluated for their anticancer potential through VEGFR-2 inhibition. Among the synthesized compounds, 7c demonstrated a very promising VEGFR-2 inhibitory activity (IC\u2085\u2080 = 0.098\u00a0\u00b1\u00a00.05\u00a0\u00b5M), comparable to the reference drug sorafenib (IC\u2085\u2080 = 0.1\u00a0\u00b1\u00a00.05\u00a0\u00b5M). In vitro cytotoxicity studies revealed that 7c exhibited significant anticancer activity against MDA-MB-231 (IC\u2085\u2080 = 6.92\u00a0\u00b1\u00a00.4\u00a0\u00b5M) and MCF-7 (IC\u2085\u2080 = 9.18\u00a0\u00b1\u00a00.7\u00a0\u00b5M) breast cancer cell lines, with minimal toxicity toward normal cells (WI-38 and WISH). Mechanistic studies indicated that 7c induces G0\/G1 phase arrest and apoptosis, as evidenced by increased late apoptotic populations (45.58%) and upregulation of caspase-3, Bax, and a significant reduction in Bcl-2. Computational analyses, encompassing molecular docking and 200\u00a0ns molecular dynamics (MD) simulations, demonstrated the stable interaction of 7c with VEGFR-2, highlighting its excellent binding affinity. Additionally, Swiss ADMET predictions highlighted the favorable pharmacokinetic and safety profiles of 7c, including non-mutagenic and noncarcinogenic properties, moderate absorption, and high plasma protein binding (>90%). These findings establish nicotinamid-dihydrothiadiazole hybrids, particularly 7c, as promising VEGFR-2 inhibitors with dual mechanisms of angiogenesis inhibition and apoptosis induction. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Breast cancer\",\r\n \" Dihydrothiadiazol\",\r\n \" MD simulation\",\r\n \" Nicotinamide\",\r\n \" VEGFR-2 inhibitors\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 19,\r\n \"title\": \"Tawfeek, Mohammed M.Mahdy (58506347900); Tohamy, Dalia M. (57212882341); Abdel Hamid Ahmed, Hanan M. (60133082200); Rashad, Mai Hamdy (59410526200); Nashaat Ali Rady, Ahmed M. (60132854900)\",\r\n \"authors\": \"Accelerated corneal cross-linking combined with topical voriconazole versus topical amphotericin B For the treatment of fungal keratitis with corneal melting\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105018186772&doi=10.4103%2Fejos.ejos_65_24&partnerID=40&md5=6ff878dac3ea9cfc08b77e58201547fa\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; Department of Ophthalmology, Assiut University, Asyut, Egypt; Department of Ophthalmology, The General Organization for Teaching Hospitals and Institutes, Cairo, Bab El Khalk, Egypt; Department of Microbiology, Suez University, Suez, Egypt; Department of Ophthalmology, Merit University, Sohag, Egypt; Department of Ophthalmology, Kazan Federal University, Cairo, Egypt\",\r\n \"abstract\": \"Objective This work aims to compare the safety and efficacy of accelerated corneal cross-linking (A-CXL) combined with topical voriconazole (VCZ) versus A-CXL combined with topical amphotericin B for the treatment of fungal keratitis (FK) with corneal melting. Patients and methods This is a retrospective comparative clinical cohort study. Total 40 eyes with clinically suspected and lab-confirmed FK with corneal melting were included. These eyes were classified randomly into two groups each of 20 eyes; group (A) was treated by repeated sessions of A-CXL plus topical VCZ and group (B) was treated by repeated sessions of A-CXL combined with topical amphotericin B. The end point of this study was complete corneal healing with negative culture on lab examination. Identification of organisms was done by lab study before and after treatment. Corneal healing was evaluated by corneal examination and anterior segment optical coherence tomography. Results Visual acuities improved from a mean decimal value of 0.063\u20130.25 in group (A) and from 0.08 to 0.125 in group (B) at the end of the follow-up period (12 months). Group (A) showed more improvement especially after the 3rd month compared with group (B), P less than 0.05. Corneal infiltration size reduced from mean of 32.4\u20131.15 mm in group (A), while it was reduced from 31.2 to 12.5 mm in group (B) at the end of the follow-up period. Reduction in infiltration size in group (A) was significantly reduced more than group (B), P value less than 0.001 highly significant. The success rate of treatment in group (A) was very highly significant (P<0.001) and in group (B) was weak significant (P=0.045). Comparison between the two groups showed highly significant difference (P=0.006). On the other hand, treatment failure was 0 in group (A) and eight cases in group (B) with highly significant difference (P<0.001). Conclusion The success of A-CXL in the treatment of FK is summarized by its known effect of reversal of corneal melting and anti-infective properties. A-CXL combined with topical VCZ was found to be more effective in treating FK with corneal melting than A-CXL combined with amphotericin B with better visual outcomes. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"accelerated corneal cross-linking (A-CXL)\",\r\n \" amphotericin B\",\r\n \" corneal melting\",\r\n \" fungal keratitis\",\r\n \" voriconazole (VCK)\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 20,\r\n \"title\": \"Fahmy, Seham (59968735300); Wadee, Amir N. (25422836600); Elshinnawy, Ahmed M. (57207305722); Eraky, Zeezy S. (58640374000); Taher, Marwa (59969025400); Anwar, Alaa (59969315300)\",\r\n \"authors\": \"Influence of Electro-Acupuncture on Diplopia in Patients With Oculomotor and Abducens Nerves Palsy\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105009412623&doi=10.1002%2Fpri.70074&partnerID=40&md5=b27b93af014a57033e9cceb3ded45b08\",\r\n \"affiliations\": \"Faculty of Physical Therapy, Cairo, Egypt; Military Medical Academy, Cairo, Egypt; Department of Basic Sciences, Faculty of Physical Therapy, Giza, Egypt; Faculty of Physical Therapy, Alexandria, Egypt; Department of Physical Therapy for Neuromuscular Disorders and Its Surgery, Merit University, Sohag, Egypt; Department of Physical Therapy for Internal Medicine and Elderly, Faculty of Physical Therapy, Cairo, Egypt; Egyptian Chinese University, Cairo, Egypt; Egyptian Chinese University, Cairo, Egypt\",\r\n \"abstract\": \"Background: Diplopia (DP) can have a significant negative impact on one's quality of life, many clinical investigations lend credence to the notion that acupuncture could be used to treat DP symptoms, randomized controlled trials are lacking, and only clinical observational studies have assessed the effectiveness of acupuncture in managing DP. Purpose: To examine the influence of electro-acupuncture on diplopia in patients with oculomotor and abducens nerve palsy. Methods: Forty eyes diagnosed with diplopia were randomly classified into study group (A) that received electro acupuncture therapy and standard prophylactic medications for 4\u00a0weeks at points selected for treating double vision, and control group (B) who received standard prophylactic medications only. The Hess screen test was used to measure degrees of deviation. Results: There were statistically significant differences in the post-test (p\u00a0=\u00a00.38 and 0.003 respectively) in favor of the study group. Discussion: In conclusion, integration between acupuncture therapies and standard prophylactic medications yields better results in treating DP. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"acupuncture\",\r\n \" diplopia\",\r\n \" hess screen test\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 21,\r\n \"title\": \"Elgammal, Walid E. (57211620104); Elkady, Hazem (57203864016); Yousef, Reda G. (57225078967); Eldehna, Wagdy M. (56318690700); Husein, Dalal Z. (55917450100); Amin, Fatma G. (57223365717); Alsfouk, Bshra Ali A. (57208926635); Elkaeed, Eslam B. (56884768800); Eissa, Ibrahim H. (57189457618); Metwaly, Ahmed M. (56153972200)\",\r\n \"authors\": \"New nicotinamide-thiadiazol hybrids as VEGFR-2 inhibitors for breast cancer therapy: design, synthesis and in silico and in vitro evaluation\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105004724157&doi=10.1039%2Fd5ra01223f&partnerID=40&md5=8d31c1f4e1740e553f198cda7bf03e06\",\r\n \"affiliations\": \"Faculty of Science, Cairo, Egypt; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafr el-sheikh, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria, Egypt; Department of Chemistry, Faculty of Science, Kharga, Egypt; Department of Physics, Faculty of Science, Alexandria, Egypt; Department of Pharmaceutical Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Department of Pharmaceutical Sciences, Almaarefa University, Riyadh, Saudi Arabia; Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"Vascular endothelial growth factor receptor-2 (VEGFR-2) is a key regulator of tumor angiogenesis and has become an important target in anticancer drug development. In this study, novel nicotinamide-thiadiazol hybrids were synthesized and evaluated for their anti-breast cancer potential through VEGFR-2 inhibition. The compounds were assessed in vitro for their cytotoxicity against MDA-MB-231 and MCF-7 cell lines. Among the nicotinamide-thiadiazol hybrids, 7a exhibited the most potent anticancer activity, with IC<inf>50<\/inf> values of 4.64 \u00b1 0.3 \u03bcM in MDA-MB-231 and 7.09 \u00b1 0.5 \u03bcM in MCF-7, showing comparable efficacy to sorafenib. VEGFR-2 inhibition assays confirmed strong inhibitory potential with an IC<inf>50<\/inf> of 0.095 \u00b1 0.05 \u03bcM. In vitro cell cycle analysis indicated that 7a induced S-phase arrest, while apoptosis assays demonstrated a substantial increase in late apoptotic cells (44.01%). Other in vitro mechanistic studies further confirmed the activation of the intrinsic apoptotic pathway, as evidenced by caspase-3 activation (8.2-fold), Bax upregulation (6.9-fold), and Bcl-2 downregulation (3.68-fold). Computational studies, including molecular docking and 200 ns molecular dynamics (MD) simulations, confirmed the stable interaction of 7a with VEGFR-2, showing binding affinities comparable to sorafenib. Further validation through MM-GBSA, ProLIF, PCAT, and FEL analyses reinforced its strong binding capability. Additionally, ADMET predictions suggested favorable pharmacokinetic properties, including good absorption, high plasma protein binding, and non-CYP2D6 inhibition. Moreover, toxicity analysis classified 7a as non-mutagenic and non-carcinogenic, with a lower predicted toxicity than sorafenib. Finally, density functional theory (DFT) calculations highlighted the structural stability and reactivity of 7a, further supporting its potential as a VEGFR-2 inhibitor. These findings suggest that 7a is a promising VEGFR-2 inhibitor with significant anticancer potential, favorable pharmacokinetics, and an improved safety profile. Further preclinical studies and structural modifications are warranted to optimize its therapeutic potential. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 22,\r\n \"title\": \"Younis, Inas Youssef (57204181603); Sedeek, Mohamed S. (57211455880); Essa, Ahmed Fathi (57211229061); Elgamal, Abdelbaset M. (57219921996); Eltanany, Basma M. (57196477994); Goda, Zeinab M. (57223340333); Pont, Laura (55966943100); Benavente, Fernando (6602224284); Mohsen, Engy (57203284031)\",\r\n \"authors\": \"Exploring geographic variations in quinoa grains: Unveiling anti-Alzheimer activity via GC\u2013MS, LC-QTOF-MS\/MS, molecular networking, and chemometric analysis\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85208654067&doi=10.1016%2Fj.foodchem.2024.141918&partnerID=40&md5=e54ef600e34e0fd150288ab4dfad418e\",\r\n \"affiliations\": \"Faculty of Pharmacy, Cairo, Egypt; Department of Pharmacognosy, Field of Pharmacy, Ras Sedr, Egypt; Chemistry of Natural Compounds Department, National Research Centre, Giza, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt; Chemistry of Natural and Microbial Products Department, National Research Centre, Giza, Egypt; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo, Egypt; Department of Chemical Engineering and Analytical Chemistry, Universitat de Barcelona, Barcelona, Spain; Generalitat de Catalunya, Barcelona, Spain\",\r\n \"abstract\": \"Quinoa is an ancient Andean crop with a significant interest due to its nutritional and health benefits. This work provides a comprehensive metabolite profiling of five commercially available quinoa grains from diverse geographical origins. GC\u2013MS analysis of primary metabolites identified sugars, sugar derivatives, and lipids as the predominant classes. LC-QTOF-MS\/MS metabolomics and molecular networking facilitated the identification of 151 secondary metabolites, including 20 flavonoids, 14 saponins, and 20 lipids, which were reported for the first time in quinoa. In the AChE inhibition assay, USA white quinoa exhibited the highest activity. Chemometric analyses indicated that flavonoids and saponins were crucial for distinguishing quinoa grains. Notably, flavonoid glycosides and saponins were positively correlated with AChE inhibition. This study represents the first MS-based metabolomics investigation using molecular networking and chemometrics to explore the metabolome heterogeneity of commercial quinoa grains, underscoring their potential as a promising natural source for combating Alzheimer's disease. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Anti-Alzheimer\",\r\n \" Anticholinesterase activity\",\r\n \" Chemometrics\",\r\n \" GC\u2013MS\",\r\n \" LC-QTOF-MS\/MS\",\r\n \" Molecular networking\",\r\n \" Quinoa\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 23,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Zaki, Randa Mohammed (54792413400); Hefny, Ahmed A. (57195534027); Afzal, Obaid (53870994800); Shahataa, Mary Girgis (57190442518); Abo El-Ela, Fatma I. (56461520900); Salem, Heba Farouk (16426683200); Gamal, Amr Gamal (57204454409)\",\r\n \"authors\": \"Corrigendum to \u201cIn vitro and in vivo evaluation of isoxsuprine loaded invasomes for efficient treatment of diabetes-accelerated atherosclerosis\u201d [J. Drug Deliv. Sci. Technol. 96 (2024) 105686] (Journal of Drug Delivery Science and Technology (2024) 96, (S1773224724003551), (10.1016\/j.jddst.2024.105686))\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85214000878&doi=10.1016%2Fj.jddst.2024.106597&partnerID=40&md5=7b940d0025ddcc64420f5101b16f0565\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Faculty of Pharmacy, Beni Suef, Egypt; School of Pharmacy, University of Waterloo, Waterloo, Canada; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutical Chemistry, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Pharmacology, Faculty of Medicine, Beni Suef, Egypt; Department of Pharmacology, Faculty of Veterinary Medicine, Beni Suef, Egypt; Faculty of Pharmacy, Beni Suef, Egypt\",\r\n \"abstract\": \"The authors regret < Acknowledgements: This study was supported via Prince Sattam Bin Abdulaziz University Project number (PSAU\/2024\/R\/1445) >. The authors would like to apologise for any inconvenience caused. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 24,\r\n \"title\": \"Eissa, Manar A. (57204365848); Farag, Mohamed Ali (7006035865); Saleh, Dalia Osama (37018567000); Shabana, Marwa E. (57195197565); Abou El-Ezz, Rania F. (55550010300); El-Kersh, Dina M. (57194212137)\",\r\n \"authors\": \"Metabolome classification of Tongkat Ali (Eurycoma longifolia jack) and its commercial products via UHPLC-QTOF-MS-MS and its protective effect against 5-flurouracil-Induced testicular toxicity in male rats\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85206981774&doi=10.1016%2Fj.jep.2024.118904&partnerID=40&md5=09b20f7846548406e3a53f36bb632b6d\",\r\n \"affiliations\": \"Department of Pharmacology and Toxicology, Merit University, Sohag, Egypt; Faculty of Pharmacy, Cairo, Egypt; Department of Pharmacology, National Research Centre, Giza, Egypt; Department of Pathology, National Research Centre, Giza, Egypt; Pharmacognosy Department, Faculty of Pharmacy, Cairo, Egypt; Pharmacognosy Department, Faculty of Pharmacy, El Shorouk, Egypt; University of Mississippi School of Medicine, Jackson, United States\",\r\n \"abstract\": \"Ethnopharmacological relevance: Tongkat Ali (Eurycoma longifolia Jack) is a chief herbal medicine that is well recognized for its aphrodisiac properties, available in various commercial products worldwide. Aim of the study: The aim of this work is to identify the different classes of secondary metabolites present in Tongkat Ali commercial products versus authenticated root, and to assess its root extract mitigative effect against 5-flurouracil (5FU)-induced testicular toxicity. Materials and methods: High-resolution UHPLC-QTOF-MS\/MS metabolites analysis was utilized on the ethanolic Tongkat Ali extract (TAE) parallel to three Mlayasian commercial products, followed by a multivariate data analysis to understand the variability among UHPLC-MS metabolites datasets. Adult male rats were treated with 5-Fluorouracil (5FU) \u00b1 Tongkat Ali extract. Semen parameters, serum testosterone, LH, and FSH, and testicular oxidative stress biomarkers like malondialdehyde (MDA) levels, Nuclear factor kappa B (NF-\u03baB) and erythroid 2\u2013related factor 2 (Nrf2) were analyzed. Results: The main categories of secondary metabolites identified through UHPLC-MS\/MS profiling were quassinoids, alkaloids, fatty acids, lignans and coumarins. Long Jack Plus\u00ae ELP-2 clustered alongside authentic roots ELR on the negative side, while Naturelle\u00ae ELP-1 and Nu-Prep-LEAKI\u00ae ELP-3 were positioned on the opposite side. The OPLS-DA model was used to identify markers for preparations from authentic roots, with commercial products enriching in ailanthone epoxide. In vivo results showed that 5FU reduced sperm parameters by 42%, while TAE improved sperm quality by 35\u201343% and 58\u201374% at dose of 400 and 800 mg\/kg, respectively. Testosterone, reduced by 74% with 5FU, increased 2.3- to 3.2-fold with TAE. TAE also reduced MDA by 31\u201362%, NF-\u03baB by 32\u201355% and increased Nrf2 by 1\u20132 folds. Conclusion: The manuscript presents a comparative metabolomics study and in vivo investigation into the potential of Tongkat Ali root to improve testicular function in male rats intoxicated with 5FU, an area not previously explored. Further research is required to understand the mechanisms. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Eurycoma longifolia\",\r\n \" Metabolomics\",\r\n \" Testicular toxicity\",\r\n \" Tongkat ali\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 25,\r\n \"title\": \"Elkaeed, Eslam B. (56884768800); Elkady, Hazem (57203864016); Khattab, Ahmed M. (58255139900); Yousef, Reda G. (57225078967); Al-Ghulikah, Hanan A. (55234967400); Husein, Dalal Z. (55917450100); Ibrahim, Ibrahim M. (57208274428); Elkady, Mohamed A. (59574718100); Metwaly, Ahmed M. (56153972200); Eissa, Ibrahim H. (57189457618)\",\r\n \"authors\": \"Integrated in silico and in vitro exploration of the anti-VEGFR-2 activities of a semisynthetic xanthine alkaloid inhibiting breast cancer\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85216376157&doi=10.1371%2Fjournal.pone.0316146&partnerID=40&md5=5556204c1daff01a033e0fc2373d4abc\",\r\n \"affiliations\": \"Department of Pharmaceutical Sciences, Almaarefa University, Riyadh, Saudi Arabia; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Chemistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Department of Chemistry, Faculty of Science, Kharga, Egypt; Department of Biophysics, Faculty of Science, Giza, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"This study presents T-1-NBAB, a new compound derived from the natural xanthine alkaloid theobromine, aimed at inhibiting VEGFR-2, a crucial protein in angiogenesis. T-1-NBAB\u2019s potential to interacts with and inhibit the VEGFR-2 was indicated using in silico techniques like molecular docking, MD simulations, MM-GBSA, PLIP, essential dynamics, and bi-dimensional projection experiments. DFT experiments was utilized also to study the structural and electrostatic properties of T-1-NBAB. Computational analysis was performed to predict the ADME-Tox profiles of T-1-NBAB. After semisynthesis, the in vitro results showed that T-1-NBAB effectively inhibits VEGFR-2, with an IC<inf>50<\/inf> of 0.115 \u03bcM, compared to sorafenib\u2019s 0.0591 \u03bcM. In vitro tests also demonstrated significant activity of T-1-NBAB against breast cancer cell lines MCF7 and T47D, with IC<inf>50<\/inf> values of 16.88 \u03bcM and 61.17 \u03bcM, respectively, and high selectivity. Importantly, T-1-NBAB induced early and late apoptosis in MCF7 cells, indicating its potential as a strong anticancer agent. Additionally, T-1-NBAB reduced the migration and healing abilities of MCF7 cells, suggesting it could be a promising anti-angiogenic agent. Overall, these findings suggest that T-1-NBAB is a promising lead compound for further research as a potential treatment for breast cancer. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 26,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Hussain, Abdulzahra Abdulsamad (16417168400); Chiaretti, Massimo (6603417473); Kryvoruchko, Igor A. (60080182100); Kechagias, Aristotelis (22985131100); Elias, Abd Al Kareem (57349114100); Adsam, Abdelmonem A.M. (60161847100); Ali, Mohamed A. (57693482500); Ahmed, Saad Mohamed Ali (59781389000); Khyrallh, Ahmed (57199997926); Alsayed, Mohammed H. (57932903000); Awad, Esmail Tharwat Kamel (57338443100); Ibrahim, Emad A. (59781844800); Labib, Mohamed Fathy (57221263028); Teama, Sobhy Rezk Ahmed (58023821600); Sobhy Shaaban, Mohamed (58024021400); Elshafey, Mohammed Hassan (57212769328); Seleem, Abdelhafez (57657407600); Radwan, Amr (60162192000); Abdelkader, Hamada Rashad Mohamed (57349786500); Othman, Ahmed Fayez (60162192100); Algalaly, Nasreldin Mohammed (60161847200); Mostafa, Mostafa Mahmoud Salama (58838861600); Abouelseoud, Mohammed Abbas Abdou (60161937500); Alsaad, Mohamed Ibrahim Abo (58987233100); Ali, Abouelatta Kh (59692860600); Elbelkasi, Hamdi (58744062800); Zaid, Mahmoud Ali Abou (59781038500); Mohamed, Basma Ahmed (58213524000); Ibrahim, Islam Mohamed (60161759800); Metwally, Ahmed Gamal Eldin (60161847300); El Azawy, Mahmoud (57223313146); Khalil, Amr (60162027100); Abu-Elela, Sameh T. (57119989900); el-Taher, Ahmed Kamal (57221777128); Yassin, Mahmoud Abdou (57217355675); Lotfy, Mohamed Ahmed (57221813392); Mousa, Bassam (57710406600); Atef, Baher (57437326000); Elnemr, Mohamed M. (57219125086); Abdelaziz, Ahmed Mesbah (58894628000); Wasefy, Tamer (57748757500); Mansour, Mohamed Ibrahim (57219159269); Nawar, Abdelrahman Mohamed Hasanin (59781844900)\",\r\n \"authors\": \"Updates in surgery for colorectal cancer: incidence and risk factors for acute anastomotic leak\u2014a retrospective study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105020191628&doi=10.1007%2Fs13304-025-02411-x&partnerID=40&md5=6b5a21ccce129028fef516746ebfc7ce\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; The University of Sheffield, Sheffield, United Kingdom; University of Alkafeel, Najaf, Iraq; Department of General Surgery and Organ Transplantation, Sapienza Universit\u00e0 di Roma, Rome, Italy; Department of Surgery No. 2, Kharkiv National Medical University, Kharkiv, Ukraine; Department of Surgery, Athens General Hospital, Athens, Greece; Department of General Surgery, Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Cairo, Egypt; General Surgery Department-Faculty of Medicine, Merit University, Sohag, Egypt; Misr University for Science and Technology, 6th October, Egypt; Mataryia Teaching Hospital (GOTHI), Cairo, Egypt; General Surgery Department, El Mahala Hepatic Institute, Al Gharbia, Egypt; Faculty of Medicine, Cairo, Egypt; Department of General Surgery, Helwan University, Helwan, Egypt; Department of Surgical Oncology, Al-Ahrar Teaching Hospital, Zagazig, Egypt; General Surgery Department, Faculty of Medicine, Ismailia, Egypt\",\r\n \"abstract\": \"This study aimed to analyze the incidence and risk factors of acute anastomotic leak (AL) in patients with colorectal cancer (CRC) during and after the COVID-19 pandemic. Active COVID-19 was evaluated as a risk factor of acute AL. A retrospective multicenter analysis was performed on 390 patients with CRC between April 2020 and October 2024. Patients were divided into acute AL (n = 27) and no acute AL (no AL) (n = 363) groups. In the acute AL group, there were 24 (88.8%) men and three (11.2%) women, with a median age of 63 (65\u201367) years. Twenty-seven patients in both groups had a previous COVID-19 infection and 15 patients (55.5%) who complained of COVID-19 had AL. The incidence of clinical AL was 6.9% (27\/390), of which 11.1% (3\/27) and 88.9% (24\/27) were grade B and C, respectively. 24\/27 (88.9%) had free AL with peritonitis requiring surgical re-intervention. Multivariate analysis showed that active COVID-19 infection (OR = 176, 95% CI 14.27\u20132172.57, p < 0.001) and serum albumin level < 3\u00a0g\/dl (OR = 16.249, 95% CI 1.033\u2013255.544, p = 0.04) were associated risk predictors of AL, while the laparoscopic approach (OR = 0.032, 95% CI 0.002\u20130.434, p = 0.01) and splenic flexure mobilization (OR = 0.022, 95% CI 0.003\u20134.844, p = 0.02) were protective. The incidence of AL after CRC surgery did not increase during or after the COVID-19 pandemic. Active COVID-19 and serum albumin levels < 3\u00a0g\/dl were associated risk factors for AL, while the laparoscopic approach and splenic flexure mobilization were protective. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Anastomotic leak\",\r\n \" Colorectal cancer\",\r\n \" COVID-19\",\r\n \" Risk factors\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 27,\r\n \"title\": \"Marcus, Wagih H. (60019494800); Ruby, Hassan A. (59140891400); Awwad, Amira E. (60161863900); Mahrous, Mahrous H. (59735314700); Abouelwafa, Ebraheem (58046250400); Badawy, Mohamed A.S. (60081641500); El-Shiekh, Riham Adel (57194776386); Zaki, Eman S.A. (57196458897); Mahmoud, Mahmoud Abdelmouti (59461776200)\",\r\n \"authors\": \"Modulatory effects of bioactive natural compounds on pruritic pathways: mechanistic basis and therapeutic prospects\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105020176140&doi=10.1007%2Fs10787-025-01999-1&partnerID=40&md5=1b47c808e5ad2236df5e28139c5b445b\",\r\n \"affiliations\": \"Faculty of Pharmacy, Cairo, Egypt; Pharmacognosy Department, Faculty of Pharmacy, 6th October, Egypt; Faculty of Pharmacy, Mansoura, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Faculty of Pharmacy, Cairo, Egypt; Department of Pharmacology, Faculty of Pharmacy, Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"Chronic pruritus, characterized by persistent itching, is a significant health issue that adversely affects individuals\u2019 quality of life, particularly in palliative care environments. Conventional treatments frequently do not yield sufficient relief and may lead to undesirable side effects, which has spurred interest in exploring alternative therapeutic options. A thorough literature search was conducted across several databases such as PubMed, Web of Science, Scopus, and EKB, with an emphasis on studies involving in vitro, animal models, and clinical trials utilizing terms like \u201cplant,\u201d \u201cextract,\u201d and \u201cpruritus.\u201d All studies were considered regardless of their publication date and were limited to English-language articles. This review highlights the promise of various medicinal plants, including chamomile, Aloe vera, calendula, curcumin, lavender, licorice, and peppermint, as adjunctive therapies for pruritus. These plants possess a range of pharmacological properties, such as anti-inflammatory, antioxidant, and skin-soothing effects, which are relevant to the complex nature of pruritus. Their favorable safety profiles and natural origins enhance their appeal in holistic and patient-centered care models. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Medicinal plants\",\r\n \" Pruritus\",\r\n \" Complementary medicine\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 28,\r\n \"title\": \"Abdelfattah, Shadwa (59709418900); Mady, Fatma Mohammed (36169550300); Sarhan, Hatem Abdelmonsef A. (21740157800); Khalifa, Hazim O. (56797844900); Hashem, Hamada (60139420900); Hassan, Hesham M. (58026884300); Alkhammash, Abdullah (59195595800); Hadiya, Safy (57204194075); Ibrahem, Reham Ali (57214752474); Qelliny, Milad Reda (57209500528)\",\r\n \"authors\": \"Topical delivery of meropenem via spanlastic carbopol gel: in-vitro studies and in-vivo application in pressure ulcers\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105018681892&doi=10.3389%2Ffphar.2025.1672677&partnerID=40&md5=93f27fc1e556fcb860b61b9d2b3bf17c\",\r\n \"affiliations\": \"Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, Minia National University, New Minia, Egypt; Department of Veterinary Medicine, United Arab Emirates University, Al Ain, United Arab Emirates; Department of Pharmaceutical Chemistry, University Sohag, Sohag, Egypt; Department of Pathology, College of Medicine, Abha, Saudi Arabia; Department of Pharmacology, Shaqra University, Shaqra, Saudi Arabia; Assiut International Center of Nanomedicine, Assiut University, Asyut, Egypt; Department of Microbiology and Immunology, Faculty of Pharmacy, Minya, Egypt\",\r\n \"abstract\": \"Introduction: Spanlastics, a type of elastic nanovesicle, represents a promising drug delivery system capable of encapsulating both hydrophilic and lipophilic drug compounds. These carriers are biodegradable, biocompatible, and non-immunogenic. Meropenem (MRP), a broad-spectrum carbapenem antibiotic, is widely used to treat severe infections in both adults and children before the causative pathogens are identified. However, meropenem\u2019s aqueous formulations are highly unstable and must be administered within 24 h of preparation. This study aimed to develop a meropenem-loaded spanlastic formulation (MRP-SP) for topical application, aiming to enhance both the drug\u2019s stability and skin permeability. Methods: Spanlastics were prepared using Span 60 and Brij 35 via the ethanol injection method. The MRP-SP formulation was extensively characterized through particle size analysis, polydispersity index (PDI), zeta potential, encapsulation efficiency, in vitro drug release, scanning electron microscopy, microbiological assays, and in vivo topical efficacy studies. Results and Discussion: The optimized formulation (Batch F5), composed of Span 60 and Brij 35 in a 1:4 M ratio, exhibited a particle size of 462 nm, spherical morphology, 69.5% drug encapsulation efficiency, and 20% drug release within 6 h. The gel form of the same batch showed a comparable release profile. Antibacterial testing revealed that MRP-SP reduced the minimum inhibitory concentration by 2.4-fold against Pseudomonas aeruginosa compared to free MRP. Additionally, MRP-SP significantly downregulated the expression of mexA, a key resistance gene. In vivo, the topical application of MRP-SP demonstrated superior therapeutic activity in treating ulcerative skin lesions in non-diabetic mice, as evidenced by wound closure percent (89% at 10 days), wound area (49% at 10 days), and histopathological improvements. Overall, the meropenem-loaded spanlastic formulation shows strong potential as an effective topical therapy for bacterial skin infections. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"edge activator\",\r\n \" meropenem\",\r\n \" mexA expression\",\r\n \" pressure ulcers\",\r\n \" spanlastics\",\r\n \" transdermal\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 29,\r\n \"title\": \"Ali, Rania Abd Elmonem (60095945200); El Ghait, Amal Taha Abou (60096097600); Ali, Safaa S. (57195993926); Radwan, Eman M. (57190883689); Meligy, Fatma Y. (55043152000)\",\r\n \"authors\": \"NRF2 PATHWAY INVOLVEMENT IN THE CENTRAL NERVOUS SYSTEM\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105015705001&doi=10.58240%2F1829006X-2025.21.6-170&partnerID=40&md5=ce11aaf361f4def6b250752b1c73aaca\",\r\n \"affiliations\": \"Histology and Cell Biology Department, Faculty of Medicine, Qena, Egypt; Histology and Cell Biology Department, Sphinx University, New Assuit, Egypt; Histology and Cell Biology Department, Faculty of Medicine, Asyut, Egypt; Department of Histology and Cell Biology, Merit University, Sohag, Egypt; Department of Medical Biochemistry, Faculty of Medicine, Asyut, Egypt; Department of Biochemistry, Sphinx University, New Assuit, Egypt; Department of Restorative Dentistry and Basic Medical Sciences, University of Petra, Amman, Jordan\",\r\n \"abstract\": \"The nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a fundamental role in cellular defense against oxidative and electrophilic stress. Within the central nervous system (CNS), where neurons and glial cells are highly susceptible to oxidative damage, Nrf2 has emerged as a master regulator of antioxidant and detoxification responses. Activation of Nrf2 upregulates a wide array of genes involved in maintaining redox balance, including heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and enzymes responsible for glutathione synthesis. These adaptive responses help protect neurons from oxidative injury and support overall brain homeostasis. Dysregulation of Nrf2 signaling is increasingly recognized as a critical factor in the pathogenesis of neurodegenerative disorders such as Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, amyotrophic lateral sclerosis, and multiple sclerosis, as well as in acute neurological injuries like ischemic stroke and traumatic brain injury. Pharmacological strategies to activate Nrf2, including synthetic compounds such as dimethyl fumarate and natural agents like sulforaphane, have shown promising neuroprotective effects in both experimental and clinical settings. This review provides a comprehensive discussion on the structure and regulation of the Nrf2 pathway, its physiological role in the CNS, its involvement in neurological diseases, and therapeutic approaches targeting Nrf2 signaling. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"antioxidant response\",\r\n \" central nervous system\",\r\n \" Keap1\",\r\n \" neurodegeneration\",\r\n \" neuroprotection\",\r\n \" Nrf2\",\r\n \" oxidative stress\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 30,\r\n \"title\": \"Atwan, Hany (58124357400); Mondy, Madleen (60078456000); Altalab, Gergis (59907492700); Elgendy, Mena (60078735600)\",\r\n \"authors\": \"Post-craniotomy headache and botulinum toxin A: A systematic review of case reports and case series\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105014653155&doi=10.1177%2F25158163251371150&partnerID=40&md5=3d1ecb4f41f14456b7d636dc1b8afb4a\",\r\n \"affiliations\": \"Faculty of Medicine, Asyut, Egypt; Faculty of Medicine, Merit University, Sohag, Egypt; College of Medicine, 6th October, Egypt\",\r\n \"abstract\": \"Background: Post-craniotomy headache (PCH) is a common, often debilitating complication with limited treatment options and unclear pathophysiology. While botulinum toxin A (BoNT-A) is effective for various headache disorders, its use in PCH is underexplored. This systematic review examines case reports and series on BoNT-A's efficacy and safety for PCH. Methods: A systematic search of PubMed, Scopus, and Web of Science was conducted in February 2025 using relevant keywords. Case reports and series on BoNT-A treatment for PCH were included, while unrelated studies, reviews, and incomplete abstracts were excluded. Data on patient characteristics, treatment protocols, efficacy, and adverse events were extracted. Results: Five case series published up to 2025 report on 15 patients from France, Canada, and the United States. Each study enrolled only three or four patients, all with persistent PCH unresponsive to standard analgesics. BoNT-A regimens differed widely, ranging from 15 to 165 U, and included single versus repeated sessions, as well as injection sites such as the temporalis muscle, incision margins, and cranial suture lines, highlighting the lack of a standardized protocol. Eleven patients achieved 75\u2013100% pain relief within 10\u201315 days, with therapeutic effects persisting for several weeks to over 5 years. Many also demonstrated improvements in daily functioning and a reduction in analgesic consumption. No serious adverse events were reported, supporting BoNT-A as a safe and promising treatment for PCH. Conclusion: BoNT-A is a well-tolerated and effective option for patients with refractory PCH, offering substantial pain relief and functional improvement. However, given the reliance on small-scale studies, larger clinical trials are needed to confirm its efficacy and establish standardized treatment protocols. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"botulinum toxin A (BoNT-A)\",\r\n \" headache\",\r\n \" neurosurgical complications\",\r\n \" post-Craniotomy\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 31,\r\n \"title\": \"Hamad, Ahmed Abdulhafez (57193447791); Mohammed, Bassam Shaaban (57211554238); Abdelsalam Ouf, Abdelsalam Mohamed (58777897900); Darwish, Ibrahim Ali (6701813769); Ashkar, Abdulsalam (59541306200); Haredy, Ahmed M. (56895997900)\",\r\n \"authors\": \"Sustainable Fluorescence-off Based Analytical Approach for the Quantification of Linagliptin Using a Biocompatible Sensor; Erythrosine B Dye\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105009942276&doi=10.1007%2Fs10895-025-04418-4&partnerID=40&md5=6f3b6da20c4309229ef62c167172c13e\",\r\n \"affiliations\": \"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Shibin El Kom, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Menofia, Egypt; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Chemistry, College of Pharmacy, Riyadh, Saudi Arabia; Department of Health Sciences, Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d, Vercelli, Italy; Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"A fluorescence quenching strategy was conceptualized to establish an environmentally compatible analytical system for trace-level detection of Linagliptin (LGP), an anti-diabetic pharmaceutical compound. This research delineates a biochemical sensing mechanism relying on an electrostatic coupling between LGP and Erythrosine B (EB), a biologically certified fluorophore, within optimized acidic parameters. The molecular association induced a concentration-dependent reduction in EB\u2019s intrinsic emission intensity at \u03bb<inf>em<\/inf> 554\u00a0nm, attributed to the generation of a non-luminescent LGP-EB supramolecular assembly. Methodical optimization of operational parameters governing the recognition process\u2014including pH modulation, stoichiometric ratios, and temporal stability\u2014yielded a linear response across 0.30\u20132.50\u00a0\u00b5g\/mL, with detection and quantification capacities reaching 0.0286\u00a0\u00b5g\/mL and 0.0943\u00a0\u00b5g\/mL, respectively. Validation studies confirmed adherence to International Council for Harmonization (ICH) criteria, exhibiting \u2264 1.9% relative standard deviation in precision assessments and 98.9\u2013100.8% recovery rates in spiked samples. The technique\u2019s efficacy was verified across multiple matrices, encompassing raw drug substances, pharmaceutical formulations, and simulated biological media. Ecological compatibility was rigorously evaluated through modern sustainability metrics aligned with green analytical chemistry principles. Implementation of the White Analytical Chemistry (WAC) protocol via the RGB 12 algorithm designated the methodology as \u201cenvironmentally considerate,\u201d reflecting minimal reagent consumption and energy requirements. Concurrent analysis using the BAGI (Biocompatible Analytical Greenness Index) tool produced exceptional scores in ecological safety and methodological adaptability, confirming its proficiency in harmonizing analytical precision with sustainable practices. This dual-focused approach addresses critical needs in pharmaceutical quality control while advancing eco-responsible analytical methodologies. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Ecological impact evaluation\",\r\n \" Electrostatic biosensing\",\r\n \" Fluorescence-quenching analytical platform\",\r\n \" Sustainable detection using biocompatible EB dye\",\r\n \" Trace-level LGP analysis\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 32,\r\n \"title\": \"Mabrouk, M. I. (57724297900); Abdalbary, Sahar Ahmed (57188714822); Abdelmonem, Asmaa Foad (58073411200); Abdelhakiem, Nadia Mohamed (57221741774); Ahmed, Alaa Anwar (59958664500); Gelany, Fathia Mostafa (59957590200); Abd El Rahim, Ahmed A. (59958664600)\",\r\n \"authors\": \"The impact of aerobic and balance exercises on anxiety and dizziness in post-COVID-19 patients: a randomised clinical trial\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105008828911&doi=10.5114%2Fpq%2F190527&partnerID=40&md5=830f3bac000b4a08deb73b2cc2c038eb\",\r\n \"affiliations\": \"Department of Physiotherapy, Applied Science Private University, Amman, Jordan; Department of Orthopaedics, Faculty of Physical Therapy, Beni Suef, Egypt; Department of Biomechanics, Faculty of Physical Therapy, Giza, Egypt; Department of Neuromuscular Disorders and its Surgery, Deraya University, New Minia, Egypt; Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Cairo, Egypt; Department of Growth and Development Disorders in Children and its Surgery, Merit University, Sohag, Egypt; Department of Basic Sciences, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Introduction. Examine how aerobic exercises, relaxation techniques, and balance exercises affect patients\u2019 anxiety and dizziness post-COVID-19 patients. Methods. Thirty participants post-COVID-19, complaining of anxiety and dizziness, aged 45\u201365 years, of both sexes, selected from the outpatient clinic of our hospital, were enrolled in the study after a COVID-19 infection. Treatment sessions were 3 times weekly for 4 weeks, and the patients were treated separately in group therapy. The 15 patients in group A were given aerobic, balancing, and relaxation techniques. The 15 patients in the control group (group B) were given only relaxation exercises. Assessments of the two groups were completed both before and after the course of treatment by the Hamilton Anxiety Scale (HAMA) and the Berg Balance Scale. Respiratory function was also assessed using maximum voluntary ventilation. Results. There were significant differences between the two groups after the treatment. The mean values of the HAMA after treatment were 17.2 \u00b1 1.7 and 21.7 \u00b1 1.4 in groups A and B, respectively. After treatment, the mean values of the Berg Balance Scale were 26.7 \u00b1 5.7 and 22.2 \u00b1 3.6 in groups A and B, respectively. The mean values of maximum voluntary ventilation were 117.2 \u00b1 16.7 and 108.1 \u00b1 16.3 in groups A and B, respectively. Both groups showed a significant decrease in anxiety and dizziness and a significant increase in maximum voluntary ventilation at the end of the 4 weeks of the training program. Participants in group A showed a significantly greater decrease in anxiety and dizziness and a significantly greater increase in maximum voluntary ventilation (p < 0.05) after the training program. Conclusions. Ultimately, it can be said that aerobic exercises, balance exercises, and relaxation techniques can raise maximal voluntary breathing and lessen anxiety and dizziness in post-COVID patients. Therefore, it might be regarded as a successful, secure, cost-effective, and efficient supplementary treatment method for lowering anxiety and vertigo in COVID-19 patients. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"aerobic exercises\",\r\n \" anxiety disorder\",\r\n \" balance exercises\",\r\n \" dizziness\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 33,\r\n \"title\": \"Hashem, Hamada (59345170800); Abdelfattah, Shadwa (59709418900); Hassan, Hesham M. (58026884300); Al-Emam, Ahmed (57163602000); Alqarni, Mohammed Ahmed (57221053161); Alotaibi, Ghallab Hamoud Sinhat (57371627300); Radwan, Ibrahim Taha (57205102710); Kaur, Kirandeep (57214547228); Rao, Devendra Pratap (35119371500); Br\u00e4se, Stefan J. (7005396290); Alkhammash, Abdullah (59195595800)\",\r\n \"authors\": \"Discovery of a novel 4-pyridyl SLC-0111 analog targeting tumor-associated carbonic anhydrase isoform IX through tail-based design approach with potent anticancer activity\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105003065163&doi=10.3389%2Ffchem.2025.1571646&partnerID=40&md5=ac6f74b8db08f95e35c85ac1ae2d5319\",\r\n \"affiliations\": \"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pathology, College of Medicine, Abha, Saudi Arabia; Department of Pharmaceutical Chemistry, Taif University, Taif, Saudi Arabia; Department of Pharmacology, Shaqra University, Shaqra, Saudi Arabia; Supplementary General Sciences Department, Faculty of Oral & Dental Medicine, New Cairo, Egypt; Department of Chemistry, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Bathinda, India; Department of Chemistry, Dayanand Anglo-Vedic (PG) College, Kanpur, India; Institute of Biological and Chemical Systems, Karlsruher Institut f\u00fcr Technologie, Karlsruhe, Germany\",\r\n \"abstract\": \"Introduction: Carbonic anhydrase IX (CA IX) is a tumor-associated enzyme involved in cancer progression and survival. Targeting CA IX with selective inhibitors like SLC-0111 has shown therapeutic potential. This study aimed to develop a novel 4-pyridyl analog (Pyr) of SLC-0111 with enhanced anticancer activity. Methods: Pyr was synthesized using a tail-based design and characterized by NMR. Its cytotoxicity was tested against cancer and normal cell lines. CA inhibition, cell cycle effects, apoptosis induction, and protein expression changes were evaluated. Molecular docking and ADMET predictions assessed binding and drug-like properties. Results and Discussion: Pyr showed selective cytotoxicity toward cancer cells and potent CA IX inhibition. It induced G0\/G1 arrest, apoptosis, and modulated p53, Bax, and Bcl-2 levels. Docking confirmed strong CA IX binding, and ADMET analysis indicated good oral bioavailability. These results support Pyr as a promising anticancer candidate. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"apoptosis\",\r\n \" carbonic anhydrase\",\r\n \" cytotoxicity\",\r\n \" SLC-0111\",\r\n \" sulphonamide\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 34,\r\n \"title\": \"Alsfouk, Aisha A. (57208242449); Al Ward, Maged Mohammed Saleh (57222123911); Al-Qadhi, Mustafa A. (58480352000); El-Metwally, Souad A. (36682085000); Yousef, Reda G. (57225078967); Elkaeed, Eslam B. (56884768800); Husein, Dalal Z. (55917450100); Amin, Fatma G. (57223365717); Elkady, Hazem (57203864016); Metwaly, Ahmed M. (56153972200); Eissa, Ibrahim H. (57189457618)\",\r\n \"authors\": \"Anti-breast cancer potential of thieno-pyrimidine derivatives as VEGFR-2 inhibitors\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-105000333613&doi=10.1080%2F17568919.2025.2479422&partnerID=40&md5=544ac45cf53862532fd550ade7a3f84b\",\r\n \"affiliations\": \"Department of Pharmaceutical Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Department of Medicinal Chemistry, Al-Razi University, Sana'a, Yemen; Department of Medicinal Chemistry, Sana'a University, Sana'a, Yemen; Department of Basic Sciences, Higher Technological Institute, Tenth of Ramadan City, Egypt; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Chemistry, Merit University, Sohag, Egypt; Department of Pharmaceutical Sciences, Almaarefa University, Riyadh, Saudi Arabia; Department of Chemistry, Faculty of Science, Kharga, Egypt; Department of Physics, Faculty of Science, Alexandria, Egypt; Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"Background: Thieno-pyrimidine derivatives have emerged as promising candidates for VEGFR-2 inhibition. This study aimed to design, synthesize, and evaluate novel thieno-pyrimidine derivatives for their anti-cancer potential. Methods: A series of thieno-pyrimidine compounds were synthesized and screened for in vitro cytotoxicity against MDA-231 and MCF-7 cell lines. The most active compound, 6b, was further analyzed for VEGFR-2 kinase inhibition, wound healing, apoptosis induction, and cell cycle arrest. Molecular docking, 200 ns molecular dynamics simulations, MM-GBSA, ProLIF PCAT, and FEL analyses were conducted to assess binding stability. DFT calculations evaluated electronic properties, while in silico ADMET profiling predicted pharmacokinetics and toxicity. Results: Compound 6b exhibited potent cytotoxicity with IC<inf>50<\/inf> values of 5.91 \u00b5M (MDA-231) and 7.16 \u00b5M (MCF-7). It demonstrated VEGFR-2 inhibition is comparable to sorafenib (IC<inf>50<\/inf>: 53.63 \u00b1 3.14 nM). Wound healing assays showed significant inhibition of MDA-231 migration. Flow cytometry confirmed apoptosis induction (57.20% early apoptosis) and G1 phase arrest. Gene expression analysis revealed upregulation of pro-apoptotic markers and downregulation of Bcl-2. Computational studies confirmed stable VEGFR-2 binding, and ADMET predictions indicated a favorable safety profile. Conclusion: Compound 6b exhibits strong VEGFR-2 inhibition, potent anti-cancer effects, and a favorable toxicity profile, highlighting its potential for further therapeutic development. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"apoptosis\",\r\n \" breast cancer\",\r\n \" DFT\",\r\n \" MD simulations\",\r\n \" Thieno-pyrimidine\",\r\n \" VEGFR-2\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 35,\r\n \"title\": \"Elrosasy, Amr M. (58299324200); Maher, Ahmed (58727943900); Ramadan, Abdelraouf (57848892900); Hamam, Nada G. (59383277100); Soliman, Mohamed Mohsen (57907443800); Kamal, Sara K. (58782392400); Milik, Beshoy Emad (59411337900); Shahat, Abdullah Ali (59410954800); Kamel, Menna Nabil (59411148500); Ali, Ahmed Abdeltawab (59411148600); Hassan, Loay Abdelnabi (59410954900); Zabady, Ahmed Hamdy (59394731500); Abo-Zeid, Mohamed Gamal (58866318400); Abdelmottaleb, Wael A. (57219122953); Nassar, Sameh M. (57283577300)\",\r\n \"authors\": \"A Network Meta-Analysis of Vasodilator Therapies in Pulmonary Hypertension Patients Undergoing Mitral Valve Replacement Surgery: Insights for Optimizing Hemodynamics\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85209142273&doi=10.1007%2Fs40261-024-01404-9&partnerID=40&md5=2912cab415c2c136f4f140d7d6de4461\",\r\n \"affiliations\": \"Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Cairo, Egypt; Faculty of Medicine, Merit University, Sohag, Egypt; Faculty of Science, Damanhour, Egypt; Faculty of Medicine, Tanta, Egypt; Department of Medicine, New York Medical College, Valhalla, United States; Department of Cardiology, West Virginia University, Morgantown, United States\",\r\n \"abstract\": \"Background and Objective: Pulmonary hypertension (PH) is a progressive hemodynamic condition associated with significant morbidity and mortality, especially in patients undergoing cardiac surgery. Therefore, the objective of this network meta-analysis (NMA) is to compare the efficacy of various pulmonary vasodilators in perioperative control of PH among patients undergoing mitral valve replacement surgery (MVRS), aiming to address the existing knowledge gap and improve perioperative outcomes. Methods: Electronic databases including PubMed, Cochrane Central Registry of Controlled Trials, Scopus, Embase, and Web of Science (WOS) from inception to 17 September 2024. Only randomized controlled trials (RCTs) evaluating vasodilators in PH patients undergoing MVRS were included. We used netmeta package in RStudio to analyze the outcome data with their corresponding mean difference (MD) and confidence intervals (CI). Results: Seventeen RCTs including 862 patients were analyzed. Prostacyclin, nitric oxide (NO), and sodium nitroprusside (SN) significantly reduced mean pulmonary arterial pressure with effect sizes [MD, 95% confidence interval (CI)] of (11.77, \u2212\u00a018.78; \u2212\u00a04.76; \u2212\u00a08.3, \u2212\u00a015.9; \u2212\u00a00.6; \u2212\u00a011.02, \u2212\u00a020.1; \u2212\u00a03.8, respectively). While no treatment showed significant efficacy on pulmonary capillary wedge pressure, systolic pulmonary arterial pressure, or heart rate, nitroglycerin, NO, and prostacyclin, showed significant increases in cardiac index with effect sizes (MD, 95% CI) of (1, 0.3; 1.7; 1.2 0.8; 1.6; 1.2 0.8; 1.6, respectively). Additionally, NO, prostacyclin, SN, and nitroglycerin demonstrated significant reductions in systemic vascular resistance (SVR), with effect sizes of. (\u2212\u00a00.54, \u2212\u00a00.82; \u2212\u00a00.26, \u2212\u00a00.37, \u2212\u00a00.65; \u2212\u00a00.09; \u2212\u00a00.47, \u2212\u00a00.77; \u2212\u00a00.16; \u2212\u00a00.14, \u2212\u00a00.24; \u2212\u00a00.03, respectively). Conclusions: This NMA highlights prostacyclin, nitroglycerin, NO, and SN as consistently effective in improving hemodynamics for patients with PH undergoing MVRS, and provides valuable insights for surgeons to choose the suitable vasodilator for these surgeries. However, limitations and the need for further RCTs are acknowledged. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 36,\r\n \"title\": \"Salama, Eman S. (59367999800); Hussein, Mostafa (35554674300); Fetih, Ahmed Nabil (6506295698); Abul-Fadl, Azza Mohamed A.M. (35483215100); Elghazally, Shimaa A. (57208304065)\",\r\n \"authors\": \"High-risk pregnancy and risk of breastfeeding failure\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85206494443&doi=10.1186%2Fs42506-024-00172-w&partnerID=40&md5=a26cf7c44f9b7da29e06fe7ab1f4424d\",\r\n \"affiliations\": \"Department of Obstetrics and Gynecology, Merit University, Sohag, Egypt; Department of Obstetrics and Gynecology, Faculty of Medicine, Asyut, Egypt; Certified Lactation Consultant, Faculty of Medicine, Benha, Egypt; Department of Public Health and Community Medicine, Faculty of Medicine, Asyut, Egypt\",\r\n \"abstract\": \"Background: There is growing evidence that supports the role of breastfeeding in reducing the burden of non-communicable diseases (NCDs). There are considerable gaps in breastfeeding outcomes in mothers with chronic diseases due to a lack of knowledge and support in the postpartum period. Mothers who have NCDs and pregnancy complications are at risk of breastfeeding failure. Aim: To compare breastfeeding outcomes in mothers with NCDs with healthy mothers and determine the underlying challenges that lead to poor outcomes. Methods: A prospective cohort study was conducted among 150 women (50 with high-risk pregnancies (HRP) and 100 with normal pregnancies (NP)). They were recruited from those attending the immunization and outpatient clinics at Sohag General Hospital. Mothers were recruited at 34\u00a0weeks gestation and were followed up at 2\u00a0weeks, 6\u00a0weeks, and 6\u00a0months after delivery. A pretested and validated questionnaire was used to collect detailed epidemiological, personal, health-related status, medications, hospitalizations, reproductive history, current delivery, and previous breastfeeding experiences. On follow-up they were assessed for breastfeeding practices, their health and health and growth of their children, and\u00a0social support. Results: Delivery by cesarean section and postpartum bleeding were commoner among HRP patients. Initiation of breastfeeding in the 1st hour of delivery was significantly lower among women with HRP than those with normal pregnancies (48.0% versus 71.0%, p = 0.006). The most common reason for not initiating breastfeeding among the NP group was insufficient milk (34.5%), while in the HRP group, it was the mother\u2019s illness (80.8%). Skin-to-skin contact with the baby after birth was significantly less practiced in the HRP than in the NP group (38.0% vs 64.0% at p = 0.003). Herbs (such as cumin, caraway, cinnamon, aniseed, and chamomile) were the most common pre-lacteal feeds offered (63.0% in NP vs 42.0% in HRP). Artificial milk was more used in HRP than NP (24.0% vs 4.0%). Breast engorgement was 3 times more common in the HRP compared to the NP group (61.5% vs19.6%). Stopping breastfeeding due to breast problems was 2.5 times higher in the HRP than in the NP group (38.5% vs. 15.2%, p = 0.003). Nipple fissures were twice as common among the NP than among the HRP group ((73.0%) vs. (38.5%), p = 0.026). Exclusive breastfeeding during the period of follow-up was lower in the HRP than in the NP group (40.0% vs 61.0%, p < 0.05) and formula feeding was twice as common in the HRP as in the NP group (34.0% vs. 18.0%, p = 0.015). Child illness was significantly higher among women with HRP than those with NP (66.0% vs 48.0%, p = 0.037). Conclusions: Women with HRP are at a high risk of poor breastfeeding outcomes with increased lactation problems and formula feeding rates. Encouraging women especially those with HRP to achieve optimal breastfeeding practices is a simple intervention that can be included in daily practice and may have a positive impact on mothers\u2019 health. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Casarean section\",\r\n \" Exclusive breastfeeding\",\r\n \" High-risk pregnancy\",\r\n \" Noncommunicable diseases\",\r\n \" Pregnancy\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 37,\r\n \"title\": \"Abd-Elkareem, M. (57193520825); Alnasser, Sulaiman Mohammed Abdullah (57202385164); Meshal, Alotaibi (58065801700); Abdullah, Raghda Ismail (58691072300); Ali, Ahmed U. (57213590141)\",\r\n \"authors\": \"The effect of Norethisterone acetate on the uterus of albino rats: histological, histochemical and ultrastructure study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85202867267&doi=10.1186%2Fs12917-024-04219-0&partnerID=40&md5=929c1639751a8d892cf79f70f7157177\",\r\n \"affiliations\": \"Department of Cell and Tissues, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Pharmacology and Toxicology, Qassim University, Al-Mulida, Saudi Arabia; College of Pharmacy, University of Hafr Al-Batin, Hafar al Batin, Saudi Arabia; Department of Anatomy, College of Veterinary Medicine, Kharga, Egypt; Department of Pharmaceutics, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Background: Norethisterone acetate (NETA), also known as norethindrone acetate is a progestogens medication that is widely used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders as abnormal uterine bleeding and endometriosis. There is a lack of detailed histological information regarding the effects of NETA on the uterine structure. So, the present study focuses on the uterine histological, histochemical and ultrastructure changes following the exposure to NETA in the albino rats. To do this aim, fourteen adult female albino rats were used. They were randomly divided into two equally groups: Control group and NETA treated group. Albino rats of control group were administered daily food, water and orally distilled water only, while rats of NETA treated group were administered daily orally 20\u00a0\u00b5g of NETA dissolved in 2\u00a0ml distilled water, food, and water. The experiment was continued for three weeks. Results: The findings of the present work indicated that the use of NETA has negative effects on the endometrial epithelium (proliferation, autophagy and apoptosis), glands (necrotic, apoptotic or pseudosecretory glands) and stromal and myometrial reactions (granulocytes, connective tissue remodeling, apoptosis, myocytes hypertrophy). Conclusion: This work revealed that NETA has desynchronized progestogenic effect on the uterine tissues of the albino rat and thereby prevent implantation and pregnancy. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Apoptosis\",\r\n \" Endometrium\",\r\n \" Norethisterone acetate\",\r\n \" Rat\",\r\n \" Uterine glands\",\r\n \" Uterus\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 38,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Podda, Mauro Guido (7004555508); Chiaretti, Massimo (6603417473); Kechagias, Aristotelis (22985131100); Lled\u00f3, Jos\u00e9 Bueno (24462324800); Kalmoush, Abd Elfattah (57727380200); Mustafa, Fawzy M. (58227729800); Nassar, Mohammed Shaaban (57727355400); Labib, Mohamed Fathy (57221263028); Teama, Sobhy Rezk Ahmed (58023821600); Elshafey, Mohammed Hassan (57212769328); Elbelkasi, Hamdi (58744062800); Alsaad, Mohamed Ibrahim Abo (58987233100); Sallam, Ahmed M. (57203144124); Ashour, Hassan Rabea Galal (57203575895); Mansour, Mohamed Ibrahim (57219159269); Mostafa, Abdelshafy (58744089300); Elshahidy, Tamer Mohamed Mahmoud (57219158772); Yehia, Ahmed Mohamed (57210598249); Rushdy, Tamer (57211491570); Ramadan, Alaaedin (57924392600); Hamed, Abd Elwahab M. (58986714100); Yassin, Mahmoud Abdou (57217355675); Metwalli, Abd Elrahman M. (57219157262)\",\r\n \"authors\": \"Comparative study of laparoscopic ventral mesh rectopexy versus perineal stapler resection for external full-thickness rectal prolapse in elderly patients: enhanced outcomes and reduced recurrence rates\u2014a retrospective cohort study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85190433927&doi=10.1007%2Fs10151-024-02919-1&partnerID=40&md5=84dd70c3073512e2c46a7de80bc969b1\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; Department of Surgical Sciences, Azienda Ospedaliero Universitaria di Cagliari, Cagliari, Italy; Sapienza Universit\u00e0 di Roma, Rome, Italy; Department of Surgery, Hospital Universitari i Polit\u00e8cnic La Fe, Valencia, Spain; General Surgery Department, Faculty of Medicine, Cairo, Egypt; General Surgery Department, Mataryia Teaching Hospital (GOTHI), Cairo, Egypt; General Surgery Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Background: In elderly patients with external full-thickness rectal prolapse (EFTRP), the exact differences in postoperative recurrence and functional outcomes between laparoscopic ventral mesh rectopexy (LVMR) and perineal stapler resection (PSR) have not yet been investigated. Methods: We conducted a retrospective multicenter study on 330 elderly patients divided into LVMR group (n = 250) and PSR (n = 80) from April 2012 to April 2019. Patients were evaluated before and after surgery by Wexner incontinence scale, Altomare constipation scale, and patient satisfaction questionnaire. The primary outcomes were incidence and risk factors for EFTRP recurrence. Secondary outcomes were postoperative incontinence, constipation, and patient satisfaction. Results: LVMR was associated with fewer postoperative complications (p < 0.001), lower prolapse recurrence (p < 0.001), lower Wexner incontinence score (p = 0.03), and lower Altomare\u2019s score (p = 0.047). Furthermore, LVMR demonstrated a significantly higher surgery\u2013recurrence interval (p < 0.001), incontinence improvement (p = 0.019), and patient satisfaction (p < 0.001) than PSR. Three and 13 patients developed new symptoms in LVMR and PSR, respectively. The predictors for prolapse recurrence were LVMR (associated with 93% risk reduction of recurrence, OR\u00a00.067, 95%\u00a0CI 0.03\u20130.347, p = 0.001), symptom duration (prolonged duration was associated with an increased risk of recurrence, OR\u00a01.131, 95%\u00a0CI 1.036\u20131.236, p = 0.006), and length of prolapse (increased length was associated with a high recurrence risk (OR = 1.407, 95% CI = 1.197\u20131.655, p < 0.001). Conclusions: LVMR is safe for EFTRP treatment in elderly patients with low recurrence, and improved postoperative functional outcomes. Trial registration: Clinical Trial.gov (NCT05915936), retrospectively registered on June 14, 2023. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Elderly\",\r\n \" Functional outcomes\",\r\n \" Laparoscopic ventral mesh rectopexy\",\r\n \" Perineal stapler resection\",\r\n \" Rectal prolapse\",\r\n \" Recurrence\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 39,\r\n \"title\": \"Abd-Eldayem, Ahmed Mohammed (57195596545); Makram, Sohayla Mahmoud (58187419600); Messiha, Basim Anwar Shehata (56431085800); Abd-Elhafeez, Hanan H. (57216658260); Abdel-Reheim, Mustafa Ahmed (57194939309)\",\r\n \"authors\": \"Cyclosporine-induced kidney damage was halted by sitagliptin and hesperidin via increasing Nrf2 and suppressing TNF-\u03b1, NF-\u03baB, and Bax\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85188816578&doi=10.1038%2Fs41598-024-57300-x&partnerID=40&md5=c75662b2e217bf46fb74f9ebaff4557d\",\r\n \"affiliations\": \"Department of Medical Pharmacology, Faculty of Medicine, Asyut, Egypt; Department of Pharmacology, Merit University, Sohag, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Cell and Tissues, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Pharmaceutical Sciences, Shaqra University, Shaqra, Saudi Arabia\",\r\n \"abstract\": \"Cyclosporine A (CsA) is employed for organ transplantation and autoimmune disorders. Nephrotoxicity is a serious side effect that hampers the therapeutic use of CsA. Hesperidin and sitagliptin were investigated for their antioxidant, anti-inflammatory, and tissue-protective properties. We aimed to investigate and compare the possible nephroprotective effects of hesperidin and sitagliptin. Male Wistar rats were utilized for induction of CsA nephrotoxicity (20\u00a0mg\/kg\/day, intraperitoneally for 7\u00a0days). Animals were treated with sitagliptin (10\u00a0mg\/kg\/day, orally for 14\u00a0days) or hesperidin (200\u00a0mg\/kg\/day, orally for 14\u00a0days). Blood urea, serum creatinine, albumin, cystatin-C (CYS-C), myeloperoxidase (MPO), and glucose were measured. The renal malondialdehyde (MDA), glutathione (GSH), catalase, and SOD were estimated. Renal TNF-\u03b1 protein expression was evaluated. Histopathological examination and immunostaining study of Bax, Nrf-2, and NF-\u03baB were performed. Sitagliptin or hesperidin attenuated CsA-mediated elevations of blood urea, serum creatinine, CYS-C, glucose, renal MDA, and MPO, and preserved the serum albumin, renal catalase, SOD, and GSH. They reduced the expressions of TNF-\u03b1, Bax, NF-\u03baB, and pathological kidney damage. Nrf2 expression in the kidney was raised. Hesperidin or sitagliptin could protect the kidney against CsA through the mitigation of oxidative stress, apoptosis, and inflammation. Sitagliptin proved to be more\u00a0beneficial than hesperidin. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Cyclosporine\",\r\n \" Hesperidin\",\r\n \" Nephrotoxicity\",\r\n \" NF-\u03baB\",\r\n \" Nrf2\",\r\n \" Sitagliptin\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 40,\r\n \"title\": \"Sayed, Alaa El Din H. (59100118600); Abou-Khalil, Nasser Sayed (57160296500); Alghriany, Alshaimaa A.I. (57224211446); Abd El-Ghaffar, Sary Kh (10440451100); Hussein, Asmaa A.A. (36641259100)\",\r\n \"authors\": \"Prefeeding of Clarias gariepinus with Spirulina platensis counteracts petroleum hydrocarbons-induced hepato- and nephrotoxicity\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85188748429&doi=10.1038%2Fs41598-024-57420-4&partnerID=40&md5=8f55d74ead1dda7f511a3350842b5a78\",\r\n \"affiliations\": \"Molecular Biology Research & Studies Institute, Assiut University, Asyut, Egypt; Faculty of Science, Asyut, Egypt; Department of Medical Physiology, Faculty of Medicine, Asyut, Egypt; Department of Basic Medical Sciences, Merit University, Sohag, Egypt; Department of Clinical Pathology, Faculty of Veterinary Medicine, Asyut, Egypt; School of Veterinary Medicine, Asyut, Egypt\",\r\n \"abstract\": \"Petroleum aromatic hydrocarbons are considered one of the most dangerous aquatic pollutants due to their widespread across water bodies, persistence, and extension to the food chain. To our knowledge, there hasn\u2019t been any research investigating the hepatorenoprotective effects of Spirulina platensis (SP) against toxicity induced by these environmental toxicants in fish. Thus, we decided to explore its potential safeguarding against benzene and toluene exposure in adult Clarias gariepinus. To achieve this objective, fish were divided into five groups (60 per group; 20 per replicate). The first group served as a control. The second and third groups were intoxicated with benzene and toluene at doses of 0.762 and 26.614\u00a0ng\/L, respectively for 15\u00a0days. The fourth and fifth groups (SP + benzene and SP + toluene, respectively) were challenged with benzene and toluene as previously mentioned following dietary inclusion of SP at a dose of 5\u00a0g\/kg diet for 30\u00a0days. The marked increase in liver metabolizing enzymes, glucose, total protein, albumin, globulin, albumin\/globulin ratio, and creatinine confirmed the hepato- and nephrotoxic impacts of benzene and toluene. These outcomes were coupled with cytopathological affections and excessive collagen deposition. The incorporation of SP in ration formulation, on the contrary, restored the previously mentioned toxicological profile due to its antioxidant and cytoprotective attributes. Regardless of SP intervention, the renal tissues still displayed histo-architectural lesions, because of insufficient dose and timeframe. Additional research will be required to identify the ideal SP remediation regimen. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Fish\",\r\n \" Kidney\",\r\n \" Liver\",\r\n \" Microalga\",\r\n \" Petroleum hydrocarbons\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 41,\r\n \"title\": \"Alghriany, Alzahraa A. (58702438700); Ali, Ahmed U. (57213590141); Khallaf, Iman S.A. (57213352391); Hassan, Abeer S. (57196119456); Sayed, Marwa A. (57217417384); Fikry, Ahmed Mortada (57216749226)\",\r\n \"authors\": \"Clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction as a palatal dressing material compared to Alveogyl: randomized clinical trial\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85184543720&doi=10.1038%2Fs41598-024-53511-4&partnerID=40&md5=26fa0954907d0b3ccbc152cb2cfd592e\",\r\n \"affiliations\": \"Department of Oral Medicine, Faculty of Dentistry, Asyut, Egypt; Department of Pharmaceutics, Merit University, Sohag, Egypt; Pharmacognosy and Natural Products Department, Faculty of Pharmacy, Shibin El Kom, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Qena, Egypt; Department of Industrial Pharmacy, Faculty of Pharmacy, Asyut, Egypt\",\r\n \"abstract\": \"This study assessed the clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction (OPMF) solid dispersion as a palatal dressing material, compared with Alveogyl, in a randomized clinical trial. After harvesting free gingival grafts for 18 patients in three groups, the donor site in group I received OPMF; group II received Alveogyl; and group III received placebo dough material. The visual analog scale (VAS) pain score in group I showed the lowest value in week one without a significant difference. In week 2, there was a substantial decrease in pain in group I compared to group III. Week 4 showed reduced pain scores in all groups without significant differences. The results of the number of analgesic pills revealed, after 1\u00a0week, the lowest number of pills consumed in group I, with a considerable difference compared to group III. Healing process results showed that group I had the highest healing values in each interval, with a significant difference between group I and group III at 1 and 2\u00a0weeks. Color matching parameter showed slight differences between the groups\u2019 readings in favor of group I in all intervals without a statistically significant difference. The results suggest OPMF as a palatal dressing material that facilitates hemostasis, pain relief, and palatal wound healing. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 42,\r\n \"title\": \"Ragab, Sohair M.M. (56747567100); ALmohaimeed, Hailah M. (57219174113); Alghriany, Alshaimaa A.I. (57224211446); Abou-Khalil, Nasser Sayed (57160296500); Abd-Allah, Elham A. (57804727300)\",\r\n \"authors\": \"Protective effect of Moringa oleifera leaf ethanolic extract against uranyl acetate-induced testicular dysfunction in rats\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85181886558&doi=10.1038%2Fs41598-023-50854-2&partnerID=40&md5=9dc1afdd272e6742db34d2480fc06892\",\r\n \"affiliations\": \"Department of Zoology and Entomology, Faculty of Science, Asyut, Egypt; Department of Basic Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Department of Zoology and Entomology, Faculty of Science, Asyut, Egypt; Department of Basic Medical Sciences, Merit University, Sohag, Egypt; Department of Medical Physiology, Faculty of Medicine, Asyut, Egypt; Department of Zoology, Faculty of Science, Kharga, Egypt\",\r\n \"abstract\": \"Uranyl acetate (UA) is used in civilian and military applications, predisposing it to wide dispersion in ecosystems. Using high-performance liquid chromatography, gas chromatography\u2013mass spectrometry, and 2,2-Diphenyl-1-picrylhydrazyl scavenging radical analysis, we confirmed that Moringa oleifera leaf ethanolic extract (MLEE) is rich in biologically active phytochemicals. Thus, this study aims to investigate the possible defensive effect of MLEE against UA-induced testicular dysfunction. To achieve this, rats were divided randomly and evenly into three groups for 14 days. The control group received no treatment, while the UA group received a single intraperitoneal injection of UA at a dose of 5\u00a0mg\/kg BW dissolved in saline on the 12th day of the experiment, followed by no treatment the following day. The MLEE + UA group received daily oral administration of MLEE (300 mg\/kg BW) dissolved in distilled water before exposure to UA intoxication. The disruption observed in the pituitary\u2013gonadal axis of UA-intoxicated rats was characterized by a significant decrease in luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol 17beta levels. Additionally, there was a notable increase in malondialdehyde and a decrease in catalase, superoxide dismutase, reduced glutathione, and nitric oxide, accompanied by an up-regulation in the immuno-expression of nuclear factor-kappa B, indicating a disturbance in the redox balance. The TUNEL assay confirmed a substantial rise in apoptotic cell numbers in the UA group. Testicular histopathological changes, excessive collagen deposition, and reduced glycogen content were evident following UA exposure. However, supplementation with MLEE effectively countered these mentioned abnormalities. MLEE is proposed to combat the toxicological molecular targets in the UA-affected testis by restoring the balance between oxidants and antioxidants while obstructing the apoptotic cascade. MLEE contains an abundance of redox-stabilizing and cytoprotective phytochemicals that have the potential to counteract the mechanistic pathways associated with UA exposure. These findings encourage further research into other plausible protective aspects of Moringa oleifera against the UA challenge. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 43,\r\n \"title\": \"Saleem, Tahia Hashem (35608413200); Rizk, Mohamed Ahmed (53664349900); Abdelhafez, Nashwa F. (58791219900); Sabra, Ahmed (58791691300); Radwan, Eman M. (57190883689)\",\r\n \"authors\": \"Upregulation of BRCA1 and 2 protein expression is associated with dysregulation in amino acids profiles in breast cancer\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85181244493&doi=10.1007%2Fs11033-023-09028-6&partnerID=40&md5=19bc729367097e716fb5547ed885191a\",\r\n \"affiliations\": \"Department of Medical Biochemistry, Faculty of Medicine, Asyut, Egypt; Faculty of Medicine, Asyut, Egypt; Anesthesia and Intensive Care Unit, Faculty of Medicine, Asyut, Egypt; Department of Medical Biochemistry, Merit University, Sohag, Egypt; Department of Biochemistry, Sphinx University, New Assuit, Egypt\",\r\n \"abstract\": \"Background: The prevalence of breast cancer (BC) is high among cancers in Egypt, ranking it the most common cause of cancer mortality in women. BRCA1 and BRCA2 tumor suppressors proteins have a specific relationship with BC. Plasma free amino acids levels (PFAAs) have been reported to exhibit altered profiles among cancer patients. Thus, the present study aims to examine the alteration of the PFAAs profiles and investigate their association with BRCA1 and 2 circulating levels in Egyptian females diagnosed with BC and in females with family history of BC to establish potential early detection strategies for BC. Methods and results: This study included 26 BC patients, 22 females with family history of BC (relatives) in addition to 38 healthy females as control group. Quantitative measurement of PFAAs was determined by the ion exchange separation method through high performance liquid chromatography. BRCA1 and BRCA2 concentrations were determined using ELISA. Our results showed PFAAs profiles in BC patients and in females with BC family history with significant upregulation in mean plasma levels of Alanine, Phenylalanine, Glutamate and Cysteine and downregulation of Taurine, Threonine, Serine, Glycine, Valine, Methionine and Histidine levels compared to controls. Also, a significant positive correlation was observed between plasma BRCA1 and Valine levels while a significant negative correlation was observed between BRCA2 and Lysine plasma levels. Conclusion: PFAAs profile can potentially be used in early screening for BC patients and for susceptible females. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Amino acids\",\r\n \" BRCA\",\r\n \" Breast cancer\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 44,\r\n \"title\": \"Khalil, Eman M. (58218941100); Madney, Yasmin M. (57193872234); Hassan, Mahmoud (55669885400); Fahmy, Alzhraa M. (57384219700); Alshammari, Saud O. (57204353584); Alshammari, Qamar A. (57204352937); Abou-Taleb, Heba A. (57197775199); Taha, Ahmed Abdelrahem (57188559442); Elgendy, Marwa O. (56926529900); Ali, Hamada Ashry Abd El Wahed (57200288809)\",\r\n \"authors\": \"Maternal and Fetal Outcome of COVID-19 Infection among Pregnant Women\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85207685199&doi=10.3390%2Fmedicina60101676&partnerID=40&md5=8f72fbf67267ab7e08ec13e966742534\",\r\n \"affiliations\": \"Faculty of Medicine, Beni Suef, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Internal Medicine, Faculty of Medicine, Beni Suef, Egypt; Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Beni Suef, Egypt; Department of Pharmacognosy and Alternative Medicine, Northern Border University, Arar, Saudi Arabia; Department of Pharmacology and Toxicology, Northern Border University, Arar, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Clinical Pharmacy, Faculty of Pharmacy, Beni Suef, Egypt\",\r\n \"abstract\": \"Background and Objectives: Pregnant women face an increased risk of experiencing negative consequences due to COVID-19 infection. Our study aimed to identify outcomes for both mothers and fetuses associated with COVID-19 during each trimester, as well as to identify post-COVID symptoms in this population. Materials and Methods: Among the total population, 14 females were infected during the first trimester, 25 during the second, and 66 during the third trimester. Weekly follow-ups were conducted until delivery. Seventy-five females (71.4%; 95% CI:26.9\u2013115.9%) were admitted to the hospital secondary to COVID-19 infection. Maternal hospitalization was independently associated with COVID-19 severity (adjusted odds ratio (aOR) = 3.9; 95% CI: 1.6\u20139.2 at p = 0.002 relative to the reference group (mild infection)) and the presence of dyspnea at initial assessment (aOR = 6.9; 95% CI: 1.7\u201328.2 at p = 0.007 relative to nondyspneic patients). Results: The duration of hospitalization (mean \u00b1 SD) was higher in the third trimester than the first and second trimesters (10.1 \u00b1 0.8 vs. 4.0 \u00b1 1.2 days and 10.1 \u00b1 0.8 vs. 6.2 \u00b1 1.4 days, respectively, at p < 0.05). The number of maternal deaths in the third trimester was higher than in the first and second trimesters (16 (24.2%) vs. no deaths and 16 (24.2%) vs. 1 (4%) deaths, respectively, at p < 0.05). In terms of fetal outcomes, a good fetal condition was more likely if the mother was infected during the first trimester (92.9%) than the second (80%) or third trimesters (66.7%), but the difference was not significant. The percentage of preterm deliveries was insignificantly higher in the second trimester (16%) than the first (7.1%) and third (4.5%) trimesters. Conclusions: The most common post-COVID symptoms included persistent loss of smell, dry eyes, post-partum depression, knee pain, and myalgia. Post-COVID symptoms were more prevalent in patients infected during the third trimester. The adverse outcomes of COVID-19 infection for both mother and fetus were more severe in cases where the infection occurred during the third trimester compared to the second and first trimesters. Therefore, it is crucial to adhere to precautionary measures against COVID-19, prioritize vaccination, and provide comprehensive care for pregnant mothers. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"COVID-19\",\r\n \" fetus\",\r\n \" post-COVID syndrome\",\r\n \" pregnancy\",\r\n \" SARS-CoV-2\",\r\n \" three trimesters\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 45,\r\n \"title\": \"Hamdy, Aya (58046302000); Hassanein, Khaled M.A. (36863873500); Ali, Magda Mahmoud (7404486251); Ali, Ahmed U. (57213590141); Khallaf, Iman S.A. (57213352391); Abdelhakiem, Mohammed Ahmed Hamdy (56922161200)\",\r\n \"authors\": \"Evaluation of the subconjunctival injection of Hesperidin with or without olive oil on the healing of alkali burn corneal ulcer in rabbits\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85206880190&partnerID=40&md5=150d2f9fdd95b6eeb941a42481f1718c\",\r\n \"affiliations\": \"Department of Surgery, Faculty of Veterinary Medicine, Asyut, Egypt; Faculty of Veterinary Medicine, Asyut, Egypt; Department of Pharmaceutics, Merit University, Sohag, Egypt; Department of Pharmacognosy and Natural Products, Faculty of Pharmacy, Shibin El Kom, Egypt\",\r\n \"abstract\": \"Corneal ulcers represent an anxious problem in animals and humans. The alkali burn corneal ulcer is severe and may be associated with damage to most of the corneal structure. The healing of the corneal ulcer is mainly complicated by the impairment of vision. The striving to find a new therapy that promotes the healing of corneal injuries with the maintenance of the power of vision is the main aim of most studies. The current study was conducted to evaluate the effect of hesperidin with or without olive oil after its deposition under the bulbar con-junctiva on the healing of induced alkali burn corneal ulcers. For carrying out the study, 18 New Zealand albino rabbits were included. They were divided into three equal groups. Group I (control) received 0.5 ml of normal saline 0.9% under the bulbar conjunctiva 5 times at one-week intervals. Group II (H) received 0.5 ml of hesperi-din nanovesicles subconjunctivally 5 times at one-week intervals. Group III (HO) received 0.5 ml of nanovesicles of hesperidin with olive oil under the bulbar conjunctiva 5 times one week apart. The right eye of animals was subjected to induction of corneal ulcer using 1% NaOH before the commencement of treatment. The left eye was used as a negative control one. The animals were examined clinically (lacrimation, neovascularization, pus formation, corneal perforation, measurement of corneal ulcer), and with fluorescein test staining every week just before each treatment. The animals were examined on days 1, 8, 15, 22, 29, 36 post corneal ulcer induction. At the end of the experiment, the treated and nontreated eye samples were collected for histopathological and electron microscopy examination. The results showed an improvement in the total clinical score in groups H and HO especially in the fifth week, while the control group displayed increasing in the inflammatory process of the injured eye throughout the time of experiment. There was a significant difference between both of H and HO groups and the control group in the third, fourth, and fifth weeks. The results of the histopathological and electron microscopy revealed the superiority of hesperidin with olive oil over hesperidin alone in promoting the healing of corneal ulcers (p= 0.045). The current study concluded that the subconjunctival injection of hes-peridin with or without olive oil has a beneficial and promoting effect in the healing and regeneration of alkali burn corneal ulcers in rabbits. Moreover, subconjunctival injections can ensure long-term drug maintenance compared to topical methods, which in turn saves time and effort. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Corneal ulcer\",\r\n \" Hesperidin\",\r\n \" Olive oil\",\r\n \" Rabbits\",\r\n \" Subcon-junctival injection\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 46,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Mohamed, Mohamed S. (57211757868); Zayed, Gamal M.S. (36865467400); Abdelaty, Lamiaa N. (57214763588); Makki, Mahmoud A.E. (57188804969); Abdel-Aleem, Hazem L. (58225883900); El-Mokhtar, Mohamed Ahmed (57190683185); Hetta, Helal F. (55939372100); Abdullah, Nidaa (59345080100); Saddik, Mohammed S. (57214806788)\",\r\n \"authors\": \"HPMC-Zein Film-forming Gel Loaded with 5-Fluorouracil Coupled with CO2 Laser Dermabrasion for Managing Stable Vitiligo\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85205073412&doi=10.1208%2Fs12249-024-02937-0&partnerID=40&md5=4c8066c8fc4e92f1987201d50aa36bf5\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Cairo, Egypt; Department of Clinical Pharmacy, Faculty of Pharmacy, 6th October, Egypt; Department of Dermatology and Andrology, Faculty of Medicine, Cairo, Egypt; Gilbert and Rose-Marie Chagoury School of Medicine, Byblos, Lebanon; Immunology and Biotechnology, University of Tabuk, Tabuk, Saudi Arabia; Department of Medical Sterilization, Ohud Hospital, Medina, Saudi Arabia; Faculty of Pharmacy, Sohag, Egypt; College of Pharmacy, Al-Ayen Iraqi University, AUIQ, An Nasiriyah, Iraq\",\r\n \"abstract\": \"Vitiligo is a significant dermatological challenge affecting 0.5 to 2% of the global population. Despite the various existing medical approaches, current vitiligo treatments are far from ideal. The present study aimed to prepare and evaluate a film-forming gel of 5 fluorouracil (5FU) using different ratios of hydroxypropyl methylcellulose (HPMC) and Zein for treating vitiligo. The prepared film-forming gels were fully characterized in terms of morphology, Fourier-transform infrared spectroscopy, drug content, pH, drying time, in-vitro drug release, and clinical investigation. A 32-full factorial design was used to study the impact of varying concentrations of HPMC (X1) and Zein (X2) on the percentage of 5FU released (Y1) from the prepared film-forming gels. Scanning electron microscopy (SEM) revealed a cross-linked network structure between polymers. An increase in HPMC concentration (2\u20134%) correlated with higher 5FU release, whereas increased Zein concentration (1\u20132%) resulted in reduced 5FU release. Furthermore, patients treated with 5FU film-forming gel after dermabrasion with fractional CO2 (FCO2) laser exhibited a significant decrease in JAK3 gene expression and higher effectiveness than those treated with FCO2 laser alone. Our results suggest that the film-forming gel of 5FU is promising as an effective formulation for treating vitiligo. Graphical Abstract: (Figure presented.) \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"5-Fluorouracil (5FU)\",\r\n \" dermabrasion\",\r\n \" film-forming gel\",\r\n \" JAK3 expression\",\r\n \" vitiligo\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 47,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Araujo-Castro, Marta (57195685068); Chiaretti, Massimo (6603417473); Podda, Mauro Guido (7004555508); Aiolfi, Alberto (6508362055); Kryvoruchko, Igor A. (59374914600); Manangi, Mallikarjuna (57219159683); Shelat, Vishalkumar G. (16744511800); Kalmoush, Abd Elfattah (57727380200); Labib, Mohamed Fathy (57221263028); Elshafey, Mohammed Hassan (57212769328); Ibrahim, Sameh Mohamed Mahmoud (59206142600); Abo Alsaad, Mohamed Ibrahim (58743979200); Elbelkasi, Hamdi (58744062800); Mansour, Mohamed Ibrahim (57219159269); Elshahidy, Tamer Mohamed Mahmoud (57219158772); Heggy, Ibrahim A. (59018529000); Elsayed, Rasha S. (58310525400); Fiad, Alaa A. (51863395700); Yehia, Ahmed Mohamed (57210598249); Yassin, Mahmoud Abdou (57217355675); Elballat, Mahmoud R. (59205549400); Hebeishy, Mohamed H. (59205743000); AboZeid, Ahmed Khaled (59205349300); Saleh, Mohamed Adel Ahmed (58588452500); Hamed, Abd Elwahab M. (58986714100); Abdelghani, Amr A. (57913319900); Mousa, Bassam (57710406600)\",\r\n \"authors\": \"Side-specific factors for intraoperative hemodynamic instability in laparoscopic adrenalectomy for pheochromocytoma: a comparative study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85197632427&doi=10.1007%2Fs00464-024-10974-w&partnerID=40&md5=e193b8c99221a7ded81664b912442fbc\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; Neuroendocrinology & amp; Adrenal Unit of the Endocrinology & amp; Nutrition Department, Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain; Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria, Madrid, Spain; Department of General Surgery and Organ Transplantation, Sapienza Universit\u00e0 di Roma, Rome, Italy; Department of Surgical Sciences, Universit\u00e0 degli Studi di Cagliari, Cagliari, Italy; Surgery Department #2, Kharkiv National Medical University, Kharkiv, Ukraine; Bangalore Medical College and Research Institute, Bengaluru, India; General Surgery, Tan Tock Seng Hospital, Singapore City, Singapore; General Surgery Department, Faculty of Medicine, Cairo, Egypt; Armed Forces College of Medicine, Cairo, Egypt; General Surgery Department-Faculty of Medicine, Merit University, Sohag, Egypt; Mataryia Teaching Hospital (GOTHI), Cairo, Egypt\",\r\n \"abstract\": \"Background: Adrenalectomy for pheochromocytoma (PHEO) is challenging because of the high risk of intraoperative hemodynamic instability (HDI). This study aimed to compare the incidence and risk factors of intraoperative HDI between laparoscopic left adrenalectomy (LLA) and laparoscopic right adrenalectomy (LRA). Methods: We retrospectively analyzed two hundred and seventy-one patients aged > 18\u00a0years with unilateral benign PHEO of any size who underwent transperitoneal laparoscopic adrenalectomy at our hospitals between September 2016 and September 2023. Patients were divided into LRA (N = 122) and LLA (N = 149) groups. Univariate and multivariate logistic regression analyses were used to predict intraoperative HDI. In multivariate analysis for the prediction of HDI, right-sided PHEO, PHEO size, preoperative comorbidities, and preoperative systolic blood pressure were included. Results: Intraoperative HDI was significantly higher in the LRA group than in the LLA (27% vs. 9.4%, p < 0.001). In the multivariate regression analysis, right-sided tumours showed a higher risk of intraoperative HDI (odds ratio [OR] 5.625, 95% confidence interval [CI], 1.147\u201327.577, p = 0.033). The tumor size (OR 11.019, 95% CI 3.996\u201330.38, p < 0.001), presence of preoperative comorbidities [diabetes mellitus, hypertension, and coronary heart disease] (OR 7.918, 95% CI 1.323\u201347.412, p = 0.023), and preoperative systolic blood pressure (OR 1.265, 95% CI 1.07\u20131.495, p = 0.006) were associated with a higher risk of HDI in both LRA and LLA, with no superiority of one side over the other. Conclusion: LRA was associated with a significantly higher intraoperative HDI than LLA. Right-sided PHEO was a risk factor for intraoperative HDI. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Adrenalectomy\",\r\n \" Hemodynamic instability\",\r\n \" Laparoscopic adrenalectomy\",\r\n \" Pheochromocytoma\",\r\n \" Transperitoneal\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 48,\r\n \"title\": \"Ahmed, Marwa A. (59607360600); Kamel, Esam Omar (57211744749); Abd-Eldayem, Ahmed Mohammed (57195596545)\",\r\n \"authors\": \"Role of cAMP\/pCREB and GSK-3\u03b2\/NF-\u03baB p65 signaling pathways in the renoprotective effect of mirabegron against renal ischemia-reperfusion injury in rats\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85191467946&doi=10.1016%2Fj.ejphar.2024.176617&partnerID=40&md5=601ce2f3570ecf5f4293122bbd5ae6a8\",\r\n \"affiliations\": \"Department of Pharmacology, Faculty of Medicine, Asyut, Egypt; Department of Histology and Cell Biology, Faculty of Medicine, Cairo, Egypt; Department of Pharmacology, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Acute kidney injury and other renal disorders are thought to be primarily caused by renal ischemia-reperfusion (RIR). Cyclic adenosine monophosphate (cAMP) has plenty of physiological pleiotropic effects and preserves tissue integrity and functions. This research aimed to examine the potential protective effects of the \u03b2<inf>3<\/inf>-adrenergic receptors agonist mirabegron in a rat model of RIR and its underlying mechanisms. Male rats enrolled in this work were given an oral dose of 30 mg\/kg mirabegron for two days before surgical induction of RIR. Renal levels of kidney injury molecule-1 (KIM-1), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-\u03b1), Interleukin-10 (IL-10), cAMP, cAMP-responsive element binding protein (pCREB), and glycogen synthase kinase-3 beta (GSK-3\u03b2) were assessed along with blood urea nitrogen and serum creatinine. Additionally, caspase-3 and nuclear factor-kappa B (NF-\u03baB) p65 were explored by immunohistochemical analysis. Renal specimens were inspected for histopathological changes. RIR led to renal tissue damage with elevated blood urea nitrogen and serum creatinine levels. The renal KIM-1, MCP-1, TNF-\u03b1, and GSK-3\u03b2 were significantly increased, while IL-10, cAMP, and pCREB levels were reduced. Moreover, upregulation of caspase-3 and NF-\u03baB p65 protein expression was seen in RIR rats. Mirabegron significantly reduced kidney dysfunction, histological abnormalities, inflammation, and apoptosis in the rat renal tissues. Mechanistically, mirabegron mediated these effects via modulation of cAMP\/pCREB and GSK-3\u03b2\/NF-\u03baB p65 signaling pathways. Mirabegron administration could protect renal tissue and maintain renal function against RIR. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"cAMP\",\r\n \" CREB\",\r\n \" GSK-3\u03b2\",\r\n \" Mirabegron\",\r\n \" Renal ischemia\/reperfusion\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 49,\r\n \"title\": \"Salem, Heba Farouk (16426683200); Aboud, Heba M. (55558016900); Abdellatif, Mostafa M. (58947107100); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Nose-to-Brain Targeted Delivery of Donepezil Hydrochloride via Novel Hyaluronic Acid-Doped Nanotransfersomes for Alzheimer's Disease Mitigation\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85188219286&doi=10.1016%2Fj.xphs.2024.02.014&partnerID=40&md5=9389508de3cc2a93a5868220e3496569\",\r\n \"affiliations\": \"Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Alzheimer's disease is the most serious neurodegenerative disorder characterized by cognitive and memorial defects alongside deterioration in behavioral, thinking and social skills. Donepezil hydrochloride (DPZ) is one of the current two FDA-approved cholinesterase inhibitors used for the management of Alzheimer's disease. The current study aimed to formulate hyaluronic acid-coated transfersomes containing DPZ (DPZ-HA-TFS) for brain delivery through the intranasal pathway to surpass its oral-correlated GIT side effects. DPZ-HA-TFS were produced using a thin film hydration method and optimized with a 24 factorial design. The influence of formulation parameters on vesicle diameter, entrapment, cumulative release after 8 h, and ex vivo nasal diffusion after 24 h was studied. The optimal formulation was then evaluated for morphology, stability, histopathology and in vivo biodistribution studies. The optimized DPZ-HA-TFS formulation elicited an acceptable vesicle size (227.5 nm) with 75.83% entrapment efficiency, 37.94% cumulative release after 8 h, 547.49 \u00b5g\/cm2 permeated through nasal mucosa after 24 h and adequate stability. Histopathological analysis revealed that the formulated DPZ-HA-TFS was nontoxic and tolerable for intranasal delivery. Intranasally administered DPZ-HA-TFS manifested significantly superior values for drug targeting index (5.08), drug targeting efficiency (508.25%) and direct nose-to-brain transport percentage (80.32%). DPZ-HA-TFS might be deemed as a promising intranasal nano-cargo for DPZ cerebral delivery to tackle Alzheimer's disease safely, steadily and in a non-invasive long-term pattern. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Alzheimer's disease\",\r\n \" Donepezil hydrochloride\",\r\n \" Hyaluronic acid\",\r\n \" Intranasal\",\r\n \" Pharmacokinetics\",\r\n \" Transfersomes\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 50,\r\n \"title\": \"Ali, Ahmed U. (57213590141); Khallaf, Iman S.A. (57213352391); Hassan, Abeer S. (57196119456); Sayed, Marwa A. (57217417384); Hamdy, Aya (58046302000); Ali, Magda Mahmoud (7404486251); Hassanein, Khaled M.A. (36863873500); Badry, Mahmoud El (59307289800); Abdelhakiem, Mohammed Ahmed Hamdy (56922161200)\",\r\n \"authors\": \"Effect of Olive Oil on Hesperidin Nanovesicles in Treatment of Induced Corneal Ulcers in Rabbits, Morphological and Histopathologic Study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85202744131&doi=10.22037%2Fijps.v20i2.44223&partnerID=40&md5=55f6c1c4c5959027482cb0649bb67420\",\r\n \"affiliations\": \"Faculty of Pharmacy, Merit University, Sohag, Egypt; Department of pharmacognosy and natural products Faculty of Pharmacy, Menoufia University, Shibin El Kom, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Qena, Egypt; Department of Industrial Pharmacy, Faculty of Pharmacy, Asyut, Egypt; Department of Surgery, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Clinical Pathology, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Asyut, Egypt; Assiut International Center of Nanomedicine, Assiut University, Asyut, Egypt\",\r\n \"abstract\": \"Hesperidin (HSP) and Olive oil possess many biological activities that are required for the safe and effective treatment of corneal ulcers. However, the poor aqueous solubility of HSP hinders its topical utilization. This work aims at enhancing the dissolution of HSP and combining the powerful effectiveness of Olive oil in treating corneal ulcers. HSP was isolated from orange peel and described by spectroscopic methods (1H NMR and 13C NMR), then HSP nanovesicles were prepared with and without Olive oil using the ethanol injection method. Nanovesicles were applied topically to rabbits\u2019 eyes in which alkali burn corneal ulcers were induced. After five weeks, histopathological studies were performed. No ulcers were determined after topical application of HSP, and the inclusion of Olive oil returned the eye to its normal conditions. Thus, this study clarified the potential role of the HSP - Olive oil combination in managing corneal ulcers. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Corneal ulcer\",\r\n \" Hesperidin\",\r\n \" Histopathology\",\r\n \" nanovesicles\",\r\n \" Olive oil\",\r\n \" rabbits\",\r\n \" Topical application\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 51,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Zaki, Randa Mohammed (54792413400); Hefny, Ahmed A. (57195534027); Afzal, Obaid (53870994800); Shahataa, Mary Girgis (57190442518); Abo El-Ela, Fatma I. (56461520900); Salem, Heba Farouk (16426683200); Gamal, Amr Gamal (57204454409)\",\r\n \"authors\": \"In vitro and in vivo evaluation of isoxsuprine loaded invasomes for efficient treatment of diabetes\u2010accelerated atherosclerosis\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85190945098&doi=10.1016%2Fj.jddst.2024.105686&partnerID=40&md5=1a45ab8e1f24a245e4866367d9adcbe2\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Faculty of Pharmacy, Beni Suef, Egypt; School of Pharmacy, University of Waterloo, Waterloo, Canada; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutical Chemistry, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Pharmacology, Faculty of Medicine, Beni Suef, Egypt; Department of Pharmacology, Faculty of Veterinary Medicine, Beni Suef, Egypt; Faculty of Pharmacy, Beni Suef, Egypt\",\r\n \"abstract\": \"Hyperglycemia in diabetes mellitus exacerbates vascular disarray in atherosclerosis by damaging endothelial cells and vascular smooth muscles. It's a major contributor to deaths from cardiovascular disease. Isoxsuprine (IXS) is an oral beta-adrenergic agonist that improves arterial blood flow due to its vasodilatation effect and boosts insulin secretion. However, oral IXS has low efficacy, low bioavailability and patient incompliance due to its high dose frequency, short biological half-life and fast clearance. The goal of this research was to develop a nasal formulation of IXS-loaded invasomes to sustain IXS's release and improve its permeation and efficacy as a potential diabetes-accelerated atherosclerosis treatment. Different IXS-loaded invasomes formulations were developed using design expert software to study the effects of ethanol, phospholipid, and cineole concentrations. Based on the desirability index, the formulation with 1 % ethanol, 0.5 % cineole, and 2.48 % phospholipid was chosen as the optimum formulation. The optimum IXS-loaded invasomes formulation showed an encapsulation efficiency of 72.03 % and a particle size of 210.26 nm. Production of nasal IXS-loaded invasomes formulation increased the permeation of IXS with a ratio of 2.25 and sustained its release. The optimum IXS-loaded invasomes formulation was non-cytotoxic and showed a good binding mode with serum proteins. When optimum IXS-loaded invasomes formulation was evaluated in vivo against a rat model of experimental diabetes and atherosclerosis, it showed anti-diabetic and anti-atherosclerotic effects. It substantially increased the levels of HDL by 45.11 % and substantially decreased the levels of glucose, LDL, triglycerides, and cholesterol by 41.35 %, 89.76 %, 51.01 %, and 60.18 %, respectively. Histopathology also showed that atherosclerotic lesions got improved in rats given optimum IXS-loaded invasomes formulation. In conclusion, nasal administration of IXS-loaded invasomes could be a potential diabetes-accelerated atherosclerosis treatment. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Atherosclerosis\",\r\n \" Cineole\",\r\n \" Diabetes mellitus\",\r\n \" Invasomes\",\r\n \" Isoxsuprine\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 52,\r\n \"title\": \"Eissa, Manar A. (57204365848); Hashim, Yumi Zuhanis Has Yun (9435676000); Badawi, Noha M. (57201151660)\",\r\n \"authors\": \"Unlocking the potential of chitosan-based polymeric nanoparticles for the treatment of neurological disorders\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85189696053&doi=10.22038%2FNMJ.2024.74564.1812&partnerID=40&md5=4b6a7ff463667035ad70dce7c072c8dd\",\r\n \"affiliations\": \"Department of Pharmacology and Toxicology, Merit University, Sohag, Egypt; International Institute for Halal Research and Training, International Islamic University Malaysia, Kuala Lumpur, Malaysia; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, El Shorouk, Egypt\",\r\n \"abstract\": \"Neurological disorders are the diseases associated with the central and peripheral nervous system. They are among the most serious and prevalent diseases nowadays. However, most of the pharmacological agents used to treat neurological disorders demonstrate severe toxicities and side effects, along with failure to achieve the desired outcomes due to their inability to cross the blood-brain barrier (BBB). Therefore, efforts have been made to develop potential drug carriers that can enhance the penetration of various therapeutic agents across the BBB. Due to the remarkable selectivity of nanoparticles and their ability to penetrate the BBB, they have attracted enormous interest as a viable solution to overcome these challenges. Polymeric nanoparticles used as drug delivery systems, in particular, demonstrated multiple advantages over traditional drug delivery systems in the treatment of neurological and psychological disorders due to several beneficial properties. This minireview article discusses the current literature on the use of chitosan nanoparticles in particular as promising carriers for delivering therapeutic agents to the brain for the treatment of different neurological diseases. The article emphasizes the advantages of using chitosan over other natural and synthetic polymers, and illustrates the methods of preparation of chitosan nanoparticles, in addition to the characterization of chitosan-based nanoparticles. The article also discusses the specific application of chitosan-based nanoparticles for brain targeting with the aim of the treatment of neurological disorders. Furthermore, challenges and future prospects were also discussed. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Chitosan\",\r\n \" Drug delivery systems\",\r\n \" Nanocapsules\",\r\n \" Neurological disorders\",\r\n \" Polymer\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 53,\r\n \"title\": \"Zaher, Ahmed M. (55816802700); Anwar, Walaa S. (58082428700); Makboul, Makboul A. (6508060541); Abdel-Rahman, Iman A.M. (57217534275)\",\r\n \"authors\": \"Potent anticancer activity of (Z)-3-hexenyl-\u03b2-D-glucopyranoside in pancreatic cancer cells\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85173799800&doi=10.1007%2Fs00210-023-02755-4&partnerID=40&md5=24454a2103bfba08d1085f12ecfd0782\",\r\n \"affiliations\": \"Faculty of Pharmacy, Asyut, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Qena, Egypt\",\r\n \"abstract\": \"This current study reports, for the first time, on the potent cytotoxicity of (Z)-3-hexenyl-\u03b2-<inf>D<\/inf>-glucopyranoside, as well as its cellular and molecular apoptotic mechanisms against Panc1 cancer cells. The cytotoxicity of three compounds, namely (Z)-3-hexenyl-\u03b2-<inf>D<\/inf>-glucopyranoside (1), gallic acid (2), and pyrogallol (3), which were isolated from C. rotang leaf, was investigated against certain cancer and normal cells using the MTT assay. The cellular apoptotic activity and Panc1 cell cycle impact of compound (1) were examined through flow cytometry analysis and Annexin V-FITC cellular apoptotic assays. Additionally, RT-PCR was employed to evaluate the effect of compound (1) on the Panc1 apoptotic genes Casp3 and Bax, as well as the antiapoptotic gene Bcl-2. (Z)-3-hexenyl-\u03b2-<inf>D<\/inf>-glucopyranoside demonstrated the highest cytotoxic activity against Panc1 cancer cells, with an IC<inf>50<\/inf> value of 7.6\u00a0\u00b5M. In comparison, gallic acid exhibited an IC<inf>50<\/inf> value of 21.8\u00a0\u00b5M, and pyrogallol showed an IC<inf>50<\/inf> value of 198.2\u00a0\u00b5M. However, (Z)-3-hexenyl-\u03b2-<inf>D<\/inf>-glucopyranoside displayed minimal or no significant cytotoxic activity against HepG2 and MCF7 cancer cells as well as WI-38 normal cells, with IC<inf>50<\/inf> values of 45.8\u00a0\u00b5M, 108.7\u00a0\u00b5M, and 194. \u00b5M, respectively. (Z)-3-hexenyl-\u03b2-<inf>D<\/inf>-glucopyranoside (10\u00a0\u00b5M) was demonstrated to induce cellular apoptosis and cell growth arrest at the S phase of the cell cycle in Panc1 cells. These findings were supported by RT-PCR analysis, which revealed the upregulation of apoptotic genes (Casp3 and Bax) and the downregulation of the antiapoptotic gene Bcl-2. This study emphasizes the significant cellular potency of (Z)-3-hexenyl-\u03b2-<inf>D<\/inf>-glucopyranoside in specifically inducing cytotoxicity in Panc1 cells. Graphical Abstract: (Figure presented.). \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"(Z)-3-hexenyl-\u03b2-D-glucopyranoside\",\r\n \" Bax\",\r\n \" Bcl-2\",\r\n \" Casp3\",\r\n \" Panc1\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 54,\r\n \"title\": \"El-Hawary, Seham Salah Dine (6505933617); Hassan, Marwa H.A. (56468563000); Hudhud, Ahmed O. (58122425100); Al-Karmalawy, Ahmed A. (57210596269); Mustafa, Muhamad (56588496500); Hamed, El Sayed A.E. (57091344200); Abdelmohsen, Usama Ramadan (36056037900); Mohammed, Rabab (54963341500)\",\r\n \"authors\": \"LC-HRMS Profiling and Cytotoxic Potential of Actinomycetes Associated with the Red Sea Soft Coral Sarcophyton glaucum: In vitro and In silico Studies\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85186913430&doi=10.1002%2Fcbdv.202301617&partnerID=40&md5=a5320dd53683a0fd35c937d7271b1a34\",\r\n \"affiliations\": \"Faculty of Pharmacy, Cairo, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt; Department of Pharmaceutical Chemistry, Horus University - Egypt, New Damietta, Egypt; Faculty of Pharmacy, 6th October, Egypt; Institut des Biomol\u00e9cules Max Mousseron, Montpellier, France; Department of Medicinal Chemistry, Deraya University, New Minia, Egypt; National Institute of Oceanography and Fisheries, Cairo, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Minya, Egypt; Department of Pharmacognosy, Deraya University, New Minia, Egypt\",\r\n \"abstract\": \"In the current study, the actinomycetes associated with the red sea-derived soft coral Sarcophyton glaucum were investigated in terms of biological and chemical diversity. Four different media, M1, ISP2, Marine Agar (MA), and Actinomycete isolation agar (AIA) were used for the isolation of three strains of actinomycetes that were identified as Streptomyces sp. UR 25, Micromonospora sp. UR32 and Saccharomonospora sp. UR 19. LC-HRMS analysis was used to investigate the chemical diversity of the isolated actinobacteria. The LC-HRMS data were statistically processed using MetaboAnalyst 5.0 viz to differentiate the extract groups and determine the optimal growth culturing conditions. Multivariate data statistical analysis revealed that the Micromonospora sp. extract cultured on (MA) medium is the most distinctive extract in terms of chemical composition. While, the Streptomyces sp. UR 25 extracts are differ significantly from Micromonospora sp. UR32 and Saccharomonospora sp. UR 19. Biological investigation using in vitro cytotoxic assay for actinobacteria extracts revealed the prominent potentiality of the Streptomyces sp. UR 25 cultured on oligotrophic medium against human hepatoma (HepG2), human breast adenocarcinoma (MCF-7) and human colon adenocarcinoma (CACO2) cell lines (IC<inf>50<\/inf>=3.3, 4.2 and 6.8 \u03bcg\/mL, respectively). SwissTarget Prediction speculated that among the identified compounds, 16-deethyl, indanomycin (8) could have reasonable affinity on HDM2 active site. In this respect, molecular docking study was performed for compound (8) to reveal a substantial affinity on HDM2 active site. In addition, molecular dynamics simulations were carried out at 200 ns for the most active compound (8) compared to the co-crystallized inhibitor DIZ giving deeper information regarding their thermodynamic and dynamic properties as well. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Actinomycetes\",\r\n \" docking\",\r\n \" Micromonospora\",\r\n \" Molecular dynamics and MM-GBSA calculations\",\r\n \" Streptomyces, Saccharomonospora, multivariate\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 55,\r\n \"title\": \"Waly, Hanan S.A. (55623917400); Abdelfattah, Mostafa Galal (57209069196); Abou-Khalil, Nasser Sayed (57160296500); Ragab, Sohair M.M. (56747567100)\",\r\n \"authors\": \"Role of Eruca sativa L. seeds in boosting the reproductive performance of male Japanese quails (Coturnix c. japonica)\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85178966399&doi=10.1111%2Fjpn.13912&partnerID=40&md5=513750a3cbf4f5fb4a4d2f0751befd66\",\r\n \"affiliations\": \"Department of Zoology and Entomology, Faculty of Science, Asyut, Egypt; Department of Poultry Production, Faculty of Agriculture, Asyut, Egypt; Department of Medical Physiology, Faculty of Medicine, Asyut, Egypt; Department of Basic Medical Sciences, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Herein we attempt to shed light on the potential improving effect of Eruca sativa seeds (ESS) on the reproductive aspects of male Japanese quails. To accomplish this objective, two groups of quails were supplemented with ESS powder at doses of 5 and 10 g\/kg feed from 7 days to 140 days of age, in addition to the control group, which did not receive treatment. Forty males were reared singly in cages to evaluate sperm characters and 32 males were raised with 64 females to evaluate fertility and sperm penetrability. Sixty-six phytochemical compounds were found according to gas chromatography\u2013mass spectrometry analysis of ESS. The most plentiful ones are 13-docosenoic acid methyl ester, 9-octadecenoic acid methyl ester, and linoleic acid methyl ester. Both 5 g\/kg and 10 g\/kg doses of ESS showed similar effectiveness in enhancing various reproductive parameters, including gonadal index, sperm characteristics, fertility, libido, and cloacal gland attributes. However, some aspects like sperm concentration and testosterone levels exhibited a dose-dependent response. There is no significant change in mortality rate of supplemented groups compared to the control one. ESS also caused a reduction in feed intake and an enhancement in feed conversion ratio without affecting final body weight and body weight gain. This suggests potential nutritional benefits beyond reproductive health. The low-dose-fed group showed a significant reduction in total cholesterol and malondialdehyde compared to the high-dose-fed and unfed groups. The higher dose notably increased total antioxidant capacity compared to the lower dose and control group. Despite the positive effects on male reproductive parameters, there wasn't a significant impact on hatchability percentage, indicating that while male fertility improved, it might not have directly affected the viability of the eggs. Overall, the study suggests that ESS could be a safe and promising addition to the diet of male Japanese quails to enhance their reproductive capabilities without adverse effects. The findings could have implications for poultry farming by potentially improving breeding efficiency and health outcomes in quails. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"antioxidants\",\r\n \" cloacal gland\",\r\n \" Eruca sativa seeds\",\r\n \" male Japanese quails\",\r\n \" physiology\",\r\n \" semen\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 56,\r\n \"title\": \"Eissa, Manar A. (57204365848); Abdullah, Raihan (59482494900); Sharif, Mohd Faez (57205264279); Nasir, Mohd Hamzah (57212019419)\",\r\n \"authors\": \"Repeated Blood Sampling from an Adult Danio Rerio\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85212742742&doi=10.1201%2F9781003402893-6&partnerID=40&md5=693beeae245dd58652fbf18084dc87e9\",\r\n \"affiliations\": \"Merit University, Sohag, Egypt; International Islamic University Malaysia, Kuala Lumpur, Malaysia\",\r\n \"abstract\": \"Zebrafish (Danio rerio) has emerged as an enormously powerful and popular model for biomedical and preclinical research over the past few years. This is largely attributed to the significant genetics and physiological homology with higher vertebrates, especially humans, and the emerging opportunities for genetic manipulation and live in vivo imaging. Furthermore, the body fluids of zebrafish, including blood, plasma, and interstitial and cerebrospinal fluids, can also provide an insightful data on health and disease status. The high similarity between zebrafish and human plasma proteins makes zebrafish an excellent alternative model organism for studying hematologic and metabolic diseases in the quest for a new therapy. The analysis of the metabolites and the blood parameters of zebrafish is essential, as it might provide important details about the physiological condition of the fish. Besides, the longitudinal analysis of individual zebrafish provides a better insight of metabolic dynamics than the single point blood analysis. Despite the advantages of employing zebrafish for metabolic and blood research studies, it can be difficult to collect blood samples from these tiny aquatic creatures, owing to the fact that a 4-cm-long adult zebrafish only has about 0.05-0.07 ml of blood. As a result, several techniques for routine blood collecting from adult zebrafish have been developed. These techniques include decapitation, lateral incision in the dorsal aorta, tail-clipping, and heart puncture. Some of these techniques have been deemed as invasive or even harmful, whereas others are non-invasive and safe to employ for repeated blood samples from the same fish. The various blood collection techniques are briefly compared in this chapter, along with their benefits and drawbacks. It is important to keep in mind that some blood sampling techniques are not better than others; instead, the best techniques should be chosen based on the objectives of the study and the bare minimum quantity of blood needed for analysis. This chapter will also introduce a new and low-cost instrument that can be used for repeated blood sampling from adult zebrafish for blood glucose monitoring, with a survival rate of 93%. The fabricated instrument comprised a pulled microcapillary glass needle with an outer tip diameter of about 20 \u00b5m. The needle is inserted at the caudal vein, where 5-7 \u00b5l of blood were drawn at 30 minutes to 1-hour time intervals. This proposed device can be simply fabricated in new labs for drawing blood from zebrafish with high survival rate and at minimal cost. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 57,\r\n \"title\": \"Abdelkader, Hamdy (20336654000); Alfatease, Adel M. (57193644396); Fathalla, Zeinab M.A. (57188965212); Shoman, Mai E. (24559439600); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Meloxicam-amino acids salts\/ion pair complexes with advanced solubility, dissolution, and gastric safety\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85207516201&doi=10.1080%2F10837450.2024.2417766&partnerID=40&md5=3f3c10254743230e854087158d6ce316\",\r\n \"affiliations\": \"Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Amino acids have attracted attention as a potential functional excipient for optimizing biopharmaceutics characteristics of poorly soluble drugs. The amino acids are a diverse class with many functional groups, natural compounds, biocompatible, and low-molecular-weight substances. Two amino acids serine and arginine were investigated with meloxicam. Meloxicam has extremely low solubility; being NSAIDs, gastric upset, and ulcer are common side effects. Solid dispersions were produced by precipitation and physical mixing techniques. The produced combinations underwent in\u00a0vitro dissolution, docking, DSC, FTIR, XRD, solubility, and gastric ulcer formation studies. Docking indicated ion pair\/salt formation between the basic amino acid arginine and meloxicam. Both solubility and dissolution rates were increased by up to 3000-fold and 12-fold, respectively. DSC, FTIR an XRD supported these findings. Rats treated with meloxicam showed loss of surface gastric epithelium integrity and ulceration. The animal group received meloxicam: arginine showed intact gastric mucosa with the surface epithelium and gastric glands well organized and nearly similar to the untreated control. Arginine with the guanidine group that was capable of preserving gastric mucosa after repeated administration for 10 days. This study highlighted the role of arginine as a functional excipient that did not only improve solubility and dissolution rates but ameliorated the long-standing gastric side effects attributed to meloxicam. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"dissolution, arginine\",\r\n \" gastric ulcer\",\r\n \" ion pair\",\r\n \" Meloxicam\",\r\n \" salt\",\r\n \" serine\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 58,\r\n \"title\": \"Seddik, Mark Monir (59348874900); Rahmy, Awny Fouad (57189642973); Wadee, Amir N. (25422836600); Ahmad, Ahmad Mahdi (57204148188)\",\r\n \"authors\": \"Effects of different aerobic exercise protocols on regional body fatness and serum lipids in women with obesity: A randomized trial; Wp\u0142yw r\u00f3\u017cnych protoko\u0142\u00f3w \u0107wicze\u0144 aerobowych na rozmieszczenie tkanki t\u0142uszczowej i poziom lipid\u00f3w w surowicy u kobiet z oty\u0142o\u015bci\u0105: Badanie randomizowane\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85205283362&doi=10.56984%2F8ZG020AYN5&partnerID=40&md5=0420f6d5cb4090c1e7d3407e3d3e43de\",\r\n \"affiliations\": \"Department of Physical Therapy for Internal Medicine and Geriatrics, Badr University in Assuit, Asyut, Egypt; Department of Physical Therapy for Cardiovascular, Faculty of Physical Therapy, Giza, Egypt; Faculty of Physical Therapy, Merit University, Sohag, Egypt; Department of Basic Science for Physical Therapy, Faculty of Physical Therapy, Giza, Egypt; Faculty of Physical Therapy, Alexandria, Egypt\",\r\n \"abstract\": \"Aim. This study aimed to compare the effects of high-volume high-intensity interval training (HV-HIIT), low-volume high-intensity interval training (LV-HIIT), and moderate-intensity continuous training (MICT) on regional body fatness and serum lipids in adult obese women. Methods. Forty-six women with obesity and dyslipidemia completed this study. They were randomly allocated to HV-HIIT protocol (n = 15) that consisted of 4 \u00d7 4-minute intervals at 85%-95% HRmax, LV-HIIT protocol (n = 14) that consisted of 4 \u00d7 2-minute intervals at 85%-95% HRmax, and MICT protocol (n = 17) that consisted of continuous training for 30 minutes at 65%-75% HRmax. All protocols were performed three days\/week for eight weeks. The measurements included anthropometric characteristics [i.e., body mass index (BMI) and waist circumference (WC)], dual-energy x-ray absorptiometry (DXA) (i.e. for measurement of sub-total fat, leg fat, trunk fat, arm fat, lean mass, fat-free mass, and bone mineral content), self-paced maximal cycle test (i.e., for HRmax determination), and serum lipids [i.e., total cholesterol (TC), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and triglycerides (TG)]. Results. HV-HIIT induced significantly more improvements in HRmax, sub-total fat, leg fat, trunk fat, arm fat, TC, and HDL than other exercise protocols (p < 0.05). Both LV-HIIT and MICT were similar (p > 0.05) in reducing TC; however, LV-HIIT was better than MICT in improving HDL (P < 0.05). Conclusion. HV-HIIT could lead to the greatest improvements in regional body fatness, TC, and HDL. LV-HIIT could lead to higher improvements in HDL than MICT. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"aerobic exercise\",\r\n \" high-intensity interval training\",\r\n \" obese\",\r\n \" regional body fatness\",\r\n \" serum lipids\",\r\n \" women\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 59,\r\n \"title\": \"Hammam, Radwa Fayek (57216980347); Alshimy, Ahmed Magdy (58537265300); Mosaad, Andrew Anis Fakhrey (59335461700); Ibrahim, Maha Gamal (59336291800)\",\r\n \"authors\": \"Effect of foot muscle energy technique in patients with diabetic neuropathy: a randomized controlled trial\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85204419092&doi=10.5114%2Fpq%2F174937&partnerID=40&md5=2bdb224ce33f7fcec548d73899e1ef8b\",\r\n \"affiliations\": \"Faculty of Physical Therapy, Cairo, Egypt; Faculty of Physical Therapy, Al-Ryada University for Science and Technology, Sadat City, Egypt; Faculty of Physical Therapy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Introduction. This study investigated the effect of foot muscle energy technique (MET) on nerve conduction velocity (NCV) and isometric muscle strength in patients with type 2 diabetic neuropathy (DN). Methods. Forty-four patients were randomly assigned to either the MET group (group A) or the conventional physical therapy program group (group B). Electrophysiological measurements, including peroneal and tibial motor NCV studies, and isometric muscle strength using a toe strength dynamometer, were conducted. The assessment period ranged from April to November 2022, with measurements taken before the first session and after 4 weeks of treatment. Results. Significant improvements were observed in post-treatment peroneal motor NCV (p < 0.001), tibial motor NCV (p < 0.001), and isometric muscle strength (p < 0.001) in group A, but not in group B. Conclusions. MET enhances motor NCV and isometric muscle strength in patients with type 2 DN. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"diabetic neuropathy\",\r\n \" foot muscle energy technique\",\r\n \" isometric muscle strength\",\r\n \" motor nerve conduction velocity study\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 60,\r\n \"title\": \"Alqarni, Abdulmalik M. (57204497870); Haredy, Ahmed M. (56895997900); Abdelrahman, Kamal S. (57218117868); Soltan, Osama M. (57216819679); Abdel-Aal, Mohamed A.A. (57209617417); Alrofaidi, Mohammad A. (58026863900); Aalamri, Abdulwahab (58581035300); Osman, Mhdia Elhadi D. (58096090300); Alamri, Ahmed Awadh Saleh (58820661300); Hamad, Ahmed Abdulhafez (57193447791)\",\r\n \"authors\": \"Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85182687259&doi=10.1002%2Fbio.4661&partnerID=40&md5=6781acdc003e8a35569903896bb8aa65\",\r\n \"affiliations\": \"Department of Pharmaceutical Chemistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutical Chemistry, Al Baha University, Al Aqiq, Saudi Arabia; Department of Pharmacology and Toxicology, University of Ha'il, Ha'il, Saudi Arabia; Department of Clinical Pharmacy, University of Ha'il, Ha'il, Saudi Arabia; Medical Services, Ministry of Interior, Riyadh, Saudi Arabia; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"The suggested study adheres to a particular protocol to ensure that the process is environmentally friendly and sustainable. It is worth mentioning that several tools have been adopted as prospective measures of the method greenness. Fortunately, the established analytical method is identified as white by the white analytical chemistry (WAC) concept, which uses the red\/ green\/blue color scheme (RGB 12 tool) to combine ecological and functional factors for the first time in studying of the cited drug. Amlodipine (AMD), a cardiovascular treating agent, belongs to the dihydropyridine class of oral calcium channel-blocking agents. This article presents a novel, simple, green, one-pot-processed, fast, and ultrasensitive fluorimetric approach for monitoring and assessment of AMD using molecular-size-dependent fluorescence augmentation of the light scattering-driven signal of eosin, a biological stain at a wavelength of 415 nm. This enhancement was directly proportional to the size of the produced complex. The linearity range was from 30 to 900 ng mL\u22121, with corresponding sensitivity limits (detection and quantitation levels) of 9.2 and 28 ng mL\u22121, respectively. The planned approach was also successfully used to track AMD content in bulk, dosage forms, and bio-fluids (human plasma and urine). The developed method's eco-friendliness was established by different eco-rating metric tools. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"amlodipine\",\r\n \" biological dye probe\",\r\n \" content homogeneity testing\",\r\n \" green and white analytical chemistry\",\r\n \" molecular-size-dependent system\",\r\n \" sustainability profile\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 61,\r\n \"title\": \"Botla, Afaf Mohamed Mahmoud (57207855357); Mustafa, Jehan H. (58561282900); Abd-Elmonem, Amira M. (57203746938); Sayed, Mohamed D. (58561283000); Shehata, Mai M.A. (57801091200)\",\r\n \"authors\": \"Effect of laser acupuncture on monosymptomatic nocturnal enuresis in adolescent females: A randomized controlled trial\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85169670238&doi=10.1002%2Fpri.2048&partnerID=40&md5=192f9fcaf9a0e9e9ca6b21e180efe761\",\r\n \"affiliations\": \"Department of Physical Therapy for Women\u2019s Health, Faculty of Physical Therapy, Giza, Egypt; Department of Physical Therapy for Women's Health, Merit University, Sohag, Egypt; Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Giza, Egypt; Department of Urology, Faculty of Medicine, Sohag, Egypt\",\r\n \"abstract\": \"Background and aim: Nocturnal enuresis (NE) is prevalent in children and adolescents and affects their social life later. Therefore, the objective of this study was to ascertain laser acupuncture (LA) therapy's effect on NE in adolescent females. Methods: Sixty adolescent females diagnosed with chronic monosymptomatic nocturnal enuresis (MNE) were randomly divided into two equal groups: The intervention group (received LA and desmopressin) and the control group (received desmopressin only) (n\u00a0=\u00a030 each). Treatment was delivered and LA was used three times a week for 12\u00a0successive weeks. Abdominal ultrasonography and voiding calendar were used to assess bladder capacity and maximum voiding volume (MVV), respectively. The frequency of bed wetness was assessed throughout the trial period in a diary. Results: Statistically significant differences were reported in the intervention group. Bladder capacity significantly increased in the intervention group (LA and desmopressin) than in the control group. Conclusions: The results of this study suggest the beneficial influences of LA on MNE, despite the very poor quality of the literature's available evidence. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"adolescent\",\r\n \" desmopressin\",\r\n \" laser acupuncture\",\r\n \" monosymptomatic nocturnal enuresis\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 62,\r\n \"title\": \"Zaher, Ahmed M. (55816802700); Salama, Fawzy Mahmoud (7005616732); El-Tayeh, Noha A. (54890792000); El-Naggar, Sara H. (57224613149); Sultan, Raoof (57216129507); Gaafar, Ali Al Saied (57210886120)\",\r\n \"authors\": \"INFLUENCES OF ENVIRONMENTAL FACTORS ON THE ACTIVE METABOLITES AND CERTAIN BIOACTIVITIES OF DESERT DATE LEAF AND FRUIT (BALANITES AEGYPTIACA L. DELILE) GROWN IN EGYPT\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85181312499&doi=10.21608%2FBFSA.2023.327683&partnerID=40&md5=7afddcc97c394dc1328fddd8ac0888e0\",\r\n \"affiliations\": \"Faculty of Pharmacy, Asyut, Egypt; Faculty of Science, Asyut, Egypt; Department of Botany & Microbiology, Faculty of Science, Qena, Egypt; Botany and Microbiology Department, Faculty of Science, Kharga, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Balanites aegyptiaca (L.) Delile is a medicinal wild tree, naturally distributed in wide regions of Africa and South Asia. The fruits are commercially available in Egypt as antidiabetic natural products. The current study aimed to determine the effects of environmental factors on the metabolites and the bioactivities of fruit and leaf extracts. The main ecological differences between the sites of collection, Wadi El-Gemal and Baris Oasis, are temperature, aridity, humidity, and location. The fruit extract of Baris Oasis showed higher saponin content and saponin metabolites (LC-MS analysis) than the fruit extract of Wadi El-Gemal. Baris Oasis fruit extract showed twice the inhibition of \u03b1-Glucosidase than Wadi El-Gemal fruit extract. Twelve phenolics and flavonoids were detected in Baris Oasis leaf extract, while ten compounds were detected in Wadi El-Gemal leaf extract using HPLC. The higher quality and quantity of flavonoids and phenolics of Baris Oasis leaf extract than Wadi El-Gemal leaf extract, have significant effects on the antioxidant and acetylcholinesterase inhibitory activities. In conclusion, elevation of temperature and aridity have significant positive effects on the synthesis and accumulation of B. aegyptiaca saponins, phenolics and flavonoids. The bioactivities of the fruit and leaf extracts are directly proportional to the variation in metabolites due to abiotic stresses. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Balanites aegyptiaca L\",\r\n \" Ecological Factors\",\r\n \" Flavonoids\",\r\n \" Phenolics\",\r\n \" Saponins\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 63,\r\n \"title\": \"Elmileegy, Ibtisam M.H. (57459044600); Waly, Hanan S.A. (55623917400); Alghriany, Alshaimaa A.I. (57224211446); Abou-Khalil, Nasser Sayed (57160296500); Mahmoud, Sara M.M. (58206942200); Negm, Eman Ahmed (56246401100)\",\r\n \"authors\": \"Gallic acid rescues uranyl acetate induced-hepatic dysfunction in rats by its antioxidant and cytoprotective potentials\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85177592727&doi=10.1186%2Fs12906-023-04250-y&partnerID=40&md5=b688dec9ca86c9a4b129d9ce2cb5c0de\",\r\n \"affiliations\": \"Department of Medical Physiology, Faculty of Medicine, Asyut, Egypt; Department of Zoology and Entomology, Faculty of Science, Asyut, Egypt; Department of Zoology and Entomology, Faculty of Science, Asyut, Egypt; Department of Basic Medical Sciences, Merit University, Sohag, Egypt; Department of Physiology, Faculty of Veterinary Medicine, Asyut, Egypt\",\r\n \"abstract\": \"Background: The liver was identified as a primary target organ for the chemo-radiological effects of uranyl acetate (UA). Although the anti-oxidant and anti-apoptotic properties of gallic acid (GA) make it a promising phytochemical to resist its hazards, there is no available data in this area of research. Methods: To address this issue, eighteen rats were randomly and equally divided into three groups. One group was received carboxymethyl cellulose (vehicle of GA) and kept as a control. The UA group was injected intraperitoneally with UA at a single dose of 5\u00a0mg\/kg body weight. The third group (GA + UA group) was treated with GA orally at a dose of 100\u00a0mg\/kg body weight for 14 days before UA exposure. UA was injected on the 15th day of the experiment in either the UA group or the GA + UA group. The biochemical, histological, and immunohistochemical findings in the GA + UA group were compared to both control and UA groups. Results: The results showed that UA exposure led to a range of adverse effects. These included elevated plasma levels of aspartate aminotransferase, lactate dehydrogenase, total protein, globulin, glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very-low-density lipoprotein and decreased plasma levels of high-density lipoprotein cholesterol. The exposure also disrupted the redox balance, evident through decreased plasma total antioxidant capacity and hepatic nitric oxide, superoxide dismutase, reduced glutathione, glutathione-S-transferase, glutathione reductase, and glutathione peroxidase and increased hepatic oxidized glutathione and malondialdehyde. Plasma levels of albumin and alanine aminotransferase did not significantly change in all groups. Histopathological analysis revealed damage to liver tissue, characterized by deteriorations in tissue structure, excessive collagen accumulation, and depletion of glycogen. Furthermore, UA exposure up-regulated the immuno-expression of cleaved caspase-3 and down-regulated the immuno-expression of nuclear factor-erythroid-2-related factor 2 in hepatic tissues, indicating an induction of apoptosis and oxidative stress response. However, the pre-treatment with GA proved to be effective in mitigating these negative effects induced by UA exposure, except for the disturbances in the lipid profile. Conclusions: The study suggests that GA has the potential to act as a protective agent against the adverse effects of UA exposure on the liver. Its ability to restore redox balance and inhibit apoptosis makes it a promising candidate for countering the harmful effects of chemo-radiological agents such as UA. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Apoptosis\",\r\n \" Gallic acid\",\r\n \" Liver\",\r\n \" Nrf2\",\r\n \" Physiology\",\r\n \" Uranyl acetate\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 64,\r\n \"title\": \"Emeish, Walaa F.A. (57199862558); Abd-Elhafeez, Hanan H. (57216658260); Alghamdi, Abdullah A.A. (57410884000); Ahmed, Madeha Ahmed (58421192500); Khalifa, Mahmoud Osman (57226469231); El-Mansi, Ahmed A. (57202830660); Abou-Elhamd, Alaa S. (35483139100); Khormi, Mohsen Ali (57210917357); Alkashif, Khalid (58691331400); Soliman, Soha A. (55940843600)\",\r\n \"authors\": \"Morphological changes in intraepithelial and stromal telocytes in Cyprinus carpio in response to salinity stress\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85176465051&doi=10.1038%2Fs41598-023-43279-4&partnerID=40&md5=f5555e65e5044d74bb51c07071b0afdd\",\r\n \"affiliations\": \"Department of Fish Diseases, Faculty of Veterinary Medicine, Qena, Egypt; Department of Cell and Tissues, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Biology, Al Baha University, Al Aqiq, Saudi Arabia; Department of Histology, Faculty of Veterinary Medicine, Sohag, Egypt; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Aswan, Egypt; Department of Molecular Bone Biology, Graduate School of Biomedical Sciences, Nagasaki, Japan; Department of Biology, King Khalid University, Abha, Saudi Arabia; Respiratory Therapy Department, Jazan University, Jizan, Saudi Arabia; Department of Biology, Jazan University, Jizan, Saudi Arabia; Department of Physiology, Merit University, Sohag, Egypt; Faculty of Veterinary Medicine, Qena, Egypt\",\r\n \"abstract\": \"Telocytes establish connections and communicate with various types of cells and structures. Few experimental studies have been performed on telocytes. In this study, we investigated the effect of salinity stress on telocytes in relation to osmoregulatory, immune, and stem cells. After exposing the common carp to 0.2 (control), 6, 10, or 14 ppt salinity, we extracted and fixed gill samples in glutaraldehyde, processed and embedded the samples in resin, and prepared semi-thin and ultrathin sections. Two types of telocytes were identified: intraepithelial and stromal telocytes. Intraepithelial telocytes were found to form part of the cellular lining of the lymphatic space and shed secretory vesicles into this space. Stromal telocytes were observed to shed their secretory vesicles into the secondary circulatory vessels. Both intraepithelial and stromal telocytes were enlarged and exhibited increased secretory activities as salinity increased. They exerted their effects via direct contact and paracrine signaling. The following changes were observed in samples from fish exposed to high salinity levels: chloride cells underwent hypertrophy, and their mitochondria became cigar-shaped; pavement cells were enlarged, and their micro-ridges became thin and elongated; stromal telocytes established contact with stem cells and skeletal myoblasts; skeletal muscle cells underwent hypertrophy; and macrophages and rodlet cells increased in number. In conclusion, our findings indicate that intraepithelial and stromal telocytes respond to salinity stress by activating cellular signaling and that they play major roles in osmoregulation, immunity, and regeneration. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 65,\r\n \"title\": \"Ali, Ahmed U. (57213590141); Sayed, Marwa A. (57217417384); Hassan, Abeer S. (57196119456); Elkabsh, Mai M. (57215670490); Shahat, Mohammed (57195246596); Abdelhakiem, Mohammed Ahmed Hamdy (56922161200); Kamel, Amira A. (57208054498); Abd-Eldayem, Ahmed Mohammed (57195596545); El-Badry, Mahmoud (6602674566); Amer, Enas Mahmoud (55921618900)\",\r\n \"authors\": \"Serum levels of tumor necrosis factor (TNF-\u03b1) and vaginal gene expression of toll-like receptor 2 (TLR2) & microtubule-associated protein 1 light chain 3 (LC3) after treatment of vulvovaginal candidiasis with sertaconazole nitrate spanlastics\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85176284661&doi=10.1016%2Fj.jddst.2023.105016&partnerID=40&md5=53f9b8f3bba53f15ebad3dfb64ef9d2c\",\r\n \"affiliations\": \"Department of Pharmaceutics, Merit University, Sohag, Egypt; Department of Industrial Pharmacy, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Qena, Egypt; Faculty of Veterinary Medicine, Asyut, Egypt; Department of Obstetrics and Gynecology, Faculty of Medicine, Asyut, Egypt; Department of Surgery, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Asyut, Egypt; Department of Pharmacology, Faculty of Medicine, Asyut, Egypt; Faculty of Pharmacy, Asyut, Egypt; Assiut International Center of Nanomedicine, Assiut University, Asyut, Egypt; Faculty of Science, Asyut, Egypt\",\r\n \"abstract\": \"The irritating infection known as vulvovaginal candidiasis (VVC) affects women all over the world. Around 75% of women will acquire at least one attack throughout their lives. In addition to its demonstrated antifungal properties, sertaconazole nitrate (SCN) also exhibits anti-inflammatory effects, which are of significant importance in the therapeutic management of (VVC). Despite its benefits, SCN suffers from poor solubility, which affects its biological activity. This project's objective is to construct SCN spanlstics in order to enhance its solubility as well as its antifungal and anti-inflammatory activities. SCN spanlastics were created utilizing the ethanol injection technique, after which they were characterized. Chitosan (2.5%) w\/w gels containing 2 % w\/w of SCN in the form of spanlastics were prepared, and then the in vitro antifungal activity of the prepared chitosan gel and commercial SCN cream (Dermofix) was performed. After a complete gynecological examination, vaginal swabs were obtained from patients suspected of VVC and then cultured on Sabouraud dextrose agar for phenotypic identification. VVC was then induced in nonpregnant ovariectomized female rats using isolated and identified Candida albicans (C. albicans) species. In order to detect the difference between chitosan gel containing SCN spanlastics and the commercial (Dermofix) cream, serum levels of pro-inflammatory cytokine Tumor necrosis factor (TNF- \u03b1) were detected. After sacrificing the rats, gene expression of toll-like receptor 2 (TLR2) & microtubule-associated protein 1 light chain 3 (LC3) in vaginal tissue and immunohistochemical expression of interleukin-6 (IL-6) as an inflammatory chemokine were performed in all groups. Results revealed that SCN was successfully entrapped into spanlastics, the particle size ranged from 1.6 \u00b1 0.050 to 5.7 \u00b1 0.900 \u03bcm in diameter; in-vitro dissolution of SCN was significantly enhanced from chitosan gel compared to that from Dermofix cream, the inhibition zone of prepared chitosan gel containing SCN spanlastics was significantly larger compared to that of Dermofix cream. Our results revealed that the anti-inflammatory effect of SCN in the form of spanlastics was significantly greater than that of commercial (Dermofix) cream. Finally, we recommend the use of SCN spanlastics as the best antifungal and anti-inflammatory formulation in cases of vaginal candidiasis. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"And vulvovaginal candidiasis\",\r\n \" Factorial design\",\r\n \" Immunohistochemistery\",\r\n \" Inhibition zone\",\r\n \" Sertaconazole nitrate\",\r\n \" Spanlastics\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 66,\r\n \"title\": \"Alrefaie, Zienab A. (53982701300); Bashraheel, Jana (58143165200); Hammad, Hossam A. (58143483100); Ali, Soad Shaker (35783844900); Alahmadi, Ahlam Abdulaziz (57207757871)\",\r\n \"authors\": \"Hippocampal mitochondrial Ca++ in experimentally induced Alzheimer's disease, link to calpains and impact of vitamin D3 supplementation\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85176232603&doi=10.1016%2Fj.jsps.2023.101834&partnerID=40&md5=28af53baf0adae99f24de728f63c83ba\",\r\n \"affiliations\": \"Department of Medical Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Department of Histology, Merit University, Sohag, Egypt; Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia\",\r\n \"abstract\": \"Objective: Vitamin D impact on hippocampal mitochondrial Ca++ and calpains was not previously investigated in Alzheimer's disease (AD). The current work aimed to assess the alteration in hippocampal mitochondrial Ca++, ATP & ADP and hippocampal calpains' level in (AlCl<inf>3<\/inf>)-induced AD model, and the effect of 2 regimens of vitamin D supplementation on these alterations. Methods: Forty male Wistar rats were randomized into 4 groups; control, AD (AlCl<inf>3<\/inf>100 mg\/kg, p.o. daily for 42 days), AD and vitamin D co-treated group (AlCl<inf>3<\/inf> as in AD group with vitamin D<inf>3<\/inf> 400 IU\/kg\/day, p.o. for 42 days) and AD, followed by vitamin D<inf>3<\/inf> group (AlCl<inf>3<\/inf> was given as in AD group for 42 days, then vitamin D<inf>3<\/inf> for two weeks). AD was assessed by hippocampal levels of A\u03b2<inf>42<\/inf>, p-tau and spatial memory assessment in Morris water maze. Hippocampal mitochondrial Ca++, ATP and ADP levels besides to calpain-1 & 2 and cytochrome C were assessed in addition to CA1 histological examination. Results: AD animals showed impaired mitochondrial function as denoted by high Ca++ and decreased ATP and ADP and elevated calpain-1 & 2 and cytochrome C. Hippocampal CA1 region showed increased degenerated neurons and reduced thickness of its pyramidal layer. Vitamin D administration minimized the hippocampal mitochondrial impairement induced by AD and mitigated histological alterations even when supplemented post AD establishment. Conclusion: Vitamin D administration to AD rats breaks the deleterious loop in the hippocampus that involves increased Ca++, calpain activation, mitochondrial failure, neuronal degeneration and AD disease progression. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"AD\",\r\n \" Calpain-1 & 2\",\r\n \" Hippocampus\",\r\n \" Mitochondrial Ca++\",\r\n \" Vitamin D\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 67,\r\n \"title\": \"Eissa, Manar A. (57204365848); Gohar, Eman Y. (24331652000)\",\r\n \"authors\": \"Aromatase enzyme: Paving the way for exploring aromatization for cardio-renal protection\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85175622863&doi=10.1016%2Fj.biopha.2023.115832&partnerID=40&md5=17ee3279c9b2d13333ceb5540f4573f2\",\r\n \"affiliations\": \"Department of Pharmacology and Toxicology, Merit University, Sohag, Egypt; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States\",\r\n \"abstract\": \"Documented male-female differences in the risk of cardiovascular and chronic kidney diseases have been largely attributed to estrogens. The cardiovascular and renal protective effects of estrogens are mediated via the activation of estrogen receptors (ER\u03b1 and ER\u03b2) and G protein-coupled estrogen receptor, and involve interactions with the renin-angiotensin-aldosterone system. Aromatase, also called estrogen synthase, is a cytochrome P-450 enzyme that plays a pivotal role in the conversion of androgens into estrogens. Estrogens are biosynthesized in gonadal and extra-gonadal sites by the action of aromatase. Evidence suggests that aromatase inhibitors, which are used to treat high estrogen\u2013related pathologies, are associated with the development of cardiovascular events. We review the potential role of aromatization in providing cardio-renal protection and highlight several meta-analysis studies on cardiovascular events associated with aromatase inhibitors. Overall, we present the potential of aromatase enzyme as a fundamental contributor to cardio-renal protection. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Aromatase inhibitors\",\r\n \" Cardiovascular\",\r\n \" Estrogen synthase\",\r\n \" Kidney\",\r\n \" Meta-analysis\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 68,\r\n \"title\": \"Tawfeek, Mohammed M.Mahdy (58506347900); Ahmed, Hanan Mohamed Abdel Hamid (58076476500); Bor\u2019i, Ashraf (57056277100); Rady, Ahmed M.Nashaat Ali (58536630100)\",\r\n \"authors\": \"Repeated sessions of PACK-CXL WA for the treatment of resistant bacterial keratitis: a retrospective study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85165639487&doi=10.1186%2Fs12886-023-03080-3&partnerID=40&md5=12c1b2ad54931c7eefc70d7fb290a186\",\r\n \"affiliations\": \"Zagazig University, Zagazig, Egypt; The General Organization for Teaching Hospitals and Institutes, Cairo, Bab El Khalk, Egypt; Zagazig University, Zagazig, Egypt; Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Objective: The aim of this work is to evaluate the safety and efficacy of repeated sessions of photo-activated chromophore for keratitis-cross linking (PACK-CXL) window absorption (WA) for the treatment of resistant bacterial keratitis (BK). Patients and methods: This is a retrospective clinical cohort study. Thirty eyes with clinically suspected and lab-confirmed bacterial keratitis, resistant to appropriate antibiotic therapy- which was modified by sensitivity reports- for 2 weeks with failure of epithelialization for 4 weeks after the standard anti-microbial therapy (SAT) together with one setting of PACK-CXL WA were included. If after the first session of PACK-CXL, there is a start of improvement in the form of reduction of the size of corneal ulcer and stromal infiltrates together with the start of epithelialization on clinical examination and AS-OCT, another session of PACK-CXL WA was performed after one week, and so on, till the complete healing and resolution of bacterial keratitis and confirmation by negative bacterial culture. Identification of the micro-organisms was done by lab study before and after treatment. Corneal healing was evaluated by corneal examination and anterior segment OCT (AS-OCT). Results: Thirty eyes of 30 patients were recruited in this study. They were 16 males and 14 females, their mean age was 44.3 \u00b1 5.38 years. The mean ulcer size was 3.96 \u00b1 1.87 (mm3), while the mean size of stromal infiltrates was 4.52 \u00b1 2.24 (mm3). PACK-CXL WA treatment was performed an average of 2.87 times for the 30 eyes. Complete healing and resolution (Successful treatment) was observed in 27 eyes (90%) of cases and failure of epithelialization was observed only in 3 eyes (10%). Complete corneal healing was reported in the second month postoperatively in 90% of eyes. Conclusion and recommendation: PACK-CXL WA may be a promising, non-invasive treatment option for resistant bacterial keratitis. It may have a synergistic effect with standard antimicrobial treatment (SAT). Also, it can overcome the antibiotics resistance that has become rapidly spreading worldwide. Repeated sessions of PACK-CXL WA may be more effective for the treatment of resistant bacterial keratitis till complete epithelialization and resolution of BK than a single session with few complications. However, further prospective and comparative studies to support the results are needed. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Bacterial keratitis\",\r\n \" Corneal cross linking\",\r\n \" PACK-CXL\",\r\n \" Repeated\",\r\n \" Window absorption\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 69,\r\n \"title\": \"Ali, Ahmed U. (57213590141); Abd-Elkareem, M. (57193520825); Kamel, Amira A. (57208054498); Abou-Khalil, Nasser Sayed (57160296500); Hamad, D. (58253979300); Nasr, Nasr Eldin Hussein (57223125614); Hassan, Maha Abdelazeem (7401625373); El-Faham, Tahani H. (6603115454)\",\r\n \"authors\": \"Impact of porous microsponges in minimizing myotoxic side effects of simvastatin\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85151948834&doi=10.1038%2Fs41598-023-32545-0&partnerID=40&md5=918616d161450de4668a2eb133016d1d\",\r\n \"affiliations\": \"Department of Pharmaceutics, Merit University, Sohag, Egypt; Department of Cell and Tissues, Faculty of Veterinary Medicine, Asyut, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Asyut, Egypt; Department of Medical Physiology, Faculty of Medicine, Asyut, Egypt; Faculty of Science, Asyut, Egypt; Technical Manager at Al Esraa Pharmaceutical Optima, Badr, Egypt; Faculty of Pharmacy, Asyut, Egypt\",\r\n \"abstract\": \"Simvastatin (SV) is a poorly soluble drug; its oral administration is associated with a significant problem: Myopathy. The present study aims to formulate SV microsponges that have the potential to minimize the myotoxicity accompanying the oral administration of the drug. SV microsponges were prepared by exploiting the emulsion solvent evaporation technique. The % entrapment efficiency (%EE) of the drug approached 82.54 \u00b1 1.27%, the mean particle size of SV microsponges ranged from 53.80 \u00b1 6.35 to 86.03 \u00b1 4.79\u00a0\u00b5m in diameter, and the % cumulative drug release (%CDR) of SV from microsponges was significantly higher than that from free drug dispersion much more, the specific surface area of the optimized microsponges formulation was found to be 16.6 m2\/g revealed the porosity of prepared microsponges. Histological and glycogen histochemical studies in the skeletal muscles of male albino rats revealed that microsponges were safer than free SV in minimizing myotoxicity. These findings were proven by Gene expression of Mitochondrial fusion and fission (Mfn1) & (Fis1) and (Peroxisome proliferator-activated receptor gamma co-activator 1\u03b1) PGC-1\u03b1. Finally, our study ascertained that SV microsponges significantly decreased the myotoxicity of SV. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 70,\r\n \"title\": \"Anwar, Walaa S. (58082428700); Abdel-Maksoud, Fatma M. (56976406600); Sayed, Ahmed M. (57201406179); Abdel-Rahman, Iman A.M. (57217534275); Makboul, Makboul A. (6508060541); Zaher, Ahmed M. (55816802700)\",\r\n \"authors\": \"Correction: Potent hepatoprotective activity of common rattan (Calamus rotang L.) leaf extract and its molecular mechanism (BMC Complementary Medicine and Therapies, (2023), 23, 1, (24), 10.1186\/s12906-023-03853-9)\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85148409806&doi=10.1186%2Fs12906-023-03881-5&partnerID=40&md5=458e4a1bc3246986303ccd25626af2e4\",\r\n \"affiliations\": \"Faculty of Pharmacy, Asyut, Egypt; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Asyut, Egypt; Laboratory of Biochemistry, Faculty of Science, Asyut, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Qena, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Following the publication of the original article [1], it was noted that due to a typesetting error Dr. Walaa S. Anwar and Dr. Makboul A. Makboul were incorrectly affiliated to Merit University. Correct affiliation for Dr. Walaa S. Anwar and Dr. Makboul A. Makboul should be Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, 71515 Assiut, Egypt. The affiliations have been updated above and the original article [1] has been corrected. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 71,\r\n \"title\": \"Anwar, Walaa S. (58082428700); Abdel-Maksoud, Fatma M. (56976406600); Sayed, Ahmed M. (57201406179); Abdel-Rahman, Iman A.M. (57217534275); Makboul, Makboul A. (6508060541); Zaher, Ahmed M. (55816802700)\",\r\n \"authors\": \"Potent hepatoprotective activity of common rattan (Calamus rotang L.) leaf extract and its molecular mechanism\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85146988559&doi=10.1186%2Fs12906-023-03853-9&partnerID=40&md5=677d0e2b27a4ea02f1dca6779efa64e4\",\r\n \"affiliations\": \"Department of Pharmacognosy, Merit University, Sohag, Egypt; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Asyut, Egypt; Laboratory of Biochemistry, Faculty of Science, Asyut, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Qena, Egypt\",\r\n \"abstract\": \"Background: Calamus rotang L. (CR) is an Indian shrub. The leaves and other organs of the plant are traditionally used in India for treatment of various diseases. The in vitro antioxidant property of the leaves extract was previously established. Thus, the current study aimed to evaluate the antioxidant and hepatoprotective effects of CR ethyl acetate extract at a dose of 350\u00a0mg\/kg on CCl<inf>4<\/inf> induced hepatotoxic rats through different mechanisms. Methods: Histopathological examination of the treated rats\u2019 group in comparison with positive and negative controls were performed. Quantitative measuring of the proinflammatory cytokines (TNF \u03b1), inflammatory regulators (Arginase, PPAR \u03b1) and the antiapoptotic protein Bcl-2 in comparison with positive and negative control groups was achieved using immunohistochemical examination. HPLC profiling of the polyphenol contents and molecular docking of the identified compounds against BH3 proapoptotic protein were correspondingly studied to evaluate the potential antiapoptotic property. Results: The CR extract greatly protects the liver tissue through the suppression of TNF \u03b1, arginase and PPAR \u03b1 induced by CCl<inf>4<\/inf> as well as its enhancement of the antiapoptotic Bcl-2 protein. Fourteen polyphenols of different classes were identified in CR extract and tested via molecular docking for their potential antiapoptotic activities against BH3 protein. Naringin, rutin, 7-hydroxy flavone, and ellagic acid compounds exhibit the highest affinity and potential inhibition of pro-apoptotic protein BH3 via molecular docking study. Conclusions: The ethyl acetate fraction of the leaves of C. rotang is rich in polyphenols that exhibited potent hepatoprotective effect on CCl<inf>4<\/inf> induced hepatotoxic rats through its antioxidant, anti-inflammatory, anti-steatosis and antiapoptotic properties. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Apoptosis\",\r\n \" Calamus rotang\",\r\n \" Hepatoprotective\",\r\n \" HPLC\",\r\n \" Metabolite profiling\",\r\n \" Molecular docking\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 72,\r\n \"title\": \"Habeeb, Tamer A.A.M. (57216373588); Hussain, Abdulzahra Abdulsamad (16417168400); Podda, Mauro Guido (7004555508); Aiolfi, Alberto (6508362055); Kryvoruchko, Igor A. (59374914600); Kalmoush, Abd Elfattah (57727380200); Labib, Mohamed Fathy (57221263028); Mustafa, Fawzy M. (58227729800); Elbelkasi, Hamdi (58744062800); Hamdy, Ahmed Farouk Aziz (7005577041); Abo Alsaad, Mohamed Ibrahim (58743979200); Sallam, Ahmed M. (57203144124); Zaitoun, Mohamed Abdallah (57223230279); Negm, Mohamed Ibrahim (55903490500); Mostafa, Abdelshafy (58744089300); Yassin, Mahmoud Abdou (57217355675); Elshahidy, Tamer Mohamed Mahmoud (57219158772); Elsayed, Ashraf Abdel Monem (57349226400); Mansour, Mohamed Ibrahim (57219159269); Elaidy, Mostafa M. (57211668955); Moursi, Adel Mahmoud (57223158475); Yehia, Ahmed Mohamed (57210598249); Ashour, Hassan Rabea Galal (57203575895); Metwalli, Abd Elrahman M. (57219157262); Abdelhady, Waleed Ahmed (57223158353); Abdelghani, Amr A. (57913319900); AbdAllah, Ehab Shehata (59693590100); Ramadan, Alaaedin (57924392600); Rushdy, Tamer (57211491570)\",\r\n \"authors\": \"Intraoperative endomanometric laparoscopic Nissen fundoplication improves postoperative outcomes in large sliding hiatus hernias with severe gastroesophageal reflux disease: a retrospective cohort study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85178544499&doi=10.1097%2FJS9.0000000000000659&partnerID=40&md5=6481e516010ce4198fdfbfd6d6625cb2\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; General Surgery Department, Merit University, Sohag, Egypt; General Surgery Department, Al-Azher University, Damietta, Egypt; General Surgery Department, Mataryia Teaching Hospital, Egypt; National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; Department of Surgical Sciences, Universit\u00e0 degli Studi di Cagliari, Cagliari, Italy; Department of Biomedical Science for Health, Universit\u00e0 degli Studi di Milano, Milan, Italy; Department of Surgery, Kharkiv National Medical University, Kharkiv, Ukraine; Department of General Surgery, Homerton University Hospital NHS Foundation Trust, London, United Kingdom\",\r\n \"abstract\": \"Background: Laparoscopic Nissen fundoplication (LNF) is the gold standard surgical intervention for gastroesophageal reflux disease (GERD). LNF can be followed by recurrent symptoms or complications affecting patient satisfaction. The aim of this study is to assess the value of the intraoperative endomanometric evaluation of esophagogastric competence and pressure combined with LNF in patients with large sliding hiatus hernia (> 5 cm) with severe GERD (DeMeester score > 100). Materials and methods: This is a retrospective, multicenter cohort study. Baseline characteristics, postoperative dysphagia and gas bloat syndrome, recurrent symptoms, and satisfaction were collected from a prospectively maintained database. Outcomes analyzed included recurrent reflux symptoms, postoperative side effects, and satisfaction with surgery. Results: Three hundred sixty patients were stratified into endomanometric LNF (180 patients, LNF +) and LNF alone (180 patients, LNF). Recurrent heartburn (3.9 vs. 8.3%) and recurrent regurgitation (2.2 vs. 5%) showed a lower incidence in the LNF + group (P = 0.012). Postoperative score III recurrent heartburn and score III regurgitations occurred in 0 vs. 3.3% and 0 vs. 2.8% cases in the LNF + and LNF groups, respectively (P = 0.005). Postoperative persistent dysphagia and gas bloat syndrome occurred in 1.75 vs. 5.6% and 0 vs. 3.9% of patients (P = 0.001). Score III postoperative persistent dysphagia was 0 vs. 2.8% in the two groups (P = 0.007). There was no redo surgery for dysphagia after LNF + . Patient satisfaction at the end of the study was 93.3 vs. 86.7% in both cohorts, respectively (P = 0.05). Conclusions: Intraoperative high-resolution manometry and endoscopic were feasible in all patients, and the outcomes were favorable from an effectiveness and safety standpoint. \u00a9 2025 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"anti-reflux surgery\",\r\n \" fundoplication\",\r\n \" gastroesophageal reflux disease\",\r\n \" high-resolution manometry\",\r\n \" lower esophageal sphincter\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 73,\r\n \"title\": \"Hamad, Ahmed Abdulhafez (57193447791); Mohammed, Bassam Shaaban (57211554238); Hassan, Yasser F. (57212006840); Batubara, Afnan S. (57239981200); Haredy, Ahmed M. (56895997900)\",\r\n \"authors\": \"Facile decoration of one-pot fluorescence probe-patterned reaction for sensing and ultrasensitive determination of tradjenta, a new type 2 diabetes oral therapy\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85158141319&doi=10.1016%2Fj.saa.2023.122808&partnerID=40&md5=272157593bdbd4387c4fc5c86cb82dab\",\r\n \"affiliations\": \"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo, Egypt; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Shibin El Kom, Egypt; Department of Pharmaceutical Chemistry, Umm Al-Qura University, Makkah, Saudi Arabia; Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Type 2 diabetes can be cured by using tradjenta (also known as Linagliptin), a new therapeutic drug that is an inhibitor of the dipeptidyl peptidase-4 enzyme. Tradjenta is administered orally alone or in combination with metiguanide or empagliflozin. An easy and specific fluorimetric analysis of Tradjenta was developed and demonstrated in the present investigation. The Hantzsch reaction method, which generates a fluorescent dihydropyridine derivative, is the basis of this assay. In a Toerell-Stenhagen buffered solution, the unsubstituted amine group of Tradjenta interacted with 2,4-Pentadione\/Oxomethane. Spectrofluorimetry was utilized for this investigation at an excitation\/emission wavelength of 421\/480 nm. When comparing the Tradjenta concentration to the tracked fluorimetric signal, the method revealed linearity over the concentration range of 0.05 to 1.2 \u00b5g\/mL. By strictly altering system parameters and analyzing the validation factors following International Council for Harmonisation (ICH) requirements, the outcomes were achieved. Finally, the proposed approach was successfully applied to assay the drug not only in its raw form and prescribed formulations but also to evaluate the tablet's uniformity of content. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Dosage form\",\r\n \" Fluorimetric assay\",\r\n \" Hantzsch derivatization reaction\",\r\n \" Method greenness evaluation\",\r\n \" Tradjenta\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 74,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Aldosari, Basmah N. (35081654900); Zaki, Randa Mohammed (54792413400); Afzal, Obaid (53870994800); Tulbah, Alaa S. (56182231200); Shahataa, Mary Girgis (57190442518); Abo El-Ela, Fatma I. (56461520900); Salem, Heba Farouk (16426683200); Gamal, Amr Gamal (57204454409)\",\r\n \"authors\": \"Formulation and Therapeutic Evaluation of Isoxsuprine-Loaded Nanoparticles against Diabetes-Associated Stroke\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85172484963&doi=10.3390%2Fpharmaceutics15092242&partnerID=40&md5=f40a351c739cc14faeddc8941a8b8e4c\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, College of Pharmacy, Riyadh, Saudi Arabia; Department of Pharmaceutics, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutical Chemistry, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Pharmaceutics, Umm Al-Qura University, Makkah, Saudi Arabia; Department of Pharmacology, Faculty of Medicine, Beni Suef, Egypt; Department of Pharmacology, Faculty of Veterinary Medicine, Beni Suef, Egypt; Faculty of Pharmacy, Beni Suef, Egypt\",\r\n \"abstract\": \"Ischemic stroke is the second-leading cause of death. Hyperglycemia, which is characteristic of diabetes mellitus, contributes to the development of endothelial dysfunction and increases the risk of stroke. Isoxsuprine is an efficient beta-adrenergic agonist that improves blood flow to the ischemic aria and stops the infarct core from growing. However, low bioavailability, a short biological half-life, and first-pass hepatic metabolism reduce the therapeutic efficacy of oral isoxsuprine. Therefore, the authors focused on developing isoxsuprine-loaded liposomes containing ethanol and propylene glycol (ILEP) formulation as nasal drops for the treatment of ischemic stroke in diabetic patients. Different ILEP formulations were optimized using Design Expert software, and the selected formulation was examined in vivo for its anti-stroke effect using a rat model of diabetes and stroke. The optimized ILEP, composed of 15% propylene glycol, 0.16% cholesterol, 10% ethanol, and 3.29% phospholipid, improved the sustainability, permeation, and targeting of isoxsuprine. Furthermore, the in vivo studies verified the improved neurological behavior and decreased dead shrunken neurons and vascular congestion of the rats treated with the optimized ILEP formulation, demonstrating its anti-stroke activity. In conclusion, our study found that treatment with an optimized ILEP formulation prevented the initiation and severity of stroke, especially in diabetic patients. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"diabetes mellitus\",\r\n \" isoxsuprine\",\r\n \" liposomes\",\r\n \" propylene glycol\",\r\n \" stroke\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 75,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Fathalla, Zeinab M.A. (57188965212); Naguib, Demiana M. (57193580045); Alfatease, Adel M. (57193644396); Abdelkader, Hamdy (20336654000)\",\r\n \"authors\": \"Chitosan\/Solid-Lipid Nanoparticles Hybrid Gels for Vaginal Delivery of Estradiol for Management of Vaginal Menopausal Symptoms\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85172452190&doi=10.3390%2Fph16091284&partnerID=40&md5=91408e0358c34a1a6f36c364c09cea1b\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia\",\r\n \"abstract\": \"Hormonal replacement therapy is the mainstay treatment to improve quality of life and reduce mortality. With the increasing number of young women with early menopause, women now live longer (increased life expectancy). However, poor patient compliance with oral estrogen therapy has emerged. Intravaginal estrogen therapy can provide significant benefits with minimal risk for postmenopausal women with symptoms of the lower urinary tract and vaginal area but who do not want to take oral estrogen. In this study, estradiol-loaded solid lipid nanoparticles (SLPs) were prepared from compritol ATO 888 and precirol ATO 5, and two different stabilizers (Pluronic F127 and Tween 80) were studied. Selected SLPs (F3 and F6) were coated with different concentrations of the mucoadhesive and sustained-release polymer chitosan. Furthermore, gelation time, viscosity, mucoadhesion, ex vivo permeation, and in vitro irritation for vaginal irritation were studied. Particle sizes ranged between 450\u2013850 nm, and EE% recorded 50\u201383% for the six SLPs depending on the type and amount of lipids used. Cumulative % drug release was significantly enhanced and was recorded at 51% to 83%, compared to that (less than 20%) for the control suspension of estradiol. Furthermore, extensive thermal gelation and mucoadhesion were recorded for chitosan-coated SLPs. Up to 2.2-fold increases in the permeation parameters for SLPs gels compared to the control suspension gel were recorded, revealing a slight to moderate irritation on Hela cell lines. These findings demonstrated chitosan-coated estradiol SLPs as novel and promising vaginal mucoadhesive hybrid nanogels. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"estradiol\",\r\n \" irritation\",\r\n \" menopause\",\r\n \" permeability\",\r\n \" vaginal deliver\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 76,\r\n \"title\": \"Abdelkader, Hamdy (20336654000); Abdel-Aleem, Jelan A. (55390544500); Mousa, Heba Salah (36495289200); Elgendy, Marwa O. (56926529900); Alfatease, Adel M. (57193644396); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Captopril Polyvinyl Alcohol\/Sodium Alginate\/Gelatin-Based Oral Dispersible Films (ODFs) with Modified Release and Advanced Oral Bioavailability for the Treatment of Pediatric Hypertension\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85172229896&doi=10.3390%2Fph16091323&partnerID=40&md5=4a9bbb6fd6ceae004dbb5de35ed0694d\",\r\n \"affiliations\": \"Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia; Department of Industrial Pharmacy, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Qena, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Clinical Pharmacy, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Hypertension can begin in childhood; elevated blood pressure in children is known as pediatric hypertension. Contrary to adult hypertension, there is a scarcity of commercial medications suitable for the treatment of pediatric hypertension. The aim of this study was to develop orally dispersible films (ODFs) loaded with captopril for the treatment of hypertension in children. Captopril-loaded ODFs were composed of different blends of synthetic polymers, such as polyvinyl alcohol (PVA) and polyvinyl pyrrolidone, and natural polymers, such as sodium alginate (SA) and gelatin. The ODFs were characterized based on their mechanical and thermal properties, drug content, surface morphology, in vitro disintegration, in vitro release, and bioavailability. A novel HPLC method with precolumn derivatization was developed to precisely and selectively determine captopril levels in plasma. A low concentration of PVA and a high concentration of SA generated ODFs with faster hydration and disintegration rates. SA-based films exhibited fast disintegration properties (1\u20132 min). The optimized modified-release film (F2) showed significant (p < 0.05) enhancement in bioavailability (AUC = 1000 ng min\/mL), with a value 1.43 times that of Capoten\u00ae tablets (701 ng min\/mL). While the plasma concentration peaking was in favor of the immediate-release tablet, T<inf>max<\/inf> was significantly prolonged by 5.4 times for the optimized ODF (3.59 h) compared with that of the tablets (0.66 h). These findings indicate uniform and sustained plasma concentrations, as opposed to the pulsatile and rapid plasma peaking of captopril from the immediate-release tablets. These findings suggest that the modified release of oral films could offer more favorable plasma profiles and better control of hypertension than the conventional release tablets. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"captopril\",\r\n \" hypertension\",\r\n \" oral films\",\r\n \" oral mucosa\",\r\n \" pediatric\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 77,\r\n \"title\": \"El Gazzar, Walaa Bayoumie (57194634097); Sliem, Rania E. (58250376200); Bayoumi, Heba (57219487533); Nasr, Hend Elsayed (57270493600); Shabanah, Manar (58208705100); Elalfy, Amira Kamal El Din Mohammed (57271026700); Radwaan, Shaimaa E. (58249675400); Gebba, Mohammed A. (58242198500); Mansour, Heba Mahmoud (58459297600); Badr, Amul M. (57205124942); Amer, Marwa Fathy (57202005616); Ashour, Sara Salama (57417715200); Morsi, Heba Mohamed Abdelhafiz (55273576200); Aboelkomsan, Elshaimaa Ahmed Fahmy (58567581300); Baioumy, Bodour (57271026800); Sayed, Alaa El Din H. (59100118600); Farag, Amina Ali (57316248600)\",\r\n \"authors\": \"Melatonin Alleviates Intestinal Barrier Damaging Effects Induced by Polyethylene Microplastics in Albino Rats\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85170241988&doi=10.3390%2Fijms241713619&partnerID=40&md5=fdcf4f10a9262ee8d52b891038c7a207\",\r\n \"affiliations\": \"Department of Anatomy, Hashemite University, Zarqa, Jordan; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Benha, Egypt; Faculty of Science, Benha, Egypt; Department of Histology and Cell Biology, Faculty of Medicine, Benha, Egypt; Faculty of Medicine, Mansoura, Egypt; Faculty of Veterinary Medicine Benha University, Toukh, Egypt; Department of Anatomy and Embryology, Merit University, Sohag, Egypt; Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences and Drug Manufacturing, 6th October, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Cairo, Egypt; Department of Pathology, New Giza University, Giza, Egypt; Faculty of Science, Asyut, Egypt; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha, Egypt\",\r\n \"abstract\": \"There have been concerns about the potential health risks posed by microplastics (MP). The detection of MP in a variety of food products revealed that humans are ingesting MP. Nevertheless, there is a paucity of data about their impacts, as well as their uptake, on intestinal barrier integrity. This study examined the toxic effects of oral administration of two doses of polyethylene microplastics (PE-MP) (3.75 or 15 mg\/kg\/day for 5 weeks; mean particle size: 4.0\u20136.0 \u00b5m) on the intestinal barrier integrity in rats. Moreover, the effect of melatonin treatment with MP exposure was also assessed. The PE-MP particle uptake, histopathological changes, Alcian blue staining, Muc2 mRNA, proinflammatory cytokines (IL-1\u03b2 and TNF-\u03b1), and cleaved caspase-3, as well as tight junction proteins (claudin-1, myosin light-chain kinase (MLCK), occludin, and zonula occludens-1 (ZO-1)) were assessed. Oral administration of PE-MP resulted in apparent jejunal histopathological alterations; significantly decreased mucin secretion, occludin, ZO-1, and claudin-1 expression; and significantly upregulated MLCK mRNA, IL-1\u03b2 concentration, and cleaved caspase-3 expression. Melatonin reversed these altered parameters and improved the PE-MP-induced histopathological and ultrastructure changes. This study highlighted the PE-MP\u2019s toxic effect on intestinal barrier integrity and revealed the protective effect of melatonin. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"intestinal barrier\",\r\n \" melatonin\",\r\n \" polyethylene microplastics\",\r\n \" proinflammatory cytokines\",\r\n \" tight junction proteins\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 78,\r\n \"title\": \"Abd El-Emam, Mahran Mohamed (57435232000); Mostafa, Mahmoud E. (57619859800); Farag, Amina Ali (57316248600); Youssef, Heba S. (58227767200); El-Demerdash, Azza Salah Eldin (57190969352); Bayoumi, Heba (57219487533); Gebba, Mohammed A. (58242198500); El-Halawani, Sawsan M. (56106760100); Saleh, Abdulrahman M. (57222647990); Badr, Amira M. (57208267192); El Sayed, Shorouk (57200595854)\",\r\n \"authors\": \"The Potential Effects of Quercetin-Loaded Nanoliposomes on Amoxicillin\/Clavulanate-Induced Hepatic Damage: Targeting the SIRT1\/Nrf2\/NF-\u03baB Signaling Pathway and Microbiota Modulation\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85169148621&doi=10.3390%2Fantiox12081487&partnerID=40&md5=7a8824802d4ba792e2724d082015701c\",\r\n \"affiliations\": \"Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Zagazig, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha, Egypt; Department of Physiology, Faculty of Medicine, Benha, Egypt; Department of Microbiology, Animal Health Research Institute, Giza, Egypt; Department of Histology and Cell Biology, Faculty of Medicine, Benha, Egypt; Faculty of Veterinary Medicine Benha University, Toukh, Egypt; Department of Anatomy and Embryology, Merit University, Sohag, Egypt; Department of Biotechnology, Mansoura University, Urology and Nephrology Center, Mansoura, Egypt; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Cairo, Egypt; Faculty of Pharmacy, College of Pharmacy, Riyadh, Saudi Arabia; Department of Microbiology, Faculty of Veterinary Medicine, Zagazig, Egypt\",\r\n \"abstract\": \"Amoxicillin\/clavulanate (Co-Amox), a commonly used antibiotic for the treatment of bacterial infections, has been associated with drug-induced liver damage. Quercetin (QR), a naturally occurring flavonoid with pleiotropic biological activities, has poor water solubility and low bioavailability. The objective of this work was to produce a more bioavailable formulation of QR (liposomes) and to determine the effect of its intraperitoneal pretreatment on the amelioration of Co-Amox-induced liver damage in male rats. Four groups of rats were defined: control, QR liposomes (QR-lipo), Co-Amox, and Co-Amox and QR-lipo. Liver injury severity in rats was evaluated for all groups through measurement of serum liver enzymes, liver antioxidant status, proinflammatory mediators, and microbiota modulation. The results revealed that QR-lipo reduced the severity of Co-Amox-induced hepatic damage in rats, as indicated by a reduction in serum liver enzymes and total liver antioxidant capacity. In addition, QR-lipo upregulated antioxidant transcription factors SIRT1 and Nrf2 and downregulated liver proinflammatory signatures, including IL-6, IL-1\u03b2, TNF-\u03b1, NF-\u03baB, and iNOS, with upregulation in the anti-inflammatory one, IL10. QR-lipo also prevented Co-Amox-induced gut dysbiosis by favoring the colonization of Lactobacillus, Bifidobacterium, and Bacteroides over Clostridium and Enterobacteriaceae. These results suggested that QR-lipo ameliorates Co-Amox-induced liver damage by targeting SIRT1\/Nrf2\/NF-\u03baB and modulating the microbiota. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Co-Amox-induced hepatotoxicity\",\r\n \" gut dysbiosis\",\r\n \" quercetin antioxidant activity\",\r\n \" quercetin liposomes\",\r\n \" SIRT1, Nrf2 and NF-\u03baB targeting\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 79,\r\n \"title\": \"Hamad, Ahmed Abdulhafez (57193447791); Haredy, Ahmed M. (56895997900)\",\r\n \"authors\": \"Designing a unique molecular size-dependent approach for determining levamisole via synergizing Rayleigh Scattering response of Cilefa Pink B dye; application to bulk, dosage forms, and biofluids; method greenness evaluation\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85149708638&doi=10.1016%2Fj.talo.2023.100196&partnerID=40&md5=f40329077ba274da24704607dfda8ad8\",\r\n \"affiliations\": \"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo, Egypt; Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Levamisole is an anti-helminthic agent employed medically to treat worm-causative disease, also used as an immune system modifying agent in rheumatic arthritis and as assistant therapy for treating the cancers of the head, colorectal, and neck regions. The first innovative size-dependent approach for levamisole drug analysis is described in this study. It is both efficient and environmentally benign. The drug was evaluated and validated using a green, one-pot, and direct size-dependent technique in this approach. An instant complex was created by combining levamisole and Cilefa Pink B in a mildly acidic medium. The fluorimetric investigation was based on the augmentation effect of levamisole on the Rayleigh scattering response amplitude of a biological dye (Cilefa Pink B) at 424 nm. which was related to produced complex's molecular size. Linearity ranged from 0.08 to 2.0 \u00b5g mL\u22121, with sensitivity limits of 0.023 and 0.069 \u00b5g mL\u22121, respectively. Analytical modulation of Levamisole-Cilefa Pink B complexes was done for all system parameters. In addition, the system was found to meet ICH criteria. Moreover, this technique successfully recovered the substance in the prescribed medicinal dosage forms. The created fluorimetric technique was also successfully employed to track the drug of interest in human biofluids, which was a significant accomplishment. Finally, an eco-scale was applied to recognize the designed method's environmental friendliness. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Biofluids\",\r\n \" Cilefa pink B\",\r\n \" Eco-rating\",\r\n \" Levamisole\",\r\n \" Resonance Rayleigh Scattering\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 80,\r\n \"title\": \"Alwafi, Hanadi Abdullah (57218902404); Ali, Soad Shaker (35783844900); Kotha, Sunil Babu (57189875766); Abuljadayel, Layla Waleed (56495355300); Ibrahim, Maha (57846148000); Elahi, Ibrahim Rashad Noor (57845485300); Alwafi, Hebah Abdullah (56613610900); Finkelman, Matthew David (24558635500); El-Shitany, Nagla Abd Aziz (24179446000)\",\r\n \"authors\": \"Imbalanced salivary electrolytes, COVID-19 severity, and dysgeusia\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85164596577&doi=10.22514%2Fsv.2023.005&partnerID=40&md5=79fcb076909caa317f49d2f6b3d6e3ac\",\r\n \"affiliations\": \"Department of Preventive Dentistry, Riyadh Elm University, Riyadh, Saudi Arabia; Department of Histology and Cell Biology, Faculty of Medicine, Asyut, Egypt; Department of Histology, Merit University, Sohag, Egypt; Department of Pediatric and Preventive Dentistry, Datta Meghe Institute of Higher Education & Research (Deemed to be University), Wardha, India; Department of Dental Public Health, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Hematology, MSF for Medical Research and Development, Jeddah, Saudi Arabia; Consultant of Preventive Medicine and Public Health, Directorate of Health Affairs for Public Health Division, Jeddah, Saudi Arabia; General surgery resident, Security Forces Hospital, Dammam, Saudi Arabia; Department of Public Health and Community Service, Tufts University School of Dental Medicine, Boston, United States; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta, Egypt; Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia\",\r\n \"abstract\": \"Early studies of patients who progressed to severe coronavirus disease 2019 (COVID-19) reported various serum electrolyte disturbances. Hyposalivation and dysgeusia are two of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection oral symptoms. This study investigated how SARS-CoV-2 infection affects saliva volume, pH, zinc, and inorganic components (sodium, potassium, calcium). The association between these salivary properties and dysgeusia was also investigated in patients with mild and severe COVID-19. Saliva volume, pH, zinc, sodium, potassium, and calcium were measured in 142 healthy persons (control) and 158 COVID-19 patients (72 mild and 86 severe). This study showed that saliva volume, pH, zinc, sodium, potassium, and calcium levels reduced dramatically during COVID-19. Likewise, these saliva characteristics were significantly lower in severe COVID-19 individuals than in mild COVID-19 cases. In addition, there was no correlation between dysgeusia and salivary composition, volume, or pH. All salivary indicators were reduced in the COVID-19 group reporting the loss of taste and smell and the group who perceived neither. These data suggested that COVID-19 is associated with many salivary abnormalities, including hyposalivation, decreased pH, and electrolyte imbalances. These were more pronounced in severe COVID-19 cases. According to the current study, saliva characteristics could be utilized for early diagnosis, quarantine, and therapy in COVID-19 patients. As a result, the virus transmission can be stopped, and the optimum therapeutic results might be obtained. COVID-19-associated dysgeusia was unrelated to the reduction of these changes. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"COVID-19\",\r\n \" Dysgeusia\",\r\n \" Electrolytes\",\r\n \" pH\",\r\n \" Saliva\",\r\n \" Severity\",\r\n \" Volume\",\r\n \" Zinc\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 81,\r\n \"title\": \"Tawfeek, Mohammed M.Mahdy (58506347900); Ahmed, Hanan Mohamed Abdel Hamid (58076476500); Bor\u2019i, Ashraf (57056277100); Rady, Ahmed M.Nashaat Ali (58536630100)\",\r\n \"authors\": \"SMILE lenticule versus amniotic membrane graft (AMG) augmented with platelet-rich plasma (PRP) for the treatment of perforated corneal ulcer\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85146743649&doi=10.1007%2Fs10792-023-02631-3&partnerID=40&md5=8511b357762d9f1016360022a53fdf1f\",\r\n \"affiliations\": \"Zagazig University, Faculty of Medicine, Zagazig, Egypt; The General Organization for Teaching Hospitals and Institutes, Cairo, Bab El Khalk, Egypt; Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Purpose: To evaluate the safety and efficacy of stromal lenticule obtained from small-incision lenticule extraction (SMILE) surgery versus amniotic membrane graft (AMG) augmented with platelet-rich plasma (PRP) for the treatment of perforated corneal ulcers and compare the results between the two groups. Patients and methods: This is a comparative retrospective study that included 40 eyes with medium-sized corneal perforations, which were classified into two equal groups of 20 eyes each; group (A) was treated with SMILE lenticule graft and group (B) was treated with AMG augmented with PRP. Pre- and postoperative evaluations were carried out using both slit-lamp (SL) examination and anterior segment optical coherence tomography (AS-OCT), including closure of perforation, complete healing, and best corrected visual acuity (BCVA). Results: Complete closure of the perforation was achieved in both groups. However, healing was faster in the SMILE lenticule group than in the AMG with PRP group (P < 0.05). Complete healing was achieved in\u00a0both groups: 100% in SMILE lenticule group and 95% in AMG with PRP group (P > 0.05). Both groups had few insignificant complications (30% in each), which were managed. Conclusion: Both methods achieved adequate healing of corneal perforations within few weeks without significant complications. However, the stromal lenticule obtained from small-incision lenticule extraction (SMILE) surgery tended to be safer with faster healing than AMG with PRP. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"AMG\",\r\n \" Perforated corneal ulcer\",\r\n \" PRP\",\r\n \" Stromal lenticule obtained from small-incision lenticule extraction (SMILE) surgery\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 82,\r\n \"title\": \"El-Hefnawy, Sally Mohammed (57184192200); El-Naidany, Sherin Sobhy (56353251000); Alhanafy, Alshimaa Mahmoud (57039017800); Badr, Nehad (57751681100); Ellaithy, Manal Abd El Monem (57225945510)\",\r\n \"authors\": \"Prognostic impact of serum vascular endothelial growth factor and VEGF gene polymorphism (rs2010963) in breast cancer patients\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85151439426&doi=10.1016%2Fj.humgen.2023.201168&partnerID=40&md5=068b2b239c13be9a8984e8927f2f03a1\",\r\n \"affiliations\": \"Medical Biochemistry and Molecular Biology Department, Menoufia University Faculty of Medicine, Shibin El Kom, Egypt; Department of Clinical Oncology and Nuclear Medicine, Menoufia University Faculty of Medicine, Shibin El Kom, Egypt; Public Health and Community Medicine Department, Menoufia University Faculty of Medicine, Shibin El Kom, Egypt; Medical Biochemistry & Molecular Biology Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Back ground: Vascular Endothelial Growth Factor (VEGF) mediates breast carcinogenesis. Several studies shown that, VEGF is associated with increased breast cancer risk. However its prognostic significance and expression in different molecular subtypes remain unclear. The current study aimed to evaluate the diagnostic and prognostic role of serum VEGF and VEGF rs2010963 polymorphism in Egyptian women with breast cancer. Aim: The current study aimed to evaluate the diagnostic and prognostic role of serum VEGF and VEGF rs2010963 polymorphism in Egyptian women with breast cancer. Subjects and methods: This study was held in Menoufia University Hospital and included 275 participants, 150 women with invasive breast cancer and 125 women as healthy controls. Serum VEGF was assayed by ELISA technique and genotyping of VEGF rs2010963 polymorphism was analyzed by real time PCR. Results: The frequency of GG, CG genotypes and G allele were higher in breast cancer group when compared to the control group (p value = 0.001). In breast cancer patients there was significant relation between VEGF gene (C\/G) polymorphism and patient age, tumor and nodal stage, molecular subtype and higher level of serum of CA15\u20133, CEA and VEGF for patients with GG genotype (P \u2264 0.05). Multivariate Cox regression analysis of factors affecting survival showed that advanced tumor stage, presence of metastasis, serum level of VEGF and GG rs 2010963VEGF gene polymorphism were independent factors affecting patient survival (P \u2264 0.05). Conclusion: rs2010963 VEGF gene polymorphism and serum VEGF could be considered as potential risk factors for breast cancer, Patients with breast cancer presenting the GG genotype have the highest serum VEGF levels, large tumor size, advanced tumor stage and shorter survival than CC carriers. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Breast cancer\",\r\n \" Genotype\",\r\n \" PCR\",\r\n \" Prognostic gene\",\r\n \" VEGF\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 83,\r\n \"title\": \"Aboelkhair, Noran Talaat (57218158329); Mashal, Samya S. (58142476600); El-Hefnawy, Sally Mohammed (57184192200); Alhanafy, Alshimaa Mahmoud (57039017800); Khodeer, Seham Ahmed (54583660200); Montaser, Belal Abdelmohsen M. (57192925452)\",\r\n \"authors\": \"The role of long non-coding RNA UCA1 and MALAT1 in bladder cancer patients\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85150016528&doi=10.1016%2Fj.humgen.2023.201164&partnerID=40&md5=8c47510cf884724729dabd126a2f9058\",\r\n \"affiliations\": \"Menoufia University Faculty of Medicine, Shibin El Kom, Egypt; Department of Biochemistry and Molecular Biology, Menoufia University, Shibin El Kom, Egypt; Medical Biochemistry and Molecular Biology Department, Merit University, Sohag, Egypt; Department of Clinical Oncology and Nuclear Medicine, Menoufia University Faculty of Medicine, Shibin El Kom, Egypt\",\r\n \"abstract\": \"Background: Bladder cancer (BC) is considered the most prevalent tumor of the urinary tract, and incidence rates are rising globally. Long noncoding RNAs (lncRNAs) can serve as biomarkers to help the diagnosis and anticipation of recurrence in cancer patients as they are implicated in carcinogenesis and tumor progression. This study targeted to investigate the expression of lncRNA as urothelial cancer associated 1 (UCA1) as well as metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the diagnosis of BC. Subjects and methods: The study included 70 BC patients, 70 benign urinary tract diseases and 70 controls. The UCA1 and MALAT1 expressions were studied utilizing quantitative real-time polymerase chain reaction. Results: The UCA1 and MALAT1 expression were significantly increased in patients with BC than patients with chronic cystitis and controls (p < 0.001). The sensitivity and specificity for the diagnosis of BC for UCA1(87.14%, 97.14% respectively) and MALAT1 (92.86%, 90% respectively). Multivariate logistic regression analysis showed that UCA1 and MALAT1 were risk factors for the development of BC where the odds ratio (OR) for UCA1 was 1.262 (CI 1.004\u20131.587) and MALAT1 was 2.201(CI 1.036\u20134.676). Conclusion: UCA1 and MALAT1 could be potential diagnostic biomarkers with good specificity and sensitivity in bladder cancer. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Bladder cancer\",\r\n \" Long non-coding RNAs\",\r\n \" MALAT1\",\r\n \" UCA1\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 84,\r\n \"title\": \"Ali, Ahmed U. (57213590141); Khallaf, Iman S.A. (57213352391); Kamel, Amira A. (57208054498); Badran, Aya Y. (57209326769); Gomaa, Ahmed Shawky (57211605576); El-Faham, Tahani H. (6603115454); Mortagi, Yasmin Ismail M. (55753556700)\",\r\n \"authors\": \"Corrigendum to \u201cImpact of quercetin spanlastics on livin and caspase-9 expression in the treatment of psoriasis vulgaris\u201d [J. Drug Deliv. Sci. Technol. 76(2022) 103809] (Journal of Drug Delivery Science and Technology (2022) 76, (S1773224722007201), (10.1016\/j.jddst.2022.103809))\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85150049707&doi=10.1016%2Fj.jddst.2023.104314&partnerID=40&md5=48f77b52606ee13eb1467a24ce05a58e\",\r\n \"affiliations\": \"Department of Pharmaceutics, Merit University, Sohag, Egypt; Pharmacognosy and Natural Products Department, Faculty of Pharmacy, Shibin El Kom, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Asyut, Egypt; Department of Dermatology, Faculty of Medicine, Asyut, Egypt; Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutics, Sinai University, El-Arish, Egypt\",\r\n \"abstract\": \"The authors regret that the affiliation of the authors Aya Y. Badran and Ahmed S. Gomaa was incomplete. The correct affiliation is as follows: dDepartment of Dermatology, Venereology, Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt. The authors would like to apologise for any inconvenience caused. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 85,\r\n \"title\": \"Mansoury, Manal M.S. (57215721450); Almukadi, Haifa S. (57220247407); Turkistani, Arwa Mohammed Shukri (57901832200); Khattab, Hala A.H. (55892011600); Ali, Soad Shaker (35783844900); Hassanein, Emad H.M. (57201654198); Alahmadi, Bassam Abdulaziz (57188537067); Al-Jaouni, Soad K. (6508203673); El-Shitany, Nagla Abd Aziz (24179446000)\",\r\n \"authors\": \"Apocynin attenuates methotrexate-induced mucositis by regulating NF-\u03baB, PPAR-\u03b3 and Bax\/Bcl-2\/Puma signals\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85161260342&doi=10.36721%2FPJPS.2023.36.2.REG.457-466.1&partnerID=40&md5=cf048486d8aae9ed35adab776cfa05fc\",\r\n \"affiliations\": \"Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; Faculty of Home Economics, Helwan, Egypt; Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Histology, Merit University, Sohag, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo, Egypt; Department of Biology, Taibah University, Medina, Saudi Arabia; Department of Pediatric Hematology-Oncology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta, Egypt\",\r\n \"abstract\": \"Oxidative stress, inflammation, and apoptosis are the primary inducers of Methotrexate (MTX)-induced mucositis. This research aimed to determine whether apocynin (APO) could protect against MTX-induced mucositis. The antioxidants, anti-inflammatory, and anti-apoptotic actions of APO in this model will be evaluated. The experiment was performed on 32 rats. A single dose (20 mg\/kg) of MTX was injected i.p. to induce intestinal mucositis. APO was given orally once per day at a dose of 100mg\/kg (five days prior to and five days following an MTX injection). APO safeguarded the histological structure of the duodenal mucosa, as observed by the conserved histology of goblet cells (villi and crypts). APO mitigated oxidative stress by reducing intestin MDA and raising GSH, SOD and GST, also suppressing NF-\u03baB mRNA expression. Intestinal content of proinflammatory cytokines was reduced in APO-treated MTX rats, with downregulation of proinflammatory iNOS and upregulation of anti-inflammatory PPAR-\u03b3 proteins. The intestinal mucosa of rats treated with APO and MTX displayed weekly positive immune staining for cleaved caspase-3. APO upregulate the anti-apoptotic Bcl2 mRNA and down regulate the proapoptotic Bax and Puma mRNA in the duodenal mucosa. The results indicate the possibility of using APO as a novel therapeutic agent to prevent MTX-induced mucositis. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"apocynin\",\r\n \" apoptosis\",\r\n \" Methotrexate\",\r\n \" NF-\u03baB\",\r\n \" PPAR-\u03b3\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 86,\r\n \"title\": \"El-Hawary, Seham Salah Dine (6505933617); Hassan, Marwa H.A. (56468563000); Hudhud, Ahmed O. (58122425100); Abdelmohsen, Usama Ramadan (36056037900); Mohammed, Rabab (54963341500)\",\r\n \"authors\": \"Elicitation for activation of the actinomycete genome's cryptic secondary metabolite gene clusters\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85149138552&doi=10.1039%2Fd2ra08222e&partnerID=40&md5=d3b17befb93d035b8e13e3fdd02abbe5\",\r\n \"affiliations\": \"Faculty of Pharmacy, Cairo, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmacognosy, Merit University, Sohag, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Minya, Egypt; Department of Pharmacognosy, Deraya University, New Minia, Egypt\",\r\n \"abstract\": \"This review summarizes the recent advances in the elicitation approaches used to activate the actinomycete genome's cryptic secondary metabolite gene clusters and shows the diversity of natural products obtained by various elicitation methods up to June 2022, such as co-cultivation of actinomycetes with actinomycetes, other non-actinomycete bacteria, fungi, cell-derived components, and\/or algae. Chemical elicitation and molecular elicitation as transcription factor decoys, engineering regulatory genes, the promoter replacement strategy, global regulatory genes, and reporter-guided mutant selection were also reported. For researchers interested in this field, this review serves as a valuable resource for the latest studies and references. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 87,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Shoman, Mai E. (24559439600); Makram, Tarek Saad (6506095690); Abdel-Aleem, Jelan A. (55390544500); Abdelkader, Hamdy (20336654000)\",\r\n \"authors\": \"Exploration of the Safety and Solubilization, Dissolution, Analgesic Effects of Common Basic Excipients on the NSAID Drug Ketoprofen\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85149123402&doi=10.3390%2Fpharmaceutics15020713&partnerID=40&md5=1aa2abd67af0566e2779b734f341e3ee\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, 6th October, Egypt; Department of Industrial Pharmacy, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia\",\r\n \"abstract\": \"Since its introduction to the market in the 1970s, ketoprofen has been widely used due to its high efficacy in moderate pain management. However, its poor solubility and ulcer side effects have diminished its popularity. This study prepared forms of ketoprofen modified with three basic excipients: tris, L-lysine, and L-arginine, and investigated their ability to improve water solubility and reduce ulcerogenic potential. The complexation\/salt formation of ketoprofen and the basic excipients was prepared using physical mixing and coprecipitation methods. The prepared mixtures were studied for solubility, docking, dissolution, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), in vivo evaluation for efficacy (the writhing test), and safety (ulcerogenic liability). Phase solubility diagrams were constructed, and a linear solubility (AL type) curve was obtained with tris. Docking studies suggested a possible salt formation with L-arginine using Hirshfeld surface analysis. The order of enhancement of solubility and dissolution rates was as follows: L-arginine > L-lysine > tris. In vivo analgesic evaluation indicated a significant enhancement of the onset of action of analgesic activities for the three basic excipients. However, safety and gastric protection indicated that both ketoprofen arginine and ketoprofen lysine salts were more favorable than ketoprofen tris. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"basic amino acids\",\r\n \" gastric ulcer\",\r\n \" ketoprofen\",\r\n \" L-arginine\",\r\n \" L-lysine\",\r\n \" tris\",\r\n \" writhing\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 88,\r\n \"title\": \"Elsayed, Mohamed (59088212000); Mohamed, Mohamed Ahmed (58862493900); Ali, Mohammad F. (58861249800); Dabash, Ghada R. (58862246700); El Din Taha, Taher Salah (58862738600); Abdelrahim, Reham M. (58861499200)\",\r\n \"authors\": \"Effect of Muscle Energy Technique versus Graston Technique on nonspecific neck pain; Efecto de la t\u00e9cnica de energ\u00eda muscular versus la t\u00e9cnica de Graston sobre el dolor de cuello inespec\u00edfico\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85184026792&doi=10.6018%2Fsportk.599011&partnerID=40&md5=7a02af723be740482f75d1e743760220\",\r\n \"affiliations\": \"Badr University Hospital, Helwan, Egypt; Department of Basic Sciences, Sphinx University, New Assuit, Egypt; Department of Physical Therapy for Internal Medicine and Surgery, Faculty of Physical Therapy, 6th October, Egypt; Department of Orthopedic Physical Therapy, Faculty of Physical Therapy, Beni Suef, Egypt; Department of Physical Therapy, Buraydah Private Colleges, Buraidah, Saudi Arabia; Woman\u2019s Health Department, Modern University for Technology and Information, Cairo, Egypt; Sohag Educational Administration, Sohag, Egypt; Merit University, Sohag, Egypt; Basic Sciences Department, Modern University for Technology and Information, Cairo, Egypt\",\r\n \"abstract\": \"Background: Numerous researches have been carried out in order to determine the most effective physical therapy strategy for treating nonspecific neck pain (NSNP). Purpose: To contrast between the outcomes of Graston Technique (GT) and Muscle Energy Technique (MET) on both pain intensity and functional disability in patients with NSNP. Methods: Forty-two (30 males and 12 females) patients with NSNP divided randomly into three groups: Group A: received Graston Technique and traditional physiotherapy treatment (TPT), Group B: received muscle energy technique and TPT, and Group C: received TPT only. Intervention lasted for 12 sessions (3 per week). At the start and finish of the fourth week, a visual analogue scale was used to quantify pain intensity and a neck disability index (NDI) questionnaire was used to measure functional disability. Results: There were significant mean effects of time (pre\/post) and intervention group (Graston, MET, conventional) and significant interaction on pain and disability (p<0.05). MET group had higher changes in the pain than both Graston and control groups (p<0.05). However, no significant differences among groups in the functional change. Conclusion: GT and MET had similar effects on the function in patients with NSNP, but MET had higher effects on reducing pain. \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Graston Technique\",\r\n \" Instrument-assisted soft tissue mobilization\",\r\n \" Muscle energy technique\",\r\n \" Neck disability\",\r\n \" Non-specific neck pain\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 89,\r\n \"title\": \"Abdelkader, Hamdy (20336654000); El-Wahab, Asmaa Abd (58573421200); El-Gendy, Ahmed Osama (55582023600); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Formulation and optimization of lipid- and Poloxamer-tagged niosomes for dermal delivery of terbinafine: preparation, evaluation, and in\u00a0vitro antifungal activity\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85170706310&doi=10.1080%2F10837450.2023.2255889&partnerID=40&md5=568b4bab5fece8b1a95eda55dc6aef8c\",\r\n \"affiliations\": \"Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia; Faculty of Pharmacy, Beni Suef, Egypt; Department of Microbiology and Immunology, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Fungal skin diseases are recognized as a global burden disease that affect human quality adjusted life. Terbinafine belongs to allylamine and broad-spectrum antifungal drugs but considered practically insoluble. Different lipids\/surfactant with two different molar ratios were investigated with Span 40-based niosomes; characterized for size, morphology, loading capacity (EE%), in\u00a0vitro release, kinetics, and antifungal activities. Vesicle sizes (0.19\u20131.23\u00a0\u00b5m), EE% (25\u201399%), zeta potential (> \u221232 mV), and in\u00a0vitro release rates were dependent on both lipid types and ratios. Higher ratios of Poloxamer 407 preferably formed mixed micelles rather than forming noisome bilayers. Both Compritol and Precirol were deemed to be potential alternatives to cholesterol as bilayer membrane stabilizers. Terbinafine-loaded Compritol and Precirol stabilized niosomes were successfully prepared and demonstrated superior antifungal activities in\u00a0vitro (inhibition zones) using Candida albicans ATCC 60913. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Compritol\",\r\n \" membrane additives\",\r\n \" niosomes\",\r\n \" Precirol\",\r\n \" Terbinafine\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 90,\r\n \"title\": \"Al-Ghamdi, Maryam A. (55796092800); Huwait, Etimad A. (36646153400); El-Sawi, Nagwa M. (8344020000); Ali, Soad Shaker (35783844900); Sayed, Ahmed M. (57201406179)\",\r\n \"authors\": \"Thymoquinone ameliorates acrylamide-induced reproductive toxicity in female rats: An experimental study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85147446723&doi=10.18502%2Fijrm.v21i1.12668&partnerID=40&md5=2bfb3fc1d0bb40fa628e24246283d60d\",\r\n \"affiliations\": \"Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Experimental Biochemistry Unit, King Fahd Medical Research Center, Jeddah, Saudi Arabia; Vitamin D Pharmacogenomics Research Group, King Abdulaziz University, Jeddah, Saudi Arabia; Laboratory of Biochemistry, Faculty of Science, Sohag, Egypt; Faculty of Medicine, Merit University, Sohag, Egypt; Laboratory of Biochemistry, Faculty of Science, Asyut, Egypt\",\r\n \"abstract\": \"Background: Acrylamide (AA) is a carcinogenic compound that causes severe reproductive impairments and represents a high environmental risk factor. Thymoquinone (TQ) has a unique antioxidant activity and has been widely used as a protective agent against various types of toxicity. Objective: To evaluate the protective effects of TQ against AA-induced reproductive toxicity in female rats. Materials and Methods: In this experimental study, 40 female albino rats (120-150 gr, 8-10 wk) were sorted into 4 groups, (n = 10\/each), vehicle group (received a daily oral administration of 0.5 ml saline [9%]); AA group (received a daily oral administration with freshly prepared AA, 20 mg\/kg body weight) for 21 days which is less than the lethal dose LD<inf>50<\/inf> of AA in rats (20 mg\/kg body weight); AA+TQ group (received a daily oral administration of TQ, 10 mg\/kg body weight) after AA intoxication for 21 days, and TQ group (received a daily oral administration of TQ only, 10 mg\/kg body weight) for 21 consecutive days. Reproductive hormones, carcinogenic biomarkers, and oxidative stress markers were measured. The histological assessment showed the protective effect of TQ against AA-induced ovarian injury. Network pharmacology analysis and molecular docking approach were carried out to determine the binding affinity of TQ with cyclooxygenase 2. Results: TQ administration significantly enhanced the functional capacity of the ovary at hormones, oxidative biomarkers, and tumor markers at a significant level of p < 0.001. Besides, TQ protects the ovary of AA-treated rats from the severe degeneration effect. Conclusion: TQ showed a promising protective effect against AA-induced reproductive toxicity in female rats. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Acrylamide\",\r\n \" Cyclooxygenase 2\",\r\n \" Inflammation\",\r\n \" Oxidative stress\",\r\n \" Rats\",\r\n \" Thymoquinone\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 91,\r\n \"title\": \"Alfatease, Adel M. (57193644396); Shoman, Mai E. (24559439600); Abourehab, Mohammed A.S. (56641727000); Abou-Taleb, Heba A. (57197775199); Abdelkader, Hamdy (20336654000)\",\r\n \"authors\": \"A Novel Curcumin Arginine Salt: A Solution for Poor Solubility and Potential Anticancer Activities\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85145736868&doi=10.3390%2Fmolecules28010262&partnerID=40&md5=7a90640c950a0a78313a93598f31efbc\",\r\n \"affiliations\": \"Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia; Department of Medicinal Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics, Umm Al-Qura University, Makkah, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Curcumin is a natural polyphenolic compound with well-known anticancer properties. Poor solubility and permeability hamper its use as an anticancer pharmaceutical product. In this study, L-arginine, a basic amino acid and a small hydrophilic molecule, was utilized to form a salt with the weak acid curcumin to enhance its solubility and potentiate the anticancer activities of curcumin. Two methods were adopted for the preparation of curcumin: L-arginine salt, namely, physical mixing and coprecipitation. The ion pair or salt was characterized for docking, solubility, DSC, FTIR, XRD, in vitro dissolution, and anticancer activities using MCF7 cell lines. The molecular docking suggested a salt\/ion-pair complex between curcumin and L-arginine. Curcumin solubility was increased 335- and 440-fold by curcumin in L-arginine, physical, and co-precipitated mixtures, respectively. Thermal and spectral analyses supported the molecular docking and formation of a salt\/ion pair between curcumin and L-arginine. The cytotoxicity of curcumin L-arginine salt significantly improved (p < 0.05) by 1.4-fold, as evidenced by the calculated IC<inf>50%<\/inf>, which was comparable to Taxol (the standard anticancer drug but with common side effects). \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"breast cancer\",\r\n \" curcumin\",\r\n \" cytotoxicity\",\r\n \" L-arginine\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 92,\r\n \"title\": \"Abdelkader, Hamdy (20336654000); Alfatease, Adel M. (57193644396); Fathalla, Zeinab M.A. (57188965212); Shoman, Mai E. (24559439600); Abou-Taleb, Heba A. (57197775199); Abourehab, Mohammed A.S. (56641727000)\",\r\n \"authors\": \"Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85141846223&doi=10.3390%2Fpharmaceutics14112283&partnerID=40&md5=50b4997f120eae0a4b9b3cbb21414230\",\r\n \"affiliations\": \"Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, Umm Al-Qura University, Makkah, Saudi Arabia\",\r\n \"abstract\": \"Curcumin is one of the most researched phytochemicals by pharmacologists and formulation scientists to unleash its potential therapeutic benefits and tackle inherent biopharmaceutic problems. In this study, the native \u03b2-cyclodextrin (CD) and three derivatives, namely, Captisol (sulfobutyl ether \u03b2-CD), hydroxypropyl \u03b2-cyclodextrin, and hydroxyethyl \u03b2-cyclodextrin were investigated for inclusion complexes with curcumin using two preparation methods (physical mixing and solvent evaporation). The prepared complexes were studied for docking, solubility, FTIR, DSC, XRD, and dissolution rates. The best-fitting curcumin: cyclodextrins (the latter of the two CDs) were evaluated for cytotoxicity using human breast cell lines (MCF-7). Dose-dependent cytotoxicity was recorded as IC50% for curcumin, curcumin: hydroxyethyl \u03b2-cyclodextrin, and curcumin: hydroxypropyl \u03b2-cyclodextrin were 7.33, 7.28, and 19.05 \u00b5g\/mL, respectively. These research findings indicate a protective role for the curcumin: hydroxypropyl \u03b2-cyclodextrin complex on the direct cell lines of MCF-7. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"curcumin\",\r\n \" cyclodextrins\",\r\n \" cytotoxicity\",\r\n \" hydroxyethyl \u03b2-cyclodextrin\",\r\n \" MCF-7\",\r\n \" solubility\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 93,\r\n \"title\": \"Abbas, Noha S. (57203950222); Mohamed, Yahya Abduh Salim (55759946600); Derayea, Sayed Mohamed (55530732800); Omar, Mahmoud Ahmed (15733097700); Saleh, Gamal A. (7003720153)\",\r\n \"authors\": \"Micellar Thin Layer Chromatography and Computer-Aided Analysis of Empagliflozin, Linagliptin and Metformin HCl Ternary Mixture\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85133901721&doi=10.1093%2Fchromsci%2Fbmac008&partnerID=40&md5=bce81491bd112003774b0e1e2f346cb2\",\r\n \"affiliations\": \"Egyptian Ministry of Health and Population, Cairo, Egypt; Department of Pharmaceutical Medicinal and Organic Chemistry, Sana'a University, Sana'a, Yemen; Department of Analytical Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Pharmacognosy and Pharmaceutical Chemistry, Taibah University, Medina, Saudi Arabia; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutical Analytical Chemistry, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"The present work was performed in order to study the mechanism of micellar thin layer chromatography (MTLC) and to develop a new simple and sensitive simultaneous MTLC method for separation of empagliflozin, Linagliptin and metformin hydrochloride ternary mixture. The study was done using three different surfactants; sodium dodecyl sulphate (SDS), benzalkonium chloride (BAC) and polysorbate 80 (tween 80). Chromatographic procedure was performed using micellar mobile phase that composed of aqueous solution of each surfactant and methanol (6: 4 v\/v) and micellar TLC determination at \u03bbmax 237 nm. Separation using SDS (anionic surfactant) and BAC (cationic surfactant) depends on ionization potential (AMI-IP), partition coefficient (logP (o\/w)) and hydrogen bond donor atoms (a-don), whereas separation using tween 80 depends mainly on the lipophilicity (R<inf>M0<\/inf>), solvation energy (E-sol) and Van der Waals energy (E-vdw). Quantitative structure\u2013retention relationships study was carried out, modeled, evaluated and validated using molecular operating environment software. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 94,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Sayed, Ahmed M. (57155946600); Refaat, Hesham (57224139658); Alsenani, Faisal (57198490138); Alaaeldin, Eman (55693863500); Mokhtar, Fatma Alzahraa (26323715100); Abdelmohsen, Usama Ramadan (36056037900); Shady, Nourhan Hisham (57194451949)\",\r\n \"authors\": \"Network Pharmacological Analysis of the Red Sea Sponge Hyrtios erectus Extract to Reveal Anticancer Efficacy of Corresponding Loaded Niosomes\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85140582940&doi=10.3390%2Fmd20100628&partnerID=40&md5=fb359e45f7d1774fcc99fb17f0155278\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmacognosy, Almaaqal University, Basra, Iraq; Department of Pharmacognosy, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Pharmaceutics, Deraya University, New Minia, Egypt; Department of Pharmacognosy, Umm Al-Qura University, Makkah, Saudi Arabia; Department of Pharmacognosy, AlSalam University in Egypt, Tanta, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Minya, Egypt; Department of Pharmacognosy, Deraya University, New Minia, Egypt\",\r\n \"abstract\": \"In this study, the LC-HRMS-assisted chemical profiling of Hyrtios erectus sponge led to the annotation of eleven major compounds (1\u201311). H. erectus-derived crude extract (HE) was tested in vitro for its antiproliferative activity against three human cancer cell lines, Hep-G2 (human liver cancer cell line), MCF-7 (breast cancer cell line), and Caco-2 (colon cancer cell line), before and after encapsulation within niosomes. Hyrtios erectus extract showed moderate in vitro antiproliferative activities towards the studied cell lines with IC<inf>50<\/inf> values 18.5 \u00b1 0.08, 15.2 \u00b1 0.11, and 13.4 \u00b1 0.12, respectively. The formulated extract-containing niosomes (size 142.3 \u00b1 10.3 nm, PDI 0.279, and zeta potential 22.8 \u00b1 1.6) increased the in vitro antiproliferative activity of the entrapped extract significantly (IC<inf>50<\/inf> 8.5 \u00b1 0.04, 4.1 \u00b1 0.07, and 3.4 \u00b1 0.05, respectively). A subsequent computational chemical study was performed to build a sponge\u2013metabolite\u2013targets\u2013cancer diseases network, by focusing on targets that possess anticancer activity toward the three cancer types: breast, colon, and liver. Pubchem, BindingDB, and DisGenet databases were used to build the network. Shinygo and KEGG databases in addition to FunRich software were used for gene ontology and functional analysis. The computational analysis linked the metabolites to 200 genes among which 147 genes related to cancer and only 64 genes are intersected in the three cancer types. The study proved that the co-occurrence of compounds 1, 2, 3, 7, 8, and 10 are the most probable compounds possessing cytotoxic activity due to large number of connections to the intersected cytotoxic genes with edges range from 9-14. The targets possess the anticancer effect through Pathways in cancer, Endocrine resistance and Proteoglycans in cancer as mentioned by KEGG and ShinyGo 7.1 databases. This study introduces niosomes as a promising strategy to promote the cytotoxic potential of H. erectus extract. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"cytotoxicity\",\r\n \" enrichment analysis\",\r\n \" Hyrtios\",\r\n \" marine sponge\",\r\n \" metabolic\",\r\n \" network pharmacology\",\r\n \" niosomes\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 95,\r\n \"title\": \"Ali, Ahmed U. (57213590141); Khallaf, Iman S.A. (57213352391); Kamel, Amira A. (57208054498); Badran, Aya Y. (57209326769); Gomaa, Ahmed Shawky (57211605576); El-Faham, Tahani H. (6603115454); Mortagi, Yasmin Ismail M. (55753556700)\",\r\n \"authors\": \"Impact of quercetin spanlastics on livin and caspase-9 expression in the treatment of psoriasis vulgaris\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85138773433&doi=10.1016%2Fj.jddst.2022.103809&partnerID=40&md5=5eee84ca1a9117fc78822be158914297\",\r\n \"affiliations\": \"Department of Pharmaceutics, Merit University, Sohag, Egypt; Pharmacognosy and Natural Products Department, Faculty of Pharmacy, Shibin El Kom, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Asyut, Egypt; Department of Dermatology, Andrology, Asyut, Egypt; Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutics, Sinai University, El-Arish, Egypt\",\r\n \"abstract\": \"Psoriasis is a chronic immune-mediated disease presented by erythematic lesions. It is an incurable disease; however, topical treatment attempts to stop the uncontrolled proliferation of skin cells. Quercetin (Qc) is a natural compound plentiful in several natural plant species and plays a vital role in treating psoriasis; however, it has poor aqueous solubility and penetrability. Consequently, our work aims to enhance Qc's dissolution and anti-psoriatic activity. In this work, Qc was isolated from Psidium guajava leaves, and spanlastics were prepared using the ethanol injection method. The % encapsulation efficiency (%EE) of Qc ranged from 76.40 \u00b1 1.42 to 98.29 \u00b1 0.2,4, and the Particle size (P.size) varied between 414.66 \u00b1 1.94 to 748.33 \u00b1 5.19 nm. In vitro release studies of Qc from spanlastic preparations were significantly higher than those from free drug dispersion. Selected Qc spanlastics formulation was included in Sodium carboxymethylcellulose (SCMC) 3.5% gel for biological application. Clinical improvement after eight weeks of treatment was powerfully distinguished. By the end of 8 weeks of treatment, Psoriasis Area and Severity Index (PASI) score decreased from 5.19 \u00b1 1.14 at baseline to 2.26 \u00b1 1.1. Qc is famous for its apoptotic-inducing activity, livin is one of the Inhibitors of apoptosis proteins (IAPs), and its function is mediated through the inhibition of caspase activation. Quantitative real-time polymer chain reaction (qrt- PCR) declared that the expression of livin (p = 0.002) was lowered while that of caspase-9 (P < 0.001) was elevated in comparison to those before treatment with QC spanlastics; thus, Qc spanlastics are promising easily prepared formulation for the treatment of psoriasis. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Ethanol injection method\",\r\n \" Factorial design\",\r\n \" Livin and caspase)\",\r\n \" Psoriasis\",\r\n \" Quercetin\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 96,\r\n \"title\": \"Elsayed, Mahmoud M.A. (57218323683); Aboelez, Moustafa O. (57191738528); Mohamed, Mohamed S. (57211757868); Mahmoud, Reda A. (57223227945); El-Shenawy, Ahmed Ahmed (57192806043); Mahmoud, Essam A. (57221280023); Al-Karmalawy, Ahmed A. (57210596269); Santali, Eman Y. (39762585800); Alshehri, Sameer (57204084546); Elsadek, Mahmoud Elkot Mostafa (57666064900); A. El Hamd, Mohamed (55265969200); El Hakim Ramadan, Abd (57217825641)\",\r\n \"authors\": \"Tailoring of Rosuvastatin Calcium and Atenolol Bilayer Tablets for the Management of Hyperlipidemia Associated with Hypertension: A Preclinical Study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85137405032&doi=10.3390%2Fpharmaceutics14081629&partnerID=40&md5=007fdf515ede585f0fc02a6d29b7c269\",\r\n \"affiliations\": \"Faculty of Pharmacy, Sohag, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag, Egypt; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Cairo, Egypt; Faculty of Veterinary Medicine, Zagazig, Egypt; Department of Pharmaceutical Medicinal Chemistry, Horus University - Egypt, New Damietta, Egypt; Department of Pharmaceutical Chemistry, Taif University, Taif, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Taif University, Taif, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutical Sciences, Shaqra University, Shaqra, Saudi Arabia; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Qena, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Port Said, Egypt\",\r\n \"abstract\": \"Hyperlipidemia is still the leading cause of heart disease in patients with hypertension. The purpose of this study is to make rosuvastatin calcium (ROS) and atenolol (AT) bilayer tablets to treat coexisting dyslipidemia and hypertension with a single product. ROS was chosen for the immediate-release layer of the constructed tablets, whereas AT was chosen for the sustained-release layer. The solid dispersion of ROS with sorbitol (1:3 w\/w) was utilized in the immediate-release layer while hydroxypropyl methylcellulose (HPMC), ethylcellulose (EC), and sodium bicarbonate were incorporated into the floating sustained-release layer. The concentrations of HPMC and EC were optimized by employing 32 full factorial designs to sustain AT release. The bilayer tablets were prepared by the direct compression method. The immediate-release layer revealed that 92.34 \u00b1 2.27% of ROS was released within 60 min at a pH of 1.2. The second sustained-release layer of the bilayer tablets exhibited delayed release of AT (96.65 \u00b1 3.36% within 12 h) under the same conditions. The release of ROS and AT from the prepared tablets was found to obey the non-Fickian diffusion and mixed models (zero-order, Higuchi and Korsmeyer\u2013Peppas), respectively. Preclinical studies using rabbit models investigated the impact of ROS\/AT tablets on lipid profiles and blood pressure. A high-fat diet was used to induce obesity in rabbits. Bilayer ROS\/AT tablets had a remarkable effect on decreasing the lipid profiles, slowing weight gain, and lowering blood pressure to normal levels when compared to the control group. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"atenolol\",\r\n \" bilayer tablets\",\r\n \" factorial design\",\r\n \" hyperlipidemia\",\r\n \" hypertension\",\r\n \" preclinical studies\",\r\n \" rosuvastatin calcium\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 97,\r\n \"title\": \"Farrag, Sherien A. (57760120000); Rageh, Azza H. (21233802300); Askal, Hassan F. (6601931305); Saleh, Gamal A. (7003720153)\",\r\n \"authors\": \"Biocompatible magnetite nanoparticles coated with ionic liquid-based surfactant as a hydrophilic sorbent for dispersive solid phase microextraction of cephalosporins prior to their quantitation by HPTLC\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85132552851&doi=10.1016%2Fj.jchromb.2022.123339&partnerID=40&md5=9eabf66dd1f12b5403aacd2a346673fb\",\r\n \"affiliations\": \"Faculty of Pharmacy, Asyut, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Asyut, Egypt; Faculty of Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Extraction of highly hydrophilic compounds from biological fluids including urine or plasma samples is a dilemma due to high hydrophilicity of the matrix itself. The main aim of the current work is to explore the competence of ionic liquid (IL)-based surfactant-coated mineral oxide nanoparticles (NPs) in dispersive solid-phase microextraction (d-SPME) of highly hydrophilic analytes taking cefoperazone (CPZ) as a model analyte for the study. The IL-based surfactant coated Fe<inf>3<\/inf>O<inf>4<\/inf> NPs is utilized as an innovative adsorbent for the separation and pre-concentration of CPZ after intramuscular injection (I.M) in rabbits. The utilized magnetite NPs were synthesized via simple and reliable co-precipitation procedure, which doesn't require any air-free environment and depends on a single iron (III) salt. Characterization of the as-synthesized NPs was achieved by X-ray powder diffraction (XRD), Fourier transform infrared (FT-IR) and energy dispersive X-ray (EDX). Surface area measurements show that Fe<inf>3<\/inf>O<inf>4<\/inf> NPs have large surface area of 75 m2 g\u22121. The developed approach utilizes the unique properties of the IL-based surfactant including multiple polar interaction types provided by the polar head in addition to merits of Fe<inf>3<\/inf>O<inf>4<\/inf> nanoparticles, which include large adsorptive capacity and magnetic properties, to improve separation, save time, and achieve satisfactory recovery. Comprehensive study was developed for the factors, that affect the adsorption capacity such as pH, NPs amount, IL-based surfactant concentration, ionic strength, adsorption time, and desorption conditions. Moreover, the adsorption data was fitted to Langmuir and second-order kinetic models as reflected by the reasonable determination coefficients of 0.9319 and 0.9726, respectively. Under the optimized conditions, the developed approach achieves good correlation coefficient of 0.9975, and 0.9981 over linearity range of 0.7\u201312.0 and 4.0\u201350.0 \u00b5g mL\u22121 for both CPZ standard solutions and spiked rabbit plasma, respectively. It also provides good sensitivity expressed by the low values of limit of detection (LOD) of 0.2 and 1.2 \u00b5g mL\u22121 and limit of quantitation (LOQ) of 0.7 and 4.0 \u00b5g mL\u22121 for both the standard solutions and spiked plasma, respectively. The developed approach was also applied successfully for monitoring CPZ in rabbit plasma samples with satisfactory recovery % (83\u2013110). In addition, a detailed pharmacokinetic study is performed where pharmacokinetic parameters of CPZ in rabbit plasma samples were calculated. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Cefoperazone\",\r\n \" Dispersive solid phase microextraction\",\r\n \" High-performance thin layer chromatography\",\r\n \" In-vivo analysis\",\r\n \" Ionic liquid based-surfactant\",\r\n \" Magnetic Fe3O4 NPs\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 98,\r\n \"title\": \"Al\u2013Farhan, Badriah Saad (57224940566); Gahlan, Ahmed A. (57215860803); Haredy, Ahmed M. (56895997900); Fargaly, O. A. (57737325800)\",\r\n \"authors\": \"Cathodic Stripping Voltammetric Determination of Lisinopril in Dosage Forms and Biological Fluids\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85131814084&doi=10.21608%2Fejchem.2021.104642.4835&partnerID=40&md5=50e2b72d7f3e65025889a32c3dc27a02\",\r\n \"affiliations\": \"Department of Chemistry, King Khalid University, Abha, Saudi Arabia; Department of Chemistry, Faculty of Science, Cairo, Egypt; Department of Chemistry, Al Baha University, Al Aqiq, Saudi Arabia; Pharmaceutical Analytical Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Lisinopril (LSP) in pharmaceutical dosage forms and biological fluids was studied using the square wave cathodic stripping voltammetric method (SWCSV) at a carbon paste electrode (CPE). To maximize the method's circumstances, many parameters were defined. The linear concentration range of 3.53 \u2013 44.17 ng\/mL was effectively determined at ideal conditions of 0.08 M Britton-Robinson buffers (pH = 9.00) at accumulation times 15, 30 sec., and 2.64 \u2013 44.17 ng\/mL at 60 sec. With good results, the standard addition method was employed to determine LSP in pure solutions, tablets, and biological fluids. The proposed method is compared to the previously published standard method. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Biological Fluids\",\r\n \" Cathodic Stripping Voltammetric\",\r\n \" Dosage Forms\",\r\n \" Lisinopril\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 99,\r\n \"title\": \"Alshora, Doaa Hasan (56998666500); Ibrahim, Mohamed Abbas (58516410900); Zayed, Gamal M.S. (36865467400); Al Rwashed, Mohammed A. (57468461600); Abou-Taleb, Heba A. (57197775199); Ali, Marwa Farouk (57211363599)\",\r\n \"authors\": \"The role of sodium lauryl sulfate on formulation of directly compressed tablets containing simvastatin and aspirin: Effect on drugs dissolution and gastric mucosa\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85125307281&doi=10.1016%2Fj.jsps.2022.02.006&partnerID=40&md5=b4809242634e1f989119228327b835d2\",\r\n \"affiliations\": \"Department of Pharmaceutics, College of Pharmacy, Riyadh, Saudi Arabia; Faculty of Pharmacy, Cairo, Egypt; Al-Azhar University, Cairo, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Faculty of Medicine, Asyut, Egypt\",\r\n \"abstract\": \"According to the American College of Cardiology\/American Heart Association (ACC\/AHA), both aspirin and statin are used in the primary prevention of cardiovascular diseases. Aspirin (ASA) is contraindicated if there is gastrointestinal bleeding because it will exaggerate the condition. In this study, the effect of surfactant; sodium lauryl sulfate (SLS), in enhancing the in vitro dissolution of simvastatin (SIM) and ASA, as well as gastric irritation and upset, was studied. Oral tablets containing both ASA and SIM with and without the SLS were manufactured using the direct compression technique. The prepared tablets were characterized with respect to hardness, friability, uniformity of dosage units, in vitro disintegration, and dissolution. The effect of the addition of SLS in reducing the in vivo irritation and protection of gastric mucosa were also investigated. The results showed that the compressed tablets possessed sufficient hardness, acceptable friability, and are uniform with respect to disintegration, drugs contents, and tablet weight. The results showed that SIM alone exhibited a gastroprotective effect on the induced irritation. In addition, the incorporation of the SLS in the tablets containing SIM and ASA significantly enhanced the dissolution rates of both drugs and significantly decreased the gastric irritation and the ulcer index. The ulcer index of aspirin was decreased from 2.3 for tablets manufactured without SLS to 0.8 for tablets containing SLS. In a conclusion, the addition of pH modifier surfactant; SLS could enhance the dissolution rate of poorly soluble acidic drugs, reduce gastric upset and irritation without any effect on the main characters of the tablets. Moreover, the addition of SLS is very useful in improving the therapeutic activities and reducing the side effects of ASA and SIM for patients who require long-term administration of these drugs. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Aspirin\",\r\n \" Cytokines\",\r\n \" In vitro dissolution\",\r\n \" Simvastatin\",\r\n \" SLS\",\r\n \" Tablets\",\r\n \" Ulcer index\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 100,\r\n \"title\": \"Inam, Sana (57215504323); Irfan, Muhammad Abeer (35069404400); Lali, Noor Ul Ain (57665753700); Syed, Haroon Khalid (35734013600); Asghar, Sajid (35751888600); Khan, Ikram Ullah (57194341390); Khan, Salahuddin Ud Din (57218916034); Iqbal, Muhammad Shahid (57213578076); Zaheer, Imran (57193592227); Khames, Ahmed (24076276400); Abou-Taleb, Heba A. (57197775199); Abourehab, Mohammed A.S. (56641727000)\",\r\n \"authors\": \"Development and Characterization of Eudragit\u00ae EPO-Based Solid Dispersion of Rosuvastatin Calcium to Foresee the Impact on Solubility, Dissolution and Antihyperlipidemic Activity\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85129394271&doi=10.3390%2Fph15040492&partnerID=40&md5=66ce124d72536b9cbe097504c0d55cf7\",\r\n \"affiliations\": \"Department of Pharmaceutics, Government College University Faisalabad, Faisalabad, Pakistan; Department of Medicine, Fatima Jinnah Medical University, Lahore, Pakistan; Department of Biochemistry, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia; Department of Clinical Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Pharmacology, Shaqra University, Shaqra, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Taif University, Taif, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Pharmaceutics, Umm Al-Qura University, Makkah, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Minia University, Minya, Egypt\",\r\n \"abstract\": \"Poor solubility is the major challenge involved in the formulation development of new chemical entities (NCEs), as more than 40% of NCEs are practically insoluble in water. Solid dispersion (SD) is a promising technology for improving dissolution and, thereby, the bioavailability of poorly soluble drugs. This study investigates the influence of a pH-sensitive acrylate polymer, EPO, on the physicochemical properties of rosuvastatin calcium, an antihyperlipidemic drug. In silico docking was conducted with numerous polymers to predict drug polymer miscibility. The screened-out polymer was used to fabricate the binary SD of RoC in variable ratios using the co-grinding and solvent evaporation methods. The prepared formulations were assessed for physiochemical parameters such as saturation solubility, drug content and in vitro drug release. The optimized formulations were further ruled out using solid-state characterization (FTIR, DSC, XRD and SEM) and in vitro cytotoxicity. The results revealed that all SDs profoundly increased solubility as well as drug release. However, the formulation RSE-2, with a remarkable 71.88-fold increase in solubility, presented 92% of drug release in the initial 5 min. The molecular interaction studied using FTIR, XRD, DSC and SEM analysis evidenced the improvement of in vitro dissolution. The enhancement in solubility of RoC may be important for the modulation of the dyslipidemia response. Therefore, pharmacodynamic activity was conducted for optimized formulations. Our findings suggested an ameliorative effect of RSE-2 in dyslipidemia and its associated complications. Moreover, RSE-2 exhibited nonexistence of cytotoxicity against human liver cell lines. Convincingly, this study demonstrates that SD of RoC can be successfully fabricated by EPO, and have all the characteristics that are favourable for superior dissolution and better therapeutic response to the drug. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"anti-hyperlipidemic activity\",\r\n \" docking\",\r\n \" Eudragit\u00ae EPO\",\r\n \" improved solubility\",\r\n \" rosuvastatin calcium\",\r\n \" solid dispersion\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 101,\r\n \"title\": \"Elsayed, Mahmoud M.A. (57218323683); Aboelez, Moustafa O. (57191738528); Elsadek, Bakheet E.M. (36500633700); Sarhan, Hatem Abdelmonsef A. (21740157800); Khaled, Khaled Ali (7003878192); Belal, Amany (55749719800); Khames, Ahmed (24076276400); Hassan, Yasser A.H. (57201672273); Abdel-Rheem, Amany A. (57666064800); Elkaeed, Eslam B. (56884768800); Raafat, Mohamed (56660952500); Elsadek, Mahmoud Elkot Mostafa (57666064900)\",\r\n \"authors\": \"Tolmetin Sodium Fast Dissolving Tablets for Rheumatoid Arthritis Treatment: Preparation and Optimization Using Box-Behnken Design and Response Surface Methodology\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85129365237&doi=10.3390%2Fpharmaceutics14040880&partnerID=40&md5=8151930432ecac5ea27e07844029300f\",\r\n \"affiliations\": \"Faculty of Pharmacy, Sohag, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Cairo, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutical Chemistry, Taif University, Taif, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Taif University, Taif, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Mansoura, Egypt; Department of Pharmaceutical Sciences, Almaarefa University, Riyadh, Saudi Arabia; Department of Pharmacology and Toxicology, Umm Al-Qura University, Makkah, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Tolmetin sodium (TLM) is a non-steroidal anti-inflammatory drug (NSAIDs). TLM is used to treat inflammation, skeletal muscle injuries, and discomfort associated with bone disorders. Because of the delayed absorption from the gastro intestinal tract (GIT), the currently available TLM dosage forms have a rather protracted start to the effect, according to pharmacokinetic studies. The aim of this study was to create a combination for TLM fast dissolving tablets (TLM-FDT) that would boost the drug\u2019s bioavailability by increasing pre-gastric absorption. The TLM-FDTs were developed using a Box-Behnken experimental design with varied doses of crospovidone (CP), croscarmellose sodium (CCS) as super-disintegrants, and camphor as a sublimating agent. In addition, the current study used response surface approach to explore the influence of various formulation and process factors on tablet qualities in order to verify an optimized TLM-FDTs formulation. The optimized TLM-FDTs formula was subsequently evaluated for its in vivo anti-inflammatory activity. TLM-FDTs have good friability, disintegration time, drug release, and wetting time, as well as fast disintegration and dissolution behavior. Significant increase in drug bioavailability and reliable anti-inflammatory efficacy were also observed, as evidenced by considerable reductions in paw thickness in rats following carrageenan-induced rat paw edema. For optimizing and analyzing the effect of super-disintegrants and sublimating agents in the TLM-FDTs formula, the three-factor, three-level full factorial design is a suitable tool. TLM-FDTs are a possible drug delivery system for enhancing TLM bioavailability and could be used to treat rheumatoid arthritis. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Box-Behnken experimental design\",\r\n \" fast disintegrating tablets\",\r\n \" response surface methodology\",\r\n \" tolmetin sodium\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 102,\r\n \"title\": \"Elkomy, Mohammed H. (56176656800); Abou-Taleb, Heba A. (57197775199); Eid, Hussein M. (57189066350); Yassin, Heba A. (57219433769)\",\r\n \"authors\": \"Fabrication and In Vitro\/In Vivo Appraisal of Metronidazole Intra-Gastric Buoyant Sustained-Release Tablets in Healthy Volunteers\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85129179993&doi=10.3390%2Fpharmaceutics14040863&partnerID=40&md5=d57014567b8cdc54c8d02cee061a815a\",\r\n \"affiliations\": \"Department of Pharmaceutics, Jouf University, Sakakah, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics, El Saleheya El Gadida University, El Saleheya El Gadida, Egypt\",\r\n \"abstract\": \"Helicobacter pylori is thought to be the most common cause of peptic and duodenal ulcers. Eradication of this organism is now considered one of the lines of treatment of gastric and duodenal ulcers. This can be achieved via local delivery of antibacterial agents in high concentrations. Accordingly, our objective was to fabricate and evaluate sustained release floating tablets for metronidazole to extend the gastric residence period and control the release rate of metronidazole. Floating tablets containing cellulose derivatives and Avicel were prepared using direct compression. The rate of metronidazole release from the floating tablets (K = 6.278 mg min\u22121\/2 ) was significantly lower than that from conventional tablets (K = 10.666 mg min\u22121\/2 ), indicating sustained drug release, according to the Higuchi model, for more than 6 h in an acidic medium of 0.1 N HCl. In vivo study in healthy volunteers revealed significantly improved bioavailability; increased Tmax, AUC, and MRT; and significantly lower absorption rate constant after a single oral dose of 150 mg metronidazole as floating tablets. In addition, the significant increase in MRT indicated an in vivo sustained drug release. The floating tablets provided several benefits, including ease of preparation, absence of effervescent ingredients, and reliance on a pH-independent gel-forming agent to deliver metronidazole in a sustained manner. In conclusion, the prepared tablets could be promising for enhancing both local and systemic metronidazole efficacy. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"drug delivery system\",\r\n \" floating tablets\",\r\n \" HPLC assay of metronidazole\",\r\n \" in vitro and in vivo evaluation of metronidazole\",\r\n \" sustained-release system\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 103,\r\n \"title\": \"Tammam, Azza S. (57203940949); Gahlan, Ahmed A. (57215860803); Taher, Mahmoud Ahmed (57192438437); Haredy, Ahmed M. (56895997900)\",\r\n \"authors\": \"Hantzsch condensation reaction as a spectrofluorometric method for determination of alogliptin, an antidiabetic drug, in pure form, tablet form, and human and rat plasma\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85124583213&doi=10.1002%2Fbio.4178&partnerID=40&md5=a2904a0be0d71017bee5eb7b799b4aa8\",\r\n \"affiliations\": \"Department of Chemistry, Faculty of Science, Cairo, Egypt; Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"To analyze alogliptin in its pharmaceutical dosage forms and human plasma, a sensitive, inexpensive, simple, and precise spectrofluorimetric method was developed and tested. This method was also used to investigate the drug\u2019s pharmacokinetic behaviour in the blood of rats. This was based on the Hantzsch reaction, which produces yellowish luminous products that can be detected spectrofluorometrically at 480 and 415 nm for emission and excitation, respectively, when the primary amine group in the examined drug reacts with acetylacetone and formaldehyde. Several experimental parameters that affect the reaction product's development and stability were explored and improved. The curve of fluorescence and concentration for alogliptin was linear in the concentration range 0.05\u20133.60 \u03bcg ml\u22121. The proposed approach was validated according to International Council for Harmonization criteria. The method was successfully utilized to evaluate the examined drug in dose formulations and spiked human plasma with high accuracy. \u00a9 2023 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"alogliptin\",\r\n \" antidiabetic drug\",\r\n \" Hantzsch\",\r\n \" human\",\r\n \" pure\",\r\n \" rat plasma\",\r\n \" spectrofluorometric method\",\r\n \" tablet\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 104,\r\n \"title\": \"Abou-Taleb, Heba A. (57197775199); Mustafa, Wesam W. (57397853700); Makram, Tarek Saad (6506095690); Abdelaty, Lamiaa N. (57214763588); Salem, Hesham S. (7102055199); Abdelkader, Hamdy (20336654000)\",\r\n \"authors\": \"Vardenafil Oral Dispersible Films (ODFs) with Advanced Dissolution, Palatability, and Bioavailability\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85125665512&doi=10.3390%2Fpharmaceutics14030517&partnerID=40&md5=d3379221f5dbbc524def6cd9abb94955\",\r\n \"affiliations\": \"Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt; Department of Chemical and Pharmaceutical Sciences, Kingston University, Kingston Upon Thames, United Kingdom; Al-Mustafa University, Baghdad, Iraq; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, 6th October, Egypt; Department of Clinical Pharmacy, Faculty of Pharmacy, 6th October, Egypt; Department of Pharmaceutical Chemistry, Deraya University, New Minia, Egypt; Department of Pharmaceutics, King Khalid University, Abha, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Minya, Egypt\",\r\n \"abstract\": \"Oral, quick response, and on demand, also known as a spontaneous oral treatment for erectile dysfunction, is highly needed by both patients and physicians. Vardenafil is selective (fewer side effects) and more effective in difficult\u2010to\u2010treat conditions than sildenafil. This study aims at fostering the dual objectives of using biomolecules such as artificial sweetening agents to solubilize and mask the bitterness of vardenafil loaded on biodegradable polymeric materials (PVA, MC, SA, and PVP K30) to fabricate oral, fast\u2010dissolving films (vardenafil ODFs) in the mouth without the need for water to ingest the dosage form. Furthermore, coprecipitated\u2010dispersed mixtures of vardenafil and three sweeteners (sorbitol, acesulfame K, and sucralose) were prepared and characterized using FTIR, DSC, and solubility studies. Moreover, eight different vardenafil ODFs were prepared using the solvent\u2010casting method. Modified gustatory sensation test, in vitro disintegration, and release studies were performed. In addition, the optimized ODF (F8) was compared with the commercial film\u2010coated tablets pharmacokinetically (relative bioavailability, onset, and duration of actions were estimated). The results indicated that the three sweetening agents had comparable solubilizing capacity. However, both sucralose\u2010 and acesulfame K\u2010based ODFs have a more enhanced sweet and palatable taste than sorbitol\u2010sweetened ODF. The SA\u2010 and PVP K30\u2010based ODFs showed significantly faster disintegration times and release rates than MC. In conclusion, PVA has good film\u2010forming properties, but a higher ratio of PVA adversely affected the disintegration and release characteristics. The % relative bioavailability for ODF was 126.5%, with a superior absorption rate constant (Ka) of 1.2\u2010fold. The Cmax and estimated Tmax were compared to conventional film-coated tablets. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Acesulfame\",\r\n \" Oral dispersible films\",\r\n \" Sorbitol\",\r\n \" Spontaneity\",\r\n \" Sucralose\",\r\n \" Vardenafil\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 105,\r\n \"title\": \"Haredy, Ahmed M. (56895997900); Derayea, Sayed Mohamed (55530732800); Gahlan, Ahmed A. (57215860803); Omar, Mahmoud Ahmed (15733097700); Saleh, Gamal A. (7003720153)\",\r\n \"authors\": \"Graphene oxide modified glassy carbon electrode for determination of linagliptin in dosage form, biological fluids, and rats' feces using square wave voltammetry\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85122196668&doi=10.1016%2Fj.arabjc.2021.103663&partnerID=40&md5=42cb0ea9deb0ca919f59798443c74b39\",\r\n \"affiliations\": \"Pharmaceutical Analytical Chemistry Department, Merit University, Sohag, Egypt; Department of Analytical Chemistry, Faculty of Pharmacy, Minya, Egypt; Department of Chemistry, Faculty of Science, Cairo, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Asyut, Egypt; Department of Pharmacognosy and Pharmaceutical Chemistry, Taibah University, Medina, Saudi Arabia\",\r\n \"abstract\": \"An applicable square wave anodic adsorptive stripping voltammetric (SWAdASV) technique was utilized for linagliptin determination. A glassy carbon electrode was modified with graphene oxide to increase the electrode reactivity. The method is cheap, accurate, precise, and selective, with a good linearity range and a low detection limit. The proposed method was the first one to determine linagliptin in the feces, which is the main route for excreting the drug from the body. The electrode was characterized using various techniques, including Scanning Electron Microscope (SEM), Fourier-transform infrared (FTIR), and X-ray powder diffraction (XRD), and the oxidation mechanism of the drug was examined. The proposed method has a linear range of 9.45\u2013103.96 ng mL\u22121. The detection limit was 4.0 ng mL\u22121. The modified electrode was employed efficiently to determine the drug in tablet formulations, spiked human urine, plasma, and rats' feces with high recoveries. The proposed method's results were statistically compared with those of another previously published method. \u00a9 2021 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Graphene oxide modified glassy carbon electrode\",\r\n \" Human biological fluids\",\r\n \" Linagliptin\",\r\n \" Rats' Feces\",\r\n \" Square-wave voltammetry\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 106,\r\n \"title\": \"Mahmoud, Samah (57995805700); Gaber, Yasser (36621001600); Khattab, Rania Abdelmonem (55620838000); Bakeer, Walid I. (37115255400); Dishisha, Tarek (55258477100); Ramadan, Mohamed Abdelhalim (59796543400)\",\r\n \"authors\": \"The inhibitory effect of dextranases from Bacillus velezensis and Pseudomonas stutzeri on Streptococcus mutans biofilm\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85143517796&doi=10.18502%2Fijm.v14i6.11260&partnerID=40&md5=907ce8a030b922b0acfe553a4338029f\",\r\n \"affiliations\": \"Department of Microbiology and Immunology, Faculty of Pharmacy, Beni Suef, Egypt; Department of Microbiology and Immunology, Merit University, Sohag, Egypt; Department of Microbiology and Immunology, Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutics and Pharmaceutical Technology, Mutah University, Karak, Jordan; Faculty of Pharmacy, Cairo, Egypt\",\r\n \"abstract\": \"Background and Objectives: Dental caries is a breakdown of the teeth enamel due to harmful bacteria, lack of oral hygiene, and sugar consumption. The acid-producing bacterium Streptococcus mutans is the leading cause of dental caries. Dextra-nase is an enzyme that can degrade dextran to low molecular weight fractions, which have many therapeutic and industrial applications. The purpose of the present study was to isolate a novel dextranase-producing bacteria from a source (molasses). The cell-free extracts containing dextranases were tested as antibiofilm agents. Materials and Methods: Dextranase-producing bacteria were identified using phenotypic and genotypic methods such as 16S rRNA gene sequencing and enzymatic characterization. Results: The highest six dextranase-producing bacterial isolates were Bacillus species. The best conditions for dextranase productivity were obtained after 72 hours of culture time at pH 7. The addition of glucose to the medium enhanced the production of the enzymes. The cell-free extract of the six most active isolates showed remarkable activity against biofilm formation by Streptococcus mutans ATCC 25175. The highest inhibition activities reached 60% and 80% for Bacillus velezensis and Pseudomonas stutzeri, respectively. Conclusion: Therefore, our study added to the current dextranase-producing bacteria with potential as a source of dextra-nases. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Bacillus velezensis\",\r\n \" Biofilm\",\r\n \" Dextranase\",\r\n \" Molasses\",\r\n \" Streptococcus mutans\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 107,\r\n \"title\": \"Elkomy, Mohammed H. (56176656800); Eid, Hussein M. (57189066350); Elmowafy, Mohammed (55813135300); Shalaby, Khaled (36950469600); Zafar, Ameeduzzafar (36987334900); Abdelgawad, Mohamed A. (57189208661); Rateb, Mostafa Ezzat M. (16317169000); Ali, Mohammed R.A. (57188687759); Alsalahat, Izzeddin M.M. (36676946100); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85136056599&doi=10.1080%2F10717544.2022.2110997&partnerID=40&md5=dc05b9bd23fa66a25bbbee2361441381\",\r\n \"affiliations\": \"Department of Pharmaceutics, Jouf University, Sakakah, Saudi Arabia; Faculty of Pharmacy, Beni Suef, Egypt; Department of Pharmaceutical Chemistry, Jouf University, Sakakah, Saudi Arabia; Engineering & Physical Sciences, University of the West of Scotland, Ayr, United Kingdom; Faculty of Pharmacy, Beni Suef, Egypt; Cardiff University School of Medicine, Cardiff, United Kingdom; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Diabetes mellitus is a life-threatening metabolic disease. At the moment, there is no effective treatment available to combat it. In this study, we aimed to develop berberine-loaded bilosomes (BER-BLS) to boost the oral bioavailability and therapeutic efficacy of berberine, a natural antidiabetic medication. The BER-BLS was fabricated using a thin-film hydration strategy and optimized using a central composite design (face-centered). The average vesicle size, entrapment efficiency, and surface charge of the optimized BER-BLS preparation were 196.5 nm, 89.7%, (\u2212) 36.4 mV, respectively. In addition, it exhibited higher stability and better-sustained release of berberine than the berberine solution (BER-SOL). BER-BLS and BER-SOL were administered to streptozocin-induced diabetic rats. The optimized BER-BLS formulation had a significant hypoglycemic impact, with a maximum blood glucose decrease of 41%, whereas BER-SOL only reduced blood glucose by 19%. Furthermore, the pharmacological effect of oral BER-BLS and BER-SOL corresponded to 99.3% and 31.7%, respectively, when compared to subcutaneous insulin (1 IU). A pharmacokinetic analysis found a 6.4-fold rise in the relative bioavailability of berberine in BER-BLS when compared to BER-SOL at a dosage of 100 mg\/kg body weight. Histopathological investigation revealed that BER-BLS is suitable for oral administration. Our data demonstrate that BLS is a potential nanocarrier for berberine administration, enhancing its oral bioavailability and antidiabetic activity. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Berberine\",\r\n \" bile salts\",\r\n \" bilosomes\",\r\n \" bioavailability\",\r\n \" diabetes mellitus\",\r\n \" optimization\",\r\n \" pharmacokinetics\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 108,\r\n \"title\": \"Kachanathu, Shaji John (55652551700); Abdulwahab, Sami S. (25957549200); Hafez, Ashraf Ramadan (55546986100); Aldaihan, Mishal M. (57656956700); Nuhmani, Shibili (55266417800); Rizvi, Moattar Raza (56352155800)\",\r\n \"authors\": \"A randomised controlled trial between hamstring muscle tightness and lumbar lordotic angle\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85132721515&doi=10.3920%2FCEP220001&partnerID=40&md5=9e6b0fd5c8a3aef112584b1e270f66c7\",\r\n \"affiliations\": \"College of Applied Medical Sciences, Riyadh, Saudi Arabia; Orthopedic Physical Therapy, Merit University, Sohag, Egypt; College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; Manav Rachna International Institute of Research and Studies, Faridabad, India\",\r\n \"abstract\": \"Shortening of the hamstring muscles is a common problem in both symptomatic and asymptomatic individuals. Low back pain and injury caused by postural deficits might be caused by an imbalance of this muscle. The various degrees of hamstring muscle stiffness and its impact on trunk postures are relatively unknown. The goal of this study was to see how different hamstring muscle length (HML) ranges influenced lumbar lordotic angle (LLA). Sixty asymptomatic healthy male and female subjects with a mean age of 40.4\u00b19.2 years and a body mass index of 25.5\u00b1 2.2 kg\/m2 participated in this study. Subjects were randomly assigned to one of three groups (n=20) with hamstring muscle lengths of 111-120 degrees, 121-130 degrees, or 131-140 degrees, respectively by using a random number generator. The LLA was estimated on a lateral lumbosacral radiograph using the Kinovea application, and hamstring muscle length was measured using the active knee extension test at the university\u2019s rehabilitation centre within a week of subject selection. The Pearson correlation test was used to examine the relationship between LLA and HML, and one-way ANOVA was used to compare the two groups. The correlation coefficients were expressed using 95% confidence intervals. A significant relationship between LLA and HML was observed in 111-120 degrees and 121-130 degrees groups (P<0.05), whereas, the HML >130 degrees group had no influence on LLA (P>0.05). The findings show that hamstring muscle tightness between 111 and 130 degrees has a negative impact on lumbar curvature mechanisms. As a result, hamstring muscle tightness less than 130 degrees should be addressed first in clinical stretching programs for patients. The findings also suggest that instead of focusing on HML, rehabilitation specialists should devote more time to other high-priority interventions, particularly in patients with hamstring muscle lengths greater than 130 degrees \u00a9 2024 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Cobb\u2019s angle\",\r\n \" Hamstrings tightness\",\r\n \" Lumbar lordotic angle\",\r\n \" Posture\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 109,\r\n \"title\": \"Yassin, Heba A. (57219433769); Ibrahim, Mohamed Abbas (58516410900); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Aceclofenac-Loaded Microspheres Prepared by Vesicular Ionotropic Gelation to Minimize Drug-induced Gastric Ulcers in Rats\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85132592647&doi=10.2174%2F1389200223666220321111214&partnerID=40&md5=87e2c884931228ca7d5dd0c2b802c254\",\r\n \"affiliations\": \"Department of Pharmaceutics, El Saleheya El Gadida University, El Saleheya El Gadida, Egypt; Department of Pharmaceutics, College of Pharmacy, Riyadh, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Background: Aceclofenac is a non-steroidal anti-inflammatory drug and a potent analgesic. However, its oral ingestion may cause gastrointestinal problems, including dyspepsia, abnormal pain, nausea, diarrhea, and ulcera-tive colitis. Objective: This study aimed to prepare vesicular-based enteric microspheres containing aceclofenac by ionotropic gelation technique to minimize gastric irritation in rats. Methods: The micron-size vesicles were prepared by the ionic-orifice gelation method. Three types of vesicular-based microcapsules containing aceclofenac were prepared by employing sodium alginate as the coating material in combination with Eudragit L100, Eudragit S100, and polyvinylpyrrolidone PVP K90. The drug to sodium alginate to polymer ratios were 1:0.5:0.5, 1:1:1, and 1:1.5:1.5, respectively. Gelation of sodium alginate was induced by the dropwise addition of calcium chloride solution (10 % w\/v). Aceclofenac-loaded microspheres were evaluated in terms of aceclofenac content and in vitro drug release, and FTIR, DSC, and XRD were used for physicochemical evaluation of some selected formulae. The effects of microencapsulation on aceclofenac-induced ulcerative activity in male Wistar rats were also investigated. Results: The results indicated no interaction between aceclofenac and microcapsules forming polymers. In addition, microcapsules formulations M1, M4, and M7 gave maximal protection in acidic pH and optimal release in alkaline pH. The histopathological studies revealed that the reduction of ulceration is evident from the macroscopic and mi-croscopic studies, which showed complete protection of the tissue morphology with no ulcers, indicating the effec-tiveness of the microcapsules system against aceclofenac-induced gastric ulceration in rats again. Conclusion: Ionotropic gelation seems to be a simple, efficient technique to prepare aceclofenac-loaded micro-spheres with a reduced risk of gastric ulceration. It is possible to overcome the problem of gastric damage while utilizing aceclofenac by avoiding the exposure of the drug to the ulcer-prone area of the gastrointestinal tract. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Aceclofenac\",\r\n \" enteric microspheres\",\r\n \" in vitro release\",\r\n \" induced gastric ulcer\",\r\n \" ionotropic gelation\",\r\n \" rheumatoid arthritis\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 110,\r\n \"title\": \"Mohammed, Sherine Ahmed (57204465191); Alm, Ahmed Salah (57677914400)\",\r\n \"authors\": \"Role of macrophages in liver cirrhosis: fibrogenesis and resolution\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85129813810&doi=10.5115%2Facb.21.046&partnerID=40&md5=e859ff89dc4b735129abb9db0c59c821\",\r\n \"affiliations\": \"Histology Department, Faculty of Medicine, Sohag, Egypt; Histology Department, Faculty of Medicine, Sohag, Egypt\",\r\n \"abstract\": \"At present, chronic liver disease accounts for approximately 2 million deaths per year worldwide. Liver injury induces a series of events causing inflammation. Chronic inflammation ends in liver fibrosis. A stage of fibrinolysis occurs on stopping insult. Kupffer cells play their role to initiate inflammatory responses, while infiltrating monocyte-derived macrophages have a role both in chronic inflammation and fibrosis and in fibrosis resolution. Ly-6C high expressing monocytes act during fibrogenesis, while Ly-6C low expressing monocytes are restorative macrophages which promote resolution of fibrosis after end of the injury. Recent studies have identified new phenotypes, such as metabolically activated M, oxidized, which may have a role in fatty liver diseases \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Fibrosis\",\r\n \" Liver cirrhosis\",\r\n \" Liver cirrhosis\",\r\n \" Macrophages\",\r\n \" Macrophages\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 111,\r\n \"title\": \"Saddik, Mohammed S. (57214806788); Elsayed, Mahmoud M.A. (57218323683); El-Mokhtar, Mohamed Ahmed (57190683185); Sedky, Haitham (57336971600); Abdel-Aleem, Jelan A. (55390544500); Abu-Dief, Ahmed M. (36969028400); Al-Hakkani, Mostafa F. (57205123273); Hussein, Hazem L. (57402916200); Al-Shelkamy, Samah A. (57210421025); Meligy, Fatma Y. (55043152000); Khames, Ali (57193826810); Abou-Taleb, Heba A. (57197775199)\",\r\n \"authors\": \"Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85122446537&doi=10.3390%2Fpharmaceutics14010111&partnerID=40&md5=8198086e6dfdd6d778b03b4d805162e2\",\r\n \"affiliations\": \"Faculty of Pharmacy, Sohag, Egypt; Department of Medical Microbiology and Immunology, Faculty of Medicine, Asyut, Egypt; Faculty of Medicine, Asyut, Egypt; Department of Industrial Pharmacy, Faculty of Pharmacy, Asyut, Egypt; Department of Chemistry, Taibah University, Medina, Saudi Arabia; Faculty of Science, Sohag, Egypt; Department of Chemistry, Faculty of Science, Cairo, Egypt; Department of Chemistry, Faculty of Science, Kharga, Egypt; Department of Dermatology, Al-Azhar University, Cairo, Egypt; Department of Physics, Faculty of Science, Kharga, Egypt; Department of Histology, Faculty of Medicine, Asyut, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sohag, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Merit University, Sohag, Egypt\",\r\n \"abstract\": \"Skin is the largest mechanical barrier against invading pathogens. Following skin injury, the healing process immediately starts to regenerate the damaged tissues and to avoid complications that usually include colonization by pathogenic bacteria, leading to fever and sepsis, which further impairs and complicates the healing process. So, there is an urgent need to develop a novel pharmaceutical material that promotes the healing of infected wounds. The present work aimed to prepare and evaluate the efficacy of novel azithromycin-loaded zinc oxide nanoparticles (AZM-ZnONPs) in the treatment of infected wounds. The Box\u2013Behnken design and response surface methodology were used to evaluate loading efficiency and release characteristics of the prepared NPs. The minimum inhibitory concentration (MIC) of the formulations was determined against Staphylococcus aureus and Escherichia coli. Moreover, the anti-bacterial and wound-healing activities of the AZM-loaded ZnONPs impregnated into hydroxyl propyl methylcellulose (HPMC) gel were evaluated in an excisional wound model in rats. The prepared ZnONPs were loaded with AZM by adsorption. The prepared ZnONPs were fully characterized by XRD, EDAX, SEM, TEM, and FT-IR analysis. Particle size distribution for the prepared ZnO and AZM-ZnONPs were determined and found to be 34 and 39 nm, respectively. The mechanism by which AZM adsorbed on the surface of ZnONPs was the best fit by the Freundlich model with a maximum load capacity of 160.4 mg\/g. Anti-microbial studies showed that AZM-ZnONPs were more effective than other controls. Using an experimental infection model in rats, AZM-ZnONPs impregnated into HPMC gel enhanced bacterial clearance and epidermal regeneration, and stimulated tissue formation. In conclusion, AZM-loaded ZnONPs are a promising platform for effective and rapid healing of infected wounds. \u00a9 2022 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"Azithromycin\",\r\n \" Metal nanoparticles\",\r\n \" Wound healing\",\r\n \" Zinc oxide nanoparticles\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 112,\r\n \"title\": \"Mohamed, Samira Mahmoud (57263883500); Mohammed, Doha Saber (37026811800); Abd Elhaliem, Nesreen Gamal (55734409700); Elbadry, Mahmoud I. (56814732100); Abu-Dief, E. E. (8927490800)\",\r\n \"authors\": \"Mangosteen Can Improve Steatohepatitis through Modulating Inflammatory and Autophagy\/Apoptosis Cell Injury: An Animal Model Study\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85115168729&doi=10.3103%2FS0095452721050091&partnerID=40&md5=ea15ef8c81444a4a2e12418e087014ea\",\r\n \"affiliations\": \"Department of Histology, Faculty of Medicine, Sohag, Egypt; Department of Internal Medicine, Faculty of Medicine, Sohag, Egypt; Department of Histology, Faculty of Medicine, Sohag, Egypt\",\r\n \"abstract\": \"Abstract-Background:: Non-alcoholic fatty liver disease (NAFLD) is characterized by triglycerides deposition in hepatocytes causing their injury and leading to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Mangosteen (MG) is a tropical fruit that contains a lot of bioactive anti-oxidant, and anti-adipogenic compounds. Aim: To investigate the ability of MG to ameliorate NAFLD\/NASH and its role in the regulation of apoptosis and autophagy within the injured hepatocytes. Materials and Methods: A total number of 50 adult male mice were divided into 5 groups: GI were fed with standard diet, GII were fed with high fat diet (HFD), GIII were fed with HFD concomitant with MG by oral gavage for 16 weeks, GIV were fed with HFD for 16 weeks followed by MG for 2 weeks, and GV were fed with HFD for 16 weeks followed by standard diet (SD) for 2 weeks. Results: MG reduced body weight gain, liver weight coefficient, and plasma free fatty acids levels. There was a decrease in lipid accumulation with improved liver function. Most of the histopathological changes observed in NASH were ameliorated. Immunohistochemical results showed that MG increased autophagy process and suppressed hepatocyte apoptosis. There was a significant decrease in CD68 positive macrophages and a significant decrease in \u03b1-SMA expression. Conclusions: MG exerts effects by regulating hepatic lipid homeostasis, inflammation, apoptosis, and autophagy. Therefore, it could be a new approach to a dietary based method that suspends the onset and development of steatohepatitis, liver cirrhosis and HCC risk by the prevention and management of NAFLD\/\/NASH. \u00a9 2021 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"apoptosis\",\r\n \" autophagy\",\r\n \" mangosteen\",\r\n \" non-alcoholic fatty liver disease\",\r\n \" steatohepatitis\"\r\n ],\r\n \"year\": \"2025\"\r\n },\r\n {\r\n \"id\": 113,\r\n \"title\": \"Ahmed, Hala Rady (57222980979); Waly, Nancy Gamil Fawzy M. (57212513648); Abd El-Baky, Rehab Mahmoud (30067553600); Yahia, Ramadan (57216081885); Hetta, Helal F. (55939372100); Elsayed, Amr M. (57213973155); Ibrahem, Reham Ali (57214752474)\",\r\n \"authors\": \"Distribution of naturally -occurring NS5B resistance-associated substitutions in Egyptian patients with chronic Hepatitis C\",\r\n \"link\": \"https:\/\/www.scopus.com\/inward\/record.uri?eid=2-s2.0-85104346974&doi=10.1371%2Fjournal.pone.0249770&partnerID=40&md5=fdc3696bb9445e91353ab9dcd326e3cc\",\r\n \"affiliations\": \"Department of Microbiology and Immunology, Faculty of Pharmacy, Minya, Egypt; Department of Microbiology and Immunology, Deraya University, New Minia, Egypt; Department of Medical Microbiology and Immunology, Faculty of Medicine, Asyut, Egypt; Department of Medical Microbiology and Immunology, Faculty of Medicine, Sohag, Egypt; Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Minya, Egypt\",\r\n \"abstract\": \"Background NS5B polymerase inhibitors represent the cornerstone of the present treatment of Hepatitis C virus infection (HCV). Naturally occurring substitution mutations to NS5B inhibitors have been recorded. The current study intended to demonstrate possible natural direct acting antiviral (DAA)\u2014mutations of the HCV NS5B region in HCV patients in Minia governorate, Egypt. Methods Samples were collected from 27 treatment-na\u00efve HCV patients and 8 non-responders. Out of 27 treatment-na\u00efve patients, 17 NS5B sequences (amino acids 221\u2013345) from treatment-na\u00efve patients and one sample of non-responders were successfully amplified. Nucleotide sequences have been aligned, translated into amino acids, and compared to drug resistance mutations reported in the literature. Results NS5B amino acid sequence analysis ensures several novel NS5B mutations existence (more than 40 substitution mutations) that have not been previously documented to be correlated with a resistant phenotype. It was found that K304R (82.4%), E327D and P300T (76.5% each) substitutions were the most distributed in the tested samples, respectively. S282T, the major resistance mutation that induces high sofosbuvir-resistance level in addition to other reported mutations (L320F\/C) and (C316Y\/N) were not recognized. Q309R mutation is a ribavirin-associated resistance, which was recognized in one strain (5.9%) of genotype 1g sequences. Besides, one substitution mutation (E237G) was identified in the successfully amplified non-responder sample. Conclusion Our study showed various combinations of mutations in the analyzed NS5B genes which could enhance the possibility of therapy failure in patients administered regimens including multiple DAA. \u00a9 2021 Elsevier B.V., All rights reserved.\",\r\n \"keywords\": [\r\n \"\"\r\n ],\r\n \"year\": \"2025\"\r\n }\r\n]\r\n \r\n \/\/alert(publications.length)\r\n displayPublications(publications);\r\n updateResultsCount(publications.length);\r\n populateFilters();\r\n\r\n \/\/ Add event listeners\r\n document.getElementById('searchButton').addEventListener('click', performSearch);\r\n document.getElementById('searchInput').addEventListener('keyup', function (event) {\r\n if (event.key === 'Enter') {\r\n performSearch();\r\n }\r\n });\r\n\r\n document.getElementById('authorFilter').addEventListener('change', performSearch);\r\n document.getElementById('keywordFilter').addEventListener('change', performSearch);\r\n document.getElementById('yearFilter').addEventListener('change', performSearch);\r\n \/\/ Initialize the page\r\n \r\n \r\n\r\n\r\n \r\n\r\n \r\n\r\n \/\/ Display publications in the UI\r\n function displayPublications(publications) {\r\n const publicationsList = document.getElementById('publicationsList');\r\n publicationsList.innerHTML = '';\r\n\r\n if (publications.length === 0) {\r\n publicationsList.innerHTML = '<div class=\"no-results\">No publications found matching your criteria.<\/div>';\r\n return;\r\n }\r\n\r\n publications.forEach(pub => {\r\n const pubElement = document.createElement('div');\r\n pubElement.className = 'publication-card';\r\n\r\n pubElement.innerHTML = `\r\n <h2 class=\"publication-title\">${pub.authors}<\/h2>\r\n <p class=\"authors\">${pub.title}<\/p>\r\n <p class=\"affiliations\">${pub.affiliations}<\/p>\r\n <p class=\"abstract\">${truncateText(pub.abstract, 500)}<\/p>\r\n <div class=\"keywords\">\r\n ${pub.keywords.map(keyword => `<span class=\"keyword\">${keyword}<\/span>`).join('')}\r\n <\/div>\r\n <a href=\"${pub.link}\" target=\"_blank\" class=\"details-link\">View Details on Scopus<\/a>\r\n `;\r\n\r\n publicationsList.appendChild(pubElement);\r\n });\r\n }\r\n\r\n \/\/ Truncate text to a specified length\r\n function truncateText(text, maxLength) {\r\n if (text.length <= maxLength) return text;\r\n return text.substring(0, maxLength) + '...';\r\n }\r\n\r\n \/\/ Update the results count\r\n function updateResultsCount(count) {\r\n document.getElementById('resultsCount').textContent = count;\r\n }\r\n\r\n \/\/ Populate filter dropdowns\r\n function populateFilters() {\r\n const authorFilter = document.getElementById('authorFilter');\r\n const keywordFilter = document.getElementById('keywordFilter');\r\n\r\n \/\/ Extract unique authors and keywords\r\n const authors = new Set();\r\n const keywords = new Set();\r\n\r\n publications.forEach(pub => {\r\n \/\/ Add all authors\r\n pub.title.split(';').forEach(author => {\r\n authors.add(author.trim());\r\n });\r\n\r\n \/\/ Add all 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Research Publications Database Merit University – Scopus Indexed Publications Search Filter by Author All Authors Filter by Keyword All Keywords Filter by Year All Years20252024 Showing 1 publications Research Publications Database © 2025 | Merit University<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18862","page","type-page","status-publish","hentry"],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"admin","author_link":"https:\/\/merit.edu.eg\/main\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":" <a href=\"https:\/\/merit.edu.eg\/main\/en\/\" rel=\"tag\">English<\/a>","rttpg_excerpt":"Struggling Student System Please Wait….. Research Publications Database Merit University – Scopus Indexed Publications Search Filter by Author All Authors Filter by Keyword All Keywords Filter by Year All Years20252024 Showing 1 publications Research Publications Database © 2025 | Merit University","_links":{"self":[{"href":"https:\/\/merit.edu.eg\/main\/wp-json\/wp\/v2\/pages\/18862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/merit.edu.eg\/main\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/merit.edu.eg\/main\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/merit.edu.eg\/main\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/merit.edu.eg\/main\/wp-json\/wp\/v2\/comments?post=18862"}],"version-history":[{"count":13,"href":"https:\/\/merit.edu.eg\/main\/wp-json\/wp\/v2\/pages\/18862\/revisions"}],"predecessor-version":[{"id":18889,"href":"https:\/\/merit.edu.eg\/main\/wp-json\/wp\/v2\/pages\/18862\/revisions\/18889"}],"wp:attachment":[{"href":"https:\/\/merit.edu.eg\/main\/wp-json\/wp\/v2\/media?parent=18862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}